Chemoselective thioacylation of amino acids. Preparation of the four monothiothymopentin analogs and their biological activity

Bioorganic and Medicinal Chemistry Letters

Volumn 3, Issue 4, 1993, Pages 619-624

  Zacharie, Boulos ^a   Martel, Rene ^a   Sauve, Gilles ^a   Belleau, Bernard ^a  

^a Shire Canada   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

THYMOPENTIN; THYMOPENTIN DERIVATIVE;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ELECTROMYOGRAM; METHODOLOGY; NEUROTRANSMISSION; NONHUMAN;

EID: 0027471260     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)81241-5     Document Type: Article

References (37)

1. Aminosäure-thionester und Endothiopeptide, II
2. TRH analogue with C-terminal thioamide group. Synthesis, receptor binding, TSH-releasing activity and α-MSH-releasing activity
3. Étude structurale de la liaison thioamide: Synthèse et conformation de dérivés de la thioalanine et de la thioglycine
4. Studies on amino acids and peptides. Part 6. Methods for introducing thioamide bonds into the peptide backbone: synthesis of the four monothio analogues of leucine enkephalin
5. Aminosäure-thionester und Endothiopeptide, II
6. Reaktionen mit Imidsäureestern, IV.N-acylierte α-Aminoimidsäureester, Iminodipeptide und Endothiodipeptide
7. Facile regioselective formation of thiopeptide linkages from oligopeptides with new thionation reagents
8. Solution Conformation of Peptides Through 1H Nuclear Magnetic Double Resonance Measurement of Amide Hydrogen Exchange Rates: Study of the Active Pentapeptide Fragment of Thymopoietin