Immunization of breast cancer patients using a synthetic sialyl-Tn glycoconjugate plus Detox adjuvant

Cancer Immunology Immunotherapy

Volumn 36, Issue 4, 1993, Pages 215-222

  MacLean, Grant D ^a   Reddish, Mark ^b   Koganty, R Rao ^b   Wong, Ting ^b   Gandhi, Sham ^b   Smolenski, Mark ^b   Samuel, John ^a   Nabholtz, Jean Marc ^a   Longenecker, B Michael ^a,b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b Biomira Inc   (Canada)

Author keywords

Cancer vaccine; Glycoconjugate; Immunotherapy; Sialyl Tn; Synthetic cancer antigen

Indexed keywords

ADJUVANT; CANCER VACCINE; CYCLOPHOSPHAMIDE; GLYCOCONJUGATE; PHOSPHORYL LIPID A; TUMOR ANTIGEN;

ADULT; ANTIBODY PRODUCTION; ARTICLE; BREAST CANCER; CANCER IMMUNOTHERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEADACHE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; NAUSEA; PRIORITY JOURNAL; RASH; SKIN ULCER; SUBCUTANEOUS DRUG ADMINISTRATION; VOMITING;

ADJUVANTS, IMMUNOLOGIC; ANTIBODIES, NEOPLASM; ANTIBODY SPECIFICITY; ANTIGENS, TUMOR-ASSOCIATED, CARBOHYDRATE; BREAST NEOPLASMS; CARCINOMA; COMPLEMENT; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; GLYCOCONJUGATES; HAPTENS; HUMAN; IMMUNIZATION; OVARIAN NEOPLASMS; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED;

EID: 0027478209     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/BF01740902     Document Type: Article

References (23)

1. Cell-surface macromolecular and morphological changes related to allotransplantability in the TA3 tumor
2. Immunogenicity of synthetic peptides related to the core peptide sequence encoded by the human MUC1 mucine gene: Effect of immunization of the growth of murine mammary adenocarcinoma cells transfected with the human MUC1 gene
3. Specific immunosuppressive activity of epiglycanin, a mucin-like glycoprotein secreted by a murine mammary adenocarcinoma (TA3-Ha)
4. Active specific immunotherapy of a murine mammary adenocarcinoma using a synthetic tumor-associated glycoconjugate
5. A B72.3 second-generation monoclonal antibody (CC49) defines the mucin-carried carbohydrate epitope Galβ(1→3)[NeuAcα(2→6)] GalNAc
6. Ovine submaxillary mucin. Primary structure and peptide substatus of UDP- N-acetylgalactosamine: mucin transferase
7. Expression of Tn, sialosyl-Tn, and T antigens in human colon cancer
8. Sialosyl-Tn: a novel mucin antigen associated with prognosis in colorectal cancer patients
9. Why are proteins O-glycosylated?
10. Preparation and characterization of monoclonal antibodies directed to the tumor-associated O-linked sialosyl 2-6-α- N-acetylgalactosaminyl (sialosyl Tn) epitope
11. Serum sialyl Tn as an independent predictor of poor prognosis in patients with epithelial ovarian cancer
12. Morphological and biochemical properties of a new human breast cancer cell line
13. Predictive value of lectin binding on breast cancer recurrence and survival
14. Monoclonal antibody against a cryptic carbohydrate antigen of murine and human lymphocytes. 1. Antigen expression in non-cryptic or unsubstituted form on certain murine lymphomas, on a spontaneous murine mammary carcinoma, and on several human adenocarcinomas
15. Active immunization of human ovarian cancer patients against a common carcinoma (Thomsen-Friedenreich) determinant using a synthetic carbohydrate antigen
16. Active specific immunotherapy for melanoma: phase I trial of allogeneic lysates and a novel adjuvant
17. Determination of apical membrane polarity in mammary epithelial cell cultures: the role of cell-cell, cell-substratum, and membrane-cytoskeleton interactions
18. Detection of polymorphic epithelial mucins in the serum of systemic breast cancer patients using the monoclonal antibody, NCRC-11
19. Epitope mapping of MAb B27.29 within the peptide core of the malignant breast carcinoma-associated mucin antigen coded for the human MUC1 gene
20. T and Tn, general carcinoma autoantigens
21. Signal transduction via leukocyte antigen CD43 (sialophorin); feedback regulation by protein kinase C
22. Tn antigen and UDP-Gal: GalNAcα-R β1-3galactosyltransferase expression in human breast carcinoma