Single Point d-Substituted Corticotropin-Releasing Factor Analogues: Effects on Potency and Physicochemical Characteristics

Journal of Medicinal Chemistry

Volumn 36, Issue 20, 1993, Pages 2851-2859

  Rivier, Jean ^a   Rivier, Catherine ^a   Galyean, Robert ^b   Miranda, Antonio ^c   Miller, Charleen ^a   Craig, A Grey ^a   Yamamoto, Gayle ^d   Brown, Marvin ^e   Vale, Wylie ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b Bachem Holding AG   (Switzerland)

^c FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^d ZYMOGENETICS INC   (United States)

^e UCSD MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR DERIVATIVE; SYNTHETIC PEPTIDE;

ADRENALECTOMY; ADRENALIN RELEASE; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; CORTICOTROPIN RELEASE; DRUG POTENCY; DRUG SYNTHESIS; HEART RATE; MEAN ARTERIAL PRESSURE; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMAL; BLOOD PRESSURE; CIRCULAR DICHROISM; COMPARATIVE STUDY; CORTICOTROPIN; CORTICOTROPIN-RELEASING HORMONE; EPINEPHRINE; HEART RATE; MALE; MOLECULAR SEQUENCE DATA; NOREPINEPHRINE; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; RATS; RATS, SPRAGUE-DAWLEY; SHEEP; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027484160     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00072a003     Document Type: Article

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