A comparison of esterified estrogens with and without methyltestosterone: Effects on endometrial histology and serum lipoproteins in postmenopausal women

Obstetrics and Gynecology

Volumn 82, Issue 6, 1993, Pages 919-924

  Hickok, Lee R ^a   Toomey, Chris ^a   Speroff, Leon ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; ESTRATEST; ESTROGEN; HIGH DENSITY LIPOPROTEIN; METHYLTESTOSTERONE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; DRUG THERAPY; ENDOMETRIUM; FEMALE; HUMAN; LIPOPROTEIN METABOLISM; POSTMENOPAUSE; PRIORITY JOURNAL;

ADULT; CHOLESTEROL; COMPARATIVE STUDY; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; ENDOMETRIUM; ESTROGEN REPLACEMENT THERAPY; ESTROGENS; FEMALE; HUMAN; LIPOPROTEINS; METHYLTESTOSTERONE; MIDDLE AGE; POSTMENOPAUSE; SUPPORT, NON-U.S. GOV'T;

EID: 0027441814     PISSN: 00297844     EISSN: 1873233X     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Hickok LR, Speroff L. Estrogen replacement therapy. In: Rayburn WF, Zuspan FP, eds. Drug therapy in obstetrics and gynecology. 3rd ed. St. Louis: CV Mosby, 1992;526-41.
2. Burger HG, Hailes J, Menelaus M, Nelson J, Hudson B, Balazs N. The management of persistent menopausal symptoms with oestradiol-testosterone implants: Clinical, lipid and hormonal results. Maturitas 1984;6:351-8.
3. Sherwin B, Gelfand M. Differential symptom response to parenteral estrogen and/or androgen administration in the surgical menopause. Am J Obstet Gynecol 1985;151:153-60.
4. Burger HG, Hailes J, Nelson J. Effect of combined implants of oestradiol and testosterone on libido in postmenopausal women. Br Med J 1987;294:936-7.
5. Studd JWW. Oestradiol and testosterone implants in the treatment of psychosexual problems in postmenopausal women. Br J Obstet Gynaecol 1977;84:314-5.
6. Sherwin BB, Gelfand MM. The role of androgen in the maintenance of sexual function in oophorectomized women. Psychosom Med 1987;49:397-409.
7. Urman B, Pride SM, Yuen HB. Elevated serum testosterone, hirsutism and virilism associated with combined androgen-estrogen hormone replacement therapy. Obstet Gynecol 1991;77: 595-8.
8. Stampfer MJ, Colditz GA, Willett WC, et al. Postmenopausal estrogen therapy and cardiovascular disease: Ten year follow-up from the nurses’ health study. N Engl J Med 1991;325:756-62.
9. Sherwin BB, Gelfand MM, Schucher R, Gabor J. Postmenopausal estrogen and androgen replacement and lipoprotein lipid concentrations. Am J Obstet Gynecol 1987;156:414-9.
10. Westaby D, Ogle SJ, Paradinas JF. Liver damage from long term methyltestosterone. Lancet 1977;2:262-3.
11. Campbell S, Whitehead M. Oestrogen therapy and the menopausal syndrome. Clin Obstet Gynecol 1977;4:31-47.
12. Detkoff EC, Crary WG, Cristo M, Lobo RA. Estrogen improves psychological function in asymptomatic postmenopausal women. Obstet Gynecol 1991;78:991-5.
13. Gelfand MM, Ferenczy A, Bergeron C. Endometrial response to estrogen-androgen stimulation. In: Hammond CB, Haseltine FB, Seniff I, eds. Menopause evaluation, treatment, and health concerns. New York: Alan R. Liss, Inc, 1989;29-40.
14. Sherwin BB. A comparative analysis of the role of androgen in human male and female sexual behavior: Behavioral specificity, critical thresholds, and sensitivity. Psychobiology 1988;16:416-25.
15. Lemer DJ, Kannel WB. Patterns of coronary heart disease morbidity and mortality in the sexes: A 26-year follow-up of the Framingham population. Am Heart J 1988;111:383-90.
16. Sullivan JM, Vander Zwaag R, Hughes JP, et al. Estrogen replacement and coronary artery disease: Effect on survival in postmenopausal women. Arch Intern Med 1990;150:2557-62.
17. Wolf PH, Madans JH, Finucane FF, Higgins M, Kleinman JC. Reduction of cardiovascular disease-related mortality among postmenopausal women who use hormones: Evidence from a national cohort. Am J Obstet Gynecol 1991;164:489-94.
18. Walsh BW, Schiff I, Rosner B, Greenberg L, Ravnikar V, Saccks FM. Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins. N Engl J Med 1991;325:1196-204.
19. Wagner JD, Clarkson TB, St. Clair RW, Schwenke DC, Shively CA, Adams MR. Estrogen and progesterone replacement therapy reduces low-density lipoprotein accumulation in the coronary arteries of surgically postmenopausal cynomolgus monkeys. J Clin Invest 1991;88:1995-2002.