Plant Antitumor Agents. 30. Synthesis and Structure Activity of Novel Camptothecin Analogs

Journal of Medicinal Chemistry

Volumn 36, Issue 18, 1993, Pages 2689-2700

  Wall, Monroe E ^a   Wani, Mansukh C ^a   Nicholas, Allan W ^a   Manikumar, Govindarajan ^a   Tele, Chhagan ^a   Moore, Linda ^b   Truesdale, Anne ^b   Leitner, Peter ^b   Besterman, Jeffrey M ^b  

^a RTI INTERNATIONAL   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN DERIVATIVE; DNA TOPOISOMERASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; INTRAVENOUS DRUG ADMINISTRATION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMAL; ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; COMPARATIVE STUDY; DNA TOPOISOMERASES, TYPE I; FEMALE; HUMAN; LEUKEMIA L1210; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED DBA; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PLANTS, MEDICINAL; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

EID: 0027435043     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00070a013     Document Type: Article

References (50)

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