Microglial and Astroglial Reactions to Ischemic and Kainic Acid-Induced Lesions of the Adult Rat Hippocampus

Experimental Neurology

Volumn 120, Issue 1, 1993, Pages 70-88

  Jørgensen, Martin B ^a,b   Finsen, Bente R ^a,b   Jensen, Michael B ^a,b   Castellano, Bernardo ^a,b   Diemer, Nils H ^a,b   Zimmer, Jens ^a,b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; KAINIC ACID; VIMENTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN ISCHEMIA; CONTROLLED STUDY; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; MALE; MICROGLIA; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; ASTROCYTES; BRAIN DISEASES; BRAIN ISCHEMIA; COMPARATIVE STUDY; HIPPOCAMPUS; IMMUNOGLOBULIN G; IMMUNOHISTOCHEMISTRY; INTERMEDIATE FILAMENT PROTEINS; KAINIC ACID; MACROPHAGE-1 ANTIGEN; MALE; NEUROGLIA; PHOSPHORIC MONOESTER HYDROLASES; RATS; RATS, WISTAR; STAINING AND LABELING; SUPPORT, NON-U.S. GOV'T;

EID: 0027511579     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1006/exnr.1993.1041     Document Type: Article

References (79)

1. Ahmed, Z., C. A. Lewis, and D. S. Faber, 1990. Glutamate stimulates release of Ca2+ from internal stores in astroglia. Brain Bes. 516: 165-169.
2. Akiyama, H., and P. L. Mcgeer, 1989. Microglial response to 6-hydroxy-dopamine-induced substantia nigra lesions. Brain Res. 489: 247-253.
3. Andersson, P. B., V. H. Perry, and S. Gordon, 1991. The kinetics and morphological characteristics of the macrophage-microglial response to kainic acid-induced neuronal degeneration. Neuroscience 42: 201-214.
4. Aono, S., and S. Kashiwamata, 1990. Glial fibrillary acidic protein under physiological and pathological conditions. Med Sci. Res. 18: 235-239.
5. Bakst, I., C. Avendano, J. H. Morrison, and D. G. Amaral, 1986. An experimental analysis of the origin of somatostatinlike immunoreactivity in the dentate gyrus of the rat. J. Neuro-sci. 6: 1452-1462.
6. Banati, R. B., G. Rothe, G. Valet, and G. W. Kreutzberg, 1991. Respiratory burst activity in brain macrophages: a flow cytometric study on cultured rat microglia. Neuropathol. Appl. Neurobiol. 17: 223-230.
7. Berdichevsky, E., C. Muñoz, N. Riveros, L. Cartier, and F. Orrego, 1987. Neuropathological changes in the rat brain cortex in vitro: Effects of kainic acid and of ion substitutions. Brain Res. 423: 213-220.
8. Bignami, A., and D. Dahl, 1974. Astrocyte-specific protein and neuroglial differentiation: An immunofluorescence study with antibodies to the glial fibrillary acidic protein. J. Comp. Neurol. 153: 27-36.
9. Brierley, J. B and D. I. Graham, 1984. Hypoxia and vascular disorders of the central nervous system. In Greenfield's Neuropathology (J. H. Adams, J. A. N. Corsellis, and W. Duchen, Eds.), 4th ed., pp, 125-207. Arnold, London.
10. Brown, J. M., and J. B. Brierley, 1972, ANOXIC-ISCHEMIC CELL CHANGE IN RAT BRAIN: LIGHT MICROSCOPIC and FINE-STRUCTURAL OBSERVATIONS. J. Neurol. Sci. 16: 59-84.
11. Castellano, B., B. Gonzalez, M. B. Jensen, E. B. Pedersen, B. R. Finsen, and J. Zimmer, 1991. A double staining technique for simultaneous demonstration of astrocytes and microglia in brain sections and astroglial cell cultures. J. Histochem. Cyto-chem. 39: 561-568.
12. Castiglioni, A. J., S. L. Peterson, E. L. Sanabria, and E. Tiffany-Castiglioni, 1990. STRUCTURAL CHANGES IN ASTROCYTES INDUCED BY SEIZURES IN A MODEL OF TEMPORAL LOBE EPILEPSY. J. Neurosci. Res. 26: 334-341.
13. Coffey, P. J., V. H. Perry, and J. N. P. Rawlins, 1990. An investigation into the early stages of the inflammatory response following ibotenic acid induced neuronal degeneration. Neuroscience 35: 121-132.
14. Del Rio-Hortega, P., and W. Penfield, 1919. Cerebral cicatrix: The reaction of neuroglia and microglia to brain wounds. Bull. Johns Hopkins Hosp. 41: 278-303.
15. Diemer, N. H., M. B. Jorgensen, and F. F. Johansen, 1987. Significance of intra-and postischemic pathophysiological processes for development of ischemic nerve cell loss. In Cerebrouas-cular Diseases (M. E. Raichle and W. J. Powers, Eds.) pp, 53-62. Raven Press, New York.
16. Diemer, N. F., and E. Siemkowicz, 1981. Regional neuron damage after cerebral ischemia in the normo-and hypo-glycaemic rat. Neuropathol. Appl. Neurobiol. 7: 217-227.
17. Dom, R., F. Baro, and J. M. Brucher, 1973. A cytometric study of putamen in different types of Huntington's chorea. In Advances in Neurology, Vol, 1, Huntington's Chorea (A. Barbeau, T, N. Chase, and G. W. Paulson, Eds.), pp, 369-385. Raven Press, New York.
18. Fagan, A. M., and F. H. Gage, 1990. Cholinergic sprouting in the hippocampus: A proposed role for IL-1. Exp. Neurol. 110: 105-120.
19. Finsen, B. R., M. B. Jorgensen, B. Castellano, M. B. Jensen, N. H. Diemer, and J. Zimmer, 1991. Glial reactions in the rat hippocampus following intraventricular kainic acid injection. Eur. J. Neurosci. Suppl. 4: 98.
20. Finsen, B. R., M. B. Jorgensen, N. H. Diemer, and J. Zimmer, 1993, Microglial MHC antigen expression after ischemic and kainic acid lesions of the adult rat hippocampus. Glia 17: 41-49.
21. Finsen, B. R., T. Sorensen, B. Castellano, E. B. Pedersen, and J. Zlmmer, 1991. LEUKOCYTE INFILTRATION and GLIAL REACTIONS IN XENOGRAFTS OF MOUSE BRAIN TISSUE UNDERGOING REJECTION IN THE ADULT RAT BRAIN: A LIGHT and ELECTRON MICROSCOPICAL IMMUNOCYTOCHEMI-CAL STUDY. J. Neuroimmunol. 32: 159-183.
22. Frei, K., and A. Fontana, 1989. Immune regulatory functions of astrocytes and microglial cells within the central nervous system. In Neuroimmune Networks: Physiology and Diseases (E. J. Goetzl and N. H. Spector, Eds.), pp, 127-136. A. R. Liss, New York.
23. Gehrmann, J., P. Bonnekoh, T. Miyazawa, K.-A. Hossmann, and G. Kreutzberg, 1992. IMMUNOCYTOCHEMICAL STUDY OF AN EARLY MICROGLIAL ACTIVATION IN ISCHEMIA. J. Cereb. Blood Flow Me-tab. 12: 257-269.
24. Gehrmann, J., P. Bonnekoh, T. Miyazawa, U. Oschelies, E. Dux, K.-A. Hossmann, and G. W. Kreutzberg, 1992. The microglial reaction in the rat hippocampus following global ischemia: immuno-electron microscopy. Acta Neuropathol. 84: 588-595.
25. Gehrmann, J., S. W. Schoen, and G. W. Kreutzberg, 1991. Lesion of the rat entorhinal cortex leads to a rapic microglial reaction in the dentate gyrus: A light and electron microscopical study. Acta Neuropathol, 82: 442-455.
26. Giulian, D., and T. J. Baker, 1986. Characterization of ameboid microglia isolated from the developing mammalian brain. J. Neurosci. 6: 2163-2178.
27. Giulian, D., J. Chen, J. E. Ingeman, J. K. George, and M. Noponen, 1989. The role of mononuclear phagocytes in wound healing after traumatic injury to adult mammalian brain. J. Neurosci. 9: 4416-4429.
28. Giulian, D., K. Vaca, and B. Johnson, 1988. Secreted peptides as regulators of neuron-glia and glia-glia interactions in the developing nervous system. J. Neurosci. Res. 21: 487-500.
29. Glaum, S. R., J. A. Holzwarth, and R. J. Miller, 1990. Glutamate receptors activate Ca2+ mobilization and Ca2+ influx into astrocytes. Proc. Natl. Acad. Sci. USA 87: 3454-3458.
30. Glenn, J. A., P. L. Booth, and W. E. Thomas, 1991. PINOCY-TOTIC ACTIVITY IN RAMIFIED MICROGLIA. Neurosci. Lett. 123: 27-31.
31. Grimaldi, R., M. Zoli, L. F. Agnati, F. Gerraguti, K. Fuxe, G. Toffano, and I. Zini, 1990. Effects of transient forebrain ischemia on peptidergic neurons and astroglial cells: Evidence for recovery of peptide immunoreactivities in neocortex and striatum but not hippocampal formation. Exp. Brain Res. 82: 123-136.
32. Hertz, L, 1981. Features of astrocytic function apparently involved in the response of central nervous tissue to ischemia-hypoxia, J. Cereb. Blood Flow Metab. 1: 143-153.
33. Hjorth-Simonsen, A, 1973. Some intrinsic connections of the hippocampus in the rat: An experimental analysis. J. Comp. Neurol. 147: 145-162.
34. Jensen, M. B., B. R. Finsen, B. Gonzalez, and J. Zimmer, 1989. Cellular occurrence of MHC and leucocytic antigens in response to anterograde axonal degeneration in the rat fascia den-tata. Eur. J. Neurosci. Suppl. 2: 71.
35. Jensen, M. B., M. B. Jorgensen, B. R. Finsen, B. Castellano, N. H. Diemer, and J. Zimmer, 1990. Microglial and astroglial reactions to transient cerebral ischemia in the adult rat hippocampus. Eur. J. Neurosci. Suppl. 3: 220.
36. Johansen, F. F., M. B. Jorgensen, and N. H. Diemer, 1983. Resistance of hippocampal CA-1 interneurons to 20 min of transient cerebral ischemia in the rat. Acta Neuropathol. 61: 135-140.
37. Johansen, F. F., J. Zimmer, and N. H. Diemer, 1987. Loss of somatostatin neurons in dentate hilus after cerebral ischemia in the rat may induce delayed CA-1 pyramidal cell loss. Acta Neuropathol. 73: 110-114.
38. Jorgensen, M. B., and N. H. Diemer, 1982. Selective neuron loss after cerebral ischemia in the rat: Possible role of transmitter glutamate. Acta Neurol. Scand. 66: 536-546.
39. Jorgensen, M. B., D. C. Wright, and N. H. Diemer, 1990. Post-ischemic glucose metabolism is modified in the hippocampal CA1 region depleted of excitatory input of pyramidal cells. J. Cereb. Blood Flow Metab. 10: 243-251.
40. KINOSHITA, A., K. YAMADA, E. KOHMURA, and T. HAYAKAWA. Effect Of Astrocyte-Derived Factors On Ischemic Brain Edema Induced By Rat Mca-Occlusion. APM1S 98: 851-857.
41. Klatzo, I, 1987. Pathophysiological aspects of brain edema. Acta Neuropathol. 72: 236-239.
42. Klaue, R, 1940. Parkinsonische Krankheit (paralysis agitans) und postencephalitischer Parkinsonismus. Arch. Psychiatr. Ner-venkrankh. 111:251-321.
43. Kraig, R. P., and C. B. Jaeger, 1990. Ionic concomitants of astroglial transformation to reactive species. Stroke 21 (Suppl. Ill): 184-187.
44. Lindholm, D., R. Heumann, M. Meyer, and H. Thoenen, 1987. Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve. Nature 330: 658-659.
45. Lorente De No, R, 1934. Studies on the structure of the cerebral cortex. II. Continuation of the study of the ammonic system. J. Psychol. Neurol. 46: 113-177.
46. Lynch, G., G. Rose, C. Gall, and C. W. Cotman, 1975. The response of the dentate gyrus to partial deafferentation. In Golgi Centennial Symposium, Proceedings, pp, 305-317. Raven Press, New York.
47. Malipiero, U. V., K. Frei, and A. Fontana, 1990. Production of hemopoietic colony-stimulating factors by astrocytes. J. Immunol. 144: 3816-3821.
48. Marty, S., I. Dusart, and M. Peschanski, 1991. Glial changes following an excitotoxic lesion in the CNS-I: Microglia/macro-phages. Neuroscience 45: 529-539.
49. Mattson, M. P., and B. Rychlik, 1990. Glia protect hippocampal neurons against excitatory amino acid-induced degeneration: involvement of fibroblast growth factor. Int. J. Dev. Neurosci. 8:399-415.
50. Meldrum, B. S., and J. A. N. Corsellis, 1984. Epilepsy. In Greenfield's Neuropathology (J. H. Adams, J. A. N. Corsellis, and L. W. Duchen, Eds.), pp, 921-950. Arnold, London.
51. Monaghan, D. T., V. R. Holets, D. W. Toy, and C. W. Cot-Man, 1983. Anatomical distributions of four pharmacologically distinct 3H-L-glutamate binding sites. Nature 306: 176-179.
52. Morioka, T., A. N. Kalehua, and W. J. Streit, 1991. The microglial reaction in the rat dorsal hippocampus following transient forebrain ischemia. J. Cereb. Blood Flow Metab. 11: 966-973.
53. Morshead, C. M., and D. Van Der Kooy, 1990. Separate blood and brain origins of proliferating cells during gliosis in adult brains. Brain Res. 535: 237-244.
54. Murabe, Y., and Y. Sano, 1982. Morphological studies on neuroglia. V. Microglial cells in the cerebral cortex of the rat, with special reference to their possible involvement in synaptic function. Cell Tissue Res. 223: 493-506.
55. Murabe, Y., Y. Ibata, and Y. Sano.1981. MORPHOLOGICAL STUDIES ON NEUROGLIA. II. RESPONSE OF GLIAL CELLS TO KAINIC ACID-INDUCED LESIONS. Cell Tissue Res. 216: 569-580.
56. Nadler, J. V., B. W. Perry, C. Gentry, and C. W. Cotman, 1980. Degeneration of hippocampal CA3 pyramidal cells induced by intraventricular kainic acid. J. Comp. Neurol. 192: 333-359.
57. Nadler, J. V., B. W. Perry, C. Gentry, and C. W. Cotman, 1980. Loss and reacquisition of hippocampal synapses after selective destruction of CA3-CA4 afferents with kainic acid. Brain Res. 191: 387-403.
58. Nieto-Sampedro, M., and M. A. Berman, 1987. Interleukin-1-like activity in rat brain: Sources, targets, and effect of injury. J. Neurosci. Res. 17: 214-219.
59. Perry, V. H., and S. Gordon, 1991. Macrophages and the nervous system. Int. Rev. Cytol. 125: 203-244.
60. Petito, C. K., S. Morgello, J. C. Felix, and M. L. Lesser, 1990. THE TWO PATTERNS OF REACTIVE ASTROCYTOSIS IN POSTISCHEMIC RAT BRAIN. J. Cereb. Blood Flow Metab. 10: 850-859.
61. Phelps, S., J. Mitchell, and H. V. Wheal, 1991. Changes tosynaptic ultrastructure in field CA1 of the rat hippocampus following intracerebroventricular injection of kainic acid. Neuroscience 40:687-699.
62. Piani, D., K. Frei, K. Quang Do, M. Cuenod, and A. Fontana, 1991. Murine brain macrophages induce NMDA receptor mes diated neurotoxicity in vitro by secreting glutamate. Neurosci. Lett. 133: 159-162.
63. Pulsinelli, W. A., J. B. Brierly, and F. Plum, 1982. Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann. Neurol. 11: 491-498.
64. Raisman, G., and P. M. Field, 1973. A quantitative investigation of the development of collateral reinnervation after partial deafferentation of the septal nuclei. Brain Res. 50: 241-264.
65. Represa, A., E. Tremblay, and Y. Ben-Ari, 1987. Kainate binding sites in the hippocampal mossy fibers and plasticity. Neuroscience 20: 739-748.
66. Rose, G., G. Lynch, and C. W. Cotman, 1976. Hypertrophy and redistribution of astrocytes in the deafferented dentate gyrus. Brain Res. Bull. 1: 87-92.
67. Schlaepfer, W. W., and U.-J. P. Zimmerman, 1981. Calcium-mediated breakdown of glial fi laments and neurofilaments in ratoptic nerve and spinal cord. Neurochem. Res. 6: 243-255.
68. Schmidt-Kastner, R., J. Szymas, and K.-A. Hossmann, 1990. Immunohistochemical study of glial reaction and serum-protein extravasation in relation to neuronal damage in rat hippocam-78. pus after ischemia. Neuroscience 38: 527-540.
69. Selmaj, K., C. S. Raine, M. Farooq, W. T. Norton, and C. F. Brosnan, 1991. Cytokine cytotoxicity against oligodendrocytes: Apoptosis induced by lymphotoxin. J. Immunol. 147: 1522-1529.
70. Siesjo, B. K, 1988. Mechanisms of ischemic brain damage. Crit. Care Med. 16: 954-963.
71. Steward, O. 1976. Topographic organization of the projections from the entorhinal area to the hippocampal formation of the rat. J. Comp. Neurol- 167: 285-314.
72. Steward, O., E. R. Torre, R. Tomasulo, and E. Lothman, 1991. Neuronal activity up-regulates astroglial gene expression. Proc. Natl. Acad. Sd-USA 88: 6819-6823.
73. Streit, W. J., M. B. Graeber, and G. W. Kreutzberg, 1988. Functional plasticity of microglia: a review. Glia 1: 301-307.
74. SUZUMURA, A., M. SAWADA, H. YAMAMOTO, and T. MARUNOU-CHI, 1990. Effects of colony stimulating factors on isolated microglia in vitro. J. Neuroimmunol. 30: 111-120.
75. Tanaka, H., M. Araki, and T. Masuzawa, 1992. Reaction of astrocytes in the gerbil hippocampus following transient ischemia: Immunohistochemical observations with antibodies against glial fibrillary acidic protein, glutamine synthetase, and S-100 protein. Exp. Neurol 116: 264-274.
76. Teichberg, V. I, 1991. Glial glutamate receptors: Likely actors in brain signalling. FASEB J. 5: 3086-3091.
77. Vorbrodt, A. W., and H. M. Wisniewski, 1982. Plasrnalemma-bcund nucleoside diphosphatase as cytochemical marker of central nervous system (CNS) mesodermal cells. J. Histochem. Cy-tochem. 30: 418-424.
78. Yoshida, K. and F. H. Gage, 1991. Fibroblast growth factors stimulate nerve growth factor synthesis and secretion by astrocytes. Brain Res. 538: 118-126.
79. Zlelasek, J., M. Tausch, K. V. Toyka, and H.-P. Hartung, 1992. Production of nitrite by neonatal rat microglial cells/brain macrophages. Cellular Immunol. 141: 111-120.