The role of oxygen radicals in human disease, with particular reference to the vascular system

Pathophysiology of Haemostasis and Thrombosis

Volumn 23, Issue , 1993, Pages 118-126

  Halliwell, Barry ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Atherosclerosis; Copper; Free radical; Hydroxyl; Iron; Lipid peroxidation; Nitric oxide; Superoxide

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; COPPER; GLUTATHIONE; HYDROXYL RADICAL; IRON; NITRIC OXIDE; OXYGEN RADICAL; PROBUCOL; SUPEROXIDE;

ATHEROSCLEROSIS; CONFERENCE PAPER; ENDOTHELIUM CELL; LIPID PEROXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL;

ANTIOXIDANTS; ARTERIOSCLEROSIS; COPPER; ENDOTHELIUM, VASCULAR; FREE RADICAL SCAVENGERS; FREE RADICALS; HUMAN; IRON; LIPID PEROXIDATION; LIPOPROTEINS, LDL; OXIDATION-REDUCTION; OXYGEN; STRESS;

EID: 0027465289     PISSN: 14248832     EISSN: 14248840     Source Type: Journal    
DOI: 10.1159/000216921     Document Type: Article

References (81)

1. Moncada S, Palmer RMJ, Higgs EA: Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;43:109-142.
2. Babbs CF, Cregor MD, Turek JJ, Badylak SF: Endothelial superoxide production in buffer perfused rat lungs, demonstrated by a new histochemical technique. Lab Invest 1991;65:484-496.
3. Britigan BE, Roeder TL, Shasby DM: Insight into the nature and site of oxygen-centered free radical generation by endothelial cell monolayers using a novel spin trapping technique. Blood 1992;79:699-707.
4. Terada LS, Willingham IR, Rosandich ME, Leff JA, Kindt GW, Repine JE: Generation of superoxide anion by brain endothelial cell xanthine oxidase. J Cell Physiol 1991;184:191-196.
5. Sundqvist T: Bovine aortic endothelial cells release hydrogen peroxide. J Cell Physiol 1991;148:152-156.
6. Arroyo CM, Carmichael AJ, Bouscarel B, Liang JH, Weglicki WB: Endothelial cells as a source of oxygenfree radicals: An ESR study. Free Radic Res Commun 1990;9:287-296.
7. Von Sonntag C: The Chemical Basis of Radiation Biology. London, Taylor & Francis, 1987.
8. Halliwell B, Gutteridge JMC: Free Radicals in Biology and Medicine, ed 2. Oxford, Clarendon Press, 1989.
9. Breimer LH: Repair of DNA damage induced by reactive oxygen species. Free Radic Res Commun 1991;14:159-171.
10. Fridovich I: Superoxide dismutases: An adaptation to a paramagnetic gas. J Biol Chem 1989;264:7761-7764.
11. Saran M, Michel C, Bors W: Reactions of NO with O2−. Implications for the action of endothelium-derived relaxing factor. Free Radic Res Commun 1990;10:221 -226.
12. Nakazono K, Watanabe N, Matsuno K, Sasaki J, Sato T, Inoue M: Does superoxide underlie the pathogenesis of hypertension? Proc Natl Acad Sci USA 1991;88:10045-10048.
13. Laurindo FRM, de Luz PL, Uint L, Rocha TF, Jaeger RG: Evidence for superoxide radical-dependent coronary vasospasm after angioplasty in intact dogs. Circulation 1991;83:1705-1715.
14. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA: Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990;87:1620-1624.
15. Halliwell B: Superoxide, iron, vascular endothelium, and reperfusion injury. Free Radic Res Commun 1989;5:315-318.
16. Rubanyi GM, Ho EH, Cantor EH, Lumma WC, Botclho LH: Cytoprotective function of nitric oxide: Inactivation of superoxide radicals produced by human leukocytes. Biochem Biophys Res Commun 1991;181:1392-1397.
17. Gardner PR; Fridovich I: Superoxide sensitivity of the Escherichia coli 6-phosphogluconate dehydratase. J Biol Chem 1991;266:1478-1483.
18. Zhang Y, Marcillat O, Giulivi C, Ernster L, Davies KJA: The oxidative inactivation of mitochondrial electron transport chain components and ATPase. J Biol Chem 1990;265:16330-16336.
19. Cumutte JT, Babior BM: Chronic granulomatous disease. Adv Hum Genet 1987;16:229-297.
20. Maly FE: The B-lymphocyte: A newly-recognized source of reactive oxygen species with immunoregulatory potential. Free Radic Res Commun 1990;8:143-148.
21. Murrell GAC, Francis MJO, Bromley L: Modulation of fibroblast proliferation by oxygen free radicals. Biochem J 1990;265:659-665.
22. Meier B, Radeke H, Selle S, Raspe HH, Sies G, Resch K, Habermehl GG: Human fibroblasts release reactive oxygen species in response to treatment with synovial fluids from patients suffering from arthritis. Free Radic Res Commun 1990;8:149-160.
23. Groner Y, Elroy-Stein O, Avraham KB, Yaram Y, Schickler M, Knobler H, Rotman G: Down syndrome clinical symptoms are manifested in transfected cells and transgenic mice overexpressing the human Cu/Znsuperoxide dismutase gene. J Physiol (Paris) 1990;84:53-77.
24. Amstad P, Peskin A, Shah G, Mirault ME, Moret R, Zbinden I, Cerutti P: The balance between Cu, Zn-superoxide dismutase and catalase affects the sensitivity of mouse epidermal cells to oxidative stress. Biochemistry 1991;30:9305-9313.
25. Ames BN: Endogenous oxidative DNA damage, aging, and cancer. Free Radic Res Commun 1989;7:121-128.
26. Marcillat O, Zhang Y, Lin SW, Davies KJ: Mitochondria contain a proteolytic system which can recognize and degrade oxidatively-denatured proteins. Biochem J 1988;254:677-683.
27. Halliwell B, Gutteridge JMC, Cross CE: Free radicals, antioxidants and human disease: Where are we now? J Lab Clin Med 1992;119:598-620.
28. Dupuy C, Virion A, Ohayon R, Kamiewski J, Deme D, Pommier J: Mechanism of hydrogen peroxide formation catalyzed by NADPH oxidase in thyroid plasma membrane. J Biol Chem 1991;266:3739-3743.
29. Manes C: Cyanide-resistant reduction of nitroblue tetrazolium and hydrogen peroxide production by the rabbit blastocyst. Mol Reprod Dev 1992;31:114-121.
30. Cochrane CG: Mechanisms of oxidant injury of cells. Mol Aspects Med 1991;12:137-147.
31. Halliwell B, Gutteridge JMC: Role of free radicals and catalytic metal ions in human disease. Methods Enzymol 1990;186:1-85.
32. Halliwell B, Gutteridge JMC: Biologically-relevant metal ion-dependent hydroxyl radical generation: An update. FEBS Lett 1992;307:108-112.
33. Weinberg ED: Iron depletion, a defense against intracellular infection and neoplasia. Life Sci 1992;50:1289-1297.
34. Halliwell B, Gutteridge JMC: Oxygen-free radicals and iron in relation to biology and medicine: Some problems and concepts. Archs Biochem Biophys 1986;246:501-508.
35. Biemond P, Van Eijk HG, Swaak AJG, Koster JF: Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes: Possible mechanism in inflammation diseases. J Clin Invest 1984;73:1576-1579.
36. Bolann BJ, Ulvik RJ: On the limited ability of superoxide to release iron from ferritin. Eur J Biochem 1990;193:899-904.
37. Gutteridge JMC: Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides. FEBS Lett 1986;201:291-295.
38. Puppo A, Halliwell B: Formation of hydroxyl radicals from hydrogen peroxide in the presence of iron: Is haemoglobin a biological Fenton catalyst? Biochem J 1988;249:185-190.
39. Gutteridge JMC, Smith A: Antioxidant protection by haemopexin of haem-stimulated lipid peroxidation. Biochem J 1988;256:861-865.
40. Balla G, Vercellotti GM, Muller-Eberhard U, Eaton J, Jacob HS: Exposure of endothelial cells to free heme potentiates damage mediated by granulocytes and toxic oxygen species. Lab Invest 1991;64:648-655.
41. Gutteridge JMC, Winyard PG, Blake DR, Lunec J, Brailsford S, Halliwell B: The behaviour of caeruloplasmin in stored human extracellular fluids in relation to ferroxidase 11 activity, lipid peroxidation, and phenanthroline-detectable copper. Biochem J 1985;230:517-523.
42. Orrenius S, McConkey DJ, Bellomo G, Nicotera P: Role of Ca2+ in toxic cell killing. Trends Pharmacol Sci 1989;10:281-285.
43. Thies RL, Autor AP: Reactive oxygen injury to cultured pulmonary artery endothelial cells: Mediation by poly(ADP-ribose) polymerase activation causing NAD depletion and altered energy balance. Arch Biochem Biophys 1991;286:353-363.
44. Spragg RG: DNA strand break formation following exposure of bovine pulmonary artery and aortic endothelial cells to reactive oxygen products. Am J Respir Cell Mol Biol 1991;4:4-10.
45. Block ER: Hydrogen peroxide alters the physical state and function of the plasma membrane of pulmonary artery endothelial cells. J Cell Physiol 1991;146:362-369.
46. Geeraerts MD, Ronveaux-Dupal MF, Lemasters JJ, Herman B: Cytosolic free Ca2+ and proteolysis in lethal oxidative injury in endothelial cells. Am J Physiol 1991;261:C889-C896.
47. Halliwell B, Aruoma OI: DNA damage by oxygen-derived species: Its mechanism and measurement in mammalian systems. FEBS Lett 1991;281:9-19.
48. Ward PA: Mechanisms of endothelial cell injury. J Lab Clin Med 1991;118:421-426.
49. Halliwell B, Gutteridge JMC: Lipid peroxidation, oxygen radicals, cell damage, and antioxidant therapy. Lancet 1984;i:1396-1398.
50. Levander OA: A global view of human selenium nutrition. Annu Rev Nutr 1987;7:227-250.
51. Muller DPR. Goss-Sampson MA: Neurochemical neurophysiological, and neuropathological studies in vitamin E deficiency. Crit Rev Neurobiol 1990;5:239-265.
52. Halliwell B, Chirico S, Kaur H, Aruoma OI, Grootveld M, Blake DR: Application of new assays for measuring free radical production to human rheumatoid patients; in Davies KJA (ed): Oxidative Damage and Repair. Oxford, Pergamon Press. 1992, pp 846-855.
53. Bolli R, Hartley CJ, Rabinovitz RS: Clinical relevance of myocardial stunning. Cardiovasc Drugs Ther 1991;5:877-890.
54. Parks DA: Oxygen radicals; mediators of gastrointestinal pathophysiology. Gut 1989;30:293-298.
55. Halliwell B: Reactive oxygen species and the central nervous system. J Neurochem 1992;59:1609-1623.
56. Hall ED, Braughler JM: Central nervous system trauma and stroke: Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation. Free Radic Biol Med 1989;6:303-338.
57. Wilson RB: Lipid peroxidation and atherosclerosis. CRC Crit Rev Food Sci Nutr 1976;8:325-338.
58. Carew TE, Schwenke DC, Steinberg D: Antiatherogenic effect of probucol unrelated to its hypocholesterolaemic effect: Evidence that antioxidants in vivo can selectively inhibit LDL degradation in macrophagerich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. Proc Natl Acad Sci USA 1987;84:7725-7729.
59. Steinberg D, Parthasarathy S, Carew TE, Choo JC, Witztum JL: Beyond cholesterol: Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 1989;320:915-924.
60. Parthasarathy S: Evidence for an additional intracellular site of action of probucol in the prevention of oxidative modification of low density lipoprotein. J Clin Invest 1992;89:1618-1621.
61. Silverman DJ, Santucci LA: Potential for free radical-induced lipid peroxidation as a cause of endothelial cell injury in Rocky Mountain spotted fever. Infect Immun 1988;56:3110-3115.
62. Mitchinson MJ, Ball RY: Macrophages and atherogenesis. Lancet 1987;ii:146-148:.
63. Goldstein JL, Ho YK, Basu SK, Brown MS: Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc Natl Acad Sci USA 1979;76:333-337.
64. Yla-Herttuala S: Macrophages and oxidized low-density lipoproteins in the pathogenesis of atherosclerosis. Ann Med 1991;23:561-567.
65. Liao F, Berliner JA, Mehrabian M, Navab M, Demer LL, Lusis AJ, Fogelman AM: Minimally modified low density lipoprotein is biologically active in vivo in mice. J Clin Invest 1991;87:2253-2257.
66. Rosenfeld ME: Oxidized LDL affects multiple atherogenic cellular responses. Circulation 1991;83:2137-2140.
67. Warso MA, Lands WEM: Lipid peroxidation in relation to prostacyclin and thromboxane physiology and pathophysiology. Br Med Bull 1983;39:277-280.
68. Holland JA, Pritchard KA, Rogers WJ, Stemerman MB: Perturbation of cultured human endothelial cells by atherogenic levels of low density lipoprotein. Am J Pathol 1988;132:474-478.
69. Yokode M, Kita T, Kikawa Y, Ogorochi T, Narumiya S, Kawai C: Stimulated arachidonate metabolism during foam cell transformation of mouse peritoneal macrophages with oxidized low density lipoprotein. J Clin Invest 1988;81:720-729.
70. Salonen JT, Salonen R, Seppanen K, Kantola M, Suntioinen S, Korpela H: Interactions of scrum copper, selenium and low density lipoprotein cholesterol in atherogenesis. Br Med J 1991;302:756-760.
71. Smith CA, Mitchinson MJ, Aruoma OI, Halliwell B: Stimulation of lipid peroxidation and hydroxyl radical generation by the contents of human atherosclerotic lesions. Bioehem J 1992;286:901-905.
72. O’Leary VJ, Darley-Usmar VM, Russell LJ, Stone D: Pro-oxidant effects of lipoxygenase-derived peroxides on the copper-initiated oxidation of low-density lipoproteins. Bioehem J 1992;282:631-634.
73. Hwang PL: Biological activities of oxygenated sterols: Physiological and pathological implications. Bioessays 1991;13:583-589.
74. Ball RY, Carpenter KLH, Mitchinson MJ: What is the significance of ceroid in human atherosclerosis? Arch Pathol Lab Med 1987;111:1134-1140.
75. Salonen JT, Herttuala SY, Yamamoto Y, Butler S, Korpela H, Salonen R, Nyyssönen K, Palinski W, Witztum JL: Autoantibody against oxidized LDL and progression of carotid atherosclerosis. Lancet 1992;339:883-887.
76. Esterbauer H, Striegl B, Puhl H, Rotheneder M: Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radic Res Commun 1989;6:67-75.
77. Esterbauer H, Puhl H, Dieber-Rotheneder M, Waeg G, Rabl H: Effect of antioxidants on oxidative modification of LDL. Ann Med 1991;23:573-581.
78. Gey KF, Puska P, Jordan P, Moser UK: Inverse correlation between plasma vitamin E and mortality from ischemic heart disease in crosscultural epidemiology. Am J Clin Nutr 1991;53:S326-S334.
79. Aruoma OI, Evans PJ, Kaur H, Sutcliffe L, Halliwell B: An evaluation of the antioxidant and potential prooxidant properties of food additives and of Trolox C, vitamin E and probucol. Free Radic Res Commun 1990;10:143-157.
80. Aruoma OI, Halliwell B, Aeschebach R, Loliger J: Antioxidant and pro-oxidant properties of active rosemary constituents: Carnosol and camosic acid. Xenobiotica 1991;22:257-268.
81. Regnström J, Nilsson J, Tornvall P, Landou C, Hamsten A: Suceptibility to low-density lipoprotein oxidation and coronary atherosclerosis in man. Lancet 1992;339:1183-1186.