5-Ethynyluracil (776C85): A potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil

Proceedings of the National Academy of Sciences of the United States of America

Volumn 90, Issue 23, 1993, Pages 11064-11068

  Baccanari, D P ^a   Davis, S T ^a   Knick, V C ^a   Spector, T ^a  

^a Burroughs Wellcome Co   (United States)

Author keywords

biochemical modulation; potentiation; therapeutic index

Indexed keywords

5 ETHYNYLURACIL; FLUOROURACIL; URACIL DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CANCER CHEMOTHERAPY; DOSE TIME EFFECT RELATION; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG METABOLISM; DRUG POTENTIATION; ENZYME INHIBITION; FEMALE; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ANIMAL; BIOLOGICAL AVAILABILITY; COLONIC NEOPLASMS; DRUG SYNERGISM; FEMALE; FLUOROURACIL; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED STRAINS; NEOPLASMS, EXPERIMENTAL; OXIDOREDUCTASES; PLASMACYTOMA; RATS; THERAPEUTIC EQUIVALENCY; URACIL;

ANIMALIA;

EID: 0027489763     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.90.23.11064     Document Type: Article

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