MDM2 Gene Amplification in Metastatic Osteosarcoma

Cancer Research

Volumn 53, Issue 1, 1993, Pages 16-18

  Ladanyi, Marc ^a   Cha, Charles ^a   Lewis, Ronald ^a   Jhanwar, Suresh C ^a   Huvos, Andrew G ^a   Healey, John H ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; COMPLEMENTARY DNA; GENE PRODUCT; MESSENGER RNA; PROTEIN P53;

ARTICLE; CANCER GRADING; CANCER RECURRENCE; DNA PROBE; GENE AMPLIFICATION; GENE EXPRESSION; GENE REARRANGEMENT; HUMAN; HUMAN TISSUE; METASTASIS; OSTEOSARCOMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; SOUTHERN BLOTTING; TUMOR GROWTH;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BASE SEQUENCE; BLOTTING, NORTHERN; CHILD; FEMALE; GENE AMPLIFICATION; HUMAN; LUNG NEOPLASMS; MALE; MIDDLE AGE; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; OSTEOSARCOMA; RNA, NEOPLASM; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027508958     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Meyers, P.A., Heller, G., Healey, J., Huvos, A., Lane, J., Marcove, R., Applewhite, A., Vlamis, V., and Rosen, G. Chemotherapy for nonmetastatic osteogenic sarcoma: the Memorial Sloan-Kettering experience. J. Clin. Oncol., 10: 5-15 1992.
2. Oliner, J.D., Kinzler, K.W., Meltzer, P.S., George, D.L., and Vogelstein, B. Amplification of a gene encoding a p. 3-associated protein in human sarcomas. Nature (Lond)., 358: 80-83, 1992.
3. Momand, J., Zambetti, G.P., Olson, D.C., George, D., and Levine, A.J. The mdm-2 oncogene product forms a complex with the p. 3 protein and inhibits p. 3-mediated transactivation. Cell, 69: 1237-1245, 1992.
4. Cahilly-Snyder, L., Yang-Feng, T., Francke, U., and George, D.L. Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line. Somatic Cell Mol. Genet., 13: 235-244, 1987.
5. Fakharzadeh, S.S., Trusko, S.P., and George, D.L. Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line. EMBOJ., 10: 1565-1569, 1991.
6. Levine, A.J., Momand, J., and Finlay. C.A. The p. 3 tumor suppressor gene. Science (Washington DC), 351: 453-56, 1991.
7. Rosen, G., Caparros, B., Huvos, A.G., Kosloff, C., Nirenberg, A., Cacavio, A., Marcove, R.C., Lane, J.M., Mehta, B., and Urban, C. Preoperative chemotherapy for osteogenic sarcoma: selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy. Cancer (Phila.), 49: 1221-1230, 1982.
8. Schwab, M., and Amler, L.C. Amplification of cellular oncogenes: a predictor of clinical outcome in human cancer. Genes Chromosomes Cancer, 1: 181-193, 1990.
9. Meltzer, P.S., Jankowski, S.A., Dal Cin, P., Sandberg, A.A., Paz, I.B., and Coccia, M.A. Identification and cloning of a novel amplified DNA sequence in human malignant fibrous histiocytoma derived from a region of chromosome 12 frequently rearranged in soft tissue tumors. Cell Growth & Differ., 2: 495-501, 1991.
10. Smith, S.H., Weiss, S.W., Jankowski, S.A., Coccia, M.A., and Meltzer, P.S. SAS amplification in soft tissue sarcomas. Cancer Res., 52: 3746-3749, 1992.
11. Roberts, W.M., Douglass. E.C., Peiper, S.C., Houghton, P.J., and Look, A.T. Amplification of the gli gene in childhood sarcomas. Cancer Res., 49: 5407-5413, 1989.
12. Gaudray, P., Szepetowski, P., Escot, C., Birnbaum, D., Theillet, C. DNA amplification at 1 lql3 in human cancer, from complexity to perplexity. Mutat. Res., 276: 317-328, 1992.
13. Mulligan, L.M., Matlashewski, G.J., Scrable, H.J., and Cavenee, W.K. Mechanisms of p. 3 loss in human sarcomas. Proc. Natl. Acad. Sci. USA, 87: 5863-5867, 1990.
14. Miller, C.W., Aslo, A., Tsay, C., Slamon, D., Ishizaki, K., Toguchida, J., Yamamuro, T., Lampkin, B., and Koeffler, H.P. Frequency and structure of p. 3 rearrangements in human osteosarcoma. Cancer Res., 50: 7950-7954, 1990.
15. Lavigueur, A., Maltby, V., Mock, D., Rossant, J., Pawson, T., and Bernstein, A. High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p. 3 oncogene. Mol. Cell. Biol., 9: 3982-3991, 1989.
16. Malkin, D., Li, F.P., Strong, L.C., Fraumeni, J.F., Jr., Nelson, C.E., Kim, D.H., Kassel, J., Gryka, M.A., Bischoff, F.Z., Tainsky, M.A., and Friend, S.H. Germ line p. 3 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science (Washington DC). 250: 1233-1238, 1990.
17. Yamaguchi, T., Toguchida, J., Yamamuro, T., Kotoura, Y., Takada, N., Kawaguchi, N., Kaneko, Y., Nakamura, Y., and Sasaki, M.S., Ishizaki, K. Allelotype analysis in osteosarcomas: frequent allele loss on 3q, 13q, 17p, and 18q. Cancer Res., 52: 2419-2423, 1992.
18. Scheffer, H., Kruize, Y.C., Osinga, J., Kuiken, G., Oosterhuis, J.W., Leeuw, J.A., Schraffordt-Koops, H., and Buys, C.H. Complete association of loss of heterozygosity of chromosomes 13 and 17 in osteosarcoma. Cancer Genet. Cytogenet., 53: 45-55, 1991.
19. Scholz. R.B., Kabisch, H., Weber, B., Roser. K., Delling, G., and Winkler, K. Studies of the RBI gene and the p. 3 gene in human osteosarcomas. Pediatr. Hematol. Oncol., 9: 125-137, 1992.