The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances

Neuroscience and Biobehavioral Reviews

Volumn 17, Issue 3, 1993, Pages 347-357

  Hardeland, R ^a   Reiter, R J ^a   Poeggeler, B ^a   Tan, D X ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Aging; Carcinogenesis; Free radicals; Indoleamines; Kynuramines; Pineal gland; Psychotogens; Carbolines

Indexed keywords

FREE RADICAL; INDOLE DERIVATIVE; KYNURAMINE; MELATONIN; MELATONIN RECEPTOR; N ACETYLSEROTONIN; SCAVENGER;

AGING; ANTIOXIDANT ACTIVITY; CARCINOGENESIS; HORMONE METABOLISM; METABOLITE; NERVE DEGENERATION; PRIORITY JOURNAL; REVIEW;

ANIMAL; FREE RADICAL SCAVENGERS; HUMAN; HYDROXYL RADICAL; MELATONIN; SUPPORT, U.S. GOV'T, NON-P.H.S.;

EID: 0027429994     PISSN: 01497634     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0149-7634(05)80016-8     Document Type: Article

References (143)

1. 3H]pinoline
2. β-Carbolines, psychoactive compounds in the mammalian body
3. The effect of environmental photoperiodicity on indole rhythms and locomotor activity in sighted and eye covered chickens
4. Role of the pineal gland in seasonal reproductive function in mammals
5. Action of kynuramine in a dinoflagellate: Stimulation of bioluminescence in Gonyaulax polyedra
6. Photoperiodism and effects of indoleamines in a unicellular alga, Gonyaulax polyedra
7. Stimulation of bioluminescence by 5-methoxylated indoleamines in the dinoflagellate, Gonyaulax polyedra
8. Circadian rhythms of indoleamines in a dinoflagellate, Gonyaulax polyedra: Persistence of melatonin rhythm in constant darkness and relationship to 5-methoxytryptamine
9. Methyltetrahydrofolic acid mediates N- and O-methylation of biogenic amines
10. In vivo formation of 5-methoxytryptamine from melatoninin rat
11. 5-Methoxyindoles in pineal gland of cow pig sheep and rat
12. Localization of melatonin in the digestive tract of the rat. Effect of maturation, diurnal variation, melatonin treatment and pinealectomy
13. Retinal melatonin is metabolized within the eye of Xenopus laevis
14. Effects of melatonin on vertebrate circadian systems
15. Pinealectomy increases oubain high-affinity binding sites and dissociation constant in rat cerbral cortex
16. Peroxidative block of glucose utilisation and survival in CNS neuronal cultures
17. Protection of DNA damage by dietary restriction
18. Oxygen radicals and Parkinson's disease
19. The generation of hydrogen peroxide, superoxide radical and hydroxyl radical by 6-hydroxydopamine, dialuric acid and related cytotoxic agents
20. Peroxide-producing potential of tissues: Inverse correlation with longevity of mammalian species
21. The metabolism of 5-methoxytryptophol
22. 125I-Iodomelatonin binding sites in hamster brain membranes: Pharmacological characteristics and regional distribution
23. Serotonin and melatonin synthesis in peripheral mononuclear cells: Stimulation by interferon γ as part of an immunomodulatory pathway
24. Carcinogen-mediated oxidant formation and oxidative DNA damage
25. Structure-activity relationships of melatonin analogues
26. Effects of 5-methoxy-N,N-dimethyltryptamine on central monoamine neurons
27. Day-night rhythm of 5-methoxytryptamine biosyn-thesis in the pineal gland of the golden hamster (Mesocricetus auratus)
28. 3H 5-hydroxytryptamine release by 5-methoxytryptamine
29. Melatonin deacetylation: Retinal vertebrate class distribution and Xenopus laevis tissue distribution
30. Recent advances in the molecular pharmacology of benzodiazepine receptors and in the structure activity relationships of their agonists and antagonists
31. Effect of the pineal gland on circadian rhythmicity of colony forming units for granulocytes and macrophages (CFU-GM) from rat bone marrow cell cultures
32. Hydroxyl radical production and lipid peroxidation parallels selective postischemic vulnurability in gerbil brain
33. Reactive oxygen species and the central nervous system
34. Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts
35. Biologically relevant metal ion-dependent hydroxyl radical generation. An update
36. Evolutionary aspects of circadian rhythmicity and indoleamine-mediated photoperiodism
37. Sleeplatency reducing pineal hormone melatonin as a scavenger of free radicals: Hemin-catalysed formation of N1-acetyl-N2-formyl-5-methoxykynuramine
38. A hypothesis on the evolutionary origins of photoperiodism based on circadian rhythmicity of melatonin in phylogenetically distant organisms
39. Rhythms and physiological significance of indoleamine 2,3-dioxygenase
40. Ageassociated oxygen damage and mutations in mitochondrial DNA in human hearts
41. In vitro and in vivo formation of two new metabolites of melatonin
42. Regulation of melatonin in the Harderian glands of golden hamsters
43. 2
44. Metabolism of exogenous melatonin in schizophrenic and nonschizophrenic volunteers
45. 6-Methoxy-1,2,3,4-tetrahydro-β-carboline in pineal gland of chicken and cock
46. Mass spectrometric identification of 6-methoxy-1,2,3,4-tetrahydro-β-carboline in pineal gland
47. N-Acetyl-5-methoxy-kynurenamine, a brain metabolite of melatonin, is a potent inhibitor of prostaglandin biosynthesis
48. 2-formyl-5-methoxykynurenamine accelerate the reintrainment of the melatonin rhythm following a phase advance of the light-dark cycle
49. Structureactivity studies of melatonin analogues in prepubertal male rats
50. Effects of protein restriction, melatonin administration, and short daylengths on brain benzodiazepine receptors in prepubertal male rats
51. The fate of melatonin in animals
52. Biosignificance of N- and O-methylated indoles to psychiatric disorders
53. Circadian variations in the immunomodulatory role of the pineal gland
54. The metabolism of melatonin (N-acetyl-5-methoxy-tryptamine)
55. Seasonal variations in pineal 5-methoxytryptophol (5-ML) concentrations and in the daily pattern of pineal 5-ML and melatonin in the desert rodent Jaculus orientalis: Effect of prolonged illumination during the night
56. Interactions of benzodiazepines and β-carbolines with a histidine residue of the benzodiazepine receptor
57. Antidepressant-binding sites in brain and platelets
58. 3H-imipramine recognition site
59. 3H]-imipramine recognition site
60. 3H-imipramine recognition site
61. 125I-melatonin
62. 6-Methoxytetrahydro-β-carboline in the retinae of rabbits and pigs
63. Evidence for multiple serotonergic influences on LH release in ovariectomized rats and for modulation of their relative effectiveness by estrogen
64. Melatonin can be differentially metabolised in the rat to produce N-acetyl-serotonin in addition to 6-hydroxy-melatonin
65. An investigation of demethylation in the metabolism of 5-methoxytryptamine and 5-methoxytryptophol
66. Melatonin shifts human circadian rhythms according to a phaseresponse curve
67. Interaction of melatonin with human lymphocytes: Evidence for binding sites coupled to potentiation of cyclic AMP stimulated by vasoactive intestinal peptide and activation of cyclic GMP
68. The biosynthesis of 5-methoxy-N,N-dimethyltryptamine in vitro
69. Inhibition of diazepam binding by tryptophan derivatives including melatonin and its brain metabolite, N-acetyl-5-methoxykynurenamine
70. Melatonin and other indoles in the rodent Harderian glands: Regulation and physiological significance
71. Effects of melatonin and 5-methoxy-tryptamine on sleep-wake patterns in the male rat
72. Both hydroxy- and methoxyindoles modify basal temperature in the rat
73. Pineal gland hydroxyindole-O-methyl transferase from rainbow trout (Salmo gairdneri) subject to temperature-dependent substrate inhibition by N-acetylserotonin
74. Relationships between methoxyindoles and hydroxyindoles formed from 5-hydroxytryptamine in rat pineal gland
75. Pineal 5-methoxytryptophol in man
76. Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress
77. Urinary studies of schizophrenics and controls
78. N,N-Dimethylated indoleamines in blood
79. Effect of melatonin and 5-methoxytrypatmine on sex steroids and thyroid hormones during the prespawning phase of the annual reproductive cycle in the freshwater teleost, Clarias batrachus
80. Inhibitory actions of pineal indoles on steroidogenesis in isolated rat Leydig cells
81. Behavioural and electrocortical spectrum power effects of 5-methoxytryptoline and other analogs after intraventricular administration in rats
82. Histological studies on the effects of pineal 5-methoxyindoles on the reproductive organs of the male golden hamster
83. Distribution and stress-induced increase of glutamate and aspartate levels in discrete brain nuclei of rats
84. Characterization of the structure and reactions of free radicals from serotonin and related indoles
85. The 5-methoxyindoles different from melatonin: Their effects on sexual axis
86. Is 5-methoxytryptamine a pineal hormone?
87. 5-Methoxyindoles, pineal peptides and reproduction
88. The integration of environmental information in mammals: Possible role of 5-methoxytryptamine
89. Circadian rhythmicity of the activity of hydroxyindole-O-methyltransferase (HIOMT) in the formation of melatonin and 5-methoxytryptophol in the pineal retina and Harderian gland of the golden hamster
90. Effect of pinealectomy and a constant high level of circulating melatonin or of 5-methoxytryptamine on the vasopressinergic innervation in the brain of the European hamster (Cricetus cricetus L)
91. Effect of 5-methoxytryptamine on testicular atrophy induced by experimental and natural short photoperiods in the golden hamster
92. Effect of 5-methoxytryptophan and 5-methoxytryptamine on the reproductive system of the male golden hamster
93. The independency of an intact pineal gland of the inhibition by 5-methoxytryptamine of the reproductive organs in the male hamster
94. 5-Methoxytryptamine physiological effects and possible mechanisms of action
95. The pineal gland and aging: The effects of melatonin and pineal grafting on survival of older mice
96. Vergleichende Untersuchungen über Melatonin und strukturverwandte Tryptophanmetabolite. Zur Rolle von Melatonin und 5- Methoxytryptamin bei einem Dinoflagellaten, Gonyaulax polyedra, sowie pinealen und extrapinealen 5-methoxylierten Indolaminen bei Vertebraten
97. Melatonin, hydroxyl radical-mediated oxidative damage and aging: A hypothesis
98. The fluorometric determination of 5-methoxytryptamine in mammalian tissues and fluids
99. The effect of 5-methoxytryptamine on golden hamster gonads is not a consequence of its acetylation into melatonin
100. Low ambient temperature does not affect the pineal concentrations of either 5-methoxytryptamine or melatonin in golden hamsters kept under short photoperiod
101. Effect of different photoperiods on the diurnal rhythm of 5-methoxytryptamine in the pineal gland of golden hamsters (Mesocricetus auratus)
102. Plasma concentrations of 5-methoxytryptamine, 5-methoxytryptophol and melatonin after 5-methoxytryptamine administration of golden hamsters: physiological implications
103. The pineal and its hormones in the control of reproduction in mammals
104. Action spectra, dose-response relationships, and temporal aspects of light's effects on the pineal gland
105. Neuroendocrinology of melatonin
106. The ageing pineal gland and its physiological consequences
107. Relative efficacy of melatonin and 5-methoxytryptamine in terms of their antigonadotrophic and counterantigonadotrophic actions in male Syrian hamsters
108. Antioxidant capacity of melatonin: A novel action not requiring a receptor
109. Solubilization and purification of melatonin receptors from lizard brain
110. Melatonin: Deacetylation to 5-methoxytryptamine by liver but not brain aryl acylaminase
111. Ability of tryptophan derivatives to mimic melatonin's action upon the Syrian hamster reproductive system
112. Melatonin injection into Syrian hamsters
113. Central GABAergic mechanisms as targets for melatonin activity in brain
114. Interaction of putative endogenous tryptolines with the hypothalamic serotoninergic system and prolactin secretion in adult male rats
115. The effect of an hallucinogen, 5-methoxy-N,N-dimethyltryptamine, on primate social behaviour
116. The rate of DNA damage and aging
117. Effect of different photoperiods on concentrations of 5-methoxytryptophol and melatonin in the pineal gland of the Syrian hamster
118. 5-Methoxytrptophol injections in the Syrian hamster. Plasma and pineal concentrations
119. Daily variation in the concentration of melatonin and 5-methoxytryptophol in the human pineal gland: Effect of age and Alzheimer's disease
120. Effects of 6-methoxy-1,2,3,4-tetrahydro-β-carboline and yohimbine on hypothalamic monoamine status and pituitary hormone release in the rat
121. Melatonin binding sites in the central nervous system
122. Melatonin receptors: Current status, facts, and hypotheses
123. Monoamine oxidase, brain ageing anddegenerative diseases
124. Involvement of cysteine, serotonin and their analogues in peroxidase-oxidase reactions
125. Melatonin. A coordinating signal for mammalian reproduction?
126. The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo
127. Effects of 5-methoxy-N,N-dimethyltryptamine on central monoamine neurons
128. Serotonin- and melatonin-dependent light emission induced by xanthine oxidase
129. Isolation, structure, and properties of the β-carboline formed from 5-hydroxytryptamine by the superoxide anion-generating system
130. Circadian rhythms in lizards: Phase response curve for melatonin
131. Presence of immunoreactive melatonin in different tissues of the pigeon (Columba livia)
132. A cyclic isomer of 2-hydroxymelatonin: A novel metabolite of melatonin
133. Age-related differences in synaptosomal peroxidative damage and membrane properties
134. Alterations in nocturnal serum melatonin levels in humans with growth and aging
135. Is Parkinson's disease progressive siderosis of substantia nigra resulting in iron and melanin induced neurodegeneration?
136. The role of monoamine oxidase, iron-melanin interaction, and intracellular calcium in Parkinson's disease
137. Melatonin is metabolized to N-acetyl-serotonin and 6-hydroxymelatonin in man
138. Persistence of circadian rhythms of melatonin and N-acetylserotonin in the serum of rats after pinealectomy
139. A proposal for reconsideration of the role of oxygen free radicals in cell differentiation and aging