Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca2+-activated neurotransmitter release

Cell

Volumn 74, Issue 6, 1993, Pages 1125-1134

  Littleton, J Troy ^a   Stern, Michael ^a   Schulze, Karen ^a   Perin, Mark ^a   Bellen, Hugo J ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b RICE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM BINDING PROTEIN; CALCIUM ION; NEUROTRANSMITTER; SYNAPTOTAGMIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; DROSOPHILA MELANOGASTER; EMBRYO; EXCITATORY JUNCTION POTENTIAL; GENE INSERTION; GENE LOCUS; GENE MUTATION; GENE STRUCTURE; GENETIC ANALYSIS; MUSCLE CONTRACTION; NEUROTRANSMITTER RELEASE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SOUTHERN BLOTTING; SYNAPSE VESICLE;

ALLELES; ANIMAL; CALCIUM; DNA MUTATIONAL ANALYSIS; DNA, COMPLEMENTARY; DROSOPHILA; EMBRYO, NONMAMMALIAN; ETHYL METHANESULFONATE; EVOKED POTENTIALS; HETEROZYGOTE; HOMOZYGOTE; LARVA; MEMBRANE GLYCOPROTEINS; MUTAGENESIS; NERVE TISSUE PROTEINS; NEUROMUSCULAR JUNCTION; NEUROTRANSMITTERS; PHENOTYPE; RESTRICTION MAPPING; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

ANIMALIA; DROSOPHILA MELANOGASTER; MELANOGASTER;

EID: 0027438591     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(93)90733-7     Document Type: Article

References (52)

1. ++ action in synaptic transmitter release
2. P-element-mediated enhancer detection: a versatile method to study development in Drosophila
3. The Drosophila couch potato protein is expressed in neural precursors and encodes nuclear proteins that contain RNA binding domains
4. Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones
5. Searching for pattern and mutation in the Drosophila genome with a P-lacZ vector
6. Inhibition of neurotransmitter release by C2-domain peptides implicates synaptotagmin in exocytosis
7. Development of the embryonic neuromuscular synapse of Drosophila melanogaster
8. ++ sensor on the synaptic vesicle surface
9. Vesicle hypothesis of release of quanta of acetylcholine
10. 2+ channels on frog motor terminals revealed by fluorescent ω-conotoxin
11. Distributions of EPSP latency at different group la-fiber α-motoneuron connections
12. Biophysical aspects of neuromuscular transmission
13. Synaptic transmission persists in synaptotagmin mutants of Drosophila
14. ++ ions in transmitter release at the neuromuscular junction
15. A role for synaptotagmin (p65) in regulated exocytosis
16. Drosophila mutants with opposing effects on nerve excitability: genetic and spatial interactions in repetitive firing
17. Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release
18. Properties of the larval neuromuscular junction in Drosophila melanogaster
19. Genetic dissection of short-term and long-term facilitation at the Drosophila neuromuscular junction
20. “Site-selected” transposon mutagenesis of Drosophila
21. The release of acetylcholine from nerve endings by graded electrical pulses
22. ++ channels and is a putative Lambert-Eaton myasthenic syndrome antigen
23. Mutagenesis with ethyl methanesulfonate
24. Tetanus toxin action: inhibition of neurotransmitter release linked to synaptobrevin proteolysis
25. Expression of synaptotagmin in Drosophila reveals transport and localization of synaptic vesicles to the synapse
26. ++ currents in squid giant synapse
27. ++ concentration in a presynaptic terminal
28. Differential effect of α-latrotoxin on exocytosis from small synaptic vesicles and from large dense-core vesicles containing calcitonin gene-related peptide at the frog neuromuscular junction
29. ++ ions into nerve terminals
30. ++ to evoke transmitter release
31. The family of protein kinase C for signal transduction
32. Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin
33. Phospholipid binding by a synaptic vesicle protein homologous to the regulatory domain of protein kinase C
34. Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans
35. Domain structure of synaptotagmin (p65)
36. Binding of synaptotagmin to the α-latrotoxin receptor implicates both in synaptic vesicle exocytosis
37. Synaptotagmin: a calcium-sensitive inhibitor of exocytosis?
38. Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin
39. Neurotransmitter release from synaptotagmin-deficient clonal variants of PC12 cells
40. Compartmentalization of the submembrane calcium activity during calcium influx and its significance in neurotransmitter release
41. ++ ions, active zones and synaptic transmitter release
42. SNAP receptors implicated in vesicle targeting and fusion
43. Decapentaplegic: a gene complex affecting morphogenesis in Drosophila melanogaster
44. Altered synaptic transmission in Drosophila hyperkinetic mutants
45. Proteins of synaptic vesicles involved in exocytosis and membrane recycling
46. A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback
47. Preferential transposition of Drosophila P-elements to nearby chromosomal sites
48. Neurexins: synaptic cell surface proteins related to the α-latrotoxin receptor and laminin
49. Synaptic vesicle proteins in exocytosis: what do we know?
50. SNAP family of NSF attachment proteins includes a brain-specific isoform