Oral gossypol in the treatment of metastatic adrenal cancer

Journal of Clinical Endocrinology and Metabolism

Volumn 76, Issue 4, 1993, Pages 1019-1024

  Flack, Mary R ^a   Pyle, Robert G ^a   Mullen, Nancy M ^a   Lorenzo, Beverly ^b   Wu, Yan W ^a   Knazek, Richard A ^c   Nisula, Bruce C ^a   Reidenberg, Marcus M ^b  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c Incorporated ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYCORTICOSTERONE; DOXORUBICIN; ESTRADIOL; ETOPOSIDE; GOSSYPOL; GOSSYPOL ACETIC ACID; HYDROCORTISONE; HYDROXYCORTICOSTEROID; MITOTANE; PRASTERONE SULFATE; SURAMIN; TESTOSTERONE;

ADRENAL CANCER; ADULT; AGED; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CLINICAL ARTICLE; FEMALE; HUMAN; ILEUS; MALE; METASTASIS; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ADOLESCENT; ADRENAL GLAND NEOPLASMS; ADULT; AGED; AGED, 80 AND OVER; FEMALE; GOSSYPOL; HUMAN; MALE; MIDDLE AGE; RADIOGRAPHY, THORACIC; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME;

MUS MUSCULUS;

EID: 0027460576     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jcem.76.4.8473376     Document Type: Article

References (21)

1. Luton JP, Cerdas S, Billaud L, et al. 1990 Clinical features of adrenocortical carcinoma, prognostic factors and the effect of mito-tane therapy. N Engl J Med. 322:1195-1201.
2. Haq MM, Legha SS, Samaan NA, Bodey GP, Burgess MA. 1980 Cytotoxic chemotherapy in adrenal cortical carcinoma. Cancer Treat Rep. 64:909-913.
3. Wu YW, Chik CL, Knazek RA. 1989 An in vitro and in vivo study of antitumor effects of gossypol on human SW-13 adrenocortical carcinoma. Cancer Res. 49:3754-3758.
4. Tso WW. 1984 Gossypol inhibits Ehrlich ascites tumor cell proliferation. Cancer Lett. 24:257-261.
5. Rao PN, Wang Y, Lotzova E, Khan AA, Rao SP, Stephens LC. 1985 Antitumor effects of gossypol on murine tumors. Cancer Chemother Pharmacol. 15:20-25.
6. Liu G, Lyle KC, Cao J. 1987 Clinical trial of gossypol as a male contraceptive drug. Part 1. Efficacy study. Fertil Steril. 48:459-461.
7. Liu G, Lyle KC. 1987 Clinical trial of gossypol as a male contraceptive drug. Part 2. Hypokalemia study. Fertil Steril. 48:462-465.
8. Wu D, Reidenberg MM, Drayer DE. 1988 Determination of gossypol enantiomers in plasma after administration of racemate using high-performance liquid chromatography with precolumn chemical derivatisation. J Chromatogr. 433:141-148.
9. Hutter AM, Kayhoe DE. 1966 Adrenal cortical carcinoma: results of treatment with o, p’DDD in 138 patients. Am J Med. 41:581-592.
10. Hesketh PJ, McCaffrey RP, Finkel HE, Larmon SS, Griffing GT, Melby JC. 1987 Cisplatin-based treatment of adrenocortical carcinoma. Cancer Treat Rep. 71:222-224.
11. Johnson DH, Greco FA. 1986 Treatment of metastatic adrenal cortical carcinoma with cisplatin and etoposide (VP-16). Cancer. 58:2198-2202.
12. Schlumberger M, Ostronoff M, Bellaiche M, Rougier P, Droz JP, Parmentier C. 1988 5-Fluorouracil, doxorubicin, and cisplatin regimen in adrenal cortical carcinoma. Cancer. 61:1492-1494.
13. van Slooten H, van Oosterom AT. 1983 CAP (cyclophosphamide, doxorubicin, and cisplatin) regimen in adrenal cortical carcinoma. Cancer Treat Rep. 67:377-379.
14. Lee CG, Moon YS, Yuan JH, Chen AF. 1982 Enzyme inactivation and inhibition by gossypol. Mol Cell Biochem. 47:65-70.
15. Qian SZ, Wang ZG. 1984 Gossypol: a potential antifertility agent for males. Annu Rev Pharmacol Toxicol. 24:329-360.
16. Wu D. 1989 An overview of the clinical pharmacology and therapeutic potential of gossypol as a male contraceptive agent and in gynaecological disease. Drugs. 38:333-341.
17. Tuszynski GP, Cossu G. 1984 Differential cytotoxic effect of gossypol on human melanoma, colon carcinoma, and other tissue culture cell lines. Cancer Res. 44:768-771.
18. Coutinho EM, Melo JF, Barbosa I, Segal SJ. 1984 Antispermato-genic action of gossypol in men. Fertil Steril. 42:424-430.
19. Benz CC, Keniry MA, Ford JM, et al. 1990 Biochemical correlates of the antitumor and antimitochondrial properties of gossypol enantiomers. Mol Pharmacol. 37:840-847.
20. Pohl U, Dezsi L, Simon B, Busse R. 1987 Selective inhibition of endothelium-dependent dilation in resistance-sized vessels in vivo. Am J Physiol. 253:H234-H239.
21. Radermacher J, Forstermann U, Froelich JC. 1990 Endothelium-derived relaxing factor influences renal vascular resistance. Am J Physiol. 259:F9-F17.