Convergent combination therapy can select viable multidrug-resistant HIV-1 in vitro

Nature

Volumn 365, Issue 6445, 1993, Pages 451-453

  Larder, Brendan A ^a   Kellam, Paul ^a   Kemp, Sharon D ^a  

^a WELLCOME RESEARCH LABORATORIES   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTIVIRUS AGENT; DIDANOSINE; EMTRICITABINE; LAMIVUDINE; NEVIRAPINE; RNA DIRECTED DNA POLYMERASE; ZIDOVUDINE;

ARTICLE; HUMAN IMMUNODEFICIENCY VIRUS 1; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; VIRUS MUTATION; VIRUS REPLICATION;

BASE SEQUENCE; DIDANOSINE; DNA, VIRAL; DRUG RESISTANCE, MICROBIAL; HELA CELLS; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMAN; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEVIRAPINE; PYRIDINES; REVERSE TRANSCRIPTASE INHIBITORS; RNA-DIRECTED DNA POLYMERASE; ZIDOVUDINE;

EID: 0027486945     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/365451a0     Document Type: Article

References (29)

1. De Clercq, £. AIDS Res. hum. Retrovir. 8, 119–134 (1992).
2. Larder, B. A., Purifoy, D. J. M., Powell, K. L. & Darby, G. Nature 327, 716–717 (1987).
3. Larder, B. A., Kemp, S. D. & Purifoy, D. J. M. Proc. natn. Acad. Sci. U.S.A. 86, 4803–4807 (1989).
4. Larder, B. A., Darby, G. & Richman, D. D, Science 243, 1731–1734 (1989).
5. Richman, D. D., Grimes, J. M. & Lagakos, S. W. J. AIDS 3, 743–746 (1990).
6. Boucher, C. A. B. et at. Lancet 336, 585–590 (1990).
7. St Clair, M. H. et al. Science 253, 1557–1559 (1991).
8. McLeod, G. X., McGrath, J. M., Ladd, E. A. & Hammer, S. M. Antimicrob. Ag. Chemother. 36, 920–925 (1992).
9. Nunberg, J. H. et al. J. Virol. 65, 4887–4892 (1991).
10. Richman, D. D. et al. Proc. natn. Acad. Sci. U.S.A. 88, 11241–11245 (1991).
11. Mellors, J.W. et al. Molec. Pharmac. 41, 446–451 (1992).
12. Balzarini, J. et al. Virology 192, 246–253 (1993).
13. Dueweke, T. J. et al. Proc. natn. Acad. Sci. U.S.A. 90, 4713–4717 (1993).
14. Larder, B. A. Antimicrob. Ag. Chemother. 36, 2664–2669 (1992).
15. Larder, B. A. & Kemp, S. D. Science 246, 1155–1158 (1989).
16. Kellam, P., Boucher, C. A. B. & Larder, B. A. Proc. natn. Acad. Sci. U.S.A. 89, 1934–1938 (1992).
17. Richman, D. et al. Antimicrob. Ag. Chemother. 35, 305–308 (1991).
18. Goldman, M. E. et al. Proc. natn. Acad. Sci. U.S.A. 88, 6863–6867 (1991).
19. Johnson, V. A. et al. J. inf. Dis. 164, 646–655 (1991).
20. Larder, B. A., Chesebro, B. & Richman, D. D. Antimicrob. Ag. Chemother. 34, 436–441 (1990).
21. Fitzgibbon, J. E. et al. Antimicrob. Ag. Chemother. 36, 153–157 (1992).
22. Chow, Y-K. et al. Nature, 361, 650–653 (1993).
23. Merluzzi, V.J. et al. Science 250, 1411–1413 (1990).
24. Schinazi, R. F. et al. Antimicrob. Ag. Chemother. 37, 875–881 (1993).
25. Tisdale, M., Kemp, S. D., Parry, N. R. & Larder, B. A. Proc. natn. Acad. Sci. USA 90, 5653–5656 (1993).
26. Emini, E. A. et al. Nature 364, 679 (1993).
27. Chow, Y.-K., Hirsch, M. S., Kaplan, J. C. & D’Aquilla, R. T. Nature 364, 679 (1993).
28. Larder, B. A., Purifoy, D. J. M., Powell, K. L. & Darby, G. EMBO J. 6, 3133–3137 (1987).
29. Larder, B. A. & Boucher, C. A.B. in Diagnostic Molecular Microbiology: Principles and Applications (eds Persing, D. H., Smith, T. F., Tenover, F. C. & White, T. J.) 527–533 (Am. Soc. Microbiol., Washington DC, 1993).