An interleukin 4 (ii,-4) mutant protein inhibits both il-4 or ii.-13-induced human immunoglobulin g4 (igg4) and ige synthesis and b cell proliferation: Support for a common component shared by ii,-4 and il-13 receptors

Journal of Experimental Medicine

Volumn 178, Issue 6, 1993, Pages 2213-2218

  Aversa, Gregorio ^a   Punnonen, Juha ^a   Cocks, Benjamin G ^a   Malefyt, René De Waal ^a   Vega, Felix ^b   Zurawski, Sandra M ^b   Zurawski, Gerard ^b   Vries, Jan E De ^a  

^a Schering Plough Biopharma   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN E; IMMUNOGLOBULIN G4; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN RECEPTOR; LYMPHOCYTE MEMBRANE IMMUNOGLOBULIN; MUTANT PROTEIN; RECOMBINANT INTERLEUKIN 4;

AGONIST; ALLERGY; AMINO ACID SUBSTITUTION; ARTICLE; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; DRUG ANTAGONISM; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; LYMPHOCYTE PROLIFERATION; MONONUCLEAR CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANTIGENS, CD; ANTIGENS, CD40; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; B-LYMPHOCYTES; HUMAN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INTERLEUKIN-13; INTERLEUKIN-4; INTERLEUKINS; LYMPHOCYTE ACTIVATION; MUTAGENESIS, SITE-DIRECTED; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-4; RECEPTORS, MITOGEN; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T;

EID: 0027435159     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.178.6.2213     Document Type: Article

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