High-affinity self-reactive human antibodies by design and selection: Targeting the integrin ligand binding site

Proceedings of the National Academy of Sciences of the United States of America

Volumn 90, Issue 21, 1993, Pages 10003-10007

  Barbas III, C F ^a   Languino, L R ^a   Smith, J W ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

cell adhesion; combinatorial libraries; drug design; metastasis; phage display

Indexed keywords

IMMUNOGLOBULIN F(AB) FRAGMENT; INTEGRIN;

ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL ADHESION; LIGAND BINDING; MUTAGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECEPTOR BINDING;

AMINO ACID SEQUENCE; ANTIBODIES; BASE SEQUENCE; BINDING SITES; COMPARATIVE STUDY; DNA PRIMERS; HUMAN; IMMUNOGLOBULINS, FAB; INTEGRINS; KINETICS; LIGANDS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; OLIGOPEPTIDES; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; POLYMERASE CHAIN REACTION; RECEPTORS, CYTOADHESIN; RECEPTORS, VITRONECTIN; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T;

EID: 0027433096     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.90.21.10003     Document Type: Article

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