Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

Cell

Volumn 75, Issue 1, 1993, Pages 135-146

  Steimle, Viktor ^a   Otten, Luc A ^a   Zufferey, Madeleine ^a   Mach, Bernard ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ARTICLE; GENE ACTIVATION; GENE DELETION; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC COMPLEMENTATION; HUMAN; HUMAN CELL; LYMPHOCYTE DEPLETION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR CLONING; PRIORITY JOURNAL;

EID: 0027490172     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(05)80090-X     Document Type: Article

References (66)

1. Human B cell variants immunoselected against a single la antigen subset have lost expression in several la antigen subsets
2. alr-1, a newly found locus on mouse chromosome 16 encoding a trans-acting activator factor for MHC class II gene expression
3. Cell lineage-specific and developmental stage-specific controls of MHC class-II-antigen expression
4. Basic local alignment search tool
5. Induction of class-I major histocompatibility complex antigens in human teratocarcinoma cells by interferon without induction of differentiation, growth-inhibition, or resistance to viral-infection
6. Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system
7. Prosite: a dictionary of sites and patterns in proteins
8. Role of MHC gene products in immune regulation
9. Class II-antigen-negative patient and mutant B-cell lines represent at least three, and probably four, distinct genetic defects defined by complementation analysis
10. Regulation of major histocompatibility complex class II genes: X, Y and other letters of the alphabet
11. The oncoprotein Bcl-3 directly transactivates through κB motifs via association with DNA-binding p50B homodimers
12. Mutant human B cell lines deficient in class II major histocompatibility complex transcription
13. Establishment of a cell line (Co-115) from a human colon carcinoma transplanted into nude mice
14. Successful treatment of an HLA-deficient SCID (“bare lymphocyte syndrome”) patient with an unrelated bone marrow transplant
15. Analysis of HLA-D region-associated molecules with monoclonal antibody
16. Transcriptional regulation of the HLA-DRA gene
17. A trans-acting class II regulatory gene unlinked to the MHC controls expression of HLA class II genes
18. Optimization of the hygromycin B resistance-conferring gene as a dominant selectable marker in mammalian cells
19. Stable variants affecting B cell alloantigens in human lymphoid cells
20. Sequences and factors: a guide to MHC class-II transcription
21. Inherited immunodeficiency with a defect in a major histocompatibility complex class II promoterbinding protein differs in the chromatin structure of the HLA-DRA gene
22. Impaired cell-to-cell interaction in partial combined immunodeficiency with variable expression of HLA antigens
23. Combined immunodeficiency with defective expression in MHC class II genes
24. In vitro antigenic modulation of human neuroblastoma cells induced by IFN-γ, retinoic acid and dibutyryl cyclic AMP
25. Stable integration of mouse DNA into la-negative human B-lymphoma cells causes reexpression of the human la-positive phenotype
26. Defective expression of HLA-D-region determinants in children with congenital agammaglobulinemia and malabsorption: a new syndrome
27. Protease treatment of nuclear extracts distinguishes between class II MHC X1 box DNA-binding proteins in wild-type and class II-deficient B cells
28. The DNA-binding defect observed in major histocompatibility complex class-II regulatory mutants concerns only one member of a family of complexes binding to the X-boxes of class-II promoters
29. Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators
30. Simple and rapid measurement of human T lymphocytes and their subclasses in peripheral blood
31. Congenital immunodeficiencies associated with absence of HLA class II antigens on lymphocytes result from distinct mutations in trans-acting factors
32. Bare lymphocyte syndrome: altered HLA class II expression in B cell lines derived from two patients
33. Cloning of a transcriptionally active human Tata binding factor
34. In vivo footprinting of MHC class II genes: bare promoters in the bare lymphocyte syndrome
35. Three in vivo promoter phenotypes in MHC class II deficient combined immunodeficiency
36. An enhancer defect in a mutant Burkitt lymphoma cell line
37. The scanning model for translation: an update
38. The mutational spectrum of single base-pair substitutions in mRNA splice junctions of human genes: Causes and consequences
39. 2 populations of la-like molecules on a human B-cell line
40. A defect in the regulation of major histocompatibility complex class II gene expression in human HLA-DR negative lymphocytes from patients with combined immunodeficiency syndrome
41. la-negative B-cell variants reveal a coordinate regulation in the transcription of the HLA class II gene family
42. Regulation and deregulation of HLA class II genes
43. Polymorphism and regulation of HLA class-II genes of the major histocompatibility complex
44. Diversity and regulation of MHC class II genes
45. The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family
46. Cell-mediated immune functions in a patient with MHC class II deficiency
47. Epstein-Barr virus shuttle vector for stable episomal replication of cDNA expression libraries in human cells
48. Magnitude of response of histocompatibility-restricted T-cell clones is a function of the product of the concentrations of antigen and la molecules
49. The prolinerich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain
50. A simple salting out procedure for extracting DNA from human nucleated cells
51. Transcriptional regulation in mammalian cells by sequence-specific DNA-binding proteins
52. Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism
53. Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X
54. Cloning of the major histocompatibility complex class II promoter binding protein affected in a hereditary defect in class II gene regulation
55. MHC class II regulatory factor RFX has a novel DNA-binding domain and a functionally independent dimerization domain
56. The P-loop: a common motif in ATP-binding and GTP-binding proteins
57. Conserved upstream sequences of human class-II major histocompatibility genes enhance expression of class-II genes in wild-type but not mutant B-cell lines
58. Procedures for constructing cDNA expression libraries in Epstein-Barr virus shuttle vectors capable of stable episomal replication
59. Defective HLA DRA X box binding in the class II transactive transcription factor mutant 6.1.6 and in cell lines from class II immunodeficient patients
60. A vector that replicates as a plasmid and can be efficiently selected in B-Lymphoblasts transformed by Epstein-Barr virus
61. Regulation of MHC gene expression
62. Structural and functional analyses of Saccharomyces cerevisiae wild-type and mutant Rna1 genes
63. Detection of a novel human class II HLA antigen
64. Analysis by sequential immunoprecipitations of the specificities of the monoclonal antibodies Tü22, Tü34, Tü35, Tü36, Tü37, Tü39, Tü43, Tü58, and Yd1/63: Hik directed against human HLA class II antigens