The androgen control of sebum production. Studies of subjects with dihydrotestosterone deficiency and complete androgen insensitivity

Journal of Clinical Endocrinology and Metabolism

Volumn 76, Issue 2, 1993, Pages 524-528

  Imperato Mc Ginley, Julianne ^a   Gautier, Teofilo ^b   Cai, Li Qun ^a   Yee, Benetta ^a   Epstein, Jane ^a   Pochi, Peter ^c  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b School of Medicine   (Dominican Republic)

^c BOSTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANOLONE; FINASTERIDE; STEROID 5ALPHA REDUCTASE; TESTOSTERONE;

ADOLESCENT; ADULT; AGED; ANDROGEN BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME DEFICIENCY; FEMALE; GENETIC DISORDER; HORMONAL REGULATION; HORMONE DEFICIENCY; HORMONE SENSITIVITY; HUMAN; MALE; MALE PSEUDOHERMAPHRODITISM; NORMAL HUMAN; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSTATE HYPERTROPHY; SEBACEOUS GLAND; SEBUM SECRETION;

ADOLESCENT; ADULT; ANDROGENS; ANDROSTENES; AZASTEROIDS; CHILD; FEMALE; FINASTERIDE; HUMAN; MALE; PSEUDOHERMAPHRODITISM; SEBUM; STANOLONE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TESTOSTERONE; TESTOSTERONE 5-ALPHA-REDUCTASE;

EID: 0027520707     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jcem.76.2.8381804     Document Type: Article

References (39)

1. Pochi PE, Strauss JS. 1974 Endocrinologic control of the development and activity of the human sebaceous gland. J Invest Dermatol. 62:191-201.
2. Strauss JS, Pochi PE. 1963 The hormonal control of human sebaceous glands. In: Montagna W, Ellis RA, Silver AF, eds. Biology of Skin. The Sebaceous Glands. Oxford: Pergamon Press; Vol IV:220-254.
3. Jacobsen E, Billings JK, Frantz R, Kinney CK, Stewart ME, Downing DT. 1985 Age-related changes in sebaceous wax exter secretion rates in men and women. J Invest Dermatol. 85:483-485.
4. Pochi PE, Strauss JS, Mescon H. 1962 Sebum secretion and urinary fractional 17-ketosteroid and total 17-hydroxycorticoid excretion in male castrates. J Invest Dermatol. 39:485-489.
5. Hamilton JB. 1941 Male hormone substance: a prime factor in acne. J Clin Endocrinol Metab. 1:570-592.
6. Pochi PE, Strauss JS, Downing DT. 1979 Age-related changes in sebaceous gland activity. J Invest Dermatol. 73:108-111.
7. Ebling EJ, Ebling E, McCaffrey V, Skinner J. 1971 The response of the sebaceous glands of the hypophysectomized-castrated male rat to 5β-dihydrotestosterone, androstenedione, déhydroépiandrostérone and androsterone. J Endocrinol. 51:181-190.
8. Takayasu S, Adachi K. 1972 The in vivo and in vitro conversion of testosterone to 17β-hydroxy-5β-androstan-3-one (dihydrotestosterone) by the sebaceous glands of hamsters. Endocrinology. 90:7380.
9. Sansone-Bazzano G, Reisner RM. 1974 Steroid pathways in sebaceous glands. J Invest Dermatol. 62:211-216.
10. Gross CMAA, Wirtz P, Vermorken AJM, Mauvais-Jarvis P. 1982 Androgenic effect of testosterone and some of its metabolites in relation to their biotransformation in the skin. Br J Dermatol. 107:549-557.
11. Takayasu S, Adachi K. 1970 Hormonal control of metabolism in hamster costovertebral glands. J Invest Dermatol. 55:13-19.
12. Takayasu S, Wakimoto H, Itami S, Sano S. 1980 Activity of testosterone 5«-reductase in various tissues of human skin. J Invest Dermatol. 74:187-191.
13. Dijkstra AC, Goos CMAA, Cunliffe WJ, Sultan C, Vermorken AJM. 1987 Is increased 5a-reductase activity a primary phenomenon in androgen-dependent skin disorders? J Invest Dermatol. 89:87-92.
14. Pochi PE. 1988 Acne: androgens and microbiology. Drug Dev Res. 13:157-168.
15. Randall VA, Ebling FJ. 1982 Is the metabolism of testosterone to 5a-dihydrotestosterone required for androgen action in the skin? Br J Dermatol. 107[Suppl 23]:47-53.
16. Schroder HG, Ziegler M, Nickisch K, Kaufmann J, Etreby MFE. 1989 Effects of topically applied antiandrogenic compounds on sebaceous glands of hamster ears and flank organs. J Invest Dermatol. 92:769-773.
17. Kligman AM, Miller DM, McGinley KJ. 1986 Sebutape: a device for visualizing and measuring human sebaceous secretion. J Soc Cosmet Chem. 37:369.
18. Nordstrom KM, Schmus HG, McGinley KJ, and Leyden JJ. 1986 Measurement of sebum output using a lipid absorbent tape. J Invest Dermatol. 87:260-263.
19. Peterson RE, Imperato-Mc ginley J, Gautier T, Sturla E. 1977 Male pseudohermaphroditism due to steroid 5«-reductase deficiency. Am J Med. 62:170-191.
20. Imperato-Mc ginley J, Peterson RE, Gautier T, Cooper G, Danner R, Arthur A, et al. 1982 Hormonal evaluation of a large kindred with complete androgen insensitivity: evidence for secondary 50-reductase deficiency. J Clin Endocrinol Metab. 54:931-941.
21. Jukier L, Kaufman M, Pinsky L, Petersen RE. 1984 Partial androgen resistance associated with secondary 5o-reductase deficiency: identification of a novel qualitative androgen receptor defect and clinical implications. J Clin Endocrinol Metab. 59:679-688.
22. Agache P, Blanc D, Barrand C, Laurent R. 1980 Sebum levels during the first year of life. Br J Dermatol. 103:643-649.
23. Ramasastry P, Downing DT, Pochi PE, Strauss JS. 1970 Chemical composition of human skin surgace lipids from birth to puberty. J Invest Dermatol. 54:139-144.
24. Pochi PE, Strauss JS, Downing DT. 1977 Skin surface lipid composition, acne, pubertal development, and urinary excretion of testosterone and 17-ketosteroids. J Invest Dermatol. 69:485-489.
25. Strauss JS, Pochi PE, Downing DT. 1975 Skin lipids and acne. Annu Rev Med. 26:27-32.
26. Sansone G, Reisner RM. 1971 Differential rates of conversion of testosterone to dihydrotestosterone in acne and in normal human skin—a possible pathogenic factor in acne. J Invest Dermatol. 56:366-372.
27. Imperato-Mc ginley J, Miller M, Wilson JD, Peterson RE, Shack-leton C, Gajdusek DC. 1991 A cluster of male pseudohermaphrodites with 5a-steroid reductase deficiency in Papua, New Guinea. Clin Endocrinol (Oxf). 34:293-298.
28. Imperato-Mc ginley J, Guerrero L, Gautier T, Peterson RE. 1974 Steroid 5a-reductase deficiency in man: an inherited form of male pseudohermaphroditism. Science. 186:1213-1215.
29. Imperato-Mc ginley J, Peterson RE, Gautier T, Sturla E. 1979 Male pseudohermaphroditism secondary to 5a-reductase: a model for the role of androgens in both the development of the male phenotype and the evolution of a male gender identity. J Steroid Biochem Mol Biol. 1:637-645.
30. Imperato-Mc ginley J, Peterson RE, Gautier T. 1981 Male pseudohermaphroditism secondary to 5«-reductase deficiency: a review. In: Novy MJ, Resko JA, eds. Fetal Endocrinology. New York: Academic Press; 359-382.
31. Grino P, Griffin JE, Wilson JD. 1990 Testosterone at high concentrations interacts with the human androgen receptor similarly to dihydrotestosterone. Endocrinology 126(2): 1165-1172.
32. Imperato-Mc ginley J, Binienda Z, Arthur A, Minenberg D, Vaughan ED, Quimby F. 1986 The development of a male pseudohermaphroditic rat using an inhibitor of the enzyme 5«-reductase. Endocrinology 116:807-812.
33. Wenderoth UK, George FW, Wilson JD. 1983 The effect of a 5a-reductase inhibitor on androgen-mediated growth of the dog prostate. Endocrinology 113:569-573.
34. Brooks JR, Berman C, Games D, et al. 1986 Prostatic effects induced in dogs by chronic or acute oral administration of 5a-reduced inhibitors. Prostate. 9:65-75.
35. Imperato-Mc ginley J, Shackleton C, Orlic S, Stoner E. 1990 C19 and C21 5β/5 metabolite ratios in subjects treated with the 5a-reductase inhibitor Finasteride—comparison of male pseudohermaphrodites with inherited 5a-reductase deficiency. J Clin Endocrinol Metab. 70(3):777-782.
36. Andersson S, Russell DW. 1990 Structural and biochemical properties of cloned and expressed human and rat steroid 5a-reductases. Proc Natl Acad Sci USA. 87:3640-3644.
37. Jenkins EP, Hsieh C-L, Milatovich A, et al. 1991 Characterization and chromosomal mapping of a human steroid 5a-reductase gene and pseudogene and mapping of the mouse homoloque. Genomics. 11:1102-1112.
38. Jenkins EP, Andersson S, Imperato-Mc ginley J, Wilson JD, Russell DW. 1992 Genetic and pharmacological evidence for more than one human steroid 5a-reductase. J Clin Invest. 89:293-300.
39. Andersson S, Berman DM, Jenkins EP, Russell DW. 1991 Deletion of steroid 5a-reductase 2 gene in male pseudohermaphroditism. Nature. 354:159-161.