Zaragozic acids: A family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 90, Issue 1, 1993, Pages 80-84

  Bergstrom, J D ^a   Kurtz, M M ^a   Rew, D J ^a   Amend, A M ^a   Karkas, J D ^a   Bostedor, R G ^a   Bansal, V S ^a   Dufresne, C ^a   VanMiddlesworth, F L ^a   Hensens, O D ^a   Liesch, J M ^a   Zink, D L ^a   Wilson, K E ^a   Onishi, J ^a   Milligan, J A ^a   Bills, G ^a   Kaplan, L ^a   Omstead, M N ^a   Jenkins, R G ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

cholesterol synthesis inhibitors; fungal metabolites

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; CHOLESTEROL; FARNESOL; HYPOCHOLESTEROLEMIC AGENT; LANOSTEROL; MEVALONIC ACID; SQUALENE; UNCLASSIFIED DRUG; ZARAGOZIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; DOSE RESPONSE; DRUG ISOLATION; DRUG MECHANISM; DRUG METABOLISM; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; DRUG TISSUE LEVEL; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME LOCALIZATION; FUNGUS; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; ASCOMYCOTA; BICYCLO COMPOUNDS; CHOLESTEROL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; FERMENTATION; HUMAN; KINETICS; LIPIDS; LIVER; MICE; MITOSPORIC FUNGI; MOLECULAR STRUCTURE; SQUALENE SYNTHETASE; TRICARBOXYLIC ACIDS; TUMOR CELLS, CULTURED;

LEPTODONTIUM; LEPTODONTIUM ELATIUS; PREUSSIA; SPORORMIELLA INTERMEDIA;

EID: 0027518332     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.90.1.80     Document Type: Article

References (0)