Age‐Dependent Vulnerability of the Striatum to the Mitochondrial Toxin 3‐Nitropropionic Acid

Journal of Neurochemistry

Volumn 60, Issue 1, 1993, Pages 356-359

  Brouillet, Emmanuel ^a   Jenkins, Bruce G ^a   Hyman, Bradley T ^a   Ferrante, Robert J ^a   Kowall, Neil W ^a   Srivastava, Rachana ^a   Roy, Deborah Samanta ^a   Rosen, Bruce R ^a   Beal, M Flint ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Aging; Excitotoxicity; Huntington's disease; Mitochondria; Neurodegenerative diseases; Striatum

Indexed keywords

LACTIC ACID; PROPIONIC ACID DERIVATIVE; TOXIN;

ADOLESCENT; AGING; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CORPUS STRIATUM; HISTOPATHOLOGY; HUNTINGTON CHOREA; MALE; MITOCHONDRION; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROCHEMISTRY; NEUROTOXICITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

ADENOSINE TRIPHOSPHATE; AGING; CORPUS STRIATUM; IN VITRO; LACTATES; LACTIC ACID; MITOCHONDRIA; NEUROTOXINS; PROPIONIC ACIDS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

ANIMALIA; SPINY;

EID: 0027448161     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.1993.tb05859.x     Document Type: Article

References (21)

1. 3‐Nitropropionate, the toxic substance of Indigofera, is a suicide inactivator of succinate dehydrogenase
2. Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses
3. Aminooxyacetic acid results in excitotoxin lesions by a novel indirect mechanism
4. Local and systemic administration of 3‐nitropropionic acid results in excitotoxic striatal lesions
5. 28K immunocytochemistry
6. Effects of aging on quinolinic acid lesions in rat striatum
7. Basal ganglia degeneration, myelin alterations, and enzyme inhibition in mice by the plant toxin 3‐nitropropanoic acid
8. Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease
9. Nature and distribution of brain lesions in rats intoxicated with 3‐nitropropionic acid: a type of hypoxic (energy deficient) brain damage
10. The relationships between aging, monoamine oxidase, striatal dopamine and the effects of MPTP in C57BL6
11. Localized proton‐NMR spectroscopy in patients with Huntington's disease (HD) demonstrates abnormal lactate levels in occipital cortex: evidence for compromised metabolism in HD
12. Using neurotoxicants to study aging and Parkinson's disease
13. Mitochondrial gene mutation: the aging process and degenerative diseases
14. 3‐Nitropropionic acid—exogenous animal neurotoxin and possible human striatal toxin
15. 3‐Nitropropionic acid decreases cellular energy levels and causes neuronal degeneration in cortical explants
16. Glutamate becomes neurotoxic via the N‐methyl‐D‐aspartate receptor when intracellular energy levels are reduced
17. Inhibition of energy metabolism by 3‐nitropropionic acid activates ATP‐sensitive potassium channels
18. l‐Methyl‐4‐phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism
19. Age‐related changes in respiratory muscle mitochondrial function in rats
20. Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in aging
21. Chemically induced hypoglycemia and anoxia: relationship to glutamate receptor‐mediated toxicity in retina