Inhibition of glucuronidase by natural glucuronides of kampo, medicines using glucuronide of SN-38 (7-ethyl-10-hydroxycamptothecin) as a substrate

Xenobiotica

Volumn 23, Issue 1, 1993, Pages 5-10

  Narita, M ^a   Nagai, E ^b   Hagiwara, H ^c   Aburada, M ^d   Yokoi, T ^a   Kamataki, T ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b DAIICHI SANKYO CO   (Japan)

^c YAKULT CENTRAL INSTITUTE FOR MICROBIOLOGICAL RESEARCH   (Japan)

^d TSUMURA AND CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; 7 ETHYL 10 HYDROXYCAMPTOTHECIN GLUCURONIDE; BETA GLUCURONIDASE; CAMPTOTHECIN; GLUCURONIDE; KAMPO; UNCLASSIFIED DRUG;

ARTICLE; ENZYME INHIBITION; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; GLUCURONATES; GLUCURONIDASE; KINETICS; SUBSTRATE SPECIFICITY; TIME FACTORS;

EID: 0027461221     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.3109/00498259309059356     Document Type: Article

References (14)

1. A phase II study of CPT-11, a new derivative of Camptothecin, for previously untreated non-small-cell lung cancer
2. 14C-CPT-11 (pp)
3. Scientific reevaluation of Kampo prescriptions using modern technology
4. Nonlinear pharmacokinetics of CPT-11 in rats
5. Metabolism and pharmacokinetics of the camptothecin analogue CPT-11 in the mouse
6. Antitumor activity of 7-ethyl-10-[4-(1-piperidino)1- piperidino]carbonyloxy-camptothecin, a novel water-soluble derivative of camptothecin, against murine tumors
7. β-Glururonidase and the hydrolysis of glucuronides
8. Synthesis of new camptothecin derivatives
9. Glucuronidation
10. An early phase II study of CPT-11: a new derivative of camptothecin, for the treatment of leukemia and lymphoma
11. Studies on the metabolic fate of CPT-11 (2), Pharmacokinetics in rats following a single intravenous dose (2), metabolites pattern in serum, liver, kidney and intestinal tissue
12. Phase I clinical study of CPT-11
13. Plant antitumor agents. I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from
14. New automatic high-performance liquid chromatographic analysis of cyclosporin A and G in human serum