Interleukin-1 contributes to the induction of nitric oxide synthase by endotoxin in vivo

European Journal of Pharmacology

Volumn 250, Issue 1, 1993, Pages 157-160

  Szabó, Csaba ^a   Wu, Chin Chen ^a   Gross, Steven S ^a   Thiemermann, Christoph ^a   Vane, John R ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Circulatory shock; Cytokine; Endotoxin shock; Vascular hyporeactivity; Vasodilatation

Indexed keywords

ESCHERICHIA COLI ENDOTOXIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NORADRENALIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; HYPOTENSION; INTRAVENOUS DRUG ADMINISTRATION; LUNG; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEPTIC SHOCK; SMOOTH MUSCLE CONTRACTILITY; TACHYCARDIA; THORACIC AORTA;

AMINO ACID OXIDOREDUCTASES; ANIMAL; AORTA, THORACIC; BLOOD PRESSURE; COMPARATIVE STUDY; ENDOTOXINS; ENZYME INDUCTION; ESCHERICHIA COLI; HEART RATE; INTERLEUKIN-1; LUNG; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; NITRIC-OXIDE SYNTHASE; NOREPINEPHRINE; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; SIALOGLYCOPROTEINS; SUPPORT, NON-U.S. GOV'T;

EID: 0027487355     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(93)90634-T     Document Type: Article

References (16)

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3. Induction of nitric oxide by cytokines in vascular smooth muscle cells
4. Multiple cytokines are required to induce hepatocyte nitric oxide production and inhibit total protein synthesis
5. Blocking interleukin-1: interleukin-1 receptor antagonist in vivo and in vitro
6. Synergism between interleukin-1 beta and interferon-gamma, an inducer of nitric oxide synthase, in rat lung fibroblasts
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8. Endothelial cell production of nitrogen oxides in response to interferon in combination with tumor necrosis factor, interleukin-1 or endotoxin
9. G-Nitroarginine (L-NOARG), a novel L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro
10. Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: and insight into endotoxin shock
11. Widespread tissue distribution, species distribution and changes in activity of calcium-dependent and calcium-independent nitric oxide synthases
12. Nitric-oxide mediated hyporeactivity to noradrenaline precedes nitric oxide synthase induction in endotoxin shock
13. Platelet-activating factor is an endogenous mediator of nitric oxide synthase induction in endotoxin shock
14. Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo
15. Vascular hyporeactivity to vasoconstrictor agents and haemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide
16. Tumour necrosis factor is an endogenous mediator of the induction of nitric oxide synthase in a rat model of endotoxin shock