Dexamethasone reduces vascular density and plasminogen activator activity in 9L rat brain tumors

Brain Research

Volumn 604, Issue 1-2, 1993, Pages 79-85

  Wolff, Johannes E A ^a,b   Guerin, Christopher ^b   Laterra, John ^a,b   Bressler, Joseph ^a,b   Indurti, Ravi R ^a   Brem, Henry ^b   Goldstein, Gary W ^a,b  

^a KENNEDY KRIEGER INSTITUTE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Angiogenesis; Endothelial cell; Glioma; Glucocorticoid; Protease

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID; PLASMINOGEN ACTIVATOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN TUMOR; CELL CULTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; GLIOMA CELL; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; BRAIN NEOPLASMS; CELL DIVISION; CELL LINE; CELLS, CULTURED; DEXAMETHASONE; ENDOTHELIUM, VASCULAR; MALE; NEOVASCULARIZATION, PATHOLOGIC; PLASMINOGEN ACTIVATORS; RATS; RATS, INBRED F344; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027468662     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(93)90354-P     Document Type: Article

References (41)

1. Medroxyprogesterone acetate, an anti-cancer and anti-angiogenic steroid, inhibits the plasminogen activator in bovine endothelial cells
2. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
3. Glucocorticoid modulation of plasminogen activators and of one of their inhibitors in the human mammary carcinoma cell line MDA-MB-231
4. High performance liquid chromatographic assay of dexamethasone in plasma and tissue
5. Further characterization of malignant glioma-derived vascular permeability factor
6. Angiostatic steroids. Method of discovery and mechanism of action
7. Angiogenesis inhibition and tumor regression caused by heparin or a a heparin fragment in the presence of cortisone
8. Immunohistochemical localization of tissue plasminogen activator in human brain tumors
9. Effects of glucocorticoids on glioma cells in culture
10. Critical factors controlling angiogenesis: cell products, cell matrix and growth factors
11. Dexamethasone inhibition of tissue-type plasminogen activator (tPA) activity: paradoxical induction of both tPA antigen and plasminogen activator inhibitor
12. Inhibition of tumor growth, vascularization and collagenolysis in rabbit cornea by medroxyprogestrone
13. Vascular differentiation and glucose transporter expression in rat gliomas: effects of steroids
14. Effects of dexamethasone and betamethasone on in vitro cultures from human astrocytoma
15. Corticosteroid effect on transplantable rat glioma
16. Stimulation of macrophage prostaglandin and neutral protease production by phorbol esters as a model for the induction of vascular changes associated with tumor promotion
17. A comparative study of the perioxidase-antiperoxidase method and an avidin-biotin complex method for studying polypeptide hormones with radioimmunoassay antibodies
18. Tissue-plasminogen activator stimulates endothelial cell migration in wound assays
19. A highly sensitive chromogenic microtiter plate assay for plasminogen activators which quantitatively discriminates between the urokinase and tissue-type activators
20. High performance liquid chromatographic determination of dexamethasone in cerebrospinal fluid and plasma in the rabbit
21. Astrocytes induce neural microvascular endothelial cells to form capillary-like structures in vitro
22. Regulation of plasminogen activator production by cultured endothelial cells
23. Content and characterization of plasminogen activators in human lung tumors and normal lung tissue
24. Phenotypic modification of human glioma and non-small cell lung carcinoma by glucocorticoids and other agents
25. Effects of dexamethasone and methylprednisolone on cell cultures of human glioblastomas
26. Glucocorticoid-modulated gene expression of tissue- and and urinary-type plasminogen activator and plasminogen activator inhibitor 1 and 2
27. Tumor-promoting phorbol esters induce angiogenesis in vitro
28. Characteristics and biological role of steroid hormone receptors in neuroepithelial tumors
29. Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro
30. Angiogenesis in developing rat brain: an in vivo and in vitro
31. Basic fibroblast growth factor is an extracellular matrix component required for supporting the proliferation of vascular endothelial cells and the differentiation of PC12 cells
32. Cell-associated plasminogen activation: regulation and physiologic functions
33. Corticosteroid hormones. Effects in an experimental brain tumor
34. Expression of heterogeneous profiles of plasminogen activators and plasminogen activator inhibitors by human glioma lines
35. Inhibition of microvascular endothelial cell migration by beta-cyclodextrin tetradecasulfate and hydrocortisone
36. Endothelium-fibrinolysis system interaction
37. Interstitial delivery of dexamethasone in the brain for the reduction of peritumoral edema
38. Determination of soluble fibrin in plasma by a rapid and quantitative spectrophotometric assay
39. Steroid inhibition of neural microvessel morphogenesis in vitro: receptor-mediation and astroglial-dependence
40. The effect of glucocorticosteroids on growth and metabolism of experimental glial tumors