Photodynamic therapy in oncology: Mechanisms and clinical use

Journal of the National Cancer Institute

Volumn 85, Issue 6, 1993, Pages 443-456

  Pass, Harvey I ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LOW DENSITY LIPOPROTEIN; OXYGEN; PHOTOFRIN I; PHOTOFRIN II; PHOTOSENSITIZING AGENT; PHTHALOCYANINE DERIVATIVE; PORPHYRIN DERIVATIVE; PURPURIN DERIVATIVE; RHODAMINE 123; TALAPORFIN;

ANTINEOPLASTIC ACTIVITY; BLOOD VESSEL REACTIVITY; BRAIN CANCER; CYTOTOXICITY; DIGESTIVE SYSTEM CANCER; DRUG ACCUMULATION; ESOPHAGUS CANCER; EYE CANCER; GYNECOLOGIC CANCER; HEAD AND NECK CANCER; HUMAN; IMMUNOMODULATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LIGHT; LIPOPHILICITY; LUNG CANCER; NONHUMAN; ONCOLOGY; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; REVIEW; SKIN CANCER; TOPICAL DRUG ADMINISTRATION; UROGENITAL TRACT CANCER;

DIHEMATOPORPHYRIN ETHER; HUMAN; INDOLES; NEOPLASMS; PHOTOCHEMOTHERAPY; PORPHYRINS;

EID: 0027446986     PISSN: 00278874     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnci/85.6.443     Document Type: Review

References (214)

1. Danifj M, Hm. JS: A history of photodynamic therapy. Aust N Z J Surg 61:340-348, 1991
2. Raab O: Ober die Wirkung Fluoreszierenden Stoffen. Infusoria Z Biol 39:524, 1900
3. Jbsionek A, Tappeiner VH: Zur Behandlung der Hautcarcinomit mil fluorescierenden Stoffen. Muench Med Wochneshr 47:2042, 1903
4. Hausman W: Die sensibilisierende Wirkung des Hematoporphyrins. Biochem Z 30:276, 1911
5. Auber H, Banger G: Untersuchungen uber die Rolle der Porphyrine bei geschwulstkranken Menschen und Tieren. Z Krebsforsch 53:65, 1942
6. Fioge FHJ, Weiland GS, Mangantello LOJ: Cancer detection and therapy. Affinity of neoplastic embryonic and traumatized tissue for porphyrins and metalloporphyrins. Proc Soc Exp Biol Med 68:640, 1948
7. Lipson RL, Baloes EJ: The photodynamic properties of a particular hematoporphyrin derivative. Arch Dermatol 82:508, 1960
8. Ljpson RL, Baloes EJ: The use of a derivative of hematoporphyrin in tumor detection. J Natl Cancer Inst 26:1, 1961
9. Ljpson RL, Baldes EJ: Hematoporphyrin derivative: A new aid for endoscopic detection of malignant disease. J Thorac Cardiovasc Surg 42:623, 1961
10. Gray M, Lipson RL, Mack JVS, et al: Use of hematoporphyrin derivative in detection and management of cervical cancer. Am J Obstet Gynecol 9:766, 1967
11. Greoorie HG, Horger EO, Ward JL, et al: Hematoporphyrin- derivative fluorescence in malignant neoplasms. Ann Surg 167:820-828, 1968
12. Lipson RL, Gray MJ, Baldes EJ: Hematoporphyrin derivative for detection and management of cancer. Proc 9th International Cancer Congress Tokyo, Japan 393, 1966
13. Kelly JF, Snell ME Berenbaum MC: Photodynamic destruction of human bladder carcinoma. Br J Cancer 31:237-244, 1975
14. Dchjoherty TJ: Activated dyes as antitumor agents. J Natl Cancer Inst 51:1333-1336, 1974
15. Dougherty TJ, Grindey GE, Fiel R, et al: Photoradiation therapy. 0. Cure of animal tumors with hematoporphyrin and light. J Natl Cancer Inst 55:115-121, 1975
16. Dougherty TJ, Kaufman JE, Goldfarb A, et al: Photoradiation therapy for the treatment of malignant tumors. Cancer Res 38:2628-2635, 1978
17. Dougherty TJ: Photoradiation therapy. Urol Suppl 23:61, 1984
18. Dougherty TJ: Photosensitizers: Therapy and detection of malignant tumors. Photochem Photobiol 45:874-889, 1987
19. Gomer CJ: Preclinical examination of first and second generation photosensitizers used in photodynamic therapy. Photochem Photobiol 54:1093-1107, 1991
20. Keller SM, Taylor PD, Weese JL: In vitro killing of human malignant mesothelioma by photodynamic therapy. J Surg Res 48:337-340, 1990
21. Rjzzoni WE, Matthews K, Pass HL et al: In vitro photodynamic therapy of human lung cancer. Influence of dose rate, hematoporphyrin concentration and incubation, and cellular targets. Surg Forum 38:452-455, 1987
22. Perry RR, Matthews W, Mitchell JB, et al: Sensitivity of different human lung cancer histologies to photodynamic therapy. Cancer Res 50:4272-1276, 1990
23. Matthews EK, Cui ZJ: Photodynamic action of sulfonated aluminum phthalocyanine (SALPC) on AR4-2J cells, a carcinoma cell line of rat exocrine pancreas. Br J Cancer 61:695-701, 1990
24. Sery TW, Shields JA, Augsburoer JJ, et al: Photodynamic therapy of human ocular cancer. Ophthalmic Surg 18:413-418, 1987
25. Pope AJ, Masters W, Macrobert AJ: The photodynamic effect of a pulsed dye laser on human bladder carcinoma cells in vitro. Urol Res 18:267-270, 1990
26. Raab GH, Schneider AF, Fierman W, et al: Response of human endometrium and ovarian carcinoma cell-lines to photodynamic therapy. Arch Gynecol Obstet 248:13-20, 1990
27. Jamieson CH, McDonald WN, Levy JG: Preferential uptake of benzoporphyrin derivative by leukemic versus normal cells. Leuk Res 14:209-219, 1990
28. Rogers DW, Lanzafame RJ, Hinshaw: Effect of argon laser and Photofrin II on murine neuroblastoma cells. J Surg Res 50:266-271, 1991
29. West CM: Size-dependent resistance of human tumour spheroids to photodynamic treatment Br J Cancer 59:510-514, 1989
30. Christensen T, Moan J, Smedshammer L, et al: Influence of hemalopoiphyrin derivative (HPD) and light on the attachment of cells to the substratum. Photochem Photobiophys 10:53, 1985
31. Denstaman SC, Dillehay LE, Williams: Enhanced susceptibility of HPD-sensitized phototoxicity and correlated resistance to trypsin detachment in SV40 transformed IMR-90 cell. Photochem Photobio- phys 10:53, 1985
32. Kessel D: Sites of photosensitization by derivatives of hema- toporphyrin. Photochem Photobiol 44:489-493, 1986
33. Volden G, Christensen T, Moan J: Photodynamic membrane damage of hematoporphyrin derivative-treated NH1K 3025 cells in vitro. Photochem Photobiophys 3:105, 1981
34. Jewell SA, Bellomo G, Thor H, et al: Bleb formation in hepatocytes during drug metabolism is caused by disturbances in thiol and calcium ion homeostastis. Science 217:1257-1259, 1982
35. Borrelli MJ, Wong RSL, Dewey WC: A direct correlation between hyperthermia-induced blebbing and survival in synchronous G, CHO cells. J Cell Physiol 126:181-190, 1986
36. Dubbelman TM, Smeets M, Boeoheim JPJ: Cell models. In Photosensitization: Molecular and Medical Aspects (Moreno G, Potter RH, Tmscott TG, eds). London: NATO AST. In press
37. Sonooa M, Krishna CM, Riesz P: The role of singlet oxygen in the photochemolysis of red blood cells sensitized by phthalocyanine sulfonates. Photochem Photobiol 46:625-631, 1987
38. Hue R, Smail DB, Murant RS: Hematoporphyrin derivative-induced photosensitivity of mitochondrial succinate dehydrogenase and selected cytosolic enzymes of R3230AC mammary adenocarcinomas of rats. Cancer Res 44:1483-1488, 1984
39. Hilf R, Murant RS, Narayanan U, et al: Relationship of mitochondrial function and cellular adenosine triphosphate levels to hematoporphyrin derivative-induced pbotosensitizalion in R3230AC mammary tumors. Cancer Res 46:211-217, 1986
40. Gomer CJ: DNA damage and repair in CHO cells following hematoporphyrin photoradiation. Cancer Lett 11:161-167, 1980
41. Moan J, Waksvdc H, Christensen T: DNA single-strand breaks and sister chromatid exchanges induced by treatment with hematoporphyrin and light or by x-rays in human NHIK 3025 cells. Cancer Res 40:2915-2918, 1980
42. Mitchell JB, Russo A, Kinsella TJ, et al The use of noo-hypoxic cell sensitizers in radiobiology and radiotherapy. Int I Radiat Oncol Biol Phys 12:1513-1518, 1986
43. Russo A, DeGraff W, Kinsella TJ, et au Potentiation of chemotherapy cytotoxicity following iododeoxyuridine incorporation in Chinese hamster cells. Int J Radiat Oncol Biol Phys 12:1371-1374, 1986
44. Gomer CJ, Rucker N, Banerjee A, et al: Comparison of mutagenicity and induction of sister chromatid exchange in Chinese hamster cells exposed to hematoporphyrin derivative, ionizing radia- tion, or ultraviolet radiation. Cancer Res 43:2622-2627, 1983
45. Ben-Hur E, Fuiihara T, Suzuki F, et al: Genetic toxicology of the photosensitization of Chinese hamster cells by phthalocyanines. Photochem Photobiol 45:227-230, 1987
46. Ryter SW, Gomer CS, Ferrario A, et al: Cellular stress responses following photodynamic therapy. In Photodynamic Therapy: Basic Principles and Clinical Applications (Henderson BW, Dougherty TJ, eds). New York: Marcel Dekker, 1992, pp 55-62
47. Kessel D, Erickson C: Porphyrin photosensitization of multi-drug resistant cell types. Photochem Photobiol 55:397-399, 1992
48. Diddens H: Role of multidrug resistance in photodynamic therapy. Proceeding of Optica] Methods for Tumor Treatment Detection. Mechanisms and techniques in photodynamic therapy. Society of Photo-Optical Instrumentation Engineers 45:115-123, 1992
49. Singh G, Wilson BC, Sharkey SM, et al: Resistance to photodynamic therapy in radiation induced fibrosarcoma-1 and Chinese hamster ovary-multi-drug resistant cells in vitro. Photochem Photobiol 54:307-312, 1991
50. Luna MC, Gomer CJ: Isolation and initial characterization of mouse tumor cells resistant to porphyrin-mediated photodynamic therapy. Cancer Res 51:4243-4249, 1991
51. Mitchell JB, McPherson S, DeGraff W, et al: Oxygen depend- ence of hematoporphyrin derivative-induced photoinactivation of Chinese hamster cells. Cancer Res 45:2008-2011, 1985
52. Lee See K, Forbes U, Betts WH: Oxygen dependency of photocytotoxicity with haematoporphyrin derivative. Photochem Photo- biol 39:631-634, 1984
53. Foote CS: Mechanisms of photooxygenation. In Porphyrin Localization and Treatment of Tumors (Doiron DR, Gomer CJ, eds). New York: Alan R. Liss, 1984, p 3
54. Athar M. Elmets CA, Bickers DR, et al: A novel mechanism for the generation of superoxide anions in hematoporphyrin derivative- mediated cutaneous photosensitization. Activation of the xanthine oxidase pathway. J Clin Invest 83:1137-1143, 1989
55. Tromberq BJ, Orenstein A, Ktmel S, et al: In vivo tumor oxygen tension measurements for the evaluation of the efficiency of photodynamic therapy delivery. Photochem Photobiol 52:375-385, 1990
56. Reed MW, Muluns AP, Anderson GL, et al: The effect of photodynamic therapy on tumor oxygenation. Surgery 106:94-99, 1989
57. Patterson MS, Madsen SJ, Wilson BC: Experimental tests of the feasibility of singlet oxygen luminescence and monitoring in vivo during photodynamic therapy. J Photochem Photobiol 5:69-84, 1990
58. Matthews W, Cook J, Mitchell JB, et al: In vitro photodynamic therapy of human lung cancer Investigation of dose-rate effects. Cancer Res 49:1718-1721, 1989
59. Foster TH, Gibson SL, Gao L, et al: Analysis of photochemical oxygen consumption effects on photodynamic therapy. Proceedings of optical methods for tumor treatment and detection: Mechanisms and techniques in photodynamic therapy. SPIE 45:104-114, 1992
60. Moan J: Properties for optimal PDT sensitizers. J Photochem Photobiol 5:521-524, 1990
61. Pass HI, Evans S, Matthews WA, et al: Photodynamic therapy of oncogene-transformed cells. J Thorac Cardiovasc Surg 101:795-799, 1991
62. Tochner Z, Mitchell JB, Smith P, et al: Photodynamic therapy of ascites tumours within the peritoneal cavity. Br J Cancer 53:733-736, 1986
63. Jori G, Tomio L, Reddi E et al: Preferential delivery of liposome- incorpoialed prophyrins to neoplastic cells in tumour-bearing rats. Br J Cancer 48:307-309, 1983
64. Barel A, Jori G, Perin A, et al: Role of high-, low- and very low- density lipoproteins in the transport and tumor-delivery of hema- toporphyrin in vivo. Cancer Lett 32:145-150, 1986
65. Maziere JC, Morliere P, Santus R: The role of the low density lipoprotein receptor pathway in the delivery of lipophilic photosen- sitizers in the photodynamic therapy of tumours. J Photochem Photobiol B 8:351-360, 1991
66. Thomas JP, Gmom AW: Glucose administration augments in vivo uptake and phototoxicity of the tumor-localizing fraction of hema- toporphyrin derivative. Photochem Photobiol 49:241-247, 1989
67. Pass HI: Photodynamic therapy for lung cancer. Chest Surg Clin North Am 1:135-151, 1991
68. Bug els ki PJ, Porter CW, Dougherty TJ: Autoradiographic distribution of bematoporphyrin derivative in normal and tumor tissue of the mouse. Cancer Res 41:4606-4612, 1981
69. Bellnier DA, Ho YK, Pandey RK, et al: Distribution and elimination of Photofrin II in mice. Photochem Photobiol 50:221-228, 1989
70. Selman SH, Kretmer-Birnbaum M, Klauntg JE, et al: Blood flow in transplantable bladder tumors treated with hematoporphyrin deriva- tive and light Cancer Res 44:1924-1927, 1984
71. Star WM, Marunissen HP, van den Bero-Blok AE et al Destruction of rat mammary tumor and normal tissue microcirculation by hematoporphyrin derivative photoradiation observed in vivo in sandwich observation chambers. Cancer Res 46:2532-2540, 1986
72. Spikes JD: Chlorins as photosensitizers in biology and medicine. J Photochem Photobiol B 6:259-274, 1990
73. 6 conjugates. Proc Natl Acad Sci USA 83:8744-8788, 1986
74. Kochubeev GA, Frolov AA, Zenkevich EL et al Characteristics of complex-formation of chlorin e6 with human and bovine serum albumins. Mol Biol 22:968-975, 1988
75. Roberts WG, Smith KM, McCullough JE et al: Skin photosen- sitivity and photodestruction of several potential photodynamic sensitizers. Photochem Photobiol 49:431-438, 1989
76. Nelson JS, Roberts WG, Berns JW: In vivo studies on the utilization of mono-L-aspartyl chlorin (NPe6) for photodynamic therapy. Cancer Res 47:4681-4685, 1987
77. Nelson JS, Liaw LH, Orenstein A, et al Mechanism of tumor destruction following photodynamic therapy with hematoporphyrin derivative, chlorin, and phthalocyanine. J Natl Cancer Inst 80:1599-1605, 1988
78. Gomer CJ, Ferrario A: Tissue distribution and photosensitizing properties in mono-L-aspartyl chlorin e6 in a mouse tumor model. Cancer Res 50:3985-3990, 1990
79. Bachor R, Shea CR, Gillies R, et al Photosensitized destruction of human bladder carcinoma cells treated with chlorin e6-conjugated micropheres. Proc Natl Acad Sci U S A 15:1580-1584, 1991
80. Moroan AR, Rampersauld A, Garbo GM: New sensitizers for photodynamic therapy: Controlled synthesis of purpurins and their effect on normal tissue. J Med Chem 32:904-908, 1989
81. 3H-BPD-MA), a new potent photosensitizer, in normal and tumor-bearing mice. J Photochem Photobiol B 5:231-244, 1990
82. Kessel D: In vitro photosensitization with a benzoporphyrin derivative. Photochem Photobiol 49:579-582, 1989
83. Richter AM, Waterfield E, Jain AK, et al: Photosensitizing potency of structural analogues of benzoporphyrin derivative (BPD) in a mouse tumour model. Br J Cancer 63:87-93, 1991
84. Rosenthal I: Phthalocyanines as photodynamic sensitizers. Photochem Photobiol 53:859-870, 1991
85. Wohrle D, Iskander N, Graschew G, et al: Synthesis of positively charged phthalocyanines and their activity in the photodynamic therapy of cancer cells. Photochem Photobiol 51:351-356, 1990
86. Rosenthal I, Ben-Hur E: Phthalocyanines in photobiology. In Phthalocyanines. Principles and Applications (Lever ABP, Leznoff CC, eds). New Yoric: VCH Publishers, 1989, pp 395-425
87. Tralau CJ, Barr H, Sanderman R, et al: Aluminum sulfonated phthalocyanine distribution in rodent tumors of the colon, brain and pancreas. Photochem Photobiol 46:777-781, 1987
88. Reddi E, Lo Castro GL, Biolo R, et al: Pharmacokinetic studies with zinc HFphthalocyanine in tumor bearing mice. Br J Cancer 56:597-600, 1987
89. van Bruooen N, Chan WS, Syha J, et al: Cell and tissue responses of a murine tumour to phthalocyanine-mediated photodynamic therapy. Eur J Cancer 28:42-46, 1992
90. Brass eur N, Au H, Langlois R, et al: Biological activities of phthalocyanines-EX. Photosensitization of V-79 Chinese hamster cells and EMT-6 mouse mammary tumor by selectively sulfonated zinc phthalocyanines. Photochem Photobiol 47:705-711, 1988
91. Canti G, Franco P, Marelli O, et al: Comparative study of the therapeutic effect of photoactivated hematoporphyrin derivative and aluminum disulfonated phthalocyanines on tumor bearing mice. Cancer Lett 53:123-127, 1990
92. Bachor R, Flotte TJ, Scholz M, et al: Comparison of intravenous and intravesical administration of chloro-aluminum sulfonated phthalo- cyanine for photodynamic therapy in a rat bladder cancer model. J Urol 147:1404-1410, 1992
93. Anholt H, Moan J: Fractionated treatment of CaD2 tumors in mice sensitized with aluminum phthalocyanine tetrasulfonate. Cancer Lett 61:263-267, 1992
94. Modica-Napoutano JS, Aprille: Basis for the selective cytotoxicity of rhodamine 123. Cancer Res 47:4361-4365, 1987
95. Oseroff AR: Cationic sensitizers, combination therapies, and new methodologies. In Photodynamic Therapy (Henderson BW, Dougherty TJ, eds). New York: Marcel Dekker, 1992, pp 79-91
96. Kreimer-Birnbaum M: Modified porphyrins, chlorins, phthalo- cyanines, and purpurins: Second-generation photosensitizers for pho- todynamic therapy. Semin Hematol 26:157-173, 1989
97. 4 and its relation to photodynamic therapy. Photochem Photobiol 46:801-807, 1987
98. Evensen JF: Distribution of tetraphenylporphyrine sulphonate in mice bearing Lewis lung carcinoma. In Photodynamic Therapy of Tumors and Other Diseases (Jori G, Perria C, eds). Padova: Libreria Progetto, 1985, pp 215-218
99. Kessel D, Thompson P, Saatio K, et al: Tumor localization and photosensitization by sulfonated derivatives of tetraphenylporphine. Photochem Photobiol 45:787-790, 1987
100. Nelson JS, Liaw LH, Lahlum RA, et al: Use of multiple photo- sensitizers and wavelengths during photodynamic therapy: A new approach to enhance tumor eradication. J Natl Cancer Inst 82:868-873, 1990
101. Reed MW, Schuschke DM, Ackermann JI, et al: The response of rat urinary bladder microcirculation to photodynamic therapy. J Urology 142:865-868, 1989
102. Wieman TJ, Mano TS, Finoar VS, et al: Effect of photodynamic therapy on blood flow in normal and tumor vessels. Surgery 104:512-517, 1988
103. Stern SJ, Flock S, Small S, et al: Chloraluminum sulphonated phthalocyanine versus dihematoporphyrin ether: Early vascular events in the rat window chamber. Laryngoscope 101:1219-1225, 1991
104. Ben-Hur E, Orenstein A: The endothelium and red blood cells as potential targets in PDT-induced vascular stasis. Int J Radial Biol 60:293-301, 1991
105. Finoar VH, Wieman TJ, Doak KW: Role of thromboxane and prostacycline release on photodynamic therapy-induced tumor destruc- tion. Cancer Res 50:2599-2603, 1990
106. Bellnier DA, Henderson BW: Determinants for photodynamic tissue destruction. In Photodynamic Therapy (Henderson BW, Dougherty TJ, eds). New York: Marcel Dekker, 1992, pp 117-127
107. Dodd NJ, Moore JV, Poppitt DG, et al: In vivo magnetic resonance imaging of the effects of photodynamic therapy. Br J Cancer 60:164-167, 1989
108. Moore JV, Dodd NJ, Wood B: Proton nuclear magnetic resonance imaging as a predictor of the outcome of photodynamic therapy of tumors. Br J Radiol 62:869-870, 1989
109. Mattiello J, Evelhoch JL, Brown E, et al: Effect of photodynamic therapy on RIF-1 tumor metabolism and blood flow examined by 31P and 2H NMR spectroscopy. NMR Biomed 3:64-70, 1990
110. Chopp M, Hetzel FW, Jiang Q: Dose-dependent metabolic response of mammary carcinoma to photodynamic therapy. Radiat Res 121:288- 294, 1990
111. Ceckler TL, Gibson SL, Hilf R, et al: In situ assessment of tumor vascularity using fluorine NMR imaging. Magn Reson Med 13:416-433, 1990
112. Elmets CA, Bowen KD: Immunological suppression in mice treated with hematoporphyrin derivative photoradiation. Cancer Res 46:1608-1611, 1986
113. Lynch DH, Haddad S, Kino VJ, et al: Systemic immunosuppression induced by photodynamic therapy (PDT) is adoptively transferred by macrophages. Photochem Photobiol 49:453-458, 1989
114. Ferrario A, Comer CT: Systemic toxicity in mice induced by localized porphyrin photodynamic therapy. Cancer Res 50:539-543, 1990
115. Ortner MJ, Abhold RH, Chignell CF: The effect of protoporphyrin on histamine secretion by rat peritoneal mast cells. A dual phototoxic reaction. Photochem Photobiol 33:355-360, 1981
116. Henderson BW, Donovan JM: Cellular prostaglandin E release after photodynamic therapy. Lasers Med Sci 3:103, 1988
117. Evans S, Matthews W, Perry R, et al: Effect of photodynamic therapy on tumor necrosis factor production by murine macrophages. J Natl Cancer Inst 82:34-39, 1990
118. Bellnier DA: Potentiation of photodynamic therapy in mice with recombinant human tumor necrosis factor-alpha. J Photochem Photobiol B 8:203-210, 1991
119. Kol R, Ben-Hur E, Marko R, et al: Inhibition of human lymphocyte stimulation by visible light and phthalocyanine photo- sensitization: Mitogen and wavelength dependency. Int J Radiat Biol 55:1015-1022, 1989
120. Krutmann J, Athar D, Mendel DB, et al: Inhibition of the high affinity Fc receptor (FcgammaRI) on human monocytes by porphyrin photosensitization is highly specific and mediated by generation of superoxide radicals. J Biol Chem 264:11407-11413, 1989
121. Shumaker BP, Hetzel FW: Clinical laser photodynamic therapy in the treatment of bladder carcinoma. Photochem Photobiol 46:899-901, 1987
122. Nseyo UO, Whalen RK, Duncan MR, et al: Urinary cytokines following photodynamic therapy for bladder cancer. A preliminary report. Urology 36:167-171, 1990
123. Heald PW, Perez MI, McKiernan G, et al: Extracorporeal photochemotherapy for CTCL. Prog Clin Biol Res 337:443-447, 1990
124. Jiang FN, Liu DJ, Neyndorff H, et al: Photodynamic killing of human squamous cell carcinoma cells using a monoclonal antibody- photosensitizer conjugate. J Natl Cancer Inst 83:1218-1225, 1991
125. Pogrebniak H, Matthews W, Black C, et al: Targeted phototherapy with sensitizer-monoclonal antibody and light. Surg Forum XLII:447-449, 1991
126. Rakestraw SL, Tompkins RG, Yarmusk MC: Antibody-targeted photolysis: In vitro studies with Sn(TV) chlorin e6 covalently bound to monoclonal antibody using a modified dextran carrier. Proc Natl Acad Sci U S A 87:4217-4221, 1990
127. Goff BA, Bamberg M, Hasan T: Pbotoimmunotherapy of human ovarian carcinoma cells ex vivo. Cancer Res 51:4762-4767, 1991
128. Moroan J, MacRobert AJ, Gray AG, et al: Use of photosensitive antibody directed liposomes to destroy target populations of cells in bone marrow. Br J Cancer 1:58-64, 1992
129. Dougherty TJ: Photosensitization of malignant tumors. Semin Surg Oncol 2:24-27, 1986
130. McCaughan JS, Guy JT, Hicks W, et al: Photodynamic therapy for cutaneous and subcutaneous malignant neoplasms. Arch Surg 124:211-216, 1989
131. Bandieramonte C, Marches ini R, Melloni E, et al: Laser phototherapy following HpD administration in superficial neoplastic lesions. Tumori 70:327-334, 1984
132. Santoro O, Bandieramonte G, Melloni E, et al: Photodynamic therapy by topical meso-tetraphenylporphinesulfoDate tetrasodium salt administration in superficial basal cell carcinomas. Cancer Res 50:4501-4503, 1990
133. Wat now SM, Lobraico RV, Kohler IK, ET al: Photodynamic therapy for treatment of malignant cutaneous lesions. Lasers Surg Med 7:451-456, 1987
134. Kennedy J: Photoradiation therapy for cancer at Kingston and Hamilton. In Porphyrin Photosensitization (Kessel D, Dougherty TJ, eds). New York: Plenum Press, 1983, p 53
135. Pennington DG, Waner M, Knox A: Photodynamic therapy for multiple skin cancers. Plast Reconst Surg 82:1067-1071, 1987
136. Wilson BW, Mang TS, Cooper MC, et al: Use of photodynamic therapy for the treatment of extensive basal cell carcinomas. Facial Plastic Surg 6:185-189, 1990
137. Tse DT, Kersten RC, Anderson RL: Hematoporphyrin derivative photoradiation therapy in managing nevoid basal-cell carcinoma syndrome: A preliminary report. Arch Opthalmol 102:990-994, 1984
138. Kennedy JC, Potter RH, Pross DC: Photodynamic therapy with endogenous protoporphyrin DC: Basic principles and present clinical experience. J Photochem Photobiol B 6:143-148, 1990
139. Aberizk WJ, Sever B, Henderson IC, et al: The use of radio- therapy for treatment of isolated locoregional recurrence of breast carcinoma after mastectomy. Cancer 58:1214-1218, 1986
140. Schuh M, Nseyo UO, Potter WR, et al: Photodynamic therapy for palliation of locally recurrent breast carcinoma. J Clin Oncol 5:1766-1770, 1987
141. Sperduto PW, Delaney TF, Thomas G, et al: Photodynamic therapy for chest wall recurrence in breast cancer. Int J Radial Oncol Biol Phys 21:441, 1991
142. Gluckman JL, Waner M, Shumrick K, et al: Photodynamic therapy. A viable alternative to conventional therapy for early lesions of the upper aerodigestive tract? Arch Otolaryngol Head Neck Surg 112:949-952, 1986
143. Gluckman JL: Hematoporphyrin photodynamic therapy: Is there truly a future in head and neck oncology? Reflections on a 5-year experience. Laryngoscope 191:36-42, 1991
144. Wee AG, Novotny J, Mason GR, et al: Photoradiation therapy of head and neck cancer. Am J Clin Oncol 6:39-43, 1984
145. Schuller DE, McCaughan JS, Rock RP: Photodynamic therapy in head and neck cancer. Arch Otolargyngol 111:351-355, 1985
146. Takata C, Imakitre M: Cancer of the ear, nose, and throat. In Lasers and Hematoporphyrin Derivative in Cancer (Hayata Y, Dougherty TJ, eds). New York: Igaku-Shoin, 1983, p 70
147. Grossweiner LI, Hel JH, Lobraico RV: Photodynamic therapy of head and neck squamous cell carcinoma: Optical dosimetry and clinical trial. Photochem Photobiol 46:911-917, 1987
148. Shikow MJ, Steinberg BM, Abramson AL: Hematoporphyrin derivative therapy of papillomas: Experimental study. Arch Otolaryngol Head Neck Surg 112:42-46, 1986
149. Abramson AL, Shtkowitz MJ, Mullooley VM, et al: Clinical effects of photodynamic therapy on recurrent laryngeal papillomas. Arch Otolaryngol Head Neck Surg 118:25-29, 1992
150. Basheda SG, Mehta AC, De Boer G, et al: Endobronchial and parenchymal juvenile laryngotracheobronchial papillomatosis. Effects of photodynamic therapy. Chest 100:1458-1461, 1991
151. Perria C, Carai M, Falzoi A, et al: Photodynamic therapy of malignant brain tumors: Clinical results of, difficulties with, questions about, and future prospects for the neurosurgical applications. Neurosurgery 23:557-563, 1988
152. Laws ER, Cortese DA, Kinsey JH, et al: Photoradiation therapy in the treatment of malignant brain tumors: A phase I (feasibility) study. Neurosurgery 9:672-678, 1981
153. Laws ER, Wharen RE, Anderson RE: Photoradiation therapy of malignant gliomas. Neurosurgical Update 260, 1990
154. McCulloch GAJ, Forbes U, See KL, et al: Phototherapy in malignant brain tumors. In Porphyrin Localization and Treatment of Tumors (Doiron DR, Gomer CJ, eds). New York: Alan R. Liss, 1984, p 709
155. Kostron H, Weiser G, Fritsch E, et al: Photodynamic therapy of malignant brain tumors: Clinical and neuropathological results. Photochem Photobiol 46:937-943, 1987
156. Kaye AH, Morstyn G, Brownbill D: Adjuvant high-dose photoradiation therapy in the treatment of cerebral glioma: A phase 1-2 study. J Neurosurg 67:500-505, 1987
157. Muller PJ, Wilson BC: Photodynamic therapy of malignant primary brain tumors: Clinical effects, post-operative ICP, and light penetration of the brain. Photochem Photobiol 46:929-935, 1987
158. Powers SK, Cush SS, Walstad DL, et al: Stereotactic intratumoral photodynamic therapy for recurrent malignant brain tumors. Neurosurg- ery 29:688-695, 1991
159. Pass HI, Pogrebniak HW: Photodynamic therapy for thoracic malignancies. Semin Surg Oncol 8:217-225, 1992
160. Pass HI, Delaney T, Smith PD, et al: Bronchoscopic phototherapy at comparable dose rates: Early results. Ann Thorac Surg 47:693-699, 1989
161. Kato H: Lung cancer. In Lasers and Hematoporphyrin Derivative in Cancer (Hayata Y, Dougherty TJ, eds). Tokyo: Kgaka-Shoin, 1983 p 39
162. Kato H, Aizawa K, Ono J, et al: Clinical measurement of tumor fluorescence using a new diagnostic system with hematoporphyrin derivative, laser photoradiation, and a spectroscope. Lasers Surg Med 4:49-58, 1984
163. Edell ES, Cortese DA: Detection and phototherapy of lung cancer. In Phototherapy of Cancer (Morstyn G, Kaye A, eds). London: Harwood, 1990, p 185
164. Doiron DR, Balchum OJ: Hematoporphyrin derivative photoradiation therapy of endobronchial lung cancer. In Porphyrin in Tumor Phototherapy (Andreoni A, Bucedda R, eds). New York: Plenum Press, 1984, p 195
165. Balchum OJ, Doiron DR, Hunt GC: Photodynamic therapy of obstructing lung cancer. In Porphyrin Localization and Treatment of Tumors (Doiron DR, Gomer CJ, eds). New York: Alan R. Liss, 1984, p 721
166. Balchum OJ: Photodynamic therapy of endobronchial lung tumors. Clayton Foundation Conference 1987 (Abstract)
167. Vincent RG, Douoherty TJ, Rao U: Photoradiation therapy in the treatment of advanced carcinoma of the trachea and bronchus. In Porphyrin Localization and Treatment of Tumors Doiron DR, Gomer CJ, New York: Alan R. Liss, 1984, p 759.
168. Forbes U, Ward AD, Jacka FJ, et al: Multidisciplinary approach to phototherapy in tumors. In Porphyrin Localization and Treatment of Tumors (Doiron DR, Gomer CJ, eds). New York: Alan R. Liss, 1984, p 693
169. Lam S, Kostashuk EC, Coy P, et al: A randomized comparative study of the safety and efficacy of photodynamic therapy using Photofrin II combined with palliative radiotherapy alone in patients with inoperable non-small cell bronchogenic carcinoma. Photochem Photobiol 5:893-897, 1987
170. Huoh-Jones P, Gardner WN: Laser photodynamic therapy for inoperable bronchogenic squamous carcinoma. J Med 243:565-581, 1987
171. Li JH, Zhao HZ: Photodynamic therapy of bronchogenic carcinoma. Proc of the Third Biennia] Meeting of the International Photodynamic Asso Vm/5:10, 1990 (Abstract)
172. Benov E, Kostadinov D, Vlasov V: Photoradiation therapy of bronchial cancer. Proc of the Third Biennial Meeting of the International Photodynamic Assoc XXTT1/3:31, 1990 (Abstract)
173. Lam S, Palcic B, McLean D, et al: Detection of early lung cancer using low dose Photofrin n. Chest 97:333-337, 1990
174. Hayata Y, Kato H, Konaka C, et au Photoradiation therapy with hematoporphrin derivative in early and stage 1 lung cancer. Chest 86:169-177, 1984
175. Nelson JS, Fairshter RD, Berns MW: Long-term survival of a lung cancer patient treated with photodynamic therapy. Lasers Surg Med 10:208-210, 1990
176. Kato H, Konaka C, Kawate N, et al: Five-year disease-free survival of a lung cancer patient treated only by photodynamic therapy. Chest 90:768-770, 1986
177. Pass HI, DeLaney T, Russo A, et al: Feasibility of intrapleural photodynamic therapy: The first eight patients. Proceedings of optical methods for tumor treatment and detection: Mechanisms and techniques in photodynamic therapy. Society of Photo-Optical Instrumentation Engineers 1645:1-9, 1992
178. Pass HI, Tochner Z, DeLaney T, et al: Intraoperative pho- todynamic therapy for malignant mesothelioma. Ann Thorac Surg 50:687-688, 1990
179. Lofgren L, Larsson M, Thaning L, et al: Transthoracic endoscopic photodynamic treatment of malignant mesothelioma. Lancet 337:359, 1991
180. Ris HB, Altermatt HJ, Inderbitzer R, et al: Photodynamic therapy with chlorins for diffuse malignant mesothelioma: Initial clinical results. Br J Cancer 64:1116-1120, 1991
181. Bruce RA, McCaughan JS: Lasers in uveal melanoma. Ophtham Clin N Am 2:597, 1989
182. Tse DT, Dutton JJ, Weingeist TA, et al: Hematoporphyrin photoradiation therapy for intraocular and orbital malignant melanoma. Arch Opthalmol 102:833-838, 1984
183. Murfhree AL, Cote M, Gomer CJ: The evolution of photodynamic therapy techniques in the treatment of intraocular tumors. Photochem Photobiol 46:919-923, 1987
184. McCaughan JS, Nims TA, Guy JT, et al: Photodynamic therapy for esophageal tumors. Arch Surg 124:74-80, 1989
185. Thomas RJ, Abbott M, Bhathal PS, et al: High-dose photoradia- tion of esophageal cancer. Ann Surg 206:193-199, 1987
186. Aida M, Hirashtma T: Cancer of the esophagus. In Lasers and Hematoporphyrin Derivative in Cancer (Hayata Y, Dougherty TJ, eds). New York: Igaktt-Shoin, 1983, p 57
187. Hayata Y, Kato H, Okitsu H, et al: Photodynamic therapy with htmatoporphyriri derivative in cancer of the upper gastrointestinal tract Semin Surg Oncol 1:1-11, 1985
188. Okuda S, Mimura S, Otani T, et al: Experimental and clinica] studies on HpD-pbotoradiation therapy for upper gastrointestinal cancer. In Porphyrins in Tumor Phototherapy (Andreoni A, Cubeddu Ft, eds). New York: Plenum Press, 1984, p 413
189. Barr H, Tralau CJ, Lewtn M. et al: Selective destruction of experimental colon cancer using photodynamic therapy. Br 1 Surg 75:611, 1988
190. Barr H, Tralau CJ, MacRobert AJ, et al: Photodynamic therapy in the normal rat colon with phthalocyanine sensitisation. Br J Cancer 56:111-118, 1987
191. Barr H, Krasner N, Bgulos PB, et al: Photodynamic therapy for colorectal cancer: A quantitative pilot study. Br 1 Surg 77:93-96, 1990
192. Patrice T, Foultter MT, Yactayo S, et al: Endoscopic photodynamic therapy with hematoporphyrin derivative in gastroen- terology. J Photochem Photobiol B 6:157-165, 1990
193. Shulok, Klaunig JE, Selman SH, et al: Cellular effects of hematoporphyrin derivative photodynamic therapy on normal and neoplastic rat bladder cells. Am J Pathol 122:277-283, 1986
194. Iocham D, Staehler G, Chaussy C, et al: Laser treatment of bladder tumors following photosensitization with hematoporphyrin derivative. First experimental experiences. Urologe 20:340-343, 1981
195. Tsuchiya A, Obara N, Mtwa M, et al: Hematoporphyrin derivative and laser photoradiation in the diagnosis and treatment of bladder cancer. J Urol 130:79-82, 1983
196. Hisazumi H, Misam T, Miyoshi N: Photoradiation therapy of bladder tumors. J Urol 130:685-687, 1983
197. Benson RC, Farrow GM, Kinsey JH, et al; Detection and localization of in situ carcinoma of the bladder with hematoporphyrin derivative. Mayo Clin Proc 57:548-555, 1982
198. Benson RC: Laser photodynamic therapy for bladder cancer. Mayo Clin Proc 61:859-864, 1986
199. Prout GR, Lin CW, Benson R, et al: Photodynamic therapy with hematoporphyrin derivative in the treatment of superficial transitional-cell carcinoma of the bladder. N Engl I Med 317:1251- 1255, 1987
200. Benson RC: Treatment of diffuse transitional cell carcinoma in situ by whole bladder hematoporphyrin derivative photodynamic therapy. J Urol 134:675-678, 1985
201. FJisazumi H, Miyoshi N, Naito K, et al: Whole bladder wall photoradiation therapy for carcinoma in situ of the bladder: A preliminary report. J Urol 131:884—887, 1984
202. Nseyo UO, Dougherty TJ, Boyle DG, et al: Study of factors mediating effect of photodynamic therapy of bladder in canine bladder model. Urology 32:41-45, 1988
203. Star WM, Marunissen HPA, Iansen H, et al: Light dosimetry for photodynamic therapy by whole bladder wall irradiation. Photochem Photobiol 46:619-624, 1987
204. Duoan M, Crawford E, Nsetyo U, et al: A randomized trial of observation (obs) vs photodynamic therapy after transurethral resection (TUR) of superficial papillary bladder carcinoma (abstract). Proc ASCO 10:173, 1991
205. Soma H, Akiya K, Nutahara S, et al: Treatment of vaginal carcinoma with laser photoirradiation following administration of haematoporphyrin derivative. Report of a case. Ann Chir Gynaecol 71:133-136, 1982
206. Dahlman A, Wile AG, Burns RG, et al: Laser photoradiation therapy of cancer. Cancer Res 43:430-434, 1983
207. Rettenmaier MA, Berman ML, Disaia PI, et al: Gynecologic uses of photoradiation therapy. In Porphyrin Localization and Treatment of Tumors (Doiron DT, Goroer CJ, eds). New York: Alan R. Liss, 1984, p 767
208. McCauohan JS, Schellhas HF, Lomano J, et al: Photodynamic therapy of gynecologic neoplasms after presensitization with hema- topoiphyrin derivative. Lasers Surg Med 5:491-498, 1985
209. Corti L, Tomio L, Maluta S, et al: Photodynamic therapy in gynecological cancer Lasers Med Sci 4:155, 1989
210. Ljele SB, Piver MS, Mano TS, et al: Photodynamic therapy in gynecologic malignancies. Gynecol Oncol 34:350-352, 1989
211. Lobraico RV, Waldow SM, Harris DM, et al: Photodynamic therapy for cancer of the lower female genital tract. Colposc Gynecol Laser Surg 2:185-199, 1986
212. DeLaney TF, Sindelar W, Smith P, et al: Initial experience with photodynamic therapy for intraperitonea] carcinomatosis. In Ovarian Cancer Biological and Therapeutic Challenges (Sharp F, Mason WP, Leake RE, eds). London: Chapman & Hall, 1990, p 371
213. Sindelar WF, DeLaney TF, Tochner Z, et al: Technique of photodynamic therapy for disseminated intraperitoneal malignancies: Phase I study. Arch Surg 126:318-324, 1991
214. DeLaney TF, Sindelar WG, Tochner Z, et al: Phase 1 study of debutking surgery and photodynamic therapy for disseminated intra- peritoneal tumors (abstract). Int J Radiat Oncol Biol Phys 21:183, 1991