Peripheral Blood Mononuclear Cells in Patients With Nonleukemic Cutaneous T-Cell Lymphoma: Reduced Proliferation and Preferential Secretion of a T Helper-2—Like Cytokine Pattern on Stimulation

Archives of Dermatology

Volumn 129, Issue 4, 1993, Pages 433-436

  Dummer, Reinhard ^a   Kohl, Oliver ^a   Gillessen, Jürgen ^a   Kägi, Martin ^a   Burg, Günter ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN; INTERLEUKIN 2; INTERLEUKIN 4; PHYTOHEMAGGLUTININ;

ADULT; AGED; ARTICLE; CELL MEDIATED CYTOTOXICITY; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOGLOBULIN BLOOD LEVEL; MONONUCLEAR CELL; NATURAL KILLER CELL; PRIORITY JOURNAL; SKIN LYMPHOMA; T CELL LYMPHOMA;

ADULT; AGED; AGED, 80 AND OVER; BLAST CRISIS; CELL DIVISION; HUMAN; INTERFERON TYPE II; INTERLEUKIN-2; INTERLEUKIN-4; INTERLEUKIN-6; LYMPHOCYTES; LYMPHOMA, T-CELL, CUTANEOUS; MIDDLE AGE; PHYTOHEMAGGLUTININS; SKIN NEOPLASMS;

EID: 0027513831     PISSN: 0003987X     EISSN: 15383652     Source Type: Journal    
DOI: 10.1001/archderm.1993.01680250045005     Document Type: Article

References (31)

1. Burg G, Braun-Falco O. Cutaneous Lymphomas, Pseudolymphomas and Related Disorders. Berlin, Germany: Springer-Verlag; 1983
2. Sterry W, Mielke V. CD4+ cutaneous T-cell lymphomas show the phenotype of helper/inducer T cells (CD45RA-, CDw29+). J Invest Dermatol. 1989; 93: 413-416.
3. Weiss L, Hu E, Wood G, et al. Clonal rearrangements of T-cell receptor genes in mycosis fungoides and dermatopathic lymphadenopathy. N Engl J Med. 1985; 313: 539-544.
4. Laroche L, Kaiserlian D. Decreased natural-killer cell activity in cutaneous T-cell lymphomas. N Engl J Med. 1983; 308: 101-102.
5. Levy S, Tempe J-L, Caussade P, et al. Stage-related decrease in natural killer activity in untreated patients with mycosis fungoides. Cancer Immunol Immunother. 1984; 18: 138-140.
6. Dummer R, Nestle F, Wiede J, et al. Coincidence of increased soluble interleukin-2 receptors, diminished natural killer cell activity and progressive disease in cutaneous T-cell lymphomas. Eur J Dermatol. 1991; 1: 135-138.
7. Wood NL, Kitces EN, Blaylock K. Depressed lymphokine activated killer cell activity in mycosis fungoides. Arch Dermatol. 1990; 126: 907-913.
8. DuVivier A, Harper R, VonderHeid E, Scott EV. Lymphocyte transformation in patients with staged mycosis fungoides and Sézary syndrome. Cancer. 1978; 42: 209-213.
9. Liebe V, Burg G. Lymphozytentransformationstest bei kutanen Lymphomen. Hautarzt. 1977; 28: S200-S203.
10. Zachariae H, Ellegaard J, Grunnet E, Sogaard H, Thulin H. Tand B-cells and IgE in mycosis fungoides. Acta Derm Venereol. 1975; 55: 466-468.
11. Edelson R. Cutaneous T-cell lymphoma: mycosis fungoides, Sézary syndrome and other variants. J Am Acad Dermatol. 1980; 1: 89-106.
12. Venencie PY, Winkelmann RK, Friedman SJ, Kyle RA, Puissant A. Monoclonal gammopathy and mycosis fungoides. J Am Acad Dermatol. 1984; 11: 576-579.
13. Van der Putte SCJ, Toonstra J, van Wichen DF, van Unnik JAM, van Vloten W. Aberrant immunophenotype in mycosis fungoides. Arch Dermatol. 1988; 124: 373-380.
14. Kerl K, Sterry W. Classification and staging. In: Burg G, Sterry W, eds. EORTC/BMFT Cutaneous Lymphoma Project Group: Recommendations for Staging and Therapy of Cutaneous Lymphomas. Brussels, Belgium: European Organization for Research in Treatment of Cancer; 1987: 1-10.
15. Landegren U. Measurement of cell numbers by means of the endogenous enzyme hexosaminidase: applications to detection of lymphokine and cell surface antigens. J Immunol Methods. 1984; 67: 379-388.
16. Gallagher G, Wilcox F, Al-Azzawi F. Interleukin-3 and interleukin-4 each strongly inhibit the induction and function of human LAK cells. Clin Exp Immunol. 1988; 74: 166-170.
17. Dummer R, Posseckert G, Nestle F, et al. Soluble interleukin-2 receptors inhibit interleukin-2 dependent proliferation and cytotoxicity: explanation for diminished natural killer cell activity in cutaneous T-cell lymphomas in vivo? J Invest Dermatol. 1992; 98: 50-54.
18. Kantor AF, Curtis RE, Vonderheid EC, van Scott EJ, Fraumeni JF. Risk of second malignancy after cutaneous T-cell lymphoma. Cancer. 1989; 63: 1612-1615.
19. Swain S, Weinberg A, English M, Huston G. IL-4 directs the development of TH2-like helper effectors. J Immunol. 1990; 11: 203-205.
20. Vowels B, Cassin M, Vonderheid E, Rook A. Aberrant cytokine production by Sézary syndrome patients: cytokine secretion pattern resembles murine Th2 cells. J Invest Dermatol. 1992; 99: 90-94.
21. Hirano T, Akira S, Taga T, Kishimoto T. Biological and clinical aspects of interleukin-6. Immunol Today. 1990; 11: 443-449.
22. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone, I: definition according to profiles of lymphokine activities and secreted proteins. J Immunol. 1986; 136: 2348-2357.
23. Romagnami S. Human TH1 and TH2 subsets: doubt no more. Immunol Today. 1991; 12: 256-257.
24. Sterry W. Die Heterogenit—t der CD4+ (Helfer)-T-Zellen: Rolle in der Pathophysiologie der Haut. Hautarzt. 1989; 40: 679-684.
25. Akbar AN, Terry L, Timms A, Beverley PC, Janossy G. Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells. J Immunol. 1988; 140: 2171-2178.
26. Gilmore SG, Benson EM, Kelly JW. T-cell subsets with a naive phenotype are selectively decreased in the peripheral blood of patients with mycosis fungoides. J Invest Dermatol. 1991; 96: 50-56.
27. Sanders ME. Human naive and memory T-cells: reinterpretation of helper-inducer and suppressor-inducer subsets. Immunol Today. 1988; 9: 195-198.
28. Vercelli D, Jabara H, Lauener R, Geha R. IL-4 inhibits the synthesis of IgE in human mixed lymphocyte cultures. J Immunol. 1990; 144: 570-573.
29. Vander Harst-Oostveen C, van Vloten W. Delayed-type hypersensitivity in patients with mycosis fungoides. Dermatologica. 1978; 157: 129-135.
30. Wierenga E, Snoek M, Groot CD. Evidence for compartmentalization of functional subsets of CD2+ T lymphocytes in atopic subjects. J Immunol. 1990; 140: 4651-4656.
31. Robinson D, Hamid Q, Ying S, et al. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med. 1992; 326: 298-304.