Regulation of iron absorption: Proteins involved in duodenal mucosal uptake and transport

Journal of the American College of Nutrition

Volumn 12, Issue 6, 1993, Pages 720-728

  Conrad, Marcel E ^a   Umbreit, Jay N ^a   Moore, Elizabeth G ^a  

^a UNIVERSITY OF SOUTH ALABAMA   (United States)

Author keywords

Calreticulin; Integrin; Metals; Mobilferrin; Mucin; Protein

Indexed keywords

FERRITIN; INTEGRIN; IRON; IRON BINDING PROTEIN; MUCIN; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; CYTOSOL; DUODENUM MUCOSA; IMMUNOBLOTTING; INTESTINE CELL; ION EXCHANGE CHROMATOGRAPHY; IRON ABSORPTION; IRON BINDING CAPACITY; IRON DEFICIENCY; IRON TRANSPORT; NONHUMAN; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; RAT; TWO DIMENSIONAL ELECTROPHORESIS;

ANIMAL; CARRIER PROTEINS; DUODENUM; INTEGRINS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; IRON; IRON-BINDING PROTEINS; MODELS, BIOLOGICAL; RATS; RATS, WISTAR; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027496419     PISSN: 07315724     EISSN: 15411087     Source Type: Journal    
DOI: 10.1080/07315724.1993.10718365     Document Type: Article

References (46)

1. Mackler B, Grace R, Finch CA: Iron deficiency in the rat: effects on oxidative metabolism in distinct types of skeletal muscle. Pediatr Res 18:499-500, 1984.
2. Beard J, Finch CA, Mackler B: Deleterious effects in iron deficiency. Prog Clin Biol Res 77:305-310, 1981.
3. Holland HK, Spivak JL: Hemochromatosis. Med Clin North Am 73:831-845, 1989.
4. Lauffer RB: “Iron and Human Disease.” Boca Raton, FL: CRC Press, 1992.
5. Salonen JT, Nyyssônen K, Korpela H, Tuonuleehto J, Sap- pànen R, Salonen R: High storage iron levels are associated with excess risk of myocardial infarction in eastern Finnish men. Circulation 86:803-811, 1992.
6. Sullivan JL: The iron paradigm of ischemic heart disease. Am Heart J 117:1177-1188, 1989.
7. Downey JM: Free radicals and their involvement during long term myocardial ischemia and reperfusion. Annu Rev Physiol 52:487-504, 1990.
8. Halliwell B: Free radicals, reactive oxygen species and human disease. A critical evaluation with special reference to atherosclerosis. Br J Exp Pathol 70:737-757, 1989.
9. Selby JV, Freidman GD: Epidemiological evidence of an association of body iron stores and risk of cancer. Int J Cancer 41:677-682, 1988.
10. Stevens RG, Jones DY, Micozzi MS, Taylor PR: Body iron stores and risk of cancer. N Engl J Med 319:1047-1052, 1988.
11. Braughler JM, Hall ED: Central nervous system trauma and stroke I. Biochemical considerations for oxygen radical formation and lipid peroxidation. Free Radical Biol Med 6:289-301, 1989
12. Sadrzadeh SMH, Eaton JW: Hemoglobin mediated oxidant damage to the central nervous system requires endogenous ascorbate. J Clin Invest 82:1510-1515, 1988.
13. Dexter DT, Wells FR, Agid F, Agid Y, Lees AJ, Jenner P, Marsden CD: Increased nigral iron content in postmortem Parkinson brain. Lancet 2:1219-1220, 1987.
14. Halliwell B, Gutteridge JM: Role of oxygen in oxygen radical reactions. Methods Enzymol 105:47-56, 1984.
15. Riederer P, Sofic E, Rausch WD, Schmidt B, Reynolds GP, Jellinger K, Youdim MBH: Transition metals, ferritin, glutathionine and ascorbic acid in Parkinsonian brain. J Neu- rochem 52:515-520, 1989.
16. Blass JP, Gibson GE: The role of oxidative abnormalities in the pathophysiology of Alzheimer’s disease. Rev Neurol 147:515-525, 1991.
17. Grundke-Igbal L, Fleming J, Tung Y-C, Lassman H, Igbal K, Joshi JG: Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia. Acta Neuropathol 81:105-110, 1990.
18. Ehmann WD, Markesberg WR, Alauddin M, Hossain TI, Brubacker EH: Brain trace elements in Alzheimer’s disease. Neurotoxicology 7:197-206, 1986.
19. DeSousa M: Iron and the lymphomyeloid system. In deSousa M, Brock JH (eds): “A Growing Knowledge of Iron in Immunology, Cancer and Inflammation.” New York: John Wiley & Sons, p 3, 1989.
20. Parmley RT, Barton JC, Conrad ME: Ultrastructural localization of transferrin, transferrin receptor and iron binding sites on human placental and duodenal microvilli. Br J Haematol 60:81-89, 1985.
21. Finch CA, Ragan HA, Dyer IA, Cook JD: Body iron loss in animals. Proc Soc Exp Biol Med 59:335-338, 1978.
22. Conrad ME, Umbreit JN, Moore EG, Peterson RDA, Jones MB: A newly identified iron binding protein in duodenal mucosa of rats. Purification and characterization of mobilfer- rin. J Biol Chem 25:5273-5279, 1980.
23. Conrad ME, Umbreit J, Moore EG, Rodning CR: Newly identified iron binding protein in human duodenal mucosa. Blood 79:244-247, 1962.
24. Conrad ME, Umbreit JN, Peterson RDA, Moore EG: Regulation of iron absorption in the small intestine. In Tomia H (ed): “Trace Elements in Clinical Medicine.” Tokyo: SpringerVerlag, pp 117-121, 1990.
25. Conrad ME, Umbreit JN, Moore EG: A role for mucin in the absorption of inorganic iron and other metal cations. Gastroenterology 100:129-136, 1991.
26. Conrad ME, Umbreit JN, Peterson RDA, Moore EG, Harper KP: Function of integrin in duodenal mucosal uptake of iron. Blood 81:517-521, 1993.
27. O’Farrell PH: High resolution two-dimensional electrophoresis of proteins. J Biol Chem 250:4007-4021, 1975.
28. International Committee for Standardization in Haematology: Recommendations for measurement of serum iron in human blood. Br J Haematol 38:291-294, 1978.
29. International Committee for Standardization in Haematology: The measurement of total and unsaturated iron binding capacity in serum. Br J Haematol 38:281-290, 1978.
30. Conrad ME, Umbreit JN, Moore EG: Mobilferrin: a homologue of calreticulin. Gastroenterology 104:1700-1704, 1993.
31. McCauliffe DO, Lux FA, Lieu T-S, Sanz I, Hanke MN, Newkuk MN, Bachinaki LL, Itoh Y, Sicliano MJ, Reichlin M, Sontheimer RD, Capra JD: Molecular cloning, expression and chromosome localization of a human Ro/SS-A autoantigen. J Clin Invest 85:1379-1391, 1990.
32. McCauliffe DP, Zappi E, Liew TS, Michalak M, Sontheimer RD, Capra JD: A human Ro/SS-A autoantigen is the homologue of calreticulin and is homologous with oncocercal RAL- 1 antigen and an aplysia “Memory Molecule.” J Clin Invest 83:332-335, 1990.
33. Simon M, LeMignon L, Fauchet R, Yaoung J, David V, Egan G, Bourel M: A study of 609 HLA haplotypes marking for the hemochromatosis gene (1). Mapping of the gene near the HLA-A locus and characters to define a heterozygous population and (2) hypothesis concerning the underlying cause of hemochromatosis-HLA association. Am J Hum Genet 41:89-105, 1987.
34. Kessler M, Acute O, Storelli C, Muer H, Müller M, Semezer G: A modified method for the rapid preparation of efficiently transporting vesicles from small intestinal brush border membranes. Biochim Biophys Acta 506:134-154, 1978.
35. Rojiani MV, Finlay BB, Gray S, Dedhar S: In vitro interaction of a polypeptide homologous to human Ro/SS-A antigen (calreticulin) with a highly conserved amino acid sequence in the cytoplasmic domain of integrin a subunits. Biochemistry 30:9859-9866, 1991.
36. Teichmann R, Stremmel W: Iron uptake by human upper small intestine microvillous membrane vesicles. J Clin Invest 86:21-45, 1990.
37. Nichols GM, Pearce AR, Alvarez X, Bibb NK, Nichols KY, Alfred CB, Glass J: The mechanisms of non-heme iron uptake determined in IEC-6 rat intestinal cells. J Nutr 122:945-952, 1992.
38. Guan G, Falick AM, Williams DE, Cashman JR: Evidence for complex formation between rabbit lung flavin containing monooxygenase and calreticulin. Biochemistry 30:9893-9900, 1991.
39. Conrad ME, Parmley RT, Osterloh K: Small intestinal regulation of iron absorption in the rat. J Lab Clin Med 110:418— 426, 1987.
40. Conrad ME, Umbreit JN: Iron absorption—the mucin- mobilferrin-integrin pathway. A competitive pathway for metal absorption. Am J Hematol 42:67-73, 1993.
41. Beutler E, Buttenweiser E: The regulation of iron absorption. I. A search for humoral factors. J Lab Clin Med 55:274-280, 1964.
42. Conrad ME, Crosby WH: The natural history of iron deficiency induced by phlebotomy. Blood 20:173-185, 1962.
43. Schade SG, Bemier GM, Conrad ME: Normal iron absorption in hypertransferrinemic rats. Br J Haematol 17:187-190, 1969.
44. Weintraub LR, Conrad ME, Crosby WH: The significance of iron turnover in the control of iron absorption. Blood 24:19— 24, 1964.
45. Brittin GM, Haley J, Brecher B: Enhancement of intestinal iron absorption by a humoral factor in parabiont rats. Proc Soc Exp Biol Med 128:178-184, 1968.
46. Finch CA, Huebers H, Eng M, Miller L: Effect of transfused reticulocytes on iron exchange. Blood 59:364-369, 1982.