Mechanism of the lipid-lowering effect of ethyl all-cis-5,8,11,14,17-icosapentaenoate

European Journal of Pharmacology

Volumn 231, Issue 1, 1993, Pages 121-127

  Mizuguchi, Kiyoshi ^a   Yano, Takashi ^a   Tanaka, Yasuo ^a   Ishibashi, Masaaki ^a   Masada, Atsuhiro ^a   Mizota, Masahiro ^a   Fukutake, Katsuhiko ^a   Saito, Yasushi ^b  

^a MOCHIDA PHARMACEUTICAL CO   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

(Rat); Cholesterol metabolism; EPA E (ethyl all cis 5,8,11,14,17 icosapentaenoate)

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; ALL CIS 5,8,11,14,17 ICOSAPENTAENOIC ACID ETHYL ESTER; ANTILIPEMIC AGENT; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; ICOSAPENTAENOIC ACID; LIPOPROTEIN; MEVALONIC ACID; PHOSPHOLIPID; RADIOISOTOPE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE SECRETION; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; INTRAVENOUS DRUG ADMINISTRATION; LIVER MICROSOME; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

5,8,11,14,17-EICOSAPENTAENOIC ACID; ADMINISTRATION, ORAL; ANIMAL; BILE; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COA REDUCTASES; INTESTINAL ABSORPTION; LIPOPROTEINS; LIVER; MALE; METABOLIC CLEARANCE RATE; MICROSOMES, LIVER; RATS; RATS, WISTAR;

EID: 0027475231     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(93)90692-B     Document Type: Article

References (26)

1. Reduction in plasma cholesterol and increase in biliary cholesterol by a diet rich in n-3 fatty acids in the rat
2. Dietary linoleate increases fluidity and influences chemical composition on plasma low density lipoprotein in adult men
3. Effects of saturated and unsaturated fats given with and without dietary cholesterol on hepatic cholesterol synthesis and hepatic lipid metabolism
4. Lipoprotein receptors in cholesterol metabolism
5. Effects of salmon oil and corn oil on plasma lipid level and hepato-biliary cholesterol metabolism in rats
6. Effect of n-3 polyunsaturated fatty acids on cholesterol synthesis and degradation in rats of different ages
7. Effect of dietary fatty acids on HMG-CoA reductase and ACAT activities in liver and intestine of the rabbit
8. A simple method for the isolation and purification of total lipids from animal tissue
9. Polyunsaturated fatty acids, hyperlipedemia and thrombosis
10. Regulation by dietary fats of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in rat liver
11. Cholesterol absorption and lymphatic transport in rat
12. Inhibition of in vitro cholesterol synthesis by fatty acids
13. Eicosapentaenoic acid: Its relevance in atherosclerosis and coronary artery diseases
14. Compartmentation and supply of cholesterol; Two important factors in the coordinate regulation of hydroxymethylglutaryl-CoA reductase and cholesterol 7 α-hydroxylase
15. On the mechanism of regulation of hepatic 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and of acyl coenzyme A: cholesterol acyltransferase by dietary fat
16. Hypolipidemic effect of ethyl all-cis-5,8,11,14,17-icosapentaenoate (EPA-E) in rats
17. Studies on the mechanism of antihypercholesterolemic action of soy protein and soy protein type amino acid mixtures in relation to the casein counterparts in rats
18. Determination for higher fatty acids in various lipid fractions of human plasma platelets and erythrocyte membrane using thin layer chromatography and gas chromatography
19. Eicosapentaenoic acid inhibits cholesterol esterification in cultured parenchymal cells and isolated microsomes from liver
20. Micro assay for 3hydroxy-3-methylglutaryl CoA reductase in rat liver and in L-cell fibroblast
21. Dietary fish oil-induced changes in intrahepatic cholesterol transport and bile acid synthesis in rats
22. Role of acyl-CoA: choleaterol acyltransferase in cellular cholesterol metabolism
23. A rapid micro-scale procedure for determination of the total lipid profile
24. Effect of 4-(4′-chlorobenzyloxy)benzyl nicotine (KCD-232) on cholesterol metabolism in rats fed an amino acid imbalance diet
25. Mechanism of hypercholesterolemia in arteriolipidosis-prone rats
26. Validation of a dual-isotope plasma ratio method for measurement of cholesterol absorption in rats