Antigen-induced B lymphocyte activation involves the p21ras and ras.GAP signaling pathway

Journal of Experimental Medicine

Volumn 178, Issue 5, 1993, Pages 1765-1769

  Lazarus, Alan H ^a   Kawauchi, Kiyotaka ^a   Rapoport, Micha J ^a   Delovitch, Terry L ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ANTIGEN; GUANINE NUCLEOTIDE BINDING PROTEIN; IMMUNOGLOBULIN F(AB')2 FRAGMENT; IMMUNOGLOBULIN M; IMMUNOGLOBULIN RECEPTOR; LYMPHOCYTE MEMBRANE IMMUNOGLOBULIN; PROTEIN P21; RAS PROTEIN; TYROSINE;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; B LYMPHOCYTE ACTIVATION; B LYMPHOCYTE DIFFERENTIATION; CANCER CELL CULTURE; CONTROLLED STUDY; MOUSE; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION;

ANIMAL; ANTIGENS; B-LYMPHOCYTES; CELL LINE; GTPASE-ACTIVATING PROTEINS; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HYBRIDOMAS; IMMUNOGLOBULINS, FAB; IMMUNOGLOBULINS, SURFACE; KINETICS; LYMPHOCYTE ACTIVATION; LYMPHOMA, B-CELL; MICE; PROTEINS; PROTO-ONCOGENE PROTEIN P21(RAS); RAS GTPASE-ACTIVATING PROTEINS; RECEPTORS, ANTIGEN, B-CELL; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0027519459     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.178.5.1765     Document Type: Article

References (49)

1. Harnett, M.M., and G.G.B. Klaus. 1988. G protein coupling of antigen receptor-stimulated polyphosphoinositide hydrolysis in B cells. J. Immunol. 140:3135.
2. Gold, M.R., D.A. Law, and A.L. DeFranco. 1990. Stimulation of protein tyrosine phosphorylation by the B lymphocyte antigen receptor. Nature (Lond.). 345:810.
3. Melamed, I., G. Wang, and C.M. Roifman. 1992. Antigen receptor-mediated protein tyrosine kinase activity is regulated by a pertussis toxin-sensitive G protein. J. Immunol. 149:168.
4. Kaziro, Y., H. Itoh, T. Kozasa, M. Nakafuku, and T. Satoh. 1991. Structure and function of signal transducing GTP-binding proteins. Annu. Rev. Biochem. 60:349.
5. ras. Biochem. J. 279:609.
6. ras upon T cell activation. Nature (Lond.). 346:719.
7. Graziadei, L., K. Riabowol, and D. Bar-Sagi. 1990. Co-capping of ras proteins with surface immunoglobulin in B lymphocytes. Nature (Lond.). 347:396.
8. Gold, M.R., M.T. Crowley, G.A. Martin, F. McCormick, and A.L. DeFranco. 1993. Targets of B lymphocyte antigen receptor signal transduction include the p21ras GTP-ase activating protein (GAP) and two GAP-associated proteins. J. Immunol. 150:377.
9. Noelle, R.J., and E.C. Snow. 1990. Cognate interactions between helper T cells and B cells. Immunol. Today. 1:361.
10. Lazarus, A.H., and T.L. Delovitch. 1993. Adv. Molec Cell. Immunol. 1A:53.
11. Bernard, N.F., P. Naquet, M. Watanabe, N. Hozumi, and T.L. Delovitch. 1989. Influence of the valency and hydrophobicity of an antigen on its efficiency of processing and presentation by antigen-specific B cells. Res. Immunol. 140:563.
12. 2+ signaling and desensitization in B cells. J. Immunol. 144:4147.
13. 2+] is not sufficient and protein kinase C activation is not required for three pathways of slgM mediated desensitization. J. Immunol. 147: 1739.
14. ras GTPase-activating protein. Mol. Cell. Biol. 11:1804.
15. ras activation. J. Exp. Med. 177:1221.
16. rasin fibroblasts. Mol. Cell. Biol. 13:1903.
17. Santos, E., and A.R. Nebreda. 1989. Structural and functional properties of ras proteins. FASEB (Fed. Am. Soc. Exp Biol.) J. 3:2151.
18. Li, B.Q., D. Kaplan, H. Kung, and T. Kamata. 1992. Nerve growth factor stimulation of the ras-guanine nucleotide exchange factor and GAP activities. Science (Wish. DC). 256:1456.
19. Koch, C.A., D. Anderson, M.F. Moran, C. Ellis, and T. Pawson. 1991. SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science (Wish. DC). 252:668.
20. Wong, G., O. Muller, R. Clark, L. Conroy, M.F. Moran, P. Polakis, and F. McCormick. 1992. Molecular cloning and nucleic acid binding properties of the GAP-associate tyrosine phos-phoprotein p62. Cell. 69:551.
21. Settleman, J., V. Narasimhan, L.C. Foster, and R.A. Weinberg. 1992. Molecular cloning of cDNAs encoding the GAP-associated protein pl90: implications for a signaling pathway from ras to the nucleus. Cell. 69:539.
22. Ropper, A.H. 1992. The Guillain-Barre syndrome. N. Engl. J. Med. 326:1130.
23. Latov, N., C.L. Koski, and P.A. Walicke. 1991. Guillain-Barre syndrome and parenteral ganglioside. Lancet. 338:757.
24. Schönhöfer, P.S. 1991. Guillain-Barr6 syndrome and parenteral gangliosides. Lancet. 338:757.
25. Figueras, A., F.J. Morales-Olivas, D. Capella, V. Palop, and J.-R. Laporte. 1992. Bovine gangliosides and acute motor polyneuropathy. Br. Med. J. 305:1330.
26. Nobile-Orazio, E., M. Carpo, N. Meucei, M.P. Grassi, E. Cap-tiani, M. Sciacco, A. Mangoni, and G.J. Scarlato. 1992. Guillain-Barre syndrome associated with high titers of anti-GMl antibodies. J. Neurol. Sei. 109:200.
27. Simone, I.L., P. Annunziata, D. Maimone, M. Liguori, R. Leante, and P. Livrea. 1993. Serum and CSF anti-GMl antibodies in patients with Guillain-Barre syndrome and chronic inflammatory demyelinating polyneuropathy. J. Neurol. Sei. 114:49.
28. Winer, J.B., R.A.C. Hughes, M.J. Anderson, D.M. Jones, H. Kangro, and R.P.F. Watkins. 1988. A prospective study of acute idiopathic neuropathy. II. Antecedent events.J. Neurol. Neu-rosurg. Psychiat. 51:613.
29. Kuroki, S., T. Saida, M. Nukina, T. Haruta, M. Yoshioka, Y. Kobayashi, and H. Nakanishi. 1993. Campylobacter jejuni strains from patients with Guillain-Barre syndrome belong mostly to Penner serogroup 19 and contain β-N-acetylglucos-amine residues. Ann. Neurol. 33:243.
30. Yuki, N., H. Yoshino, S. Sato, and T. Miyatake. 1990. Acute axonal polyneuropathy associated with anti-GMl antibodies following Campylobacter enteritis. Neurology. 40:1900.
31. Yuki, N., S. Sato, T. Itoh, and T. Miyatake. 1991. HLA-B35 and acute axonal polyneuropathy following Campylobacter infection. Neurology. 41:1561.
32. Walsh, F.S., M. Cronin, S. Koblar, P. Doherty, J. Winer, A. Leon, and R.A.C. Hughes. 1991. Association between glycoconjugate antibodies and Campylobacter infection in patients with Guillain-Barre syndrome. J. Neuroimmunol. 34:43.
33. Penner, J.L., and J.N. Hennessy. 1980. Passive hemagglutination technique for serotyping Campylobacter fetus mbsp. jejuni on the basis of soluble heat-stable antigens. J. Clin. Microbiol. 12:732.
34. Aspinall, G.O., A.G. McDonald, T.S. Raju, H. Pang, S.D. Mills, L.A. Kurjanczyk, and J.L. Penner. 1992. Serological diversity and chemical structures of Campylobacter jejuni low-molecular-weight lipopolysaccharides. J. Bacteriol. 174:1324.
35. Aspinall, G.O., A.G. McDonald, T.S. Raju, H. Pang, A.P. Moran, and J.L. Penner. 1993. Chemical structures of the core regions of Campylobacter jejuni serotypes 0:1, 0:4, 0:23, and 0:36 lipopolysaccharides. Eur. J. Biochem. 213:1017.
36. Aspinall, G.O., A.G. McDonald, T.S. Raju, H. Pang, L.A. Kurjanczyk, J.L. Penner, and A.P. Moran. 1993. Chemical structures of the core regions of Campylobacter jejuni serotype 0:2 lipopolysaccharides. Eur. J. Biochem. 213:1029.
37. Yuki, N., S. Sato, S. Fujimoto, S. Yamada, Y. Tsujino, A. Kinoshita, and T. Itoh. 1992. Serotype of Campylobacter jejuni, HLA, and the Guillain-Barre syndrome. Muscle & Nerve. 15:968.
38. Yuki, N., S. Handa, T. Taki, T. Kasama, M. Takahashi, K. Saito, and T. Miyatake. 1992. Cross-reactive antigen between nervous tissue and a bacterium elicits Guillain-Barre syndrome: molecular mimicry between ganglioside GM1 and lipopoly-saccharide from Penner’s serotype 19 of Campylobacter jejuni. Biomed. Res. 13:451.
39. Westphal, O., O. Luderitz, and F. Bister. 1952. Über die Extraktion von Bakterien mit Phenol/Waser. Z. Natuiforsch. 7b:148.
40. Chaplin, M.F. 1982. A rapid and sensitive method for the analysis of carbohydrate components in glycoproteins using gasliquid chromatography. Anal. Biochem. 123:336.
41. Farrar, T.C., and E.D. Becker. 1971. Pulse and Fourlier Transform NMR: Introduction to Theory and Methods. Academic Press Inc., New York/London. 27 pp.
42. Inagaki, F., D. Kohda, C. Kodama, and A. Suzuki. 1987. Analysis of NMR spectra of sugar chains of glycolipids by multiple relayed COSY and 2D homonuclear Hartman-Hahn spectroscopy. FEBS (Fed. Eur. Biochem. Soc) Lett. 212:91.
43. Inagaki, F. 1992. Structural analysis of oligosaccharide chains of glycolipids by two-dimensional NMR. Magn. Reson. Chem. 30:S125.
44. Moran, A.P., E.T. Rietschel, T.U. Kosunen, and U. Zahringer. 1991. Chemical characterization of Campylobacter jejuni lipopolysaccharides containing N-acetylneuraminic acid and 2,3-diamino-2,3-dideoxy-D-glucose. J. Bacteriol. 173:618.
45. Schluep, M., and A.J. Steck. 1988. Immunostaining of motor nerve terminals by IgM M protein with activity against gangliosides GM1 and GDlb from a patient with motor neuron disease. Neurology. 38:1890.
46. Michikawa, M., T. Kobayashi, and H. Tsukagoshi. 1991. Early events of chemical transmission of newly formed neuromuscular junctions in monolayers of human muscle cells co-cultured with fetal rat spinal cord explants. Brain Res. 538:79.
47. Nagai, Y., T. Momoi, M. Saito, E. Mitsuzawa, and S. Ohtani. 1976. Ganglioside syndrome, a new autoimmune neurologic disorder, experimentally induced with brain gangliosides. Neurosci. Lett. 2:107.
48. Thomas, F.P., W. Trajaborg, C. Nagy, M. Santoro, S.A. Sadiq, N. Latov, and A.P. Hays. 1991. Experimental autoimmune neuropathy with anti-GMl antibodies and immunoglobulin deposits at the nodes of Ranvier. Acta. Neuropathol. 82:378.
49. Nurminen, M., and R.-S. Olander. 1991. The role of the O antigen in adjuvant activity of lipopolysaccharide. FEMS (Fed. Eur. Microbiol. Soc.) Microbiol. Lett. 83:51.