Interferon α increases the frequency of interferon γ-producing human CD4+ T cells

Journal of Experimental Medicine

Volumn 178, Issue 5, 1993, Pages 1655-1663

  Brinkmann, Volker ^a   Geiger, Thomas ^a   Alkan, Sefik ^a   Heusser, Christoph H ^a  

^a CIBA GEIGY LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 4;

ALLERGIC DISEASE; ALLERGIC REACTION; ANTIGEN PRESENTING CELL; ARTICLE; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOREGULATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANTIGENS, CD4; CELL SEPARATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; HUMAN; INTERFERON TYPE I, RECOMBINANT; INTERFERON TYPE II; INTERLEUKIN-4; KINETICS; RNA, MESSENGER; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0027433104     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.178.5.1655     Document Type: Article

References (57)

1. DeMaeyer, E., and j. DeMaeyer-Guignard. 1988. Interferons and Other Regulatory Cytokines. John Wiley & Sons Inc., New York. 498 pp.
2. Taylor-Papadimitriou, J., and E. Rozengurt. 1985. Interferons as regulators of cell growth and differentiation. In Interferon, J. Taylor-Papadimitriou, editor. Oxford University Press, Oxford. 81-91.
3. Hoofhagle, J.H. 1990. α-Interferon therapy of chronic hepatitis R Current status and recommendations. J. Hepatol (Amst.). 11:100.
4. Week, P.K., S. Apperson, L. May, and N. Stebbing. 1991. Comparison of the anti-viral activities of various cloned human interferon alpha subtypes in mammalian cell cultures. J. Gen. Virol. 57:253.
5. DeMaeyer, E., and J. DeMaeyer-Guignard. 1988. The anti-viral effects of interferons. In Interferons and Other Regulatory Cytokines. E. DeMaeyer and J. DeMaeyer-Guignard, editors. John Wiley & Sons Inc., New York. 114-153.
6. Gresser, I.1984. Role of interferon in resistance to viral infection in vivo. In Interferon 2: Interferons and the Immune System. J. Vilcek and E. De Maeyer, editors. Elsevier, Amsterdam. 221-252.
7. Kovacs, J.A., H.C. Lane, H. Masur, B. Herpin, T. Folks, J. Feinberg, and A.S. Fauci. 1987. A phase II, placebo controlled trial of recombinant alpha interferon in asymptomatic individuals seropositive for the acquired immunodeficiency syndrome virus. Clin. Res. 50:529.
8. Francis, M.L., M.S. Meltzer, and H.E. Gendelman. 1992. Interferons in the persistence, pathogenesis, and treatment of HIV infection. AIDS Res. Human Retroviruses. 8:199.
9. Gutterman, J.U., G.R. Blumenschein, R. Alexanian, H.Y. Yap, A.U. Buzdar, F. Cabanillas, E.N. Hortobagyi, E.M. Hersch, S.L. Rasmussen, M. Harmon, et al. 1980. Leukocyte interferon induced tumor regression in human metastatic breast cancer, multiple myeloma, and malignant myeloma. Ann. Intern. Med. 93:499.
10. Gutterman, J.U., S. Fine, J.R. Quesada, S. Haming, J.F. Levine, R. Alexanian, L. Bernhard, M. Kramer, H. Spiegel, W. Colburn, et al. 1982. Recombinant leucocyte A interferon: pharmacokinetics, single dose tolerance and biological effects in cancer patients. Ann. Intern. Med. 96:549.
11. Krown, S.E., F.X. Real, and A.I. Einzig. 1985. The interferon system. In Treatment of Kaposi’s Sarcoma and Renal Cell Carcinoma with Recombinant Leucocyte A Interferon. H. Kirchner and H. Schllekens, editors. Elsevier Science, Heidelberg. 523-550.
12. DeMaeyer, E., and J. DeMaeyer-Guignard. 1988. The effects of interferons on tumor cells. In Interferons and Other Regulatory Cytokines. E. DeMaeyer and J. DeMaeyer-Guignard, editors. John Wiley & Sons, Inc., New York. 534-513.
13. Souillet, G., F. Rousset, and J.E. DeVries. 1989. Alpha interferon treatment of patient with hyper IgE syndrome. Lancet. i:1534.
14. Zielinski, R.M., and W.D. Lawrence. 1990 IFNa for the treatment of hypereosinophilic syndrome. Ann. Intern. Med. 113:716.
15. Pene, J., F. Rousset, F. Briere, I. Chretien, J.Y. Bonnefoy, H. Spitz, T. Yokota, N. Arai, K. Arai, J. Banchereau, et al. 1988. IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and by prostaglandin E2. Proc Natl. Acad. Sci. USA. 85:6880.
16. Finkelman, F.D., J. Holmes, I.M. Katona, J.F. Urban, M.P. Beckmann, L.S. Park, K.A. Schooley, R.L. Coffman, T.R. Mosmann, and W.E. Paul. 1990. Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol. 8:303.
17. Finkelman, F.D., A. Svetic, I. Gresser, C. Snapper, J. Holmes, P.P. Trotta, M. Katona, and W.C. Gause. 1991. Regulation by interferon α of immunoglobulin isotype selection and lymphokine production in mice. J. Exp Med. 174:1179.
18. Brinkmann, V., J. Baer, C. Heusser, E. Kilchherr, and F. Erard. 1992. Interferon alpha suppresses the capacity of T cells to help antibody production by human B cells. J. Interferon Res. 12:267.
19. Coffman, R.L., J. Ohara, M.W. Bond, J. Carty, A. Zlotnik, and W.E. Paul. 1986. B cell stimulatory factor-1 enhances the IgE response of lipopolisaccharide-activated B cells.J. Immunol. 151:5053.
20. Del Prete, G.F., E. Maggi, P. Parronchi, I. Chretien, A. Tiri, D. Macchia, M. Ricci, J. Banchereau, and J.E. DeVries. 1988. IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants. J. Immunol. 150:5193.
21. Pene, J., F. Rousset, F. Briere, I. Chretien, X. Paliard, J. Banchereau, H. Spits, and J.E. De Vries. 1988. IgE production by normal human B cells induced by alloreactive T cell clones is mediated by IL-4 and suppressed by IFN-gamma. J Immunol. 151:1218.
22. Snapper, C.M., and W.E. Paul. 1987. Interferon gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science (Wish. DC). 251:949.
23. Parronchi, P., M. De Carli, R. Manetti, C. Simonelli, S. Sam-pognaro, M.-P. Piccinni, D. Macchia, E. Maggi, G. Del Prete, and S. Romagnani. 1992. IL-4 and IFN (a and 7) exert opposite regulatory effects on the development of cytolytic potential by TH1 or TH2 human T cell clones.J. Immunol. 149:2977.
24. Mosmann, T.R., H. Cherwinski, M.W. Bond, M.A. Giedlin, and R.L. Coffman. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 151:2498.
25. Mosmann, T.R., and R.L. Coffman. 1989. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Ann. Rev. Immunol. 7:150.
26. Mosmann, T.R. 1991. Cytokine secretion patterns and crossregulation of T cell subsets. Immunol. Res. 10:183.
27. Swain, S.L. 1991. Regulation of the development of helper T cell subsets. Immunol. Res. 10:177.
28. Mosmann, T.R. 1991. Cytokines: is there biological meaning? Curr. Opin. Immunol. 3:511.
29. Romagnani, S. 1992. Induction of TH1 and TH2 responses: A key role for natural immune response? Immunol. Today. 13:529.
30. Sedgwick, J.D., and P.G. Holt. 1983. A solid-phase immunoen-zymatic technique for the enumeration of specific antibody-secreting cells. J. Immunol. Methods. 57:301.
31. Czerkinsky, C., L.-A. Nilsson, A. Tarkowski, W.J. Koopman, J. Mestecky, and Öuchterlony, O. 1988. The solid-phase enzyme-linked immunospot assay (ELISPOT) for enumerating antibody-secreting cells: methodology and applications. In Theoretical and Technical Aspects of ELISA and Other Solid-Phase Immunoassays. D.M. Kemeny and S.J. Challacombe, editors. John Wiley and Sons, Ltd., Oxford, p. 217.
32. Brinkmann, V., and C. Heusser. 1993. T cell dependent differentiation of human B cells: direct switch from IgM to IgE, and sequential switch from IgM via IgG to IgA production. Mol. Immunol. 29:1159.
33. Brinkmann, V., and C. Heusser. 1993. T cell dependent differentiation of human B cells into IgM, IgG, IgA, or IgE plasma cells: high rate of antibody production by IgE plasma cells, but limited clonal expansion of IgE precursors. Celt. Immunol. In press.
34. Versteegen, J.M., T. Logtenberg, and R.E. Ballieux. 1988. Enumeration of IFN-gamma-producing human lymphocytes by spot-ELISA. A method to detect lymphokine-producing lymphocytes at the single-cell level. J. Immunol. Methods. 111:25.
35. Czerkinsky, C., G. Andersson, B. Ferrua, I. Nordstrom, M. Quiding, K. Eriksson, L. Larsson, K. Hellstrand, and H.P. Erke. 1991. Detection of human cytokine-secreting cells in distinct anatomical compartments. Immunol. Rev. 119:5.
36. Van Kimmenade, A., M.W. Bond, J.H. Schumacher, C. La-quoi, and R.A. Kastelein. 1988. Expression, renaturation and purification of recombinant human interleukin 4 from Escherichia coli. Eur. J. Biochem. 173:109.
37. Meister, A., G. Uze, K. Mogensen, I. Gresser, M.G. Tovey, M. Griitter, and F. Meyer. 1986. Biological activities and receptor binding of two human recombinant interferons and their hybrids. J. Gen. Virol. 67:1653.
38. Horisberger, M.A., and K. De Staritzki. 1987. A recombinant human interferon-alpha B/D hybrid with a broad host range. J. Gen. Virol. 68:950.
39. Boyum, A. 1968. Isolation of mononuclear cells and granulocytes from human blood: isolation of mononuclear cells by one centrifugation and of sedimentation at 1 g. Scand.J. Clin. Lab. Invest. Suppl. 21:77.
40. Andersson, U., J. Andersson, A. Lindfors, K. Wagner, G. Möller, and C. Heusser. 1990. Simultaneous production of interleukin 2, interleukin 4 and interferon-γ by activated human blood lymphocytes. Eur. J. Immunol. 20:1591.
41. Carballido, J.M., N. Carballido-Perrig, G. Terres, C. Heusser, and K. Blaser. 1992. Bee venom phospholipase A2-specific T cell clones from human allergic and non-aUergic individuals: cytokine patterns change in response to the antigen concentration. Eur. J. Immunol. 22:1357.
42. Innis, M.A., D.H. Gelfand, J.J. Sninsky, and T.J. White. 1990. PCR Protocols. A Guide to Methods and Applications. Academic Press, Inc., New York. 532 pp.
43. Sambrook, J., J. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual. 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
44. Feinberg, A.P., and B. Vogelstein. 1993. A technique for radiolabeling DNA restriction fragments to high specific activity. Anal. Biochem. 132:6.
45. Coffman, R.L., B.W.P. Seymour, D.A. Lebman, D.D. Hiraki, J.A. Christiansen, B. Shrader, H.M. Cherwinski, H.F.J. Savelkoul, F.D. Finkelman, M.W. Bond, et al. 1988. The role of helper T cell products in mouse B cell differentiation and isotype regulation. Immunol. Rev. 102:5.
46. Stevens, T.L., A. Bossie, V.M. Sanders, R. Femandez-Botran, R.L. Coffman, T.R. Mosmann, and E.S. Vitetta. 1988. Regulation of antibody isotype secretion by subsets of antigen specific T cells. Nature (Lond.). 534:225.
47. Romagnani, S. 1990. Regulation and deregulation of human IgE synthesis. Immunol. Today. 11:516.
48. Heusser, C.H., V. Brinkmann, G. Delespesse, E. Kilchherr, K. Blaser, and G. LeGros. 1991. Current concepts of IgE regulation. Allergy Clin. Immunol. News. 3:52.
49. Peleman, R., J. Wu, C. Fargeas, and G. Delespesse. 1989. Recombinant interleukin 4 suppresses the production of interferon γ by human mononuclear cells.J. Exp Med. 170:1751.
50. Wagner, F., N. Fischer, C. Lersch, R. Hart, and H. Danci-gier. 1989. Interleukin 4 inhibits the Interleukin 2-induced production of its functional antagonist, interferon gamma. Immunol. Lett. 21:252.
51. Gajewski, T.F., and F. Fitch. 1988. Anti-proliferative effect of IFN-γ in immune regulation. I. IFN-γ inhibits the proliferation of TH2 but not TH1 murine helper T lymphocyte clones. J. Immunol. 150:5250.
52. Gajewski, T.F., M. Pinnas, T. Wong, and F.W. Fitch. 1991. Murine TH1 and TH2 clones proliferate optimally in response to distinct antigen-presenting cell populations. J. Immunol. 151:1750.
53. DeMaeyer, E., and j. DeMaeyer-Guignard. 1988. Macrophages as interferon producers and interferons as modulators of macrophage activity. In Interferons and Other Regulatory Cytokines. E. DeMaeyer and J. DeMaeyer-Guignard, editors. John Wiley & Sons, Inc., New York. 194-220.
54. Clerici, M., and G.M. Shearer. 1993. A TH1-TH2 switch is a critical step in the etiology of HIV infection. Immunol. Today. 14:107.
55. Gendelman, H.E., D.R. Skillman, and M.S. Meltzer. 1992. Interferon alpha (IFN)-macrophage interactions in human immunodeficiency virus (HIV) infection: role of IFN in the tempo and progression of HIV disease. Intern. Rev. Immunol. 8:53.
56. Recht, M., E.C. Borden, and K. Knight, Jr. 1991. A human 15-kDa IFN-α-induced protein induces the secretion of IFN-γ. J. Immunol. 152:2617.
57. Reinhold, U., W. Wehrmann, S. Kukel, and H.W. Kreisel. 1990. Evidence that defective interferon-γ production in atopic dermatitis patients is due to intrinsic abnormalities. Clin. Exp Immunol. 79:524.