Coordinate changes in gene expression which Mark the spinous to granular cell transition in epidermis are regulated by protein kinase C

Journal of Cell Biology

Volumn 120, Issue 1, 1993, Pages 217-225

  Dlugosz, Andrzej A ^a   Yuspa, Stuart H ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRYOSTATIN; CYCLOHEXIMIDE; DACTINOMYCIN; FILAGGRIN; GLYCEROL 2 ACETATE 1 OLEATE; KERATIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; ENZYME ACTIVATION; ENZYME INACTIVATION; EPIDERMIS; GENE EXPRESSION; GENE EXPRESSION REGULATION; GRANULAR CELL; IMMUNOBLOTTING; MESSENGER RNA SYNTHESIS; MOUSE; NEWBORN; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RNA SYNTHESIS;

ANIMAL; CALCIUM; CELL DIFFERENTIATION; DACTINOMYCIN; ENZYME ACTIVATION; EPIDERMIS; GENE EXPRESSION; IN VITRO; INTERMEDIATE FILAMENT PROTEINS; KERATIN; KERATINOCYTES; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; PROTEIN KINASE C; RNA, MESSENGER; TETRADECANOYLPHORBOL ACETATE;

EID: 0027514311     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.120.1.217     Document Type: Article

References (73)

1. Angel, P., and M. Karin. 1991. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim. Biophys. Acta Rev. Cancer. 1072:129-157.
2. Brooks, S. F., T. Herget, J. D. Erusalimsky, and E. Rozengurt. 1991. Protein kinase C activation potently down-regulates the expression of its major substrate, 8OK, in Swiss 3T3 cells. EMBO (Eur. Mol. Biol. Organ.) J. 10:2497-2505.
3. Chirgwin, J. M., A. E. Przbyla, R. J. MacDonald, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry. 18:5294-5299.
4. Choi, J. K., S. Holtzer, S. A. Chacko, Z. Lin, R. K. Hoffman, and H. Holtzer. 1991. Phorbol esters selectively and reversibly inhibit a subset of myofibrillar genes responsible for the ongoing differentiation program of chick skeletal myotubes. Mol. Cell. Biol. 11:4473-4482.
5. Cleveland, D. W., and T. J. Yen. 1989. Multiple determinants of eukaryotic mRNA stability. New Biologist. 1:121-126.
6. Coulombe, P. A., R. Kopan, and E. Fuchs. 1989. Expression of keratin K14 in the epidermis and hair follicle: Insights into complex programs of differentiation. J. Cell Biol. 109:2295-2312.
7. Davis, L. G., M. D. Dibner, and J. F. Battey. 1986. Basic Methods in Molecular Biology. Elsevier, New York. 143-146.
8. Distel, R. J., H. S. Ro, B. S. Rosen, D. L. Groves, and B. M. Spiegelman. 1987. Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos. Cell. 49:835-844.
9. Dlugosz, A. A., and S. H. Yuspa. 1991. Staurosporine induces protein kinase C agonist effects and maturation of normal and neoplastic mouse keratinocytes in vitro. Cancer Res. 51:4677-4684.
10. Dlugosz, A. A., H. Mischak, J. F. Mushinski, and S. H. Yuspa. 1992. Transcripts encoding protein kinase C α, δ, ∈, ζ, and η are expressed in basal and differentiating mouse keratinocytes in vitro and exhibit quantitative changes in neoplastic cells. Mol. Carcinogenesis. 5:286-292.
11. Dotto, G. P., M. Z. Gilman, M. Marugma, and R. A. Weinberg. 1986. c-Myc and c-fos expression in differentiating mouse epidermal keratinocytes. EMBO (Eur. Mol. Biol. Organ.) J. 5:2853-2857.
12. 3H]phorbol 12,13-dibutyrate binding in primary mouse keratinocytes at different stages of maturation. Cancer Res. 45:5540-5546.
13. Fisher, C., M. R. Byers, M. J. Iadarola, and E. A. Powers. 1991. Patterns of epithelial expression of Fos protein suggest important role in the transition from viable to cornified cell during keratinization. Development. 111:253-258.
14. Fort, P., L. Marty, M. Piechaczyk, S. el Sabrouty, C. Dani, P. Jeanteur, and J. M. Blanchard. 1985. Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family. Nucleic. Acids. Res. 13:1431-1442.
15. Fuchs, E. 1990. Epidermal differentiation: the bare essentials. J. Cell Biol. 111:2807-2814.
16. Gius, D., X. Cao, F. J. Rauscher III, D. R. Cohen, T. Curran, and V. P. Sukhatme. 1990. Transcriptional activation and repression by Fos are independent functions: the C terminus represses immediate-early gene expression via CArG elements. Mol. Cell Biol. 10:4243-4255.
17. Greenberg, M. E., and E. B. Ziff. 1984. Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature (Lond.). 311:433-438.
18. Gschwendt, M., G. Furstenberger, S. Rose-John, M. Rogers, W. Kittstein, G. R. Pettit, C. L. Herald, and F. Marks. 1988. Bryostatin 1, an activator of protein kinase C, mimics as well as inhibits biological effects of the phorbol ester TPA in vivo and in vitro. Carcinogenesis. 9:555-562.
19. Gusovsky, F., and J. S. Gutkind. 1991. Selective effects of activation of protein kinase C isozymes on cyclic AMP accumulation. Mol. Pharmacol. 39: 124-129.
20. Hennings, H., D. Michael, C. Cheng, P. Steinert, K. A. Holbrook, and S. H. Yespa. 1980. Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell. 19:245-254.
21. Huff, C. A., S. H. Yuspa, and D. Rosenthal. 1993. Identification of control elements 3′ to the human keratin 1 gene which regulates cell type and differentiation-specific expression. J. Biol. Chem. In press.
22. Imagawa, M., R. Chiu, and M. Karin. 1987. Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP. Cell. 51:251-260.
23. Isseroff, R. R., L. E. Stephens, and J. L. Gross. 1989. Subcellular distribution of protein kinase C/phorbol ester receptors in differentiating mouse keratinocytes. J. Cell Physiol. 141:235-242.
24. 2+-mediated inositol lipid metabolism in normal and neoplastic epidermal cells. Carcinogenesis. 9:1033-1038.
25. Jetten, A. M., M. A. George, G. R. Pettit, C. L. Herald, and J. I. Rearick. 1989. Action of phorbol esters, bryostatins, and retinoic acid on cholesterol sulfate synthesis: relation to the multistep process of differentiation in human epidermal keratinocytes. J. Invest. Dermatol. 93:108-115.
26. Komorowski, J. I., and B. K. Tsang. 1990. Divergent effects of 1-oleoyl-2-acetylglycerol and tumor-promoting phorbol ester on rat granulosa cell steroidogenesis in vitro. Biol. Reprod. 43:73-79.
27. Kruszewski, F. H., H. Hennings, S. H. Yuspa, and R. W. Tucker. 1991. Regulation of intracellular free calcium in normal murine keratinocytes. Am. J. Physiol. 261:C767-C773.
28. Leask, A., M. Rosenberg, R. Vassar, and E. Fuchs. 1990. Regulation of a human epidermal keratin gene: Sequences and nuclear factors involved in keratinocyte-specific transcription. Genes Dev. 4:1985-1998.
29. Leask, A., C. Byrne, and E. Fuchs. 1991. Transcription factor AP2 and its role in epidermal-specific gene expression. Proc. Natl. Acad. Sci. USA. 88: 7948-7952.
30. Lee, E., and S. H. Yuspa. 1991. Changes in inositol phosphate metabolism are associated with terminal differentiation and neoplasia in mouse keratinocytes. Carcinogenesis. 12:1651-1658.
31. Lenormand, P., D. Pribnow, K. D. Rodland, and B. E. Magun. 1992. Identification of a novel enhancer element mediating calcium-dependent induction of gene expression in response to either epidermal growth factor or activation of protein kinase C. Mol. Cell. Biol. 12:2793-2803.
32. Li, L., J. Zhou, G. James, R. Heller-Harrison, M. Czech, and E. Olson. 1993. FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA binding domains. Cell. In press.
33. Lichti, U., and S. H. Yuspa. 1988. Modulation of tissue and epidermal trans-glutaminases in mouse epidermal cells after treatment with 12-O-tetradecanoylphorbol-13-acetate and/or retinoic acid in vivo and in culture. Cancer Res. 48:74-81.
34. Luscher, B., P. J. Mitchell, T. Williams, and R. Tjian. 1989. Regulation of transcription factor AP-2 by the morphogen retinoic acid and by second messengers. Genes. Dev. 3:1507-1517.
35. Malmquist, K. C., L. E. Carlson, B. Forslind, G. M. Roomans, and D. R. Akselsson. 1984. Proton and electron microprobe analysis of human skin. Nucl. Instru. Methods Physics Res. 3:611-617.
36. Medford, R. M., H. T. Nguyen, and B. Nadal-Ginard. 1983. Transcriptional and cell cycle-mediated regulation of myosin heavy chain gene expression during muscle cell differentiation. J. Biol. Chem. 258:11063-11073.
37. Mehrel, T., D. Hohl, J. A. Rothnagel, M. A. Longley, D. Bundman, C. Cheng, U. Lichti, M. E. Bisher, A. C. Steven, P. M. Steinert, S. H. Yuspa, and D. R. Roop. 1990. Identification of a major keratinocyte cell envelope protein, loricrin. Cell. 61:1103-1112.
38. Menon, G. K., and P. M. Elias. 1991. Ultrastructural localization of calcium in psoriatic and normal human epidermis. Arch. Dermatol. 127:57-63.
39. Menon, G. K., S. Grayson, and P. M. Elias. 1985. Ionic calcium reservoirs in mammalian epidermis: ultrastructural localization by ion-capture cytochemistry. J. Invest. Dermatol. 84:508-512.
40. Molloy, C. J., and J. D. Laskin. 1987. Specific alterations in keratin biosynthesis in mouse epidermis in vivo and in explant culture following a single exposure to the tumor promoter 12-o-tetradecanoylphorbol-13-acetate. Cancer Res. 47:4674-4680.
41. Offringa, R., S. Gebel, H. Van Dam, M. Timmers, A. Smits, R. Zwart, B. Stein, J. L. Bos, A. van der Eb, and P. Herrlich. 1990. A novel function of the transforming domain of Ela: repression of AP-1 activity. Cell. 62:527-538.
42. Oshima, R. G., L. Abrams, and D. Kulesh. 1990. Activation of an intron enhancer within the keratin 18 gene by expression of c-fos and c-jun in undifferentiated F9 embryonal carcinoma cells. Genes Dev. 4:835-848.
43. Otte, A. P., and R. T. Moon. 1992. Protein kinase C isozymes have distinct roles in neural induction and competence in Xenopus. Cell. 68:1021-1029.
44. Parkinson, E. K., M. F. Pera, A. Emmerson, and P. A. German. 1984. Differential effects of complete and second-stage tumour promoters in normal but not transformed human and mouse keratinocytes. Carcinogenesis. 5:1071-1077.
45. Pettit. G. R., C. L. Herald, D. L. Doubek, and D. L. Herald. 1982. Isolation and structure of bryostatin 1. J. Am. Chem. Soc. 104:6846-6848.
46. Pfeffer, L. M., B. L. Eisenkraft, N. C. Reich, T. Improta, G. Baxter, S. Daniel-Issakani, and B. Strulovici. 1991. Transmembrane signaling by interferon α involves diacylglycerol production and activation of the ∈ isoform of protein kinase C in Daudi cells. Proc. Natl. Acad. Sci. USA. 88:7988-7992.
47. Polakowska, R. R., and L. A. Goldsmith. 1991. The cell envelope and transglutaminases. In Physiology, Biochemistry, and Molecular Biology of the Skin L. A. Goldsmith, editor. Oxford Press, New York. 168-201.
48. Roop, D. R., P. Hawley-Nelson, C. K. Cheng, and S. H. Yuspa. 1983. Keratin expression in mouse epidermis and cultured epidermal cells. Proc. Natl. Acad. Sci. USA. 80:716-720.
49. Roop, D. R., H. Huitfeldt, A. Kilkenny, and S. H. Yuspa. 1987. Regulated expression of differentiation-associated keratins in cultured epidermal cells detected by monospecific antibodies to unique peptides of mouse epidermal keratins. Differentiation. 35:143-150.
50. Roop, D. R., T. M. Krieg, T. Mehrel, C. K. Cheng, and S. H. Yuspa. 1988. Transcriptional control of high molecular weight keratin gene expression in multistage mouse skin carcinogenesis. Cancer Res. 48:3245-3252.
51. Roop, D. R., H. Nakazawa, T. Mehrel, C. Cheng, S. Chung, J. A. Rothnagel, P. M. Steinen, and S. H. Yuspa. 1988. Sequential changes in gene expression during epidermal differentiation. In The Biology of Wool and Hair. G. E. Rogers, P. J. Reis, K. A. Ward, and R. C. Marshall, editors. Chapman and Hall, London. 311-324.
52. Saceda, M., C. Knabbe, R. B. Dickson, M. E. Lippman, D. Bronzert, R. K. Lindsey, M. M. Gottardis, and M. B. Martin. 1991. Post-transcriptional destabilization of estrogen receptor mRNA in MCF-7 cells by 12-O-tetradecanoylphorbol-13-acetate. J. Biol. Chem. 266:17809-17814.
53. Sako, T., S. H. Yuspa, C. L. Herald, G. R. Pettit, and P. M. Blumberg. 1987. Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells. Cancer Res. 47:5445-5450.
54. Schlessinger, J. 1986. Allosteric regulation of the epidermal growth factor receptor kinase. J. Cell Biol. 103:2067-2072.
55. Snape, A. M., R. S. Winning, and T. D. Sargent. 1991. Transcription factor AP-2 is tissue-specific in Xenopus and is closely related or identical to Keratin Transcription Factor 1 (KTF-1). Development. 113:283-293.
56. Stabel, S., and P. J. Parker. 1991. Protein kinase C. Pharmac. Ther. 51:71-95.
57. Stanton, L. W., R. Watt, and K. B. Marcu. 1983. Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas. Nature (Lond.). 303(5916):401-406.
58. Stoler, A., R. Kopan, M. Duvic, and E. Fuchs. 1988. Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation. J. Cell Biol. 107: 427-446.
59. Strickland, J. E., A. M. Jenen, H. Kawamura, and S. H. Yuspa. 1984. Interaction of epidermal growth factor with basal and differentiating epidermal cells of mice resistant and sensitive to carcinogenesis. Carcinogenesis. 5:735-740.
60. Takimoto, M., J. P. Quinn, A. R. Farina, L. M. Staudt, and D. Levens. 1989. fos/jun and octamer-binding protein interact with a common site in a negative element of the human c-myc gene. J. Biol. Chem. 264:8992-8999.
61. Tang, W., V. A. Ziboh, R. R. Isseroff, and D. Martinez. 1988. Turnover of inositol phospholipids in cultured murine keratinocytes: possible involvement of inositol trisphosphate in cellular differentiation. J. Invest. Dermatol. 90:37-43.
62. Toftgard, R., S. H. Yuspa, and D. R. Roop. 1985. Keratin gene expression in mouse skin tumors and in mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 45:5845-5850.
63. Toullec, D., P. Pianetti, H. Coste, P. Bellevergue, T. Grand-Perret, M. Ajakane, V. Baudet, P. Boissin, E. Boursier, F. Loriolle, L. Duhamel, D. Charon, and J. Kirilovsky. 1991. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J. Biol. Chem. 266:15771-15781.
64. Tyner, A. L., and E. Fuchs. 1986. Evidence for posttranscriptional regulation of the keratins expressed during hyperproliferation and malignant transformation in human epidermis. J. Cell Biol. 103:1945-1955.
65. Wager, R. E., and R. K. Assoian. 1990. A phorbol ester-regulated ribonuclease system controlling transforming growth factor beta 1 gene expression in hematopoietic cells. Mol. Cell Biol. 10:5983-5990.
66. Weber, B., J. Horiguchi, R. Luebbers, M. Sherman, and D. Kufe. 1989. Posttranscriptional stabilization of c-fms mRNA by a labile protein during human monocytic differentiation. Mol. Cell Biol. 9:769-775.
67. Yuspa, S. H. 1985. Methods for the use of epidermal cell culture to study chemical carcinogens. In Methods in Skin Research. D. Skerrow and C. Skerrow, editors. John Wiley and Sons, Sussex. 213-249.
68. Yuspa, S. H., T. Ben, H. Hennings, and U. Lichti. 1980. Phorbol ester tumor promoters induce epidermal transglutaminase activity. Biochem. Biophys. Res. Commun. 97:700-708.
69. Yuspa, S. H., T. Ben, H. Hennings, and U. Lichti. 1982. Divergent responses in epidermal basal cells exposed to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 42:2344-2349.
70. Yuspa, S. H., A. E. Kilkenny, P. M. Steinert, and D. R. Roop. 1989. Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro. J. Cell Biol. 109:1207-1217.
71. Yuspa, S. H., H. Hennings, R. W. Tucker, A. Kilkenny, E. Lee, F. H. Kruszewski, and D. R. Roop. 1990. The regulation of differentiation in normal and neoplastic keratinocytes. In Papillomaviruses, UCLA Symposia and Molecular and Cellular Biology, New Series. P Howley and T. Broker, editors. Alan R. Liss Inc., New York. 211-222.
72. Zhu, Y.-Y., R. J. Schwartz, and M. T. Crow. 1991. Phorbol esters selectively downregulate contractile protein gene expression in terminally differentiated myotubes through transcriptional repression and message destabilization. J. Cell Biol. 115:745-754.
73. Ziboh, V. A., R. R. Isseroff, and R. Pandey. 1984. Phospholipid metabolism in calcium-regulated differentiation in cultured murine keratinocytes. Biochem. Biophys. Res. Commun. 122:1234-1240.