Mutation size and age at onset in Huntington's disease

Journal of Medical Genetics

Volumn 30, Issue 12, 1993, Pages 1008-1011

  Craufurd, D ^a   Dodge, A ^a  

^a St Mary's University Hospital   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

REPETITIVE DNA; TRINUCLEOTIDE;

ADULT; AGED; ARTICLE; CHROMOSOME; CONTROLLED STUDY; DNA SEQUENCE; FEMALE; GENE MUTATION; GENETIC SCREENING; HUMAN; HUNTINGTON CHOREA; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PREDICTION; PRIORITY JOURNAL;

EID: 0027482792     PISSN: 00222593     EISSN: None     Source Type: Journal    
DOI: 10.1136/jmg.30.12.1008     Document Type: Article

References (7)

1. Harper, P.S. Huntitngtoni's disease 1991
2. Brook, J.D.; McCurrach, M.E.; Harley, H.G. Molecular basis of mvotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3' end of a transcript encoding a protein kinase family member Cell 1992 10.1016/0092-8674(92)90154-5 68 799
3. Verkerk, A.J.M.H.; Pieretti, M.; Sutcliffe, J.S. Identification of a gene (FMR-1) containing a CCG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome Cell 1991 10.1016/0092-8674(91)90397-H 65 905
4. Snell, R.G.; MacMillan, J.C.; Cheadle, J.P. Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease Natutre Genet 1993 10.1038/ng0893-393 4 393
5. Duvao, M.P.; Ambrose, C.; Myers, R. Trinucleotide repeat length: instability and age of onset in Huntington's disease Natuire Genet 1993 10.1038/ng0893-387 4 387
6. Andrew, S.E.; Goldberg, Y.P.; Kremer, B. The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease Na\\'tre Genet 1993 4 398
7. Krawczak, M.; Bockel, B.; Sandkuijl, L. Covariatedependent age-at-onset distributions for Huntington's disease Amn J Humiii Geniet 1991 49 735