Down‐regulation of riα subunit of camp‐dependent protein kinase induces growth inhibition of human mammary epithelial cells transformed by c‐ha‐ras and c‐erbb‐2 proto‐oncogenes

International Journal of Cancer

Volumn 53, Issue 3, 1993, Pages 438-443

  Ciardiello, Fortunato ^a   Pepe, Stefano ^a   Bianco, Caterina ^a   Baldassarre, Gustavo ^a   Ruggiero, Angela ^a   Bianco, Cataldo ^a   Selvam, Mouna P ^b   Raffaele Bianco, A ^a   Tortora, Giampaolo ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 CHLOROADENOSINE 3',5' PHOSPHATE; CYCLIC AMP DEPENDENT PROTEIN KINASE;

ARTICLE; BREAST EPITHELIUM; CELL LINE; CELL TRANSFORMATION; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; GROWTH INHIBITION; HUMAN; HUMAN CELL; ONCOGENE H RAS; PRIORITY JOURNAL;

ANTISENSE ELEMENTS (GENETICS); BASE SEQUENCE; BLOTTING, WESTERN; BREAST; CELL CYCLE; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; CYCLIC AMP; EPITHELIUM; FLOW CYTOMETRY; GENES, RAS; GROWTH INHIBITORS; HUMAN; MOLECULAR SEQUENCE DATA; OLIGODEOXYRIBONUCLEOTIDES; PROTEIN KINASES; PROTO-ONCOGENE PROTEIN P21(RAS); PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENES; RECEPTOR, ERBB-2; SUPPORT, NON-U.S. GOV'T;

EID: 0027499522     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.2910530315     Document Type: Article

References (24)

1. Cellular ras oncogene expression and cell cycle measured by flow cytometry in hematopoietic cell lines
2. Transformation of human breast epithelial cells by c‐Ha‐ras oncogene
3. Correlation of the c‐erbB‐2 gene amulification and protein exuression in human breast cancer with nodal stitus and nuclear grading
4. Role of cAMP receptor proteins in growth, differentiation and suppression of malignancy: new approaches to therapy
5. Role of site‐selective cAMP analogs in the control and reversal of malignancy
6. Additive effects of c‐erbB‐2, c‐Ha‐ras, and transforming growth factor α genes on the in vitro transformation of human mammary epithelial cells.
7. Transforming growth factor α expression is enhanced in human mammary epithelial cells transformed by an activated c‐Ha‐ras protooncogene but not by the c‐neu protooncogene and overexpression of the transforming growth factor α complementary DNA leads to transformation.
8. 8‐CI‐cAMP inhibits transforming growth factor α transformation of mammary epithelial cells by restoration of the normal mRNA patterns for cAMP‐dependent protein kinase regulatory subunit isoforms which show disruption upon transformation
9. Prognostic significance of the expression of a ras protein with a molecular weight of 21,000 by human breast cancer
10. c‐erbB‐2 and ras expression levels in breast cancer are correlated and show a cooperative association with unfavorable clinical outcome.
11. Monoclonal antibodies to the p21 products of the transforming gene of the Harvey murine sarcoma virus and of the cellular ras gene family
12. Molecular cloning, complementary deoxyribonucleic acid structure and predicted full length amino acid sequence of the hormone inducible regulatory subunit of 3′, 5′ cyclic adenosine monophoshate‐dependent protein kinase from human testis
13. Activation of protein kinase isozymes by cyclic nucleotide analogs used singly or in combination
14. Exoression of p21 ras gene products in breast cancer relates to histological types and to receptor and nodal status
15. Interaction of oncogenes and growth factors in colon and breast cancer
16. Molecular cloning, cDNA structure and deduced aminoacid sequence for a type I regulatory subunit of cAMP dependent protein kinase from human testis
17. Studies of the HER‐2/neu protooncogene in human breast and ovarian cancer
18. Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF‐10
19. Oligodeoxynucleotides as inhibitors of gene expression: a review
20. Ultrastructural and immunocytochemical characterization of an immortalized human breast epithelial cell line, MCF‐10A
21. cAMP‐dependent protein kinase: framework for a diverse family of regulatory enzymes
22. Site‐selective 8‐chloro‐adenosine 3′, 5′ monophosphate inhibits transformation and transforming growth factor α production in Ki‐ras‐transformed rat fibroblasts
23. Differentiation of HL‐60 leukemia by type I regulatory subunit antisense oligodeoxynucleotide of cAMP‐dependent protein kinase
24. 8‐Chloro‐adenosine 3′, 5′‐monophosphate inhibits the growth of Chinese hamster ovary and MOLT‐4 cells through its adenosine metabolite