Antineutrophil and myocardial protecting actions of a novel nitric oxide donor after acute myocardial ischemia and reperfusion in dogs

Circulation

Volumn 88, Issue 5, 1993, Pages 2337-2350

  Lefer, David J ^a   Nakanishi, Katsuhiko ^a   Johnston, William E ^b   Vinten Johansen, Jakob ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b Bowman Gray School of Medicine ^*

Author keywords

Blood flow; Ischemia; Myocardial infarction; Neutrophils; Reperfusion

Indexed keywords

CREATINE KINASE; LEUKOTRIENE B4; MYELOPEROXIDASE; NITRIC OXIDE; SPM 5185; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; DRUG STRUCTURE; ENZYME ACTIVITY; HEART MUSCLE BLOOD FLOW; HEART MUSCLE ISCHEMIA; HEART MUSCLE NECROSIS; HEART MUSCLE REPERFUSION; HEART PROTECTION; INTRACORONARY INFUSION; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; CELL ADHESION; CORONARY CIRCULATION; CREATINE KINASE; DIPEPTIDES; DOGS; ENDOTHELIUM, VASCULAR; FEMALE; HEART; HEMODYNAMICS; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; MYOCARDIUM; NECROSIS; NEUTROPHILS; NITRIC OXIDE; PEROXIDASE; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027431321     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.88.5.2337     Document Type: Article

References (67)

1. Ku DD. Coronary vascular reactivity after acute myocardial ischemia. Science. 1982;218:576-578.
2. Van Benthuysen KM, McMurtry IF, Horwitz LD. Reperfusion after acute coronary occlusion in dogs impairs endothelium-dependent relaxation to acetylcholine and augments contractile reactivity in vitro. J Clin Invest. 1987;79:265-274.
3. Nichols WW, Mehta JL, Donnelly WH, Lawson D, Thompson L, ter Riet M. Reduction in coronary vasodilator reserve following coronary occlusion and reperfusion in anesthetized dog: role of endothelium-derived relaxing factor, myocardial neutrophil infiltration and prostaglandins. J Mol Cell Cardiol. 1988;20:943-954.
4. Sobey CG, Dusting GJ, Grossman HJ, Woodman OL. Impaired vasodilation of epicardial coronary arteries and resistance vessels following myocardial ischemia and reperfusion in anesthetized dogs. Cor Art Dis. 1990;1:363-374.
5. Tsao PS, Aoki N, Lefer DJ, Johnson G III, Lefer AM. Time course of endothelial dysfunction and myocardial injury during myocardial ischemia and reperfusion in the cat. Circulation. 1990;82: 1402-1412.
6. Ma X-L, Weyrich AS, Lefer DJ, Lefer AM. Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium. Circ Res. 1993;72: 403-412.
7. Palmer RMJ, Ferrige AG, Moncada S. Nitric oxide release accounts for biological activity of endothelium-derived relaxing factor. Nature. 1987;327:525-526.
8. Myers PR, Guerra R Jr, Harrison DG. Release of NO and EDRF from cultured bovine aortic endothelial cells. Am J Physiol. 1989; 256:H1030-H1037.
9. De May JG, Vanhoutte PM. Role of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries. J Physiol (Lond). 1981;316:437-455.
10. Furchgott RF. Role of endothelium in responses of vascular smooth muscle. Circ Res. 1983;53:557-573.
11. Tesmafariam B, Halpern W, Osol G. Effects of perfusion and endothelium on the reactivity of isolated resistance arteries. Blood Vessels. 1985;22:301-305.
12. Furlong B, Henderson AM, Lewis MJ, Smith JA. Endothelium-derived relaxing factor inhibits in vitro platelet aggregation. Br J Pharmacol. 1987;90:687-692.
13. McCall T, Whittle BJR, Broughton-Smith NK, Moncada S. Inhibition of FMLP-induced aggregation of rabbit neutrophils by nitric oxide. Br J Pharmacol. 1988;95:617P.
14. Kubes P, Suzuki M, Granger N. Nitric oxide: an endogenous modurator of leukocyte adhesion. Proc Natl Acad Sci U S A. 1991;88:4651-4655.
15. Lefer AM, Tsao PS, Lefer DJ, Ma X-L. Role of endothelial dysfunction in the pathogenesis of reperfusion injury after myocardial ischemia. FASEB J. 1991;5:2029-2034.
16. Nakanishi K, Vinten-Johansen J, Lefer DJ, Fowler WC III, McGee DS, Johnston WE. Intracoronary L-arginine during reperfusion improves endothelial function and reduces infarct size. Am J Physiol. 1992;263:H1650-H1658.
17. Forman MB, Puett DW, Bingham SE, Virmani R, Tantengco MV, Light RT, Ashor B, Price R, Gottlieb F. Preservation of endothelial cell structure and function by intracoronary perflurochemical in a canine preparation of reperfusion. Circulation. 1987; 76:469-479.
18. Mehta JL, Nichols WW, Donnelly WH, Lawson DL, Thompson L, ter Riet M, Saldeen TGP. Protection by Superoxide dismutase from myocardial dysfunction and attenuation of vasodilator reserve after coronary occlusion and reperfusion in the dog. Circ Res. 1989;65:1283-1295.
19. Johnson G, Furlong LE, Aoki N, Lefer AM. Endothelium and myocardial protecting actions of taprostene, a stable prostacyclin analogue, after acute myocardial ischemia and reperfusion injury in cats. Circ Res. 1990;66:1362-1370.
20. Johnson G III, Tsao PS, Lefer AM. Cardioprotective effects of authentic nitric oxide in myocardial ischemia with reperfusion. Crit Care Med. 1991;19:244-252.
21. Eng C, Sangho C, Factor S, Kirk ES. A nonflow basis for the vulnerability of the subendocardium. J Am Coll Cardiol. 1987;9: 374-379.
22. Vinten-Johansen J, Lefer DJ, Nakanishi K, Johnston WE, Brian CA, Cordell AR. Controlled coronary hydrodynamics at the time of reperfusion reduces postischemic injury. Cor Art Dis. 1992;3: 1081-1093.
23. Vinten-Johansen J, Gayheart PA, Johnston WE, Julian JS, Cordell AR. Regional function, blood flow, and oxygen utilization relations in repetitively occluded reperfused canine myocardium. Am J Physiol. 1991;261:H538-H547.
24. Johnston WE, Vinten-Johansen J, Tommasi E. Sodium nitroprusside and PEEP are not detrimental in canine asymmetric pulmonary edema. Crit Care Med. 1989;17:241-246.
25. Nakanishi K, Lefer DJ, Johnston WE, Vinten-Johansen J. Transient hypocalcemia during the initial phase of reperfusion extends myocardial necrosis after 2 hours of coronary occlusion. Cor Art Dis. 1991;2:1009-1021.
26. Tan P, Vinten-Johansen J, Klopfenstein HS. Calculation, processing and graphic analysis of tissue blood flow and oxygen consumption using the radio-labeled microsphere technique. In: Computers in Cardiology. Los Alamitos: IEEE Computer Society Press; 1992:291-293.
27. Toombs CF, McGee DS, Johnston WE, Vinten-Johansen J. Myocardial protective effects of adenosine: infarct size reduction with pretreatment and continued receptor stimulation during ischemia. Circulation. 1992;86:986-994.
28. Rosalki SB. Improved procedure for creatine phosphokinase determination. J Lab Clin Med. 1967;69:969-705.
29. Gornall AG, Bardowill CT, David M. Determination of serum proteins by means of the biuret method. J Biol Chem. 1949;177: 751-766.
30. Bradley PP, Priebat DA, Christensen RD, Rothstein GR. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol. 1982;78: 206-209.
31. Mullane KM, Kraemer R, Smith B. Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium. J Pharmacol Methods. 1985;14:157-167.
32. Lafrado LJ, Olsen RG. Demonstration of depressed polymorphonuclear leukocyte function in non-viremic Felv-infected cats. Cancer Invest. 1986;4:297-300.
33. Yuan Y, Fleming BP. A method for isolation and fluorescent labeling of rat neutrophils for intravital microvascular studies. Microvasc Res. 1990;40:218-229.
34. Holm S. A simple sequentially rejective multiple test procedure. Scand J Stat. 1979;6:65-70.
35. Noak EA, Sandrock K, Hutter J. Sulfhydryl-containing organic nitrates: a new class of nitrovasodilators with direct nitric oxide (NO)-donating properties. In: Moncada S, Marietta MA, Hibbs JB, eds. Biology of Nitric Oxide. London: Portland Press; 1992.
36. Siegfried MR, Erhardt J, Rider T, Ma X-L, Lefer AM. Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusion. J Pharmacol Exp Ther. 1992;260:668-675.
37. Weyrich AS, Ma X-L, Lefer AM. The role of L-arginine in ameliorating reperfusion injury after myocardial ischemia in the cat. Circulation. 1992;86:279-288.
38. Becker LC, Ambrosio G, Manissi J, Weisman HF. The no-reflow phenomenon: a misnomer? In: Sideman S, ed. Analysis and Simulation of the Cardiac System -Ischemia. Boca Raton, Fla: CRC Press; 1989:189-309.
39. Mehta JL, Nichols WW, Mehta P. Neutrophils as potential participants in acute myocardial ischemia: relevance to reperfusion. J Am Coll Cardiol. 1988;11:1309-1316.
40. Lucchesi BR, Werns SW, Fantone JC. The role of neutrophils and free radicals in ischemic myocardial injury. J Mol Cell Cardiol. 1989;21:1241-1251.
41. Engler RL, Schmid-Schonbein GW, Pavelec RS. Leukocyte capillary plugging in myocardial ischemia and reperfusion in the dog. Am J Pathol. 1983;111:98-111.
42. Engler R, Covell JW. Granulocytes cause reperfusion ventricular dysfunction after 15-minute ischemia in the dog. Circ Res. 1987; 61:20-28.
43. Dreyer WJ, Michael LH, West MW, Smith CW, Rothlein R, Rossen RD, Anderson DC, Entman ML. Neutrophil accumulation in ischemic canine myocardium: insights into time course, distribution, and mechanism of localization during early reperfusion. Circulation. 1991;84:400-411.
44. Lucchesi BR. Modulation of leukocyte-mediated myocardial reperfusion injury. Ann Rev Physiol. 1990;52:561-576.
45. Mullane KM. Myocardial ischemia-reperfusion injury: role of neutrophils and neutrophil-derived mediators. In: Marone G, Lichtestein L, Condorelly M, Fauci AS, eds. Human Inflammatory Disease: Clinical Immunology. Toronto: Decker, Inc; 1988:143.
46. Chatelain P, Latour J-G, Tran D, De Lorgeril M, Duras G, Bourassa M. Neutrophil accumulation in experimental myocardial infarcts: relation with extent of injury and effect of reperfusion. Circulation. 1987;75:1083-1090.
47. Allan G, Bhattacherjee P, Brook CD, Read NG, Parke AJ. Myeloperoxidase activity as a quantitative marker of polymorphonuclear leukocyte accumulation into an experimental myocardial infarct: the effect of ibuprofen on infarct size and polymorphonuclear leukocyte accumulation. J Cardiovasc Pharmacol. 1985;7:1154-1160.
48. Romson JL, Hook BG, Kunkel SL, Abrams GD, Schork MA, Lucchesi BR. Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog. Circulation. 1983;67: 1016-1023.
49. Engler RL, Dahlgren MD, Morris D, Peterson MA, Schmid-Schonbein G. Role of leukocytes on the response to acute myocardial ischemia and reflow in dogs. Am J Physiol. 1986;251: H314-H323.
50. Mullane KM, Read N, Salmon JA, Moncada S. Role of leukocytes in acute myocardial infarction in anesthetized dogs: relationship to myocardial salvage by anti-inflammatory drugs. J Pharmacol Exp Ther. 1984;228:510-522.
51. Ma X-L, Tsao PS, Lefer AM. Antibody to CD-18 exerts endothelial and cardiac protective effects in myocardial ischemia and reperfusion. J Clin Invest. 1991;88:1237-1243.
52. Simpson PJ, Todd RF III, Mickelson JK, Fantone JC, Gallagher KP, Lee KA, Tamura Y, Cronin M, Lucchesi BR. Sustained limitation of myocardial reperfusion injury by a monoclonal antibody that alters leukocyte function. Circulation. 1990;81:226-237.
53. Simpson PJ, Todd RF, Fantone JC, Mickelson JK, Griffin JD, Lucchesi BR. Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-Mo1, and anti-CD11b) that inhibits leukocyte adhesion. J Clin Invest. 1988;81: 624-629.
54. Winquist R, Frei P, Harrison P, McFarland M, Letts G, Van G, Andrews L, Rothlein R, Hintze T. An anti-CD-18 Mab limits infarct size in primates following ischemia and reperfusion. Circulation. 1990;82(suppl 3):III-701. Abstract.
55. Simpson PJ, Fantone JC, Mickelson JK, Gallagher KP, Lucchesi BR. Identification of a time window for therapy to reduce experimental canine myocardial injury: suppression of neutrophil activation during 72 hours of reperfusion. Circ Res. 1988;63:1070-1079.
56. Kloner RA, Giacomelli F, Alker KJ, Hale S, Matthews R, Bellows S. Influx of neutrophils into the walls of large epicardial coronary arteries in response to ischemia/reperfusion. Circulation. 1991;84: 1758-1772.
57. Bevilacqua MP, Stengelin S, Gimbrone MA, Seed B. Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science. 1989;243:1160-1165.
58. Harlan JM. Leukocyte-endothelial interactions. Blood. 1985;65-513-525.
59. Forman MB, Virmani R, Puett DW. Mechanisms and therapy of myocardial reperfusion injury. Circulation. 1990;81(suppl 4):IV-69-IV-78.
60. Abrams J. Tolerance to organic nitrates. Circulation. 1986;74: 1181-1185.
61. Lefer DJ, Nakanishi K, Vinten-Johansen J, Ma X-L, Lefer AM. Cardiac venous endothelial dysfunction after myocardial ischemia and reperfusion in dogs. Am J Physiol. 1992;263:H850-H856.
62. Ma X-L, Tsao PS, Viehman GE, Lefer AM. Neutrophil-mediated vasoconstriction and endothelial dysfunction in low-flow perfusion-reperfused cat coronary artery. Circ Res. 1991;69:95-106.
63. Nishida M, Kuzuya T, Hoshida S, Kim Y, Kitabatake A, Kamada T, Tada M. Polymorphonuclear leukocytes induced vasoconstriction in isolated canine coronary arteries. Circ Res. 1990;66: 253-258.
64. Mugge A, Heistad DD, Padgett RC, Waack BJ, Densen P, Lopez JAG. Mechanisms of contraction induced by human leukocytes in normal and atherosclerotic arteries. Circ Res. 1991;69:871-880.
65. Sheridan FM, Dauber IM, McMurtry IF, Lesnefsky EJ, Horwitz LD. Role of leukocytes in coronary vascular endothelial injury due to ischemia and reperfusion. Circ Res. 1991;69:1566-1574.
66. Radi R, Beckman JS, Bush KM, Freeman BA. Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of Superoxide and nitric oxide. Arch Biochem Biophys. 1991;288: 481-487.
67. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA. 1990;87:1620-1624.