1 Cellular insulin action and insulin resistance

Bailliere's Clinical Endocrinology and Metabolism

Volumn 7, Issue 4, 1993, Pages 785-873

  Timothy Garvey, W ^a   Birnbaum, Morris J ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; GLUCOSE; GLYCOGEN SYNTHASE; INSULIN; INSULIN RECEPTOR; PROTEIN KINASE C; PROTEIN P21; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; PYRUVATE DEHYDROGENASE; SODIUM ION;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CALCIUM CELL LEVEL; CELL SURFACE; GENE REPRESSION; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; GLUCOSE TRANSPORT; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERTENSION; INSULIN METABOLISM; INSULIN RESISTANCE; MUSCLE TISSUE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PREGNANCY DIABETES MELLITUS; PROTEIN CONTENT; PROTEIN STRUCTURE; PROTEIN TARGETING; PROTEIN TRANSPORT; RAT; REVIEW; RNA ANALYSIS; SIGNAL TRANSDUCTION; SODIUM CELL LEVEL;

ADIPOSE TISSUE; ANIMAL; BIOLOGICAL TRANSPORT; DIABETES MELLITUS, NON-INSULIN-DEPENDENT; DIABETES, GESTATIONAL; FEMALE; GLUCOSE; HUMAN; HYPERTENSION; INSULIN; INSULIN RESISTANCE; MACACA MULATTA; MICE; MONOSACCHARIDE TRANSPORT PROTEINS; MUSCLES; OBESITY; PREGNANCY; RATS; SIGNAL TRANSDUCTION; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

ANIMALIA;

EID: 0027434197     PISSN: 0950351X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0950-351X(05)80237-X     Document Type: Article

References (457)

1. 6 rat myoblasts: 1. Rate-limiting step, kinetic properties, and evidence for two systems
2. Regulation of glucose carriers in fibroblasts
3. Changing the insulin receptor to possess insulin-like growth factor I ligand specificity
4. Adipocyte insulin receptor binding and lipogenesis at term in normal pregnancy
5. Capillary supply of the quadriceps femoris muscle of man: adaptive response to exercise
6. Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase
7. C-terminal specific monoclonal antibodies against the human red cell glucose transporter
8. Decreased insulin-stimulated 3-O-methylglucose transport in in vitro incubated muscle strips from type II diabetic subjects
9. Defective insulin receptor tyrosine kinase in human skeletal muscle in obesity and type 2 (noninsulin-dependent) diabetes mellitus
10. The nucleotide sequence of a cDNA for mouse liver-type glucose transporter protein
11. The phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation
12. Insulin and nonhydrolyzable GTP analogs induce translocation of GLUT 4 to the plasma membrane in α-toxin-permeabilized rat adipose cells
13. Cloning of a Rab3 isotype predominately expressed in adipocytes
14. MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways
15. Diabetes in identical twins: a study of 200 pairs
16. Reduced capacity and affinity of skeletal muscle for insulin-mediated glucose uptake in noninsulin-dependent diabetic subjects
17. The pathogenetic role of an insulin receptor defect in diabetes mellitus of obese
18. Insulin receptor structure and function in normal and pathological conditions
19. Differential effects of diabetes on adipocyte and liver phosphotyrosine and phosphoserine phosphatase activities
20. Molecular biology of mammalian glucose transporters
21. Alternatively spliced variants of the insulin receptor protein: expression in normal and diabetic human tissues
22. Association of elevated fasting C-peptide level and increased intraabdominal fat distribution with development of NIDDM in Japanese-American men
23. Identification of a novel gene encoding an insulin-responsive glucose transport protein
24. The insulin-sensitive glucose transporter
25. Cloning and characterization of a cDNA encoding the rat brain glucose transporter protein
26. Growth factor-stimulated protein phosphorylation in 3T3-L1 cells. Evidence for protein kinase C-dependent and -independent pathways
27. Insulin activates the Raf-1 protein kinase
28. Insulin activation of protein kinase C: A reassessment
29. Insulin-induced translocation of glucose transporters from post-Golgi compartments to the plasma membrane of 3T3-adipocytes
30. Carbohydrate oxidation and storage in obese non-insulin-dependent diabetic patients
31. Correlation of muscle glycogen synthase activity and in vivo insulin action in man
32. Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects
33. Protein kinase C directly phosphorylates the insulin receptor in vitro and reduced its protein tyrosine kinase activity
34. Defects in transmembrane transport (T) and post-transport (post-T) step(s) of glucose metabolism are simultaneously present in type 2 diabetes
35. Glucose transport in human skeletal muscle: the in vivo response to insulin
36. Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase
37. Subcellular localization of GLUT4 in nonstimulated and insulin-stimulated soleus muscle of rat
38. Evaluation of β-cell secretion and peripheral insulin resistance during pregnancy and after delivery in gestational diabetes mellitus with obesity
39. Kinetics of glucose transport in human erythrocytes
40. Ca-ATPase isoenzyme expression in sarcoplasmic reticulum is altered by chronic stimulation of skeletal muscle
41. Mechanism of defective insulin-receptor kinase activity in NIDDM: evidence for two receptor populations
42. Fructose transporter in human spermatozoa and small intestine is GLUT 5
43. Insulin stimulation of gene expression mediated by p21ras
44. Human GLUT 4/muscle-fat glucose-transporter gene: characterization and genetic variation
45. Effect of insulin on oxidation of intracellularly and extracellularly derived glucose in patients with NIDDM: evidence for primary defect in glucose transport and/or phosphorylation but not oxidation
46. Insulin regulation of the two glucose transporters in 3T3-L1 adipocytes
47. Cloning of insulin receptor cDNA from an insulin resistant Pima Indian
48. Oncogenes and signal transduction
49. Studies on the mechanism of insulin resistance in the liver from humans with noninsulin-dependent diabetes
50. Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin-dependent diabetes
51. Altered coupling of the insulin receptor with Gi protein in the liver from patients with NIDDM
52. Facilitative diffusion of glucose
53. Subclinical abnormalities of glucose metabolism in subjects with previous gestational diabetes
54. A glucose transport protein expressed predominantly in insulin responsive tissues
55. rsk) in somatic cells: phosphorylation and activation during initiation of cell proliferation
56. Hormonal regulation of glucose transport in contracting skeletal muscle from normal and diabetic rats
57. Molecular scanning of the insulin-responsive glucose transporter (GLUT 4) gene in patients with noninsulin-dependent diabetes mellitus
58. Human insulin receptors mutated in the ATP-binding site fail to mediate postreceptor actions of insulin
59. Insulin receptor substrate 1 mediates insulin and insulin-like growth factor I-stimulated maturation of Xenopus oocytes.
60. rsk activity
61. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70kD S6 protein kinases
62. Mechanism of the postreceptor defect in insulin action in human obesity: decrease in glucose transport system activity
63. Role of the glucose transport system in the postreceptor defect of non-insulin dependent diabetes mellitus
64. Biochemical and functional characterization of the rat liver glucose-transport system
65. Insulin action kinetics in adipocytes from obese and noninsulin-dependent diabetes mellitus subjects: identification of multiple cellular defects in glucose transport
66. Hexose transport stimulation and membrane redistribution of glucose transporter isoforms in response to cholera toxin, dibutyryl cyclic AMP, and insulin in 3T3-L1 adipocytes
67. Protein synthesis inhibitors activate glucose transport without increasing plasma membrane glucose transporters in 3T3-L1 adipocytes
68. Determination of the rates of appearance and loss of glucose transporters at the cell surface of rat adipose cells
69. C. elegans cell signalling gene sem-5 encodes a protein with SH2 and SH3 domains
70. An insulin-stimulated ribosomal protein S6 kinase in 3T3-L1 cells
71. NIDDM associated with mutation in tyrosine kinase domain of insulin receptor gene
72. Protein kinase activity associated with the avian sarcoma virus src gene product
73. High resolution two-dimensional polyacrylamide gel electrophoresis reveals a glucose-response protein of 65 kDa in pancreatic islet cells
74. Relationship of insulin binding and insulin-stimulated tyrosine kinase activity is altered in type II diabetes
75. Role of phosphatidylinositol kinase in PDGF receptor signal transduction
76. Kinetics of 3-O-methyl-d-glucose transport in isolated rat hepatocytes
77. Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byrl gene product
78. The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product
79. Potential mechanisms of insulin action on glucose transport in the isolated rat adipose cell: apparent translocation of intracellular transport systems to the plasma membrane
80. The nature and regulation of the insulin receptor: structure and function
81. Complex regulation of simple sugar transport in insulin-responsive cells
82. Lack of glycogen synthase (GS) activation at physiological insulin concentration in skeletal muscles from obese NIDDM patients
83. Pathogenesis of impaired glucose tolerance and type II diabetes mellitus
84. Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia and atherosclerotic cardiovascular disease
85. The effect of insulin on the disposal of intravenous glucose: results from indirect calorimetry and hepatic and femoral venous catheterization
86. The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle
87. Activation of mitogen-activated protein kinase kinase by v-RAF in NIH 3T3 cells and in vitro
88. The mammalian glucose transporters
89. Effects of prior high-intensity exercise on glucose metabolism in normal and insulin-resistant men
90. An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects.
91. Decreased expression of glucose transporter in muscle from insulin-resistant patients
92. Exercise induces recruitment of the ‘insulin-responsive glucose transporter’: evidence for distinct intracellular insulin- and exercise-recruitable transporter pools in skeletal muscle
93. 2+ concentration in isolated rat adipocytes
94. The existence of an optimal range of cytosolic free calcium for insulin-induced glucose transport in rat adipocytes
95. Insulin and glucose modulate protein kinase C activity in rat adipocytes
96. Possible role of cytosolic free calcium concentrations in mediating insulin resistance of obesity and hyperinsulinemia
97. Mechanism of insulin resistance induced by sustained levels of cytosolic free calcium in rat adipocytes
98. The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signaling
99. Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity
100. A test for non-specific diffusion steps in transport across cell membranes, and its application to red cell glucose transport
101. Glucose tolerance, insulin release, and insulin sensitivity in normal-weight women with previous gestational diabetes mellitus
102. Insulin, oxytocin, and vasopressin stimulate protein kinase C activity in adipocyte plasma membranes
103. A simple resolution of the kinetic anomaly in the exchange of different sugars across the membrane of the human red blood cell
104. Quantitative ultrastructure of mammalian skeletal muscle
105. Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose
106. Structure, expression, and regulation of protein kinases involved in the phosphorylation of ribosomal protein S6
107. Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus
108. A PDGF receptor domain essential for mitogenesis but not for many other responses to PDGF
109. cDNA cloning of a novel 85 kD protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor
110. Some thoughts on the mechanism of action of insulin
111. Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways
112. Effects of insulin and phorbol esters on subcellular distribution of protein kinase C isoforms in rat adipocytes
113. Hyperglycemia markedly enhances skeletal muscle glycogen synthase activity in diabetic but not in normal conscious rats
114. Effect of insulin on the distribution and disposition of glucose in man
115. Insulin resistance in essential hypertension
116. Independent stimulation of glucose metabolism and Na+-K+ exchange by insulin in the human forearm.
117. Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes
118. Effects of aging on glucose-mediated glucose disposal and transport
119. Glucose-induced acceleration of deoxyglucose transport in rat adipocytes: evidence for a second barrier to sugar entry
120. Improvement in in vitro insulin action after one month of insulin therapy in obese noninsulin-dependent diabetes
121. Insulin sensitivity in adipocytes from subjects with varying degrees of glucose tolerance.
122. Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat
123. Transmembrane signaling by the human insulin receptor kinase. Relationship between intramolecular beta subunit trans- and cis-autophosphorylation and substrate kinase activation
124. Insulin-IGF-I hybrid receptors: implications for the dominant-negative phenotype in syndromes of insulin resistance
125. Insulin receptor kinase is not reduced in fibroblasts from subjects with non-insulin-dependent diabetes mellitus
126. Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects
127. Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus: effect of weight loss
128. In vivo stimulation of the insulin receptor kinase in human skeletal muscle: correlation with insulin-stimulated glucose disposal during euglycemic clamp studies
129. Impaired insulin-stimulated muscle glycogen synthase activation in vivo in man is related to low fasting glycogen synthase phosphatase activity
130. Immunolocalization of glucose transporter GLUT 4 within human skeletal muscle
131. Restoration of insulin responsiveness in skeletal muscle of morbidly obese patients after weight loss: effect on muscle glucose transport and glucose transporter GLUT4
132. Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein
133. Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues
134. Mitogen-activated protein kinase activation resulting from selective oncogene expression in NIH 3T3 cells and Rat 1a cells
135. The acquisition of increased insulin-responsive hexose transport in 3T3-L1 adipocytes correlates with expression of a novel transporter gene
136. Glucose transport and NIDDM
137. Correlation of in vivo and in vitro actions of insulin in obesity and noninsulin-dependent diabetes mellitus: Role of the glucose transport system
138. The effect of insulin treatment on insulin secretion and insulin action in type II diabetes mellitus
139. Insulin induces progressive insulin resistance in cultured rat adipocytes: sequential effects at receptor and multiple postreceptor sites
140. Glucose and insulin co-regulate the glucose transport system in primary cultured adipocytes: a new mechanism of insulin resistance
141. The role of glucose transporters in the cellular insulin resistance of type II non-insulin-dependent diabetes mellitus
142. Pretranslational suppression of an insulin-responsive glucose transporter in rats with diabetes mellitus
143. Expression of a glucose transporter gene cloned from brain in cellular models of insulin resistance: dexamethasone decreases transporter mRNA in primary cultured adipocytes
144. Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity
145. Gene expression of GLUT4 glucose transporters in skeletal muscle from insulin resistant patients with obesity, IGT, GDM, and NIDDM
146. Multiple defects in the adipocyte glucose transport system cause cellular insulin resistance in gestational diabetes. Heterogeneity in the number and a novel abnormality in subcellular localization of GLUT4 glucose transporters.
147. Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes
148. Insulin binding and insulin action in fibroblasts from patients with maturity-onset diabetes of the young
149. Regulation of insulin binding and stimulation of sugar transport in cultured human fibroblasts by sugar levels in the culture medium
150. Phorbol ester only partially mimics the effects of insulin on glucose transport and glucose-transporter distribution of 3T3-L1 adipocytes
151. Effect of insulin therapy on insulin resistance in type II diabetic subjects: evidence for heterogeneity
152. Oxidative and non-oxidative glucose metabolism in non-obese type 2 (non-insulin-dependent) diabetic patients
153. Glucose uptake and insulin sensitivity in rat muscle: changes during 3–96 weeks of age
154. Insulin increases the maximum velocity for glucose uptake without altering the Michaelis constant in man: evidence that insulin increases glucose uptake merely by providing additional transport sites
155. Expression of a functional glucose transporter in Xenopus oocytes
156. Expression of human glucose transporters in Xenopus oocytes: kinetic characterization and substrate specificities of the erythrocyte, liver, and brain isoforms
157. 1 protein in adipocytes from streptozocin-induced diabetic rats
158. Effects of sulfonylurea treatment on in vivo insulin secretion and action in patients with non-insulin-dependent diabetes mellitus
159. Hepatic protein phosphotyrosine phosphatase dephosphorylation of insulin and epidermal growth factor receptors in normal and alloxan diabetic rats
160. The cysteine-rich domains of the insulin and insulin-like growth factor I receptors are primary determinants of hormone binding specificity. Evidence from receptor chimeras
161. Increased insulin concentrations in nondiabetic offspring of diabetic parents
162. Incidence of type II diabetes in Mexican Americans predicted by fasting insulin and glucose levels, obesity, and body-fat distribution
163. Insulin resistance in normal rats infused with glucose for 72 h
164. Divergence between GLUT4 mRNA and protein abundance in skeletal muscle of insulin resistant rats
165. Expression of insulin regulatable glucose transporters in skeletal muscle from type 2 (non-insulin-dependent) diabetic patients
166. Intracellular targeting of the insulin regulatable glucose transporter (GLUT4) is isoform specific and independent of cell type
167. Heterogeneity of insulin responses: phases leading to type 2 (non-insulin-dependent) diabetes mellitus in the rhesus monkey
168. β-cell hyperresponsiveness: earliest event in development of diabetes in monkeys
169. Muscle group-specific regulation of GLUT 4 glucose transporters in control, diabetic, and insulin-treated diabetic rats.
170. Mechanisms of enhanced insulin action in endurance-trained athletes
171. Insulin action on activity and cell surface disposition of human HepG2 glucose transporters expressed in Chinese hamster ovary cells
172. Suppressed intrinsic catalytic activity of GLUT1 glucose transporters in insulin-sensitive 3T3-L1 adipocytes
173. Evidence that erythroid-type glucose transporter intrinsic activity is modulated by cadmium treatment of mouse 3T3-L1 cells
174. Activation of cell surface glucose transporters measured by photoaffinity labeling of insulin-sensitive 3T3-L1 adipocytes
175. Glucose deprivation and hexose transporter polypeptides of murine fibroblasts
176. Characterization of antisera to a synthetic carboxyl-terminal peptide of the glucose transporter protein
177. Biosynthesis and glycosylation of the insulin receptor. Evidence for a single polypeptide precursor of the two major subunits
178. The internalization and intracellular processing of insulin receptors
179. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
180. Platelet-derived growth factor: three isoforms and two receptor types
181. Activation of glucose transport in skeletal muscle by phospholipase C and phorbol ester
182. Glucose transporter protein content and glucose transport capacity in rat skeletal muscles
183. Effects of weight loss on mechanisms of hyperglycemia in obese non-insulin-dependent diabetes mellitus
184. Metabolic effects of hyperglycemia and hyperinsulinemia on fate of intracellular glucose in NIDDM
185. Phosphatidylinositol 3′-kinase: structure and expression of the 110kD catalytic subunit
186. The syndrome of diabetes mellitus and its causes
187. Identification of an intracellular pool of glucose transporters from basal and insulin-stimulated rat skeletal muscle
188. Characterization of cDNAs encoding human pyruvate dehydrogenase a subunit
189. Interrelated effects of insulin and glucose on diacylglycerol-protein kinase-C signalling in rat adipocytes and solei muscle in vitro and in vivo in diabetic rats
190. Variations in insulin-stimulated glucose uptake in healthy individuals with normal glucose tolerance
191. Cell surface labeling of glucose transporter isoform GLUT4 by bis-mannose photolabel: correlation with stimulation of glucose transport in rat adipose cells by insulin and phorbol ester
192. 3(H)2-deoxyglucose
193. Molecular basis of insulin receptor function
194. Insulin, cyclic nucleotide metabolism and the G-protein system
195. Activation of the MAP kinase pathway by the protein kinase rat
196. Identification of phosphorylated 422 (aP2) protein as p15, the 15-kilodalton target of the insulin receptor kinase in 3T3-L1 adipocytes
197. Isoform-specific subcellular targeting of glucose transporters in mouse fibroblasts
198. Transforming gene product of Rous sarcoma virus phosphorylates tyrosine
199. − exchanger and its role in essential hypertension and diabetes mellitus
200. Effects of endurance training on muscle fiber ATP-ase activity, capillary supply and mitochondrial content in man
201. Effects of insulin on diacylglycerol-protein kinase C signaling in rat diaphragm and soleus muscles and relationship to glucose transport
202. Insulin stimulates novel protein kinase C in rat adipocytes
203. Insulin receptor: structure and function
204. Phorbol esters stimulate the phosphorylation of receptors for insulin and somatomedin C
205. Muscle glucose metabolism in exercising rats: comparison with insulin stimulation
206. Molecular cloning and characterization of an insulin-regulatable glucose transporter
207. Effects of insulin on steady state kinetics of GLUT4 subcellular distribution in rat adipocytes
208. Transport function and subcellular distribution of purified human erythrocyte glucose transporter reconstituted into rat adipocytes
209. Insulin internalization and degradation in adipocytes from normal and type II diabetic subjects
210. Effect of increased free fatty acid supply on glucose metabolism and skeletal muscle glycogen synthase activity in normal man
211. m glucose transporter of islets of Langerhans is functionally similar to the low affinity transporter of liver and has an identical primary sequence
212. Insulin-stimulated glucose transport in rat adipose cells: modulation of transporter intrinsic activity by isoproterenol and adenosine
213. Localization of phospholamban in slow but not fast canine skeletal muscle fibers: an immunological and biochemical study
214. Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes
215. Regulation of glucose transporter gene expression in vitro and in vivo
216. Decreased in vivo glucose uptake but normal expression of GLUT1 and GLUT4 in skeletal muscle of diabetic rats
217. Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin resistant glucose transport in adipose cells without restoring glucose transporter gene expression
218. Role of insulin receptors in insulin-resistant states
219. The insulin receptor and the molecular mechanism of insulin action
220. PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex
221. Distribution of glucose transporters in membrane fractions isolated from human adipose cells: relation to cell size
222. Insulin stimulated translocation of glucose transport systems in the isolated rat adipose cell: time course, reversal, insulin concentration dependency, and relationships to glucose transport activity
223. In vitro insulin resistance of human adipocytes isolated from subjects with non-insulin-dependent diabetes mellitus
224. In vitro insensitivity of glucose transport and antilipolysis to insulin due to receptor and postreceptor abnormalities in obese Pima Indians with normal glucose tolerance
225. Insulin stimulates the phosphorylation of the 95000-dalton subunit of its own receptor
226. The structure of the insulin receptor and its subunits. Evidence for multiple non-preduced forms and a 210000 possible proreceptor
227. Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system
228. No accumulation of glucose in human skeletal muscle during euglycemic hyperinsulinemia.
229. Evidence for a family of human glucose transporter-like proteins: sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues
230. Human facilitative glucose transporters: isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6)
231. Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins
232. Functional expression of the human HepG2 and rat adipocyte glucose transporters in Xenopus oocytes
233. Isolation and characterization of the 160000-Da phosphotyrosyl protein, a putative participant in insulin signaling
234. Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in noninsulin-dependent diabetes mellitus
235. Low urinary chiro-inositol excretion in non-insulin-dependent diabetes mellitus
236. Insulin responsiveness in skeletal muscle is determined by glucose transporter (GLUT4) protein level
237. Defective insulin response of cyclic adenosine monophosphate-dependent protein kinase in insulin-resistant humans
238. Defective insulin response of phosphorylase phosphatase in insulin-resistant humans
239. Receptor-mediated transport of insulin across endothelial cells
240. Phorbolesters enhance basal d-glucose transport but inhibit insulin stimulation of d-glucose transport and insulin binding in isolated rat adipocytes
241. The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site
242. 2+ during differentiation of 3T3-L1 adipocytes: effect of insulin and relation to glucose transport
243. Insulin-induced translocation of glucose transporters in rat hindlimb muscles
244. SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins
245. The acute and chronic effects of sulfonylurea therapy in type II diabetic subjects
246. Ras p21 as a potential mediator of insulin action in Xenopus oocytes
247. Expression of the glucose transporter isoform GLUT4 is insufficient to confer insulin-regulatable hexose uptake to cultured muscle cells
248. Insulin activates the kinase activity of the Raf-1 proto-oncogene by increasing its serine phosphorylation
249. Glucose tolerance and hyperinsulinemia in obese women: role of adipose tissue distribution, muscle fiber characteristics, and androgens
250. Rate-limiting steps for insulin-mediated glucose uptake into perfused rat hindlimb.
251. Insulin secretion and insulin resistance in pregnancy and GDM: implications for diagnosis and management
252. Platelet-derived growth factor (PDGF) binding promotes the physical association of PDGF receptor with phospholipase C
253. Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase
254. Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT4) in patients with common-type non-insulin-dependent diabetes mellitus
255. Impaired tyrosine phosphatase activity in non-insulin-dependent diabetes mellitus
256. Raf-1 activates MAP kinase-kinase
257. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man: a novel mechanism for insulin resistance
258. Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM
259. A divergence in the MAP kinase regulatory defined by MEK kinase and raf
260. Rat liver insulin mediator which stimulates pyruvate dehydrogenase phosphatase contains galactosamine and d-chiroinositol
261. Insulin mediators and the control of pyruvate dehydrogenase complex
262. The association of insulin-elicited phosphotyrosine proteins with src homology 2 domains
263. Purification and characterization of the insulin-stimulated protein kinase from rabbit skeletal muscle; close similarity to S6 kinase II
264. Stimulation of glucose transport and glucose transporter phosphorylation by okadaic acid in rat adipocytes
265. Coordinated regulation of a set of genes by glucose and calcium ionophores in mammalian cells
266. Activation of extracellular signal-regulated kinase, ERK2, by p21 ras oncoprotein
267. Role of cellular calcium metabolism in abnormal glucose metabolism and diabetic hypertension
268. In vivo insulin action is familial characteristic in nondiabetic Pima Indians
269. Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man
270. Impaired glucose tolerance as a disorder of insulin action: longitudinal and cross-sectional studies in Pima Indians
271. Lymph insulin concentration in humans predicts insulin action kinetics but does not explain insulin resistance in the obese
272. Biologic actions of insulin are differentially regulated by glucose and insulin in primary cultured adipocytes: chronic ability to increase glycogen synthase activity
273. Glucose and insulin regulate insulin sensitivity in primary cultured adipocytes without affecting insulin receptor kinase activity
274. The kinetics of glucose transport in human red blood cells
275. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
276. i with antisera prepared against synthetic peptides
277. Endocytosis of insulin receptors is not required for activation or deactivation of the hormone response
278. Different ligand affinities of the two human insulin receptor splice variants are reflected in parallel changes in sensitivity for insulin action
279. A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.
280. Abnormal regulation of protein tyrosine phosphatase activities in skeletal muscle of insulin-resistant humans
281. Stabilization of glucose transporter mRNA by insulin/IGF-1 and glucose deprivation
282. A putative mediator of insulin action which inhibits adenylate cyclase and adenosine 3′,5′,-monophosphate dependent protein kinase: partial purification from rat liver, site, and kinetic mechanism of action
283. Adipocyte glycogen synthase and pyruvate dehydrogenase in obese and type II diabetic subjects.
284. The effect of starvation on insulin-induced glucose disposal and thermogenesis in humans
285. Hepatocyte plasma membrane ECTO-ATPase (pp120/HA4) is a substrate for tyrosine kinase activity of the insulin receptor
286. Glucose uptake in human adipose tissue
287. Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system: role of hexosamine biosynthesis in the induction of insulin resistance
288. New insights into the metabolic regulation of insulin action and insulin resistance: role of glucose and amino acids
289. Enhancement of hexose entry into chick fibroblast by starvation: differential effect on galactose and glucose
290. Glucose and insulin chronically regulate insulin action via different mechanisms in BC3H-1 myocytes: effects on glucose transporter gene expression
291. ras interfere with insulin-induced gene expression
292. Modifications of glucose storage and oxidation in nonobese diabetics, measured by continuous indirect calorimetry
293. Hepatic phosphotyrosine phosphatase activity and its alterations in diabetic rats
294. The kinetics of selective biological transport: IV. Assessment of three carrier systems using the erythrocyte-monosaccharide transport data
295. Influence of dietary carbohydrate on skeletal muscle glucose uptake
296. Normal insulin-receptor cDNA sequence in Pima Indians with NIDDM
297. Tissue-specific expression of two alternatively spliced insulin receptor mRNA's in man
298. Functionally distinct insulin receptors generated by tissue-specific alternative splicing
299. Altered expression of insulin receptor types A and B in the skeletal muscle of non-insulin-dependent diabetes mellitus patients
300. Sequence and structure of a human glucose transporter
301. Phorbol esters imitate in rat fat-cells the full effect of insulin on glucose-carrier translocation, but not on 3-O-methylglucose-transport activity
302. Prevention by protein kinase C inhibitors of glucose-induced insulin-receptor tyrosine kinase resistance in rat fat cells
303. The new elements of insulin signaling
304. Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-triphosphate
305. MAP kinase activator from insulin-stimulated skeletal muscle is a protein threonine/tyrosine kinase
306. Dissociation of effects of insulin and contraction on glucose transport in rat epitrochlcaris muscle
307. Glucokinase and glucose transporter expression in liver and islets: implications for control of glucose homeostasis
308. Phosphorylation state of the GLUT 4 isoform of the glucose transporter in subfractions of the rat adipose cell: effects of insulin, adenosine, and isoproterenol
309. Gas chromatographic-mass spectrometric analysis of polyols in urine and serum in uremic patients: identification of new deoxyalditols and inositol isomers
310. An activated S6 kinase in extracts from serum- and epidermal growth factor-stimulated Swiss 3T3 cells
311. Deficiency in phosphorylase phosphatase activity despite elevated protein phosphatase type-1 catalytic subunit in skeletal muscle from insulin-resistant subjects
312. A defective intramolecular auto-activation cascade may cause the reduced kinase activity of the skeletal muscle insulin receptor from patients with non-insulin-dependent diabetes mellitus
313. Hypertension and dyslipidemia in patients with insulinoma
314. Studies with antipeptide antibody suggest the presence of at least two types of glucose transporter in rat brain and adipocyte
315. The insulin receptor
316. Mutant insulin receptors in syndromes of insulin resistance
317. Detection of mutations in the insulin receptor gene in non-insulin-dependent diabetes patients by analysis of single-stranded conformational polymorphisms
318. Relation between insulin receptor number in cells, autophosphorylation and insulin-stimulated Ras • GTP formation
319. Secondary structure of Src homology 2 domain of c-Abl by heteronuclear NMR spectroscopy in solution
320. Three-dimensional solution structure of the src homology 2 domain of c-abl
321. 3H] chiroinositol in rat tissues
322. SH2 and SH3 domains: from structure to function
323. Studies of insulin receptor binding and insulin action in humans
324. Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM
325. Chelation of intracellular calcium blocks insulin action in the adipocyte
326. Identification of the stereospecific hexose transporter from starved and fed chicken embryo fibroblasts
327. The insulin receptor is an insulin-dependent tyrosine protein kinase: copurification of insulin binding and protein kinase activity to homogeneity from human placenta
328. Isolation of a Drosophila genomic sequence homologous to the kinase domain of the human insulin receptor and the detection of the phosphorylated Drosophila receptor with an antipeptide antibody
329. Insulin-responsive human adipocytes express two glucose transporter isoforms and target them to different vesicles.
330. Differential sorting of two glucose transporters expressed in insulin-sensitive cells
331. 2 terminus
332. Kinetics of glucose transport in rat muscle: effects of insulin and contractions.
333. Transcapillary insulin transport (TCIT) is rate-limiting in insulin-sensitive tissues
334. In vivo kinetics of insulin action on peripheral glucose disposal and hepatic glucose output in normal and obese subjects
335. Insulin activates a 70-kDa S6 kinase through serine/threonine specific phosphorylation of the enzyme polypeptide
336. Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase
337. Insulin binding, internalization, and insulin receptor regulation in fibroblasts from type II noninsulin-dependent diabetic subjects
338. Linkage of chromosomal markers on 4q with a putative gene determining maximal insulin action in Pima Indians
339. The glucose fatty-acid cycle: its role in insulin sensitivity and in metabolic disturbances of diabetes mellitus
340. Mechanisms decreasing glucose oxidation in diabetes and starvation: role of lipid fuels and hormones
341. Thermic effect of infused glucose and insulin in man: decreased response with increased insulin resistance in obesity and noninsulin-dependent diabetes mellitus
342. Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro
343. Positive and negative regulation of gene expression by insulin and glucagon: the model of l-type pyruvate kinase gene
344. Insulin resistance, hyperinsulinaemia, hypertriglyceridemia, and hypertension: parallels between human disease and rodent models
345. An attempt to define the nature of chemical diabetes using multidimensional analysis
346. Muscle and adipose tissue morphology and metabolism in Cushing's syndrome
347. 3T3-L1 adipocyte glucose transporter (HepG2 class): sequence and regulation of protein and mRNA expression by insulin, differentiation, and glucose starvation
348. A paired-tracer dilution method for charaterizing membrane transport in the perfused rat hindlimb: effects of insulin, feeding, and fasting on the kinetics of sugar transport
349. Lack of in vivo insulin resistance in controlled insulin-dependent, type 1, diabetic patients
350. Differential regulation of glucose transporter activity and expression in red and white skeletal muscle
351. Muscle glucose metabolism following exercise in the rat: increased sensitivity to insulin
352. Glucose-induced insulin resistance of skeletal-muscle glucose transport and uptake
353. Translocation of the glucose transporter (GLUT4) to the cell surface in permeabilized 3T3-L1 adipocytes: effects of ATP, insulin, and GTPγS and localization of GLUT4 to clathrin lattices
354. Immunocytochemical and biochemical studies of GLUT4 in rat skeletal muscle
355. Role of glycosylation in the processing of newly translated insulin pro-receptor in 3T3-L1 adipocytes
356. After insulin binds
357. Structure and function of insulin receptors
358. Phosphorylation activates the insulin receptor tyrosine protein kinase
359. Correction of hyperglycaemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats
360. Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase
361. Substrates and signalling complexes: the tortured path to insulin action
362. Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase
363. 31P nuclear magnetic resonance measurement of muscle glucose-6-phosphate
364. Insulin action during pregnancy: studies with the euglycemic clamp technique
365. Role of protein kinase C in the regulation of glucose transport in the rat adipose cell: translocation of glucose transporters without stimulation of glucose transport activity
366. Substrate regulation of the glucose transport system in rat skeletal muscle: characterization and kinetic analysis in isolated soleus muscle and skeletal muscle cells in culture
367. Insulin treatment reverses the insulin resistance of type II diabetes mellitus
368. Insulin treatment reverses the post-receptor defect in adipocyte 3-O-methyl glucose transport in type II diabetes mellitus
369. Impaired activation of glycogen synthase in people at increased risk for developing NIDDM
370. Chemistry and biology of the immunophilins and their immunosuppressive ligands
371. Insulin and insulin-like growth factor-1 binding specificity is determined by distinct regions of their cognate receptors
372. Signaling-competent receptor chimeras allow mapping of major insulin receptor binding domain determinants
373. Postprandial changes in cytosolic free calcium and glucose uptake in adipocytes in obesity and non-insulin-dependent diabetes mellitus
374. Determination of the temperature and pH dependence of glucose transfer across the human erythrocyte membrane measured by glucose exit
375. Evidence that two naturally occuring human insulin receptor α subunit variants are immunologically distinct
376. Signal transduction within the nucleus by mitogen-activated protein kinase
377. 13C nuclear magnetic resonance spectroscopy
378. Plasma insulin response among Nauruans: prediction of deterioration in glucose tolerance over 6 years
379. Insulin-receptor kinase activity of adipose tissue from morbidly obese humans with and without NIDDM
380. Adipose tissue glucose transporters in NIDDM: decreased levels of muscle fat isoform
381. Oral contraception and insulin sensitivity: in vivo assessment in normal women and women with previous gestational diabetes
382. No evidence for expression for the insulin-regulatable glucose transporter in endothelial cells
383. Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat
384. Translocation of the glucose transporter GLUT4 in cardiac myocytes of the rat
385. Immunoelectron microscopic demonstration of insulin-stimulated translocation of glucose transporters to the plasma membrane of isolated rat adipocytes and masking of the carboxyl-terminal epitope of intracellular GLUT4
386. Minimal effects of phorbol esters on glucose transport and insulin sensitivity of rat skeletal muscle
387. At the cutting edge: insulin resistance and hypertension
388. Alteration of cellular calcium metabolism as primary cause of hypertension
389. The development of insulin receptors and responses in the differentiating nonfusing muscle cell line BC3H-1
390. Mechanism of insulin action on glucose transport in rat skeletal muscle.
391. Insulin stimulation of glucose uptake can be mediated by diacylglycerol in adipocytes
392. Insulin and growth factor effects on c-fos expression in normal and protein kinase C-deficient fibroblasts and adipocytes
393. Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II
394. The structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
395. Expression and function of IRS-1 in insulin signal transmission
396. Insulin receptor signaling through non-tyrosine kinase pathways: evidence from anti-receptor antibodies and insulin receptor mutants
397. Insulin resistance associated with lower rates of weight gain in Pima Indians
398. Reassessment of the translocation hypothesis by kinetic studies on hexose transport in isolated rat adipocytes
399. Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site
400. Two distinct enzymes contribute to biphasic S6 phosphorylation in serum-stimulated chicken embryo fibroblasts
401. Activation of S6 kinase activity in 3T3-L1 cells by insulin and phorbol ester
402. Human diabetes associated with a deletion of the tyrosine kinase domain of the insulin receptor
403. Phorbol ester induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity
404. Insulin-stimulated glucose transport in muscle. Evidence for a protein-kinase-C-dependent component which is unaltered in insulin-resistant mice
405. Symmetrical kinetic parameters for 3-O-methyl-d-glucose transport in adipocytes in the presence and in the absence of insulin
406. Mutations in the insulin receptor gene
407. The effect of graded doses of insulin on total glucose uptake, glucose oxidation and glucose storage in man
408. Insulin-receptor autophosphorylation and endogenous substrate phosphorylation in human adipocytes from control, obese, and NIDDM subjects
409. Intracellular glucose oxidation and glycogen synthase activity are reduced in non-insulin-dependent (type II) diabetes independent of impaired glucose uptake
410. Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and β-pancreatic islet cells
411. Differential regulation of the HepG2 and adipocyte/muscle glucose transporters in 3T3-L1 adipocytes
412. Role of amino acids in modulating glucose-induced desensitization of the glucose transport system
413. Insulin internalization into monocytes is decreased in patients with type II diabetes mellitus
414. Intracellular insulin processing is altered in monocytes from patients with type II diabetes mellitus
415. Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
416. Hyperglycaemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes
417. Defective insulin activation of glycogen synthase in skeletal muscles of first degree relatives of patients with type 2 (non-insulin-dependent) diabetes mellitus
418. Phospholipase C-γl and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal
419. Glucose as a regulator of insulin-sensitive hexose uptake in 3T3 adipocytes
420. Phosphatidylinositol 4-kinase is a component of glucose transporter (GLUT4)-containing vesicles
421. The two isotypes of the human insulin receptor (HIR-A and HIR-B) follow different internalization kinetics
422. ras in activation of extracellular signal-related kinase 2
423. Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase C-γ in quiescent BALB/c 3T3 cells
424. Glucose-dependent regulation of glucose transport activity, protein, and mRNA in primary cultures of rat brain glial cells
425. Insulin and glucose-dependent regulation of the glucose transport system in the rat L6 skeletal muscle cell line
426. Glucose transport activity in L6 muscle cells is regulated by the coordinate control of subcellular glucose transporter distribution, biosynthesis, and mRNA transcription
427. Insulin resistance and impaired insulin secretion in subjects with histories of gestational diabetes mellitus
428. Identification of the d-glucose-inhibitable cytocholasin B binding site as the glucose transporter in rat diaphragm plasma and microsomal membranes
429. Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents
430. Insulin action on glucose transport in cardiac muscle
431. Serum insulin in essential hypertension and in peripheral vascular disease
432. Kinetic properties of the reconstituted glucose transporter from human erythrocytes
433. 1 185 000 protein in intact cells
434. Characterization of an endogenous substrate of the insulin receptor in cultured cells
435. m in the adipocyte by insulin and other factors
436. Kinetic parameters of transport of 3-O-methylglucose and glucose in adipocytes
437. Signal transduction by the platelet-derived growth factor receptor
438. Stereospecific transport of glucose in the perfused rat liver
439. ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK
440. Molecular structure of a protein-tyrosine-threonine kinase activating p4 mitogen-activated protein (MAP) kinase: MAP kinase kinase
441. Immunoassay of endogenous plasma insulin in man
442. Functional properties of two naturally occurring isoforms of the human insulin receptor in chinese hamster ovary cells
443. Trafficking of glucose transporters in 3T3-L1 cells: inhibition of trafficking by phenylarsine oxide implicates a slow dissociation of transporters from trafficking proteins
444. Insulin transport across capillaries is rate limiting for insulin action in dogs
445. Tissue distribution and species difference of the brain type glucose transporter (GLUT3)
446. Hyperglycemia decreases glucose uptake in type I diabetes
447. Kinetics of glucose disposal in whole body and across the forearm in man
448. Localization of rate-limiting defect for glucose disposal in skeletal muscle of insulin resistant type I diabetic patients
449. Insulin-resistant diabetes due to a point mutation that prevents insulin proreceptor processing
450. Effects of insulin on glucose transport and glucose transporters in rat heart
451. Risk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose tolerance
452. Insulin action in obese non-insulin-dependent diabetics and in their isolated adipocytes before and after weight loss
453. Binding properties of chimeric insulin receptors containing the cysteine-rich domain of either the insulin-like growth factor I receptor or the insulin receptor related receptor
454. Glucose transport is rate limiting for skeletal muscle glucose metabolism in normal and STZ-induced diabetic rats
455. Insulin-regulated glucose uptake in rat adipocytes is mediated by two transporter isoforms present in at least two vesicle populations