Pulmonary Surfactant Therapy

New England Journal of Medicine

Volumn 328, Issue 12, 1993, Pages 861-868

  Wood, Alastair J J ^a   Jobe, Alan H ^b,c  

^a Harbor UCLA Medical Center ^*

^b HARBOR UCLA MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPALMITOYLPHOSPHATIDYLCHOLINE; DIPALMITOYLPHOSPHATIDYLGLYCEROL; HEXADECANOL; LUNG SURFACTANT; LUNG SURFACTANT EXTRACT; SURFACTANT TA; TYLOXAPOL;

BRAIN HEMORRHAGE; COST EFFECTIVENESS ANALYSIS; DOSE RESPONSE; DRUG CLEARANCE; DRUG EFFECT; DRUG EFFICACY; HUMAN; LUNG DYSPLASIA; LUNG GAS EXCHANGE; MAJOR CLINICAL STUDY; NEWBORN; NEWBORN MORTALITY; PATENT DUCTUS ARTERIOSUS; PNEUMOTHORAX; PREMATURITY; PRESSURE VOLUME CURVE; PRIORITY JOURNAL; RESPIRATORY DISTRESS SYNDROME; REVIEW;

HUMAN; INFANT, NEWBORN; LUNG; PULMONARY SURFACTANTS; RESPIRATORY DISTRESS SYNDROME; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027476630     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199303253281208     Document Type: Review

References (95)

1. Clements JA Surface tension of lung extracts. Proc Soc Exp Biol Med 1957; 95:170-172 abstract.
2. Pattle RE Properties, function and origin of the alveolar lining layer. Nature 1955; 175:1125-1126
3. Avery ME, Mead J Surface properties in relation to atelectasis and hyaline membrane disease. Am J Dis Child 1959; 97:517-523
4. Robillard E, Alarie Y, Dagenais-Perusse P, Baril E, Guilbeault A Microaerosol administration of synthetic β-γ-dipalmitoyl-L-α-lecithin in the respiratory distress syndrome: a preliminary report. Can Med Assoc J 1964; 90:55-57
5. Chu J, Clements JA, Cotton EK, Neonatal pulmonary ischemia. I. Clinical and physiological studies. Pediatrics 1967; 40: Suppl-Suppl
6. Enhorning G, Robertson B Lung expansion in the premature rabbit fetus after tracheal deposition of surfactant. Pediatrics 1972; 50:58-66
7. Robertson B, Enhorning G The alveolar lining of the premature newborn rabbit after pharyngeal deposition of surfactant. Lab Invest 1974; 31:54-59
8. Enhorning G, Hill D, Sherwood G, Cutz E, Robertson B, Bryan C Improved ventilation of prematurely delivered primates following tracheal deposition of surfactant. Am J Obstet Gynecol 1978; 132:529-536
9. Fujiwara T, Maeta H, Chida S, Morita T, Watabe Y, Abe T Artificial surfactant therapy in hyaline-membrane disease. Lancet 1980; 1:55-59
10. Hallman M, Merritt TA, Jarvenpaa A-L, Exogenous human surfactant for treatment of severe respiratory distress syndrome: a randomized prospective clinical trial. J Pediatr 1985; 106:963-969
11. Enhorning G, Shennan A, Possmayer F, Dunn M, Chen CP, Milligan J Prevention of neonatal respiratory distress syndrome by tracheal instillation of surfactant: a randomized clinical trial. Pediatrics 1985; 76:145-153
12. Shapiro DL, Notter RH, Morin FC III, Double-blind, randomized trial of a calf lung surfactant extract administered at birth to very premature infants for prevention of respiratory distress syndrome. Pediatrics 1985; 76:593-599
13. Hoekstra RE, Jackson JC, Myers TF, Improved neonatal survival following multiple doses of bovine surfactant in very premature neonates at risk for respiratory distress syndrome. Pediatrics 1991; 88:10-18
14. Liechty EA, Donovan E, Purohit D, Reduction of neonatal mortality after multiple doses of bovine surfactant in low birth weight neonates with respiratory distress syndrome. Pediatrics 1991; 88:19-28
15. Corbet A, Bucciarelli R, Goldman S, Mammel M, Wold D, Long W Decreased mortality rate among small premature infants treated at birth with a single dose of synthetic surfactant: a multicenter controlled trial. J Pediatr 1991; 118:227-284
16. Long W, Thompson T, Sundell H, Schumacher R, Volberg F, Guthrie R Effects of two rescue doses of a synthetic surfactant on mortality rate and survival without bronchopulmonary dysplasia in 700- to 1350-gram infants with respiratory distress syndrome: the American Exosurf Neonatal Study Group I. J Pediatr 1991; 118:595-605
17. King RJ. Isolation and chemical composition of pulmonary surfactant. In: Robertson B, Van Golde LMG, Batenburg JJ, eds. Pulmonary surfactant. Amsterdam: Elsevier Science, 1984:1-15.
18. Weaver TE, Whitsett JA Function and regulation of expression of pulmonary surfactant-associated proteins. Biochem J 1991; 273:249-264
19. Possmayer F The role of surfactant-associated proteins. Am Rev Respir Dis 1990; 142:749-752
20. van Iwaarden JF, van Strijp JAG, Ebskamp MJM, Welmers AC, Verhoef J, van Golde LMG Surfactant protein A is opsonin in phagocytosis of herpes simplex virus type 1 by rat alveolar macrophages. Am J Physiol 1991; 261: L204-L209
21. Hoffman RM, Claypool WD, Katyal SL, Singh G, Rogers RM, Dauber JH Augmentation of rat alveolar macrophage migration by surfactant protein. Am Rev Respir Dis 1987; 135:1358-1362
22. Zimmerman PE, Voelker DR, McCormack FX, Paulsrud JR, Martin WJ II 120-kD surface glycoprotein of Pneumocystis carinii is a ligand for surfactant protein A. J Clin Invest 1992; 89:143-149
23. Taeusch HW, Keough KMW, Williams W, Characterization of bovine surfactant for infants with respiratory distress syndrome. Pediatrics 1986; 77:572-581
24. Fujiwara T. Surfactant replacement in neonatal RDS. In: Robertson B, Van Golde LMG, Batenburg JJ, eds. Pulmonary surfactant. Amsterdam: Elsevier Science, 1984:479-503.
25. Robertson B, Curstedt T, Johansson J, Jornvall H, Kobayashi T. Structural and functional characterization of porcine surfactant isolated by liquid-gel chromatography. In: von Wichert P, Muller B, eds. Basic research on lung surfactants. Vol. 25 of Progress in respiration research. Basel, Switzerland: Karger, 1990:237-46.
26. Notter RH, Egan EA, Kwong MS, Holm BA, Shapiro DL Lung surfactant replacement in premature lambs with extracted lipids from bovine lung lavage: effects of dose, dispersion technique, and gestational age. Pediatr Res 1985; 19:569-577
27. Ten Centre Study Group. Ten centre trial of artificial surfactant (artificial lung expanding compound) in very premature babies. BMJ 1987; 294:991-996
28. Ikegami M, Adams FH, Towers B, Osher AB The quantity of natural surfactant necessary to prevent the respiratory distress syndrome in premature lambs. Pediatr Res 1980; 14:1082-1085
29. Speer CP, Robertson B, Curstedt T, Randomized European multicenter trial of surfactant replacement therapy for severe neonatal respiratory distress syndrome: single versus multiple doses of Curosurf. Pediatrics 1992; 89:13-20
30. Soll RF. Natural surfactant extract treatment of RDS. In: Chalmers I, ed. Oxford database of perinatal trials. Version 1.2, disk issue 6, record 5206, 1991.
31. Soll RF. Prophylactic administration of natural surfactant extract. In: Chalmers I, ed. Oxford database of perinatal trials. Version 1.2, disk issue 6, record 5207, 1991.
32. Soll RF. Synthetic surfactant treatment of RDS. In: Chalmers I, ed. Oxford database of perinatal trials. Version 1.2, disk issue 6, record 5252, 1991.
33. Soll RF. Prophylactic administration of synthetic surfactant extract. In: Chalmers I, ed. Oxford database of perinatal trials. Version 1.2, disk issue 6, record 5253, 1991.
34. Merritt TA, Hallman M, Bloom BT, Prophylactic treatment of very premature infants with human surfactant. N Engl J Med 1986; 315:785-790
35. Kwong MS, Egan EA, Notter RH, Shapiro DL Double-blind clinical trial of calf lung surfactant extract for the prevention of hyaline membrane disease in extremely premature infants. Pediatrics 1985; 76:585-592
36. Kendig JW, Notter RH, Cox C, Surfactant replacement therapy at birth: final analysis of a clinical trial and comparisons with similar trials. Pediatrics 1988; 82:756-762
37. Shennan A, Dunn M Surfactant replacement trials-the need to maintain concurrent placebo controls. Pediatr Res 1989; 25:231A-231A abstract.
38. Soll RF, Hoekstra RE, Fangman JJ, Multicenter trial of single-dose modified bovine surfactant extract (Survanta) for prevention of respiratory distress syndrome. Pediatrics 1990; 85:1092-1102
39. Dunn M, Shennan A, Possmayer F Bovine surfactant prophylaxis in infants less than 30 weeks' gestation-a randomized controlled trial employing a multiple dose protocol. Pediatr Res 1990; 27:204A-204A abstract.
40. Raju TNK, Vidyasagar D, Bhat R, Double-blind controlled trial of single-dose treatment with bovine surfactant in severe hyaline membrane disease. Lancet 1987; 1:651-655
41. Soll RF, Duc G, Minoli I, Versmold H, Riegel K, Schachinger H European study of single dose surfactant TA (STA) for treatment of respiratory distress syndrome (RDS). Pediatr Res 1988; 23:525A-525A abstract.
42. Gitlin JD, Soll RF, Parad RB, Randomized controlled trial of exogenous surfactant for the treatment of hyaline membrane disease. Pediatrics 1987; 79:31-37
43. Collaborative European Multicenter Study Group. Surfactant replacement therapy for severe neonatal respiratory distress syndrome: an international randomized clinical trial. Pediatrics 1988; 82:683-691
44. Horbar JD, Soll RF, Sutherland JM, A multicenter randomized, placebo-controlled trial of surfactant therapy for respiratory distress syndrome. N Engl J Med 1989; 320:959-965
45. Horbar JD, Soll RF, Schachinger H, A European multicenter randomized controlled trial of single dose surfactant therapy for idiopathic respiratory distress syndrome. Eur J Pediatr 1990; 149:416-423
46. Lang MJ, Hall RT, Reddy NS, Kurth CG, Merritt TA A controlled trial of human surfactant replacement therapy for severe respiratory distress syndrome in very low birth weight infants. J Pediatr 1990; 116:295-300
47. Gortner L, Bernsau U, Hellwege HH, Hieronimi G, Jorch G, Reiter HL A multicenter randomized controlled clinical trial of bovine surfactant for prevention of respiratory distress syndrome. Lung 1990; 168: Suppl: 864-869
48. Chen J-Y Exogenous surfactant for treatment of respiratory distress syndrome in premature infants. J Formosan Med Assoc 1990; 89:110-114
49. Fujiwara T, Konishi M, Chida S, Surfactant replacement therapy with a single postventilatory dose of a reconstituted bovine surfactant in preterm neonates with respiratory distress syndrome: final analysis of a multicenter, double-blind, randomized trial and comparison with similar trials. Pediatrics 1990; 86:753-764
50. Halliday HL, McClure G, Reid MM, Controlled trial of artificial surfactant to prevent respiratory distress syndrome. Lancet 1984; 1:476-478
51. Bose C, Corbet A, Bose G, Improved outcome at 28 days of age for very low birth weight infants treated with a single dose of a synthetic surfactant. J Pediatr 1990; 117:947-953
52. Wilkinson AR, Jenkins PA, Jeffrey JA Two controlled trials of dry artificial surfactant: early effects and later outcome in babies with surfactant deficiency. Lancet 1985; 2:287-291
53. Phibbs RH, Ballard RA, Clements JA, Initial clinical trial of EXOSURF, a protein-free synthetic surfactant, for the prophylaxis and early treatment of hyaline membrane disease. Pediatrics 1991; 88:1-9
54. Stevenson D, Walther F, Long W, Controlled trial of a single dose of synthetic surfactant at birth in premature infants weighing 500 to 699 grams. J Pediatr 1992; 120: Suppl: S3-S12
55. Long W, Corbet A, Cotton R, A controlled trial of synthetic surfactant in infants weighing 1250 g or more with respiratory distress syndrome. N Engl J Med 1991; 325:1696-1703
56. R Pediatric in 342 750-1249 gram infants. Pediatr Res 1990; 27:200A-200A abstract.
57. Wegman ME Annual summary of vital statistics – 1990. Pediatrics 1991; 88:1081-1092
58. van Houten J, Long W, Mullett M, Pulmonary hemorrhage in premature infants after treatment with synthetic surfactant: an autopsy evaluation. J Pediatr 1992; 120: Suppl: S40-S44
59. Repka MX, Hudak ML, Parsa CF, Tielsch JM Calf lung surfactant extract prophylaxis and retinopathy of prematurity. Ophthalmology 1992; 99:531-536
60. Vaucher YE, Merritt TA, Hallman M, Jarvenpaa AL, Telsey AM, Jones BL Neurodevelopmental and respiratory outcome in early childhood after human surfactant treatment. Am J Dis Child 1988; 142:927-930
61. Dunn MS, Shennan AT, Hoskins EM, Lennox K, Enhorning G Two-year follow-up of infants enrolled in a randomized trial of surfactant replacement therapy for prevention of neonatal respiratory distress syndrome. Pediatrics 1988; 82:543-547
62. Ware J, Taeusch HW, Soll RF, McCormick MC Health and developmental outcomes of a surfactant controlled trial: follow-up at 2 years. Pediatrics 1990; 85:1103-1107 [Erratum, Pediatrics 1991;87:412.]
63. Robertson B. Pathology and pathophysiology of neonatal surfactant deficiency (“respiratory distress syndrome,” “hyaline membrane disease”). In: Robertson B, Van Golde LMG, Batenburg JJ, eds. Pulmonary surfactant. Amsterdam: Elsevier Science, 1984:383-418.
64. Merritt TA, Hallman M, Berry C, Randomized, placebo-controlled trial of human surfactant given at birth versus rescue administration in very low birth weight infants with lung immaturity. J Pediatr 1991; 118:581-594
65. Dunn MS, Shennan AT, Zayack D, Possmayer F Bovine surfactant replacement therapy in neonates of less than 30 weeks' gestation: a randomized controlled trial of prophylaxis versus treatment. Pediatrics 1991; 87:377-386
66. Kendig JW, Notter RH, Cox C, A comparison of surfactant as immediate prophylaxis and as rescue therapy in newborns of less than 30 weeks' gestation. N Engl J Med 1991; 324:865-871
67. The OSIRIS Collaborative Group. Early versus delayed neonatal administration of synthetic surfactant – the judgement of OSIRIS. Lancet 1992; 340:1363-1369
68. Ikegami M, Jobe A, Yamada T, Surfactant metabolism in surfactant-treated preterm ventilated lambs. J Appl Physiol 1989; 67:429-437
69. Hallman M, Merritt TA, Akino T, Bry K Surfactant protein A, phosphatidylcholine, and surfactant inhibitors in epithelial lining fluid: correlation with surface activity, severity of respiratory distress syndrome, and outcome in small premature infants. Am Rev Respir Dis 1991; 144:1376-1384
70. Dunn MS, Shennan AT, Possmayer F Single- versus multiple-dose surfactant replacement therapy in neonates of 30 to 36 weeks' gestation with respiratory distress syndrome. Pediatrics 1990; 86:564-571
71. Ikegami M, Jobe A, Jacobs H, Jones SJ Sequential treatments of premature lambs with an artificial surfactant and natural surfactant. J Clin Invest 1981; 68:491-496
72. Cummings JJ, Holm BA, Hudak ML, Hudak BB, Ferguson WH, Egan EA A controlled clinical comparison of four different surfactant preparations in surfactant-deficient preterm lambs. Am Rev Respir Dis 1992; 145:999-1004
73. Edwards DK, Hilton SV, Merritt TA, Hallman M, Mannino F, Boynton BR Respiratory distress syndrome treated with human surfactant: radiographic findings. Radiology 1985; 157:329-334
74. Rider ED, Jobe AH, Ikegami M, Sun B Different ventilation strategies alter surfactant responses in preterm rabbits. J Appl Physiol 1992; 73:2089-2096
75. Hall SB, Venkitaraman AR, Whitsett JA, Holm BA, Notter RH Importance of hydrophobic apoproteins as constituents of clinical exogenous surfactants. Am Rev Respir Dis 1992; 145:24-30
76. Goldsmith LS, Greenspan JS, Rubenstein SD, Wolfson MR, Shaffer TH Immediate improvement in lung volume after exogenous surfactant: alveolar recruitment versus increased distention. J Pediatr 1991; 119:424-428
77. 2 in hyaline membrane disease. Pediatr Res 1979; 13:1167-1171
78. Halliday HL, McCord FB, McClure BG, Reid MM Acute effects of instillation of surfactant in severe respiratory distress syndrome. Arch Dis Child 1989; 64:13-16
79. Clyman RI, Jobe A, Heymann M, Increased shunt through the patent ductus arteriosus after surfactant replacement therapy. J Pediatr 1982; 100:101-107
80. Heldt GP, Pesonen E, Merritt TA, Elias W, Sahn DJ Closure of the ductus arteriosus and mechanics of breathing in preterm infants after surfactant replacement therapy. Pediatr Res 1989; 25:305-310
81. Davis JM, Veness-Meehan K, Notter RH, Bhutani VK, Kendig JW, Shapiro DL Changes in pulmonary mechanics after the administration of surfactant to infants with respiratory distress syndrome. N Engl J Med 1988; 319:476-479
82. Noack G, Curstedt T, Grossmann G, Nilsson R, Robertson B Passive expiratory flow-volume recordings in immature newborn rabbits: effect of surfactant replacement on the time constant of the respiratory system. Respiration 1990; 57:1-5
83. Adams FH, Fujiwara T, Emmanouilides GC, Raiha N Lung phospholipids of human fetuses and infants with and without hyaline membrane disease. J Pediatr 1970; 77:833-841
84. Hallman M, Merritt TA, Pohjavuori M, Gluck L Effect of surfactant substitution on lung effluent phospholipids in respiratory distress syndrome: evaluation of surfactant phospholipid turnover, pool size, and the relationship to severity of respiratory failure. Pediatr Res 1986; 20:1228-1235
85. Jobe A, Ikegami M Surfactant for the treatment of respiratory distress syndrome. Am Rev Respir Dis 1987; 136:1256-1275
86. Jobe AH, Ikegami M, Seidner SR, Pettenazzo A, Ruffini L Surfactant phosphatidylcholine metabolism and surfactant function in preterm, ventilated lambs. Am Rev Respir Dis 1989; 139:352-359
87. Stewart-DeHaan PJ, Metcalfe IL, Harding PGR, Enhorning G, Possmayer F Effect of birth and surfactant treatment on phospholipid synthesis in the premature rabbit. Biol Neonate 1980; 38:238-247
88. Lewis JF, Ikegami M, Jobe AH, Tabor B Aerosolized surfactant treatment of preterm lambs. J Appl Physiol 1991; 70:869-876
89. Maniscalco WM, Kendig JW, Shapiro DL Surfactant replacement therapy: impact on hospital charges for premature infants with respiratory distress syndrome. Pediatrics 1989; 83:1-6
90. Mugford M, Piercy J, Chalmers I Cost implications of different approaches to the prevention of respiratory distress syndrome. Arch Dis Child 1991; 66:757-764
91. Crowley P, Chalmers I, Keirse MJ The effects of corticosteroid administration before preterm delivery: an overview of the evidence from controlled trials. Br J Obstet Gynaecol 1990; 97:11-25
92. Farrell EE, Silver RK, Kimberlin LV, Wolf ES, Dusik JM Impact of antenatal dexamethasone administration on respiratory distress syndrome in surfactant-treated infants. Am J Obstet Gynecol 1989; 161:628-633
93. Jobe AH, Mitchell BR, Gunkel JH Beneficial effects of the combined use of prenatal corticosteroids and postnatal surfactant on preterm infants. Am J Obstet Gynecol 1993; 168:508-513
94. Auten RL, Notter RH, Kendig JW, Davis JM, Shapiro DL Surfactant treatment of full-term newborns with respiratory failure. Pediatrics 1991; 87:101-107
95. Wiedmann H, Baughman R, deBoisblanc B, A multicenter trial in human sepsis-induced ARDS of an aerosolized synthetic surfactant (EXOSURF). Am Rev Respir Dis 1992; 145: A184-A184 abstract.