High affinity binding of TAR RNA by the human immunodeficiency virus type-1 tat protein requires base-pairs in the RNA stem and amino acid residues flanking the basic region

Journal of Molecular Biology

Volumn 230, Issue 1, 1993, Pages 90-110

  Churcher, Mark J ^a   Lamont, Christina ^a   Hamy, François ^a   Dingwall, Colin ^a   Green, Sheila M ^a   Lowe, Anthony D ^a   Butler, P Jonathan G ^a   Gait, Michael J ^a   Karn, Jonathan ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Human immunodeficiency virus type 1 (HIV 1); RNA peptide interactions; RNA protein interactions; tat protein; Trans activation

Indexed keywords

TRANSACTIVATOR PROTEIN; VIRUS PROTEIN;

ARTICLE; BINDING AFFINITY; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN NUCLEIC ACID INTERACTION;

AMINO ACID SEQUENCE; BASE SEQUENCE; BINDING, COMPETITIVE; DNA MUTATIONAL ANALYSIS; GENE EXPRESSION REGULATION, VIRAL; GENE PRODUCTS, TAT; HIV LONG TERMINAL REPEAT; HIV-1; HYDROGEN BONDING; IN VITRO; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; PEPTIDES; PROTEIN BINDING; RECOMBINANT PROTEINS; RNA, VIRAL; RNA-BINDING PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; TRANS-ACTIVATION (GENETICS);

EID: 0027452957     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1993.1128     Document Type: Article

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