Induction of epidermal hyperplasia, hyperkeratosis, and papillomas in transgenic mice by a targeted v‐Ha‐ras oncogene

Molecular Carcinogenesis

Volumn 7, Issue 2, 1993, Pages 99-110

  Greenhalgh, David A ^a   Rothnagel, Joseph A ^a   Quintanilla, Maria I ^a   Orengo, Christine C ^a   Gagne, Todd A ^a   Bundman, Donnie S ^a   Longley, Mary A ^a   Roop, Dennis R ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

In vivo; multistage; oncogene; skin carcinogenesis

Indexed keywords

CYTOKERATIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HISTOLOGY; HYPERKERATOSIS; HYPERPLASIA; IMMUNOFLUORESCENCE; MOUSE; NEWBORN; NONHUMAN; ONCOGENE H RAS; PRIORITY JOURNAL; SKIN CARCINOGENESIS; TRANSGENIC MOUSE;

AGING; ANIMAL; BACTERIOPHAGE LAMBDA; BASE SEQUENCE; CELL TRANSFORMATION, NEOPLASTIC; DISEASE MODELS, ANIMAL; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, RAS; GENETIC TECHNIQUES; HYPERPLASIA; KERATIN; KERATOSIS; MALE; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PAPILLOMA; POLYMERASE CHAIN REACTION; REGULATORY SEQUENCES, NUCLEIC ACID; RNA, NEOPLASM; SKIN NEOPLASMS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027516110     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.2940070208     Document Type: Article

References (58)

1. Mutation selection and the natural history of cancer
2. Molecular themes in oncogenesis
3. Tumor suppressor genes
4. The ras gene family and human carcinogenesis
5. ras genes
6. The ras oncogene
7. Detection and identification of activated oncogenes in human skin cancers occurring on sun‐exposed body sites
8. Ha‐ras activation in benign and self‐regressing skin tumors (keratoacanthomas) in both humans and an animal model system
9. The functions and mechanism of promoters of carcinogenesis
10. Chemical carcinogenesis from animal models to molecular models in one decade
11. Malignant conversion of mouse skin tumors is increased by tumor initiators and unaffected by tumor promoters
12. Carcinogenspecific mutation and amplification of Ha‐ras during mouse skin carcinogenesis
13. Mutagenesis of the Ha‐ras oncogene in mouse skin tumors induced by polycytic aromatic hydrocarbons
14. Carcinogen‐induced mutations in the mouse c‐Ha‐ras gene provide evidence of multiple pathways for tumor progression
15. An activated Harvey ras oncogene produces benign tumors on mouse epidermal tissue
16. v‐ras genes from Harvey and BALB murine sarcoma viruses can act as initiators of two stage mouse skin carcinogenesis
17. Malignant conversion of murine squamous papilloma cell lines by transfection with the fos oncogene
18. Two oncogenes v‐fos and v‐ras cooperate to convert normal keratinocytes to squamous cell carcinoma
19. Dissecting multistep tumorigenesis in transgenic mice
20. Pancreatic neoplasia induced by ras expression in cancer cells of transgenic mice
21. Co‐expression of mouse v‐Ha‐ras and MMTV/c‐myc genes in transgenic mice: Synergistic action of oncogenes in vivo
22. Transgenic mice provide new insights into the role of TGF‐α during epidermal development and differentiation
23. Molecular and cell biology of intermediate filaments
24. Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter
25. A human epidermal differentiation‐specific keratin gene is regulated by calcium but not negative modulators of differentiation in transgenic mouse keratinocytes
26. Development of an epidermal‐specific expression vector for targeting gene expression to the epidermis of transgenic mice
27. Structure of a gene for the human epidermal 67 kDa keratin
28. Expression of functional interleukin‐2 receptors in human light chain TAC transgenic mice
29. Harvey‐murine sarcoma virus influences of coding and non‐coding sequences on cell transformation in vitro and oncogenicity in vivo
30. The cDNA sequence of a type II cytoskeletal keratin reveals consistent and variable structural domains among keratins
31. Calcium regulation of growth and differentiation in mouse epidermal cells in culture
32. Protooncogene expression during two stage carcinogenesis in mouse skin
33. Single‐step method of RNA isolation by acid guanidium thiocyanate‐phenol‐chloroform extraction
34. Regulated expression of differentiation‐associated keratins in cultured epidermal cells detected by monospecific antibodies to unique peptides of mouse epidermal keratins
35. Transciptional control of high molecular weight keratin gene expression in multistage mouse skin carcinogenesis
36. Aberrant expression during two‐stage mouse skin carcinogenesis of a type 147‐kDa keratin, K13, normally associated with terminal differentiation of internal stratified epithelia
37. Differential keratin gene expression in developing, differentiating, preneoplastic and neoplastic mouse mammary epithelium
38. Synthetic peptides corresponding to keratin subunits elicit highly specific antibodies
39. Altered regulation of growth and expression of differentiation associated keratins in benign mouse skin tumors
40. The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells
41. Differences of expression of cytokeratin polypeptides in various epithelial skin tumors
42. Monoclonal antibody analysis of keratin expression in epidermal diseases: A 48‐ and 56‐kilodalton keratin as molecular markers for hyperproliferative keratinocytes
43. Abnormal expression and processing of keratins in pf/pf and Er/Er mutant mice
44. Keratins as markers of malignancy in mouse epidermal tumors
45. Keratin modifications in epidermis, papillomas and carcinomas during two‐stage carcinogenesis in the SENCAR mouse
46. Sequential development aneuploidy, keratin modification and glutamyltransferase expression in mouse skin papillomas
47. Early expression of type I K13 keratin in the progression of mouse skin papillomas
48. Keratinocytes blocked in phorbol ester—responsive early stage of terminal differentiation by sarcoma viruses
49. The effects of overexpression of TGF‐α on the epidermis of transgenic mice
50. Altered regulation of TGF‐β 1 and TGF‐α in primary keratinocytes and papillomas expressing v‐Ha‐ras.
51. Epidermal growth factor—like transforming growth factor II: Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells
52. Distribution and number of epidermal growth factor receptors in skin is related to epithelial cell growth
53. Epidermal tumor promotion by regeneration
54. Identifying tumor suppressor genes in human colorectal cancer
55. Transfection of activated Ha‐ras protooncogene causes mouse mammary hyperplasia