Chemical Pathways of Peptide Degradation. IV. Pathways, Kinetics, and Mechanism of Degradation of an Aspartyl Residue in a Model Hexapeptide

Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists

Volumn 10, Issue 1, 1993, Pages 95-102

  Oliyai, Cecilia ^a   Borchardt, Ronald T ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

Asp hexapeptide; Asp X hydrolysis; asparaginyl; aspartyl; conversion of Asp to isoAsp; cyclic imide; degradation pathways; iso Asp hexapeptide

Indexed keywords

AMINO ACID; ASPARTIC ACID; BUFFER; HEXAPEPTIDE; PEPTIDE;

ARTICLE; DRUG DEGRADATION; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; IONIZATION; KINETICS; PH; TEMPERATURE;

AMINO ACID SEQUENCE; ASPARTIC ACID; BUFFERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROGEN-ION CONCENTRATION; KINETICS; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; SPECTROPHOTOMETRY, ULTRAVIOLET; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TEMPERATURE;

EID: 0027463564     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1023/A:1018981231468     Document Type: Article

References (26)

1. Drug products of recombinant DNA technology
2. Pharmaceutical applications of advances in biotechnology
3. Stability of protein pharmaceuticals
4. Chemical and physical stability of protein pharmaceuticals
5. Chemical pathways of peptide degradation. I. Deamidation of adrenocorticotropic hormone
6. Chemical pathways of peptide degradation. II. Kinetics of deamidation of an asparaginyl residue in a model hexapeptide
7. Chemical pathways of peptide degradation. III. Effect of primary sequence on the pathways of deamidation of asparaginyl residues in hexapeptides
8. Formation of epsilon-(aminosuccinyl)-lysine from epsilon-(aspartyl)-lysine from bacitracin A, and from cell walls of lactobacilli
9. Kinetics of the aspartyl transpeptidation of daptomycin, a novel lipopeptide antibiotic
10. Side reactions in peptide synthesis
11. Calcium affects the spontaneous degradation of aspartyl/asparaginyl residues in calmodulin
12. Mechanism and kinetics of secretin degradation in aqueous solutions
13. Replacement of a labile aspartyl residue increases the stability of human epidermal growth factor
14. Preferential cleavage at aspartyl-prolyl peptide bonds in dilute acid
15. Cleavage at aspartic acid
16. Synthetic peptide substrates for the erythrocyte protein carboxyl methyltransferase: Detection of a new site of methylation at isomerized L-aspartyl residues
17. Solvent isotope effects on enzyme systems
18. Cleavage at aspartic acid
19. Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides