Skin Replacements: The Biotechnological Quest for Optimal Wound Closure

Archives of Surgery

Volumn 128, Issue 11, 1993, Pages 1246-1252

  Cairns, Bruce A ^a   Deserres, Suzan ^a   Peterson, H D ^a   Meyer, Anthony A ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOGRAFT; ARTICLE; AUTOGRAFT; BIOTECHNOLOGY; COST EFFECTIVENESS ANALYSIS; DONOR SITE; HUMAN; KERATINOCYTE; PRIORITY JOURNAL; SKIN DEFECT; SKIN TRANSPLANTATION; WOUND CLOSURE;

CELLS, CULTURED; CLINICAL TRIALS; COST-BENEFIT ANALYSIS; FORECASTING; HUMAN; KERATINOCYTES; POROSITY; SKIN, ARTIFICIAL; TRANSPLANTATION, AUTOLOGOUS; TRANSPLANTATION, HOMOLOGOUS; WOUND HEALING; WOUNDS AND INJURIES;

EID: 0027484046     PISSN: 00040010     EISSN: 15383644     Source Type: Journal    
DOI: 10.1001/archsurg.1993.01420230074012     Document Type: Article

References (105)

1. Serafin D. The skin: functional, metabolic, and surgical considerations. In: Sabiston DC, ed. Textbook of Surgery. Philadelphia, Pa: WB Saunders Co; 1986:1569-1595.
2. Haynes BW. The history of burn care. In: Boswick JA, ed. The Art and Science of Burn Care. Rockville, Md: Aspen Publishers Inc; 1987:3-9.
3. Deitch EA. The management of burns. N Engl J Med. 1990;323:1249-1253.
4. Herndon DN, Curreri PW, Abston S, Rutan TC, Barrow RE. Treatment of burns. Curr Probl Surg. 1987;24:341-397.
5. Chvapil M. Considerations on manufacturing principles of a synthetic burn dressing: a review. J Biomed Mater Res. 1982;16:245-263.
6. Pruitt BA Jr, Levine NS. Characteristics and uses of biologic dressings and skin substitutes. Arch Surg. 1984;119:312-322.
7. Yannas IV, Burke JF. Design of an artificial skin, I: basic design principles. J Biomed Mater Res. 1980;14:65-81.
8. Hansbrough JF. Current status of skin replacements for coverage of extensive burn wounds. J Trauma. 1990;30(suppl):155-160.
9. May SR, Still JM, Atkinson WB. Recent developments in skin banking and the clinical uses of cryopreserved skin. J Med Assoc Ga. 1984;73:233-236.
10. Zawacki BE. Temporary wound closure after burn excision. J Burn Care Rehabil. 1986;7:138-143.
11. Burke JF, Quinby WC, Bondoc CC. Primary excision and prompt grafting as a routine therapy for the treatment of thermal burns in children. Surg Clin North Am. 1976;56:477-494.
12. Herndon DN, Barrow RE, Rutan RL, Rutan TC, Desai MH, Abston S. A comparison of conservative versus early excision. Ann Surg. 1989;209:547-553.
13. Clark GT, Moon DJ, Cunningham PR, Johnson TD, Thomas JM, Thomas FT. Specific unresponsiveness to skin allografts in burns. J Surg Res. 1989;46: 401-404.
14. Mindikoglu AN, Cetinkale O. Prolonged allograft survival in a patient with extensive burns using cyclosporine. Burns. 1993;19:70-72.
15. Hewitt CW, Black KS, Achauer BM, Patel MP. Reconstructive allotransplantation: considerations regarding integumentary/musculoskeletal grafts, cyclosporine, wound coverage in thermal injury, and the immune response. J Burn Care Rehabil. 1990;11:74-85.
16. Nanchahal J, Ward CM. New grafts for old? a review of alternatives to autologous skin. Br J Plast Surg. 1992;45:354-363.
17. Rudolph R, Klein L. Healing process in skin grafts. Surg Gynecol Obstet. 1973; 136:641-654.
18. Branham GH, Thomas JR. Skin grafts. Otolaryngol Clin North Am. 1990;23: 889-897.
19. Zitelli JA. Synthetic skin. Adv Dermatol. 1989;4:323-342.
20. Bos JD, Kapensberg ML. The skin immune system: progress in cutaneous biology. Immunol Today. 1993;14:75-78.
21. Yannas IV, Hansbrough JF, Ehrlich HP. What criteria should be used for designing artificial skin replacements and how well do the current grafting materials meet these criteria? J Trauma. 1984;24:S29-S39.
22. Burke JF, Yannas IV, Quinby WC Jr, Bondoc CC, Jung WK. Successful use of a physiologically acceptable artificial skin in the treatment of extensive burn injury. Ann Surg. 1981;194:413-428.
23. Bell E, Ehrlich HP, Buttle DJ, Nakatsuji T. Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickness. Science. 1981;211:1052-1054.
24. Cooper ML, Hansbrough JF. Use of a composite skin graft composed of cultured human keratinocytes and fibroblasts and a collagen-GAG matrix to cover full-thickness wounds on athymic mice. Surgery. 1991;109:198-207.
25. Cuono C, Langdon R, McGuire J. Use of cultured epidermal autografts and dermal allografts as skin replacement after burn injury. Lancet. 1986;i:1123-1124.
26. Cuono CB, Langdon R, Birchall N, Barttelbort S, McGuire J. Composite autologous-allogeneic skin replacement: development and clinical application. Plast Reconstr Surg. 1987;80:626-637.
27. Hansbrough JF, Boyce ST, Cooper ML, Foreman TJ. Burn wound closure with cultured autologous keratinocytes and fibroblasts attached to a collagen-glycosaminoglycan substrate. JAMA. 1989;262:2125-2130.
28. Yannas IV, Lee ER, Orgill DP, Skrabut EM, Murphy GF. Synthesis and characterization of a model extracellular matrix that induces partial regeneration of adult mammalian skin. Proc Natl Acad Sci U S A. 1989;86:933-937.
29. Gallico GG, O'Connor NE, Compton CC, Kehinde O, Green H. Permanent coverage of large burn wounds with autologous cultured human epithelium. N Engl J Med. 1984;311:448-451.
30. Compton CC, Gill JM, Bradford DA, Regauer S, Gallico GG, O'Connor NE. Skin regenerated from cultured epithelial autografts on full-thickness burn wounds from 6 days to 5 years after grafting. Lab Invest. 1989;60:600-612.
31. Woodley DT, Briggaman RA, Herzog SA, Meyer AA, Peterson HD, O'Keefe EJ. Characterization of ‘neo-dermis’ formation beneath cultured human epidermal autografts transplanted on muscle fascia. J Invest Dermatol. 1990;95: 20-26.
32. Rheinwald JG, Green H. Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell. 1975; 6:331-344.
33. Green H, Kehinde O, Thomas J. Growth of cultured human epidermal cells into multiple epithelia suitable for grafting. Proc Natl Acad Sci U S A. 1979; 76:5665-5668.
34. O'Connor NE, Mulliken JB, Banks-Schlegel S, Kehinde O, Green H. Grafting of burns with cultured epithelium prepared from autologous epidermal cells. Lancet. 1981;i:75-78.
35. Teepe RG, Ponec M, Kreis RW, Hermans RP. Improved grafting method for treatment of burns with autologous cultured human epithelium. Lancet. 1986; i:385.
36. Eldad A, Burt A, Clarke JA. Cultured epithelium as a skin substitute. Burns. 1987;13:173-180.
37. Herzog SR, Meyer AA, Woodley D, Peterson HD. Wound coverage with cultured autologous keratinocytes: use after burn wound excision, including biopsy followup. J Trauma. 1988;28:195-198.
38. Kumagai N, Nishina H, Tanabe H, Hosaka T, Ishida H, Ogino Y. Clinical application of autologous cultured epithelia for the treatment of burn wounds and burn scars. Plast Reconstr Surg. 1988;82:99-108.
39. DeLuca M, Albanese E, Bondanza S, et al. Multicentre experience in the treatment of burns with autologous and allogeneic cultured epithelium, fresh or preserved in a frozen state. Burns. 1989;15:303-309.
40. Munster AM, Weiner SH, Spence RJ. Cultured epidermis for the coverage of massive burn wounds. Ann Surg. 1990;211:676-680.
41. Clugston PA, Snelling CF, Macdonald IB, et al. Cultured epithelial autografts: three years of clinical experience with eighteen patients. J Burn Care Rehabil. 1991;12:533-539.
42. McAree KG, Klein RL, Boeckman CR. The use of cultured epithelial autografts in the wound care of severely burned patients. J Pediatr Surg. 1993;28:166-168.
43. Rue LW III, Cioffi WG, McManus WF, Pruitt BA Jr. Wound closure and outcome in extensively burned patients treated with cultured autologous keratinocytes. J Trauma. 1993;34:662-668.
44. Hefton JM, Caldwell D, Biozes DG, Balin AK, Carter DM. Grafting of skin ulcers with cultured autologous epidermal cells. J Am Acad Dermatol. 1986; 14:399-405.
45. Gallico GG, O'Connor NE, Compton CC, Remensnyder JP, Kehinde O, Green H. Cultured epithelial autografts for giant congenital nevi. Plast Reconstr Surg. 1989;84:1-9.
46. Carter DM, Lin AN, Varghese MC, Caldwell D, Pratt LA, Eisinger M. Treatment of junctional epidermolysis bullosa with epidermal autografts. J Am Acad Dermatol. 1987;17:246-250.
47. Premachandra DJ, Woodward BM, Milton CM, Sergeant RJ, Fabre JW. Treatment of postoperative otorrhea by grafting of mastoid cavities with cultured autologous epidermal cells. Lancet. 1990;335:365-367.
48. Arons JA, Wainwright DJ, Jordon RE. The surgical applications and implications of cultured human epidermis: a comprehensive review. Surgery. 1991; 111:4-11.
49. Fisher JC. Skin—the ultimate solution for the burn wound. N Engl J Med. 1984;311:466-467.
50. Odessey R. Addendum: multicenter experience with cultured epidermal autograft for treatment of burns. J Burn Care Rehabil. 1992;13:174-180.
51. Woodley DT. Covering wounds with cultured keratinocytes. JAMA. 1989;262: 2140-2141.
52. Woodley DT, Peterson HD, Herzog SR, et al. Burn wounds resurfaced by cultured epidermal autografts show abnormal reconstitution of anchoring fibrils. JAMA. 1988;259:2566-2571.
53. Desai MH, Mlakar JM, McCauley RL, et al. Lack of long-term durability of cultured keratinocyte burn-wound coverage: a case report. J Burn Care Rehabil. 1991;12:540-545.
54. Johnson MC, Meyer AA, deSerres S, Herzog S, Peterson HD. Persistence of fetal bovine serum proteins in human keratinocytes. J Burn Care Rehabil. 1990;11:504-509.
55. Johnson LF, deSerres S, Herzog SR, Peterson HD, Meyer AA. Antigenic cross-reactivity between media supplements for cultured keratinocyte grafts. J Burn Care Rehabil. 1991;12:306-312.
56. Blight A, Mountford EM, Cheshire IM, Clancy JM, Levick PL. Treatment of full skin thickness burn injury using cultured epithelial grafts. Burns. 1991;17: 495-498.
57. Warden G. The fifth quinquennium: 1989-1993. J Burn Care Rehabil. 1993; 14:247-251.
58. Heimbach DM. In discussion: Munster AM. Cultured epidermal autograft in the management of burn patients. J Burn Care Rehabil. 1992;13:166-172.
59. Petersen MJ, Lessane B, Woodley DT. Characterization of cellular elements in healed cultured keratinocyte autografts used to cover burn wounds. Arch Dermatol. 1990;126:175-180.
60. Merrick P, Meyer AA, Herzog S, Woodley D. Scanning electron microscopy of cultured human keratinocytes. J Burn Care Rehabil. 1990;11:228-236.
61. Compton CC, Regauer S, Seiler GR, Landry DB. Human merkel cell regeneration in skin derived from cultured keratinocyte grafts. Lab Invest. 1990; 62:233-241.
62. Siwy BK, Compton CC. Cultured epidermis: Indiana University Medical Center experience. J Burn Care Rehabil. 1992;13:130-137.
63. Phillips TJ. Cultured skin grafts: past, present, future. Arch Dermatol. 1988; 124:1035-1038.
64. Pittelkow MR, Scott RE. New techniques for the in vitro culture of human skin keratinocytes and perspectives on their use for grafting of patients with extensive burns. Mayo Clin Proc. 1986;61:771-777.
65. Eisinger M, Monden M, Raaf JH, Fortner JG. Wound coverage by a sheet of epidermal cells grown in vitro from dispersed single cell preparations. Surgery. 1980;88:287-293.
66. Breidahl AF, Judson RT, Clunie GJ. Review of keratinocyte culture techniques: problems of growing skin. Aust N Z J Surg. 1989;59:485-497.
67. Meyer AA, Manktelow A, Johnson M, deSerres S, Herzog S, Peterson HD. Antibody response to xenogeneic proteins in burned patients receiving cultured keratinocyte grafts. J Trauma. 1988;28:1054-1059.
68. Cairns BA, deSerres S, Brady LA, Meyer AA. Fibroblasts from feeder layer persist in cultured keratinocyte grafts. Presented at the 25th Annual Meeting of the American Burn Association; March 25, 1993; Cincinnati, Ohio.
69. Teepe RG, Kreis RW, Koebrugge EJ, et al. The use of cultured autologous epidermis in the treatment of extensive burn wounds. J Trauma. 1990;30: 269-275.
70. Cooper ML, Boyce ST, Hansbrough JF, Foreman TJ, Frank DH. Cytotoxicity to cultured human keratinocytes of topical antimicrobial agents. J Surg Res. 1990;48:190-195.
71. Heimbach DM. A nonuser's questions about cultured epidermal autograft. J Burn Care Rehabil. 1992;13:127-129.
72. Herndon DN, Rutan RL. Comparison of cultured epidermal autograft and massive excision with serial autografting plus homograft overlay. J Burn Care Rehabil. 1992;13:154-157.
73. Hefton JM, Madden MR, Finkelstein JL, Shires GT. Grafting of burn patients with allografts of cultured epidermal cells. Lancet. 1983;ii:428-430.
74. Morhenn VB, Benike CJ, Cox AJ, Charron DJ, Engleman EG. Cultured human epidermal cells do not synthesize HLA-DR. J Invest Dermatol. 1982;78:32-37.
75. Thivolet J, Faure M, Demidem A, Mauduit G. Long-term survival and immunological tolerance of human epidermal allografts produced in culture. Transplantation. 1986;42:274-280.
76. Thivolet J, Faure M, Demidem A, Mauduit G. Cultured human epidermal allografts are not rejected for a long period. Arch Dermatol Res. 1986;278: 252-254.
77. Madden MR, Finkelstein JL, Staiano-Coico L, et al. Grafting of cultured allogeneic epidermis on second- and third-degree burn wounds on 26 patients. J Trauma. 1986;26:955-962.
78. Aubock J, Irschick E, Romani N, et al. Rejection, after a slightly prolonged survival time, of Langerhans cell-free allogeneic cultured epidermis used for wound coverage in humans. Transplantation. 1988;45:730-737.
79. Brain A, Purkis P, Coates P, Hackett M, Navsaria H, Leigh I. Survival of cultured allogeneic keratinocytes transplanted to deep dermal bed assessed with probe specific for Y chromosome. BMJ. 1989;298:917-919.
80. Burt AM, Pallett CD, Sloane JP, et al. Survival of cultured allografts in patients with burns assessed with probe specific for Y chromosome. BMJ. 1989;298: 915-917.
81. Yang-bing Z, Xiong-fei Z, Ao(Ngao) L, et al. Clinical observations and methods for identifying the existence of cultured epidermal allografts. Burns. 1992; 18:4-8.
82. Eisinger M. Regeneration of epidermis by cells grown in tissue culture. J Am Acad Dermatol. 1985;12:402-408.
83. Hammond EJ, Ng RL, Stanley MA, Munro AJ. Prolonged survival of cultured keratinocyte allografts in the nonimmunosuppressed mouse. Transplantation. 1987;44:106-112.
84. Fabre JW, Cullen PR. Rejection of cultured keratinocyte allografts in the rat. Transplantation. 1989;48:306-315.
85. Demidem A, Chiller JM, Kanagawa O. Dissociation of antigenicity and immunogenicity of neonatal epidermal allografts in the mouse. Transplantation. 1990; 49:966-971.
86. Carver N, Navsaria HA, Green CJ, Leigh IM. Acute rejection of cultured keratinocyte allografts in nonimmunosuppressed pigs. Transplantation. 1991; 52:918-921.
87. Cairns BA, deSerres S, Kilpatrick KL, Frelinger JA, Meyer AA. Cultured keratinocyte allografts fail to induce sensitization in vivo. Surgery. 1993;114:416-422.
88. Gielen V, Faure M, Mauduit G, Thivolet J. Progressive replacement of human cultured epithelial allografts by recipient cells as evidenced by HLA class I antigens expression. Dermatologica. 1987;175:166-170.
89. Cony M, Donatien PH, Beylot C, et al. Treatment of leg ulcers with an allogeneic cultured-keratinocyte-collagen dressing. Clin Exp Dermatol. 1990;15: 410-414.
90. Leigh IM, Purkis PE, Navasaria HA, Phillips TJ. Treatment of chronic venous ulcers with sheets of cultured allogenic keratinocytes. Br J Dermatol. 1987; 117:591-597.
91. Phillips TJ, Gilchrest BA. Cultured epidermal allografts as biological wound dressings. Prog Clin Biol Res. 1991;365:77-94.
92. Bell E, Ehrlich HP, Sher S, et al. Development and use of a living skin equivalent. Plast Reconstr Surg. 1981;67:386-392.
93. Tompkins RG, Burke JF. Progress in burn treatment and the use of artificial skin. World J Surg. 1990;14:819-824.
94. Yannas IV, Burke JF, Gordon PL, Huang C, Rubenstein RH. Design of an artificial skin, II: control of chemical composition. J Biomed Mater Res. 1980; 14:107-131.
95. Dagalakis N, Flink J, Staikelis P, Burke JF, Yannas IV. Design of an artificial skin, III: control of pore structure. J Biomed Mater Res. 1980;14:511-528.
96. Heimbach D, Luterman A, Burke J, et al. Artificial dermis for burns. Ann Surg. 1988;208:313-320.
97. Boyce ST, Hansbrough JF. Biologic attachment, growth, and differentiation of cultured human epidermal keratinocytes on a graftable collagen and chondroitin-6-sulfate substrate. Surgery. 1988;103:421-431.
98. Boyce ST, Christianson DJ, Hansbrough JF. Structure of a collagen-GAG dermal skin substitute optimized for cultured human epidermal keratinocytes. J Biomed Mater Res. 1988;22:939-957.
99. Cooper ML, Hansbrough JF, Spielvogel RL, Cohen R, Bartel RL, Naughton G. In vivo optimization of a living dermal substitute employing cultured human fibroblasts on a biodegradable polyglycolic acid or polyglactin mesh. Biomaterials. 1991;12:243-248.
100. Cooper ML, Hansbrough JF, Foreman TJ. In vitro effects of matrix peptides on a cultured dermal-epidermal skin substitute. J Surg Res. 1990;48:528-533.
101. Matsuda K, Suzuki S, Isshiki N, et al. Evaluation of a bilayer artificial skin capable of sustained release of an antibiotic. Biomaterials. 1992;13:119-122.
102. Heck EL, Bergstresser PR, Baxter CR. Composite skin graft: frozen dermal allografts support the engraftment and expansion of autologous epidermis. J Trauma. 1985;25:106-112.
103. Nave M. Wound bed preparation: approaches to replacement dermis. J Burn Care Rehabil. 1992;13:147-153.
104. Clarke JA. HIV transmission and skin grafts. Lancet. 1987;i:983.
105. Cuono CB. Burn Wound Management in Preparation for Composite Allo-Auto Skin Grafting. Cambridge, Mass: Biosurface Technology Inc; 1992:1-13.