메뉴 건너뛰기




Volumn 123, Issue 2, 1993, Pages 204-215

Neuronal vacuolization and necrosis induced by the noncompetitive N-methyl-D-aspartate (NMDA) antagonist MK(+)801 (dizocilpine maleate): A light and electron microscopic evaluation of the rat retrosplenial cortex

Author keywords

[No Author keywords available]

Indexed keywords


EID: 0027521274     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1993.1153     Document Type: Article
Times cited : (235)

References (29)
  • 1
    • 0025057202 scopus 로고
    • Phencyclidine, dizocil-pine, and cerebrocortical neurons
    • Allen, H. L., and L. L. Iversen. 1990. Phencyclidine, dizocil-pine, and cerebrocortical neurons. Science 247: 221.
    • (1990) Science , vol.247 , pp. 221
    • Allen, H.L.1    Iversen, L.L.2
  • 2
    • 84936053394 scopus 로고
    • Détection and confirmation of neuronal necrosis in toxicity studies. Vet
    • Abstract
    • Anderson, T. D., R. Arceo, Z. Rüben, and D. Feldman. 1992. Détection and confirmation of neuronal necrosis in toxicity studies. Vet. Pathoi 29: 465. [Abstract].
    • (1992) Pathoi , vol.29 , pp. 465
    • Anderson, T.D.1    Arceo, R.2    Rüben, Z.3    Feldman, D.4
  • 3
    • 84921174154 scopus 로고
    • A time sequence study of neuronal vacuoles induced by dextrorphan hydrochloride (DH) in the rat: Light and electrón microscopic observations
    • press
    • Arceo, R., L. Kaufman, D. Feldman, Z. Rüben, and T. D. Anderson. 1993. A time sequence study of neuronal vacuoles induced by dextrorphan hydrochloride (DH) in the rat: Light and electrón microscopic observations. Toxicol. Pathoi. 21: in press.
    • (1993) Toxicol. Pathoi , vol.21
    • Arceo, R.1    Kaufman, L.2    Feldman, D.3    Rüben, Z.4    Anderson, T.D.5
  • 4
    • 0027116042 scopus 로고
    • Bench to bedside: The glutamate connec tion
    • Choi, D. W. 1992. Bench to bedside: The glutamate connec tion. Science 258: 241-243.
    • (1992) Science , vol.258 , pp. 241-243
    • Choi, D.W.1
  • 5
    • 0024433455 scopus 로고
    • Keta-mine and MK 801 prevent degeneration of thalamic neurons induced by focal cortical seizures. Exp
    • Clifford, D. B., C. F. Zorumski, and J. W. Olney. 1989. Keta-mine and MK 801 prevent degeneration of thalamic neurons induced by focal cortical seizures. Exp. Neurol, 105: 272-279.
    • (1989) Neurol , vol.105 , pp. 272-279
    • Clifford, D.B.1    Zorumski, C.F.2    Olney, J.W.3
  • 6
    • 0020078583 scopus 로고
    • Central sympathomimetic activity of (+)-5-methyl-10, ll-5H-dibenzo[a, d]cyclohepten-5, 10-imine (MK801), a substance with potent anticonvuisant, central sympathomimetic, and apparent anxiolytic properties
    • Clineschmidt, B. V., G. E. Martin, P. R. Bunting, and N. L. Papp. 1992. Central sympathomimetic activity of (+)-5-methyl-10, ll-5H-dibenzo[a, d]cyclohepten-5, 10-imine (MK801), a substance with potent anticonvuisant, central sympathomimetic, and apparent anxiolytic properties. Drug Dev, Res. 2: 135-145.
    • (1992) Drug Dev, Res , vol.2 , pp. 135-145
    • Clineschmidt, B.V.1    Martin, G.E.2    Bunting, P.R.3    Papp, N.L.4
  • 7
    • 0001936444 scopus 로고
    • General pathoiogy of neurons and neuro-glia
    • J. H. Adams, J. A. N. Cor-sellis, and L. W. Duchen, Eds.), John Wiley and Sons, New York
    • Duchen, L. W. 1984. General pathoiogy of neurons and neuro-glia. In Greenfield's Neuropathology (J. H. Adams, J. A. N. Cor-sellis, and L. W. Duchen, Eds.), pp. 1-52. John Wiley and Sons, New York.
    • (1984) Greenfield's Neuropathology , pp. 1-52
    • Duchen, L.W.1
  • 9
    • 0343100182 scopus 로고
    • Dose-dependent neuronal degeneration induced by the NMDA antagonist MK{+)801 in the rat cerebral cortex
    • Abstract
    • Fix, A. S., K. A. Wightman, C. A. Johnson, L. Truex, R. Smith, E. Gomez, G. G. Long, and R. W. Storts. 1992. Dose-dependent neuronal degeneration induced by the NMDA antagonist MK{+)801 in the rat cerebral cortex. Vet. PathoL 29; 447. [Abstract].
    • (1992) Vet. Pathol , vol.29 , pp. 447
    • Fix, A.S.1    Wightman, K.A.2    Johnson, C.A.3    Truex, L.4    Smith, R.5    Gomez, E.6    Long, G.G.7    Storts, R.W.8
  • 10
    • 0023273862 scopus 로고
    • The novel anticonvul-sant MK-801 binds to the activated state of the iV-methyl-Daspartate receptor in rat brain
    • Foster, A. C., and E. H. F. Wong. 1987. The novel anticonvul-sant MK-801 binds to the activated state of the iV-methyl-Daspartate receptor in rat brain. Br. J. Pharmacol. 91: 403-409.
    • (1987) Br. J. Pharmacol , vol.91 , pp. 403-409
    • Foster, A.C.1    Wong, E.H.F.2
  • 11
    • 0023941585 scopus 로고
    • MK-801 is neuroprotective in gerbils when administered during the post-ischemic period
    • Gill, R., A. C. Foster, and G. N. Woodruff. 1988. MK-801 is neuroprotective in gerbils when administered during the post-ischemic period. Neuroscience 25: 847-855.
    • (1988) Neuroscience , vol.25 , pp. 847-855
    • Gill, R.1    Foster, A.C.2    Woodruff, G.N.3
  • 12
    • 0001249750 scopus 로고
    • Block of iV-methyl-D-aspartate-activated current by the anticonvuisant MK-801: Selective bin din g to open channels
    • Huettner, J. E., and B. P. Bean. 1988. Block of iV-methyl-D-aspartate-activated current by the anticonvuisant MK-801: Selective bin din g to open channels. Proc. Natl. Acad. Sei. USA 85: 1307-1311.
    • (1988) Proc. Natl. Acad. Sei. USA , vol.85 , pp. 1307-1311
    • Huettner, J.E.1    Bean, B.P.2
  • 13
    • 0343762855 scopus 로고
    • NMDA antagonista induce pathomorphologicâl changes in cerebrocorti-cal neurons
    • Abstr, Abstract
    • Labruyere, J., M. T. Price, and J. W. Olney. 1989. NMDA antagonista induce pathomorphologicâl changes in cerebrocorti-cal neurons. Soc. Neurosci. Abstr. 15: 761. [Abstract].
    • (1989) Soc. Neurosci , vol.15 , pp. 761
    • Labruyere, J.1    Price, M.T.2    Olney, J.W.3
  • 14
    • 0026576890 scopus 로고
    • Does modulation of glu-taminergic function represent a viable therapeutic strategy in Alzheimer's disease?
    • Lawlor, B. A., and K. L. Davis. 1992. Does modulation of glu-taminergic function represent a viable therapeutic strategy in Alzheimer's disease? Biol. Psychiatry 31: 337-350.
    • (1992) Biol. Psychiatry , vol.31 , pp. 337-350
    • Lawlor, B.A.1    Davis, K.L.2
  • 15
    • 0026569410 scopus 로고
    • Models of neuronal injury in AIDS: Another role for the NMDA receptor?
    • Lipton, S. A. 1992. Models of neuronal injury in AIDS: Another role for the NMDA receptor? Trends Neurosci. 15: 75-79.
    • (1992) Trends Neurosci , vol.15 , pp. 75-79
    • Lipton, S.A.1
  • 16
    • 0026087014 scopus 로고
    • Ischemic brain disease-prevention with compétitive and non-competitive antagonists of ÀT-methyl-D-aspartate receptors
    • Mcculloch, J. 1991. Ischemic brain disease-prevention with compétitive and non-competitive antagonists of ÀT-methyl-D-aspartate receptors. Drug Res. 41: 319-324.
    • (1991) Drug Res , vol.41 , pp. 319-324
    • McCulloch, J.1
  • 17
    • 0026076110 scopus 로고
    • Autoradiographic as-sessment of the effects of iV-methyl-D-asparate receptor antagonists in vivo
    • Mcculloch, J., and L. L. Iversen. 1991. Autoradiographic as-sessment of the effects of iV-methyl-D-asparate receptor antagonists in vivo. Neurochem. Res. 16: 951-963.
    • (1991) Neurochem. Res , vol.16 , pp. 951-963
    • McCulloch, J.1    Iversen, L.L.2
  • 18
    • 0024596865 scopus 로고
    • The excitatory amino acid receptors: Their classes, pharmacology, and distinct properties in the function of the central nervous system
    • Monaghan, D. T., R. J. Bridges, and C. W. Cotman. 1989. The excitatory amino acid receptors: Their classes, pharmacology, and distinct properties in the function of the central nervous system. Annu. Rev. Pharmacol. Toxicol. 29: 365-402.
    • (1989) Annu. Rev. Pharmacol. Toxicol , vol.29 , pp. 365-402
    • Monaghan, D.T.1    Bridges, R.J.2    Cotman, C.W.3
  • 19
    • 0020263571 scopus 로고
    • The toxic effects of glutamate and related compounds irv the retina and brain
    • Olney, J. W, 1982. The toxic effects of glutamate and related compounds irv the retina and brain. Retina 2: 341-359.
    • (1982) Retina , vol.2 , pp. 341-359
    • Olney, J.W.1
  • 20
    • 0024356295 scopus 로고
    • Excitotoxicity and iV-methyl-D-aspartate receptors
    • Olney, J. W. 1989. Excitotoxicity and iV-methyl-D-aspartate receptors. Drug Dev. Res. 17: 299-319.
    • (1989) Drug Dev. Res , vol.17 , pp. 299-319
    • Olney, J.W.1
  • 21
    • 0024338054 scopus 로고
    • Pathologi-cal changes induced in cerebrocortical neurons by phencyclidine and related drugs
    • Olney, J. W., J. Labruyere, and M. T. Price. 1989. Pathologi-cal changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science 244: 1360-1362.
    • (1989) Science , vol.244 , pp. 1360-1362
    • Olney, J.W.1    Labruyere, J.2    Price, M.T.3
  • 25
    • 0022620257 scopus 로고
    • Glutamate and the pathophysiology of hypoxic-ischemic brain damage
    • Rothman, S. M., and J. W. Olney. 1986. Glutamate and the pathophysiology of hypoxic-ischemic brain damage. Ann. Neurol. 19: 105-111.
    • (1986) Ann. Neurol , vol.19 , pp. 105-111
    • Rothman, S.M.1    Olney, J.W.2
  • 26
    • 84989476563 scopus 로고
    • Heat shock protein (HSP72) response to NMDA antagonists is blocked by anticholinergics or gabamimetics. Soc. Neurosci
    • Sesma, M. A., M. T. Price, and J. W. Olney. 1991. Heat shock protein (HSP72) response to NMDA antagonists is blocked by anticholinergics or gabamimetics. Soc. Neurosci. Abstr. 17: 254.
    • (1991) Abstr , vol.17 , pp. 254
    • Sesma, M.A.1    Price, M.T.2    Olney, J.W.3
  • 27
    • 0025786634 scopus 로고
    • MK-801 and ketamine induce heat shock protein HSP72 in injured neurons in posterior cingulate and retrosplenial cortex
    • Sharp, F. R., P. Jasper, J. Hall, L. Noble, and S. Sagar. 1991. MK-801 and ketamine induce heat shock protein HSP72 in injured neurons in posterior cingulate and retrosplenial cortex. Ann. Neurol. 30: 801-809.
    • (1991) Ann. Neurol , vol.30 , pp. 801-809
    • Sharp, F.R.1    Jasper, P.2    Hall, J.3    Noble, L.4    Sagar, S.5
  • 28
    • 0026475990 scopus 로고
    • Haloperidol prevenís induction of the hsp70 heat shock gene in neurons injured by phencyclidine (PCP), MK801, and ketamine
    • Sharp, F. R., M. Butman, S. Wang, J. Koistinaho, S. H. Graham, S. M. Sagar, L. Noble, P. Berger, and F. M. Longo. 1992. Haloperidol prevenís induction of the hsp70 heat shock gene in neurons injured by phencyclidine (PCP), MK801, and ketamine. J. Neurosci. Res. 33: 605-616.
    • (1992) J. Neurosci. Res , vol.33 , pp. 605-616
    • Sharp, F.R.1    Butman, M.2    Wang, S.3    Koistinaho, J.4    Graham, S.H.5    Sagar, S.M.6    Noble, L.7    Berger, P.8    Longo, F.M.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.