Prodrugs of Peptides. 18. Synthesis and Evaluation of Various Esters of Desmopressin (dDAVP)

Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists

Volumn 10, Issue 1, 1993, Pages 68-74

  Kahns, Anne H ^a   Buur, Anders ^a   Bundgaard, Hans ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

cell culture; desmopressin (dDAVP); enzymatic hydrolysis; lipophilicity; peptide; prodrug; transport

Indexed keywords

CHYMOTRYPSIN A; DESMOPRESSIN ACETATE; ESTER; O (2 ETHYLHEXANOYL)DESMOPRESSIN; O HEXANOYLDESMOPRESSIN; O ISOBUTYLOXYCARBONYLDESMOPRESSIN; O OCTANOYLDESMOPRESSIN; O PROPIONYLDESMOPRESSIN; PRODRUG; UNCLASSIFIED DRUG; VASOPRESSIN DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL CULTURE; COLON MUCOSA; DRUG HYDROLYSIS; DRUG STABILITY; DRUG TRANSPORT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIPOPHILICITY; NONHUMAN; PARTITION COEFFICIENT; PERMEABILITY; RABBIT; TEMPERATURE;

BIOLOGICAL TRANSPORT, ACTIVE; CELL LINE; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHYMOTRYPSIN; DESMOPRESSIN; HALF-LIFE; HUMAN; HYDROGEN-ION CONCENTRATION; KINETICS; LIPIDS; PRODRUGS; SPECTROPHOTOMETRY, ULTRAVIOLET; SUPPORT, NON-U.S. GOV'T;

EID: 0027472110     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1023/A:1018973029651     Document Type: Article

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