Dynamics of HIV infection of CD4+ T cells

Mathematical Biosciences

Volumn 114, Issue 1, 1993, Pages 81-125

  Perelson, Alan S ^a   Kirschner, Denise E ^b   De Boer, Rob ^a  

^a LOS ALAMOS NATIONAL LABORATORY   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN;

CELL GROWTH; ENDEMIC DISEASE; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MATHEMATICAL MODEL; REVIEW; STEADY STATE; STEM CELL; T LYMPHOCYTE;

CD4-POSITIVE T-LYMPHOCYTES; HIV; HIV INFECTIONS; HUMAN; MATHEMATICS; MODELS, BIOLOGICAL; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0027457101     PISSN: 00255564     EISSN: None     Source Type: Journal    
DOI: 10.1016/0025-5564(93)90043-A     Document Type: Article

References (65)

1. Studies on the bioperiodicity of the immune response. I. Circadian rhythms of human T, B, and K cell traffic in the peripheral blood
2. Rapid development of isolate-specific neutralizing antibodies and consequent emergence of virus variants which resist neutralization by autologous sera
3. Mathematical and statistical studies of the epidemiology of HIV
4. Complex dynamical behavior in the interaction between HIV and the immune system
5. Replicative capacity of human immunodeficiency virus from patients with varying severity of infection
6. Biologic features of HIV-1 that correlate with virulence in the host
7. Theory of an immune system retrovirus
8. AUTO: a program for the bifurcation analysis of autonomous systems
9. Application of the mathematical model of immunological tolerance to HIV infection
10. AIDS: a syndrome of immune dysregulation, dysfunction, and deficiency
11. Current issues in developing a strategy for dealing with the acquired immunodeficiency syndrome
12. The human immunodeficiency virus: infectivity and mechanisms of pathogenesis
13. Distinct replicative and cytopathic characteristics of human immunodeficiency virus isolates
14. Susceptibility of normal human lymphocytes to infection with HTLV-III/LAV
15. Lymphocyte population kinetics in the mouse
16. Fine structure of human immunodeficiency virus (HIV) and immunolocalization of structural proteins
17. Effect of T4 count and cofactors on the incidence of AIDS in homosexual men infected with human immunodeficiency virus
18. + lymphocytes
19. T cell and B cell memory are short lived in the absence of antigen
20. Expansion, selection and maintenance of memory B cell clones
21. Detection of lymphocytes expressing human T-lymphotropic virus type III in lymph nodes and peripheral blood from infected individuals by in situ hybridization
22. Gonerrhea Transmission Dynamics and Control
23. Pathogenesis of infection with human immunodeficiency virus
24. Alterations in T4 (CD4) protein and mRNA synthesis in cells infected with HIV
25. + lymphocyte depletion in HIV infection
26. + lymphocyte dynamics in HIV infected individuals
27. Analysis of immune system retrovirus equations
28. Kinetics of HIV-1 replication and intracellular accumulation of particles in HTLV-1 transformed cells
29. A deterministic model for gonorrhea in a nonhomogeneous population
30. Immunologic abnormalities in the acquired immunodeficiency syndrome
31. Infectious complications of AIDS
32. HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy
33. Quantifying the infectivity of HIV
34. Cytopathic effect of human immunodeficiency virus in T4 cells is linked to the last stage of virus infection
35. HIV infection from an ecological viewpoint
36. A model of human immunodeficiency virus infection in T helper cell clones
37. Sources of variability in repeated T-helper lymphocyte counts from human immunodeficiency virus type 1-infected patients: total lymphocyte count fluctuations and diurnal cycle are important
38. Amplification of HTLV-III/LAV infection by antigen-induced activation of T cells and direct suppression by virus of lymphocyte blastogenic responses
39. AIDS: background and the dynamics of the decline of immunocompetence
40. Modeling the interaction of HIV with cells of the immune response
41. Emergence of viruses resistant to neutralization by V3-specific antibodies in experimental human immunodeficiency virus type 1 IIIB infection of chimpanzees
42. A mechanism of immune escape by slow-replicating HIV strains
43. Mathematical biology of HIV infections: antigenic variation and diversity threshold
44. The evolutionary dynamics of HIV-1 quasispecies and the development of immunodeficiency disease
45. Modeling the interaction of the immune system with HIV
46. Prediction of progression to AIDS by analysis of CD4 lymphocyte counts in a haemophilic cohort
47. + peripheral blood lymphocytes in healthy seropositive individuals
48. Life at low Reynolds number
49. The Walter Reed staging classification for HTLV-III/LAV infection
50. Theoretical implications of cellular immune reactions against helper lymphocytes infected by an immune system retrovirus
51. The reservoir for HIV-1 in human peripheral blood is a T cell that maintains expression of CD4
52. + T cells from patients with human immunodeficiency virus (HIV) infection reflects rapidly progressive immunosuppression and clinical disease
53. Unexpectedly high levels of HIV-1 RNA and protein synthesis in a cytocidal infection
54. CD4 percentage, CD4 number and CD4:CD8 ratio in HIV infection: which to choose and how to use
55. Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates
56. Primary HIV infection
57. CD4 expressed on earliest T-lineage precursor cells in adult murine thymus
58. HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure