A single conservative amino acid substitution in the reverse transcriptase of human immunodeficiency virus-1 confers resistance to (+)-(5S)-4,5,6,7- tetrahydro-5-methyl-6-(3-methyl-2-butenyl)imidazo[4,5,1- jk][1,4]benzodiazepin-2(1H)-thione (TIBO R82150)

Molecular Pharmacology

Volumn 43, Issue 1, 1993, Pages 11-16

  Mellors, J W ^a   Im, G J ^a   Tramontano, E ^a   Winkler, S R ^a   Medina, D J ^a   Dutschman, G E ^a   Bazmi, H Z ^a   Piras, G ^a   Gonzalez, C J ^a   Cheng, Y C ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [(2 HYDROXYETHOXY)METHYL] 6 (PHENYLTHIO)THYMINE; 3 [(4,7 DICHLORO 2 BENZOXAZOLYLMETHYL)AMINO] 5 ETHYL 6 METHYL 2(1H) PYRIDONE; 3 [(4,7 DIMETHYL 2 BENZOXAZOLYLMETHYL)AMINO] 5 ETHYL 6 METHYL 2(1H) PYRIDONE; 4,5,6,7 TETRAHYDRO 5 METHYL 6 (3 METHYL 2 BUTENYL)IMIDAZO[4,5,1 JK][1,4]BENZODIAZEPINE 2(1H) THIONE; 5 ETHYL 6 METHYL 3 (2 PHTHALIMIDOETHYL)PYRIDIN 2(1H) ONE; ANTIVIRUS AGENT; DIDANOSINE; L 693593; N ETHYL 2 [4 [(4 METHOXY 3,5 DIMETHYLPHENYL)METHYL] 1 PIPERAZINYL] 3 PYRIDINAMINE; NEVIRAPINE; PHYTOHEMAGGLUTININ; PYRIDONE DERIVATIVE; RNA DIRECTED DNA POLYMERASE; U 80493E; UNCLASSIFIED DRUG; ZALCITABINE; ZIDOVUDINE;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; DRUG RESISTANCE; DRUG SENSITIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; VIRUS MUTATION; VIRUS REPLICATION; VIRUS RESISTANCE;

ANTIVIRAL AGENTS; BASE SEQUENCE; BENZODIAZEPINES; DRUG RESISTANCE; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMAN; IMIDAZOLES; MOLECULAR SEQUENCE DATA; MUTATION; PHENOTYPE; PROVIRUSES; REVERSE TRANSCRIPTASE INHIBITORS; RNA-DIRECTED DNA POLYMERASE; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027472841     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (0)