Expression of Vascular Permeability Factor (Vascular Endothelial Growth Factor) and Its Receptors in Adenocarcinomas of the Gastrointestinal Tract

Cancer Research

Volumn 53, Issue 19, 1993, Pages 4727-4735

  Brown, Lawrence F ^a   Berse, Brygida ^a   Jackman, Robert W ^a   Tognazzi, Kathi ^a   Manseau, Eleanor J ^a   Senger, Donald R ^a   Dvorak, Harold F ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR RECEPTOR; MESSENGER RNA; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; BLOOD VESSEL PERMEABILITY; CANCER CELL CULTURE; CANCER GROWTH; CANCER LOCALIZATION; CLINICAL ARTICLE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GASTROINTESTINAL CARCINOMA; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MICROVASCULATURE; MYENTERIC PLEXUS; PRIORITY JOURNAL; PROTEIN DETERMINATION; STROMA; TUMOR NECROSIS;

ADENOCARCINOMA; ANTISENSE ELEMENTS (GENETICS); BASE SEQUENCE; COLONIC NEOPLASMS; DNA PRIMERS; ENDOTHELIAL GROWTH FACTORS; GASTROINTESTINAL NEOPLASMS; GENE EXPRESSION; HUMAN; IN SITU HYBRIDIZATION; LYMPHOKINES; MOLECULAR SEQUENCE DATA; PANCREATIC NEOPLASMS; POLYMERASE CHAIN REACTION; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, MITOGEN; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RNA, MESSENGER; STOMACH NEOPLASMS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027482251     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Folkman, J., and Shing, Y. Angiogenesis. J. Biol. Chem., 267: 10931-10934, 1992.
2. Dvorak, H.E., Sioussat, T.M., Brown, L.R., Berse, B., Nagy, J.A., Sotrel, A., Manseau, E.J., Van De Water, L., and Senger, D.R. Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: concentration in tumor blood vessels. J. Exp. Med., 174: 1275-1278, 1991.
3. Senger, D.R., Galli, S.J., Dvorak, A.M., Perruzzi, C.A., Harvey, V.S., and Dvorak, H.F. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science (Washington DC), 279: 983-985, 1983.
4. Senger, D.R., Perruzzi, C.A., Feder, J., and Dvorak, H.F. A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines. Cancer Res., 46: 5629-5632, 1986.
5. Berkman, R.A., Merrill, M.J., Reinhold, W.C., Monacci, W.T., Saxena, A., Clark, W.C., Robertson, J.T., Ali, I.U., and Oldfield, E.H. Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system tumors. J. Clin. Invest., 91: 153-159, 1993.
6. Plate, K.H., Breier, G., Weich, H.A., and Risau, W. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature (Lond.), 359: 845-848, 1992.
7. Shweiki, D., Itin, A., Soffer, D., and Keshet, E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature (Lond.), 359: 843-845, 1992.
8. Dvorak, H.R., Orenstein, N.S., Carvalho, A.C., Churchill, W.H., Dvorak, A.M., Galli, S.J., Feder, J., Bitzer, A.M., Rypysc, J., and Giovinco, P. Induction of a fibrin-gel investment: an early event in line 10 hepatocarcinoma growth mediated by tumor-secreted products. J. Immunol., 122: 166-174, 1979.
9. Senger, D.R., Connolly, D., Perruzzi, C.A., Alsup, D., Nelson, R., Leimgruber, R., Feder, J., and Dvorak, H.F., Purification of a vascular permeability factor (VPF) from tumor cell conditioned medium. Fed. Proa, 46: 2102, 1987.
10. Senger, D.R., Connolly, D.T., Van De Water, L., Feder, J., and Dvorak, H.F. Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor. Cancer Res., 50: 1774-1778, 1990.
11. Ferrara, N., and Henzel, W.J. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem. Biophys. Res. Commun., 161: 851-858, 1989.
12. Gospodarowicz, D., Abraham, J.A., and Schilling, J. Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells. Proc. Natl. Acad. Sci. USA, 86: 7311-7315, 1989.
13. Leung, D.W., Cachianes, G., Kuang, W.J., Goeddel, D.V., and Ferrara, N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science (Washington DC), 246: 1306, 1989.
14. Keck, P.J., Hauser, S.D., Krivi, G., Sanzo, K., Warren, T., Feder, J., and Connolly, D.T. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science (Washington DC), 246: 1309, 1989.
15. Conn, G., Bayne, M.L., Soderman, D.D., Kwok, P.W., Sullivan, K.A., Palisi, T.M., Hope, D.A., and Thomas, K.A. Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor. Proc. Nat. Acad. Sci. USA, 87: 2628-2632, 1990.
16. de Vries, C., Escobedo, J.A., Ueno, H., Houck, K., Ferrara, N., and Williams, L.T. The ftns-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science (Washington DC), 255: 989-991, 1992.
17. Terman, B.I., Dougher Vermazen, M., Carrion, M.E., Dimitrov, D., Armellino, D.C., Gospodarowicz, D., and Bohlen, P. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial growth factor. Biochem. Biophys. Res. Commun., 187: 1579-1586, 1992.
18. Brock, T.A., Dvorak, H.E., and Senger, D.R. Tumor-secreted vascular permeability factor increases cytosolic Ca2+ and von Willebrand factor release in human endothelial cells. Am. J. Pathol., 138: 213-221, 1991.
19. Berse, B., Brown, L.R., Van De Water, L., Dvorak, H.R., and Senger, D.R. Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors. Mol. Biol. Cell, 3: 211-220, 1992.
20. Brown, L.R., Berse, B., Tognazzi, K., Manseau, E.J., Van De Water, L., Senger, D., Dvorak, H., and Rosen, S. Vascular permeability factor mRNA and protein expression in human kidney. Kidney Int., 42: 1457-1461, 1992.
21. Tischer, E., Mitchell, R., Hartman, X., Silva, M., Gospodarowicz, D., Fiddes, J.C., and Abraham, J.A. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J. Biol. Chem., 266: 11947-11954, 1991.
22. Houck, K.A., Ferrara, N., Winer, J., Cachianes, G., Li, B., and Leung, D.W. The vascular endothelial grwoth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol. Endocrinol., 5: 1806-1814, 1991.
23. Terman, B.I., Carrion, M.E., Kovacs, E., Rasmussen, B.A., Eddy, R.L., and Shows, T.B. Identification of a new endothelial cell growth factor receptor tyrosine kinase. Oncogene, 6: 1677-1683, 1991.
24. Shibuya, M., Yamaguchi, S., Yamane, A., Ikeda, T., Tojo, A., Matsushime, H., and Sato, M. Neucleotide sequence and expression of a novel receptor-type tyrosine kinase gene (flt) closely related to thesis family. Oncogene, 5: 519-524, 1990.
25. Sioussat, T.M., Dvorak, H.R., Brock, T.A., and Senger, D.R. Inhibition of vascular permeability factor (vascular endothelial growth factor) with anti-peptide antibodies. Arch. Biochem. Biophys., 301: 15-20, 1993.
26. Bover, M.J., and Tannock, I.F. Regulation of intracellular pH in tumor cell lines: influence of microenvironmental conditions. Cancer Res., 52: 4441-4447, 1992.
27. Chaplin, D.J., Olive, P.L., and Durand, R.E. Intermittent blood flow in a murine tumor: radiobiological effects. Cancer Res., 47: 597-601, 1987.
28. Vaupel, R., Kallinowski, R., and Okunieff, R Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res., 49: 6449-6465, 1989.
29. Shweiki, D., Itin, A., Soffer, D., and Keshet, E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature (Lond.), 359: 843-345, 1992.
30. Breier, G., Albrecht, U., Sterrer, S., and Risau, W. Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development, 114: 521-532, 1992.
31. Ferrara, N., Houck, K., Jakeman, L., and Leung, D.W. Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocrine Rev., 13: 18-32, 1992.
32. Brown, L.R., Yeo, K.T., Berse, B., Yeo, T.K., Senger, D.R., Dvorak, H.R., and Van De Water, L. Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J. Exp. Med., 176: 1375-1379, 1992.
33. Mosher, D.F. Cross-linking of plasma and cellular fibronectin by plasma transglutaminase. Ann. NY Acad. Sci., 312: 38-42, 1978.
34. Van De Water, L., Ffrench-Constant, C., and Brown, L.R. Fibronectin expression during cutaneous wound healing. In: Fetal Wound Healing, pp. 281-302. New York: Elsevier, 1992.
35. Lanir, N., Ciano, R.S., Van De Water, L., McDonagh, J., Dvorak, A.M., and Dvorak, H. R Macrophage migration in fibrin gel matrices. II. Effects of clotting factor XIII, fibronectin, and glycosaminoglycan content on cell migration. J. Immunol., 140: 2340-2349, 1988.
36. Brown, L.R., Lanir, N., McDonagh, J., Czarnecki, K., Estrella, R., Dvorak, A.M., and Dvorak, H. R Fibroblast migration in fibrin gel matrices. Am. J. Pathol., 142: 273-283, 1993.
37. Hynes, R.O. Integrins: versatility, modulation, and signaling in cell adhesion. Cell, 69: 11-25, 1992.
38. Rouslahti, E. Integrins. J. Clin. Invest., 87: 1-5, 1991.
39. Dvorak, H.R., Harvey, V.S., Estrella, P., Brown, L.R., McDonagh, J., and Dvorak, A.M. Fibrin containing gels induce angiogenesis. Implications for tumor stroma generation and wound healing. Lab. Invest., 57: 673-686, 1987.
40. Connolly, D.T., Heuvelman, D.M., Nelson, R., Olander, J.V., Eppley, B.L., Delfino, J.J., Siegel, N.R., Leimgruber, R.M., and Feder, J. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J. Clin. Invest., 84: 1470-1478, 1989.
41. Clauss, M., Gerlach, M., Gerlach, H., Brett, J., Wang, R., Familletti, P.C., Pan, Y.C.E., Olander, J.V., Connolly, D.T., and Stern, D. Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity and promotes monocyte migration. J. Exp. Med., 172: 1535-1545, 1990.
42. Pepper, M.S., Ferrara, N., Orci, L., and Montesano, R. Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem. Biophys. Res. Commun., 181: 902-906, 1991.