메뉴 건너뛰기




Volumn 53, Issue 20, 1993, Pages 4907-4912

Reductive Activation of Mitomycin C by NADH:Cytochrome b5 Reductase

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME B5 REDUCTASE; DICOUMAROL; MITOMYCIN C; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

EID: 0027429970     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (110)

References (45)
  • 1
    • 0021345793 scopus 로고
    • Reductive activation of mitomycin C and mitomycin C metabolites catalyzed by NADPH-cytochrome P-450 reductase and xanthine oxidase
    • Pan, S., Andrews, P. A., Glover, C. J., and Bachur, N. R., Reductive activation of mitomycin C and mitomycin C metabolites catalyzed by NADPH-cytochrome P-450 reductase and xanthine oxidase. J. Biol. Chem., 259: 959-966, 1984.
    • (1984) J. Biol. Chem. , vol.259 , pp. 959-966
    • Pan, S.1    Andrews, P.A.2    Glover, C.J.3    Bachur, N.R.4
  • 2
    • 0022622807 scopus 로고
    • Generation of reactive oxygen radicals through bioactivation of mitomycin antibiotics
    • Pritsos, C. A. and Sartorelli, A. C., Generation of reactive oxygen radicals through bioactivation of mitomycin antibiotics. Cancer Res., 46: 3528-3532, 1986.
    • (1986) Cancer Res. , vol.46 , pp. 3528-3532
    • Pritsos, C.A.1    Sartorelli, A.C.2
  • 3
    • 0026639837 scopus 로고
    • Bioactivation of mitomycin C by xanthine dehydrogenase from EMT6 mouse mammary carcinoma tumors
    • Gustafson, D. L., and Pritsos, C. A. Bioactivation of mitomycin C by xanthine dehydrogenase from EMT6 mouse mammary carcinoma tumors. J. Natl. Cancer Inst., 84: 1180-1185, 1992.
    • (1992) J. Natl. Cancer Inst. , vol.84 , pp. 1180-1185
    • Gustafson, D.L.1    Pritsos, C.A.2
  • 4
    • 0021687360 scopus 로고
    • Role of NADPH: cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C
    • Keyes, S. R., Fracasso, P. M., Heimbrook, D. C., Rockwell, S., Sligar, S. G., and Sartorelli, A. C., Role of NADPH: cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C. Cancer Res., 44: 5638-5643, 1984.
    • (1984) Cancer Res. , vol.44 , pp. 5638-5643
    • Keyes, S.R.1    Fracasso, P.M.2    Heimbrook, D.C.3    Rockwell, S.4    Sligar, S.G.5    Sartorelli, A.C.6
  • 5
    • 0025688249 scopus 로고
    • Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells
    • Siegal, D., Gibson, N. W., Preusch, P. C., and Ross, D. Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells. Cancer Res., 50: 7483-7489, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 7483-7489
    • Siegal, D.1    Gibson, N.W.2    Preusch, P.C.3    Ross, D.4
  • 6
    • 0019349297 scopus 로고
    • Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells
    • Teicher, B. A., Lazo, J. S., and Sartorelli, A. C., Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells. Cancer Res., 41: 73-81, 1981.
    • (1981) Cancer Res. , vol.41 , pp. 73-81
    • Teicher, B.A.1    Lazo, J.S.2    Sartorelli, A.C.3
  • 7
    • 0018852436 scopus 로고
    • Preferential activation of mitomycin C to cytotoxic metabolites by hypoxic tumor cells
    • Kennedy, K. A., Rockwell, S. and Sartorelli, A. C., Preferential activation of mitomycin C to cytotoxic metabolites by hypoxic tumor cells. Cancer Res., 40: 2356-2360, 1980.
    • (1980) Cancer Res. , vol.40 , pp. 2356-2360
    • Kennedy, K.A.1    Rockwell, S.2    Sartorelli, A.C.3
  • 8
    • 0022575753 scopus 로고
    • Regulation of reductive processes by glutathione
    • Reed, D. J., Regulation of reductive processes by glutathione. Biochem. Pharmacol., 35: 7-13, 1986.
    • (1986) Biochem. Pharmacol. , vol.35 , pp. 7-13
    • Reed, D.J.1
  • 9
    • 0021750808 scopus 로고
    • Effects of mitomycin C on metabolism in a rat liver preparation
    • Kimpel, D. L., and Sagone, A. L., Effects of mitomycin C on metabolism in a rat liver preparation. Biochem. Pharmacol., 33: 3479-3484, 1984.
    • (1984) Biochem. Pharmacol. , vol.33 , pp. 3479-3484
    • Kimpel, D.L.1    Sagone, A.L.2
  • 10
    • 0006493790 scopus 로고
    • Mechanistic aspects of mitomycin C activation by flavopro-tein transhydrogenases
    • Fisher, J. and Olsen, R. Mechanistic aspects of mitomycin C activation by flavopro-tein transhydrogenases. Dev. Biochem., 21: 240-243, 1982.
    • (1982) Dev. Biochem. , vol.21 , pp. 240-243
    • Fisher, J.1    Olsen, R.2
  • 11
    • 0022007423 scopus 로고
    • pH dependence of mitomycin C-induced cross-linking activity in EMT6 tumor cells
    • Kennedy, K. A., McGurl, J. D., Leondaridis, L. and Alabaster, O. pH dependence of mitomycin C-induced cross-linking activity in EMT6 tumor cells. Cancer Res., 45: 3541-3547, 1985.
    • (1985) Cancer Res. , vol.45 , pp. 3541-3547
    • Kennedy, K.A.1    McGurl, J.D.2    Leondaridis, L.3    Alabaster, O.4
  • 12
    • 0024475230 scopus 로고
    • Modification of the metabolism and cytotoxicity of bioreductive alkylating agents by dicoumarol in aerobic and hypoxic murine tumor cells
    • Keyes, S. R., Rockwell, S. and Sartorelli, A. C., Modification of the metabolism and cytotoxicity of bioreductive alkylating agents by dicoumarol in aerobic and hypoxic murine tumor cells. Cancer Res., 49: 3310-3313, 1989.
    • (1989) Cancer Res. , vol.49 , pp. 3310-3313
    • Keyes, S.R.1    Rockwell, S.2    Sartorelli, A.C.3
  • 13
    • 0017603563 scopus 로고
    • In vivo-in vitro tumor systems: new models for studying the response of tumors in therapy
    • Rockwell, S. In vivo-in vitro tumor systems: new models for studying the response of tumors in therapy. Lab. Anim. Sci., 27: 831-851, 1977.
    • (1977) Lab. Anim. Sci. , vol.27 , pp. 831-851
    • Rockwell, S.1
  • 14
    • 0015391488 scopus 로고
    • Characteristics of a serially transplanted mouse mammary tumor and its tissue-culture-adapted derivative
    • Rockwell, S., Kallman, R. F., and Fajardo, L. F., Characteristics of a serially transplanted mouse mammary tumor and its tissue-culture-adapted derivative. J. Natl. Cancer Inst., 49: 735-749, 1972.
    • (1972) J. Natl. Cancer Inst. , vol.49 , pp. 735-749
    • Rockwell, S.1    Kallman, R.F.2    Fajardo, L.F.3
  • 15
    • 0015986836 scopus 로고
    • Interrelationships of some chemical, physiochemical, and biological activities of several l-(2-haloethyl)-1-nitrosoureas
    • Wheeler, G. P., Bowdon, B. J., Gremsley, J. A., and Lloyd, H. H., Interrelationships of some chemical, physiochemical, and biological activities of several l-(2-haloethyl)-1-nitrosoureas. Cancer Res., 34: 194-200, 1974.
    • (1974) Cancer Res. , vol.34 , pp. 194-200
    • Wheeler, G.P.1    Bowdon, B.J.2    Gremsley, J.A.3    Lloyd, H.H.4
  • 19
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U. K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.), 227: 680-685, 1970.
    • (1970) Nature (Lond.) , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 21
    • 77957000392 scopus 로고
    • DT-Diaphorase
    • Ernster, L. DT-Diaphorase. Methods Enzymol., 10: 309-317, 1967.
    • (1967) Methods Enzymol. , vol.10 , pp. 309-317
    • Ernster, L.1
  • 22
    • 0008499252 scopus 로고
    • Uncouplers and inhibitors of oxidative phosphorylation
    • In: R.M. Hochster and J.H. Quastel (eds.), New York: Academic Press
    • Slater, E. C., Uncouplers and inhibitors of oxidative phosphorylation. In: R.M. Hochster and J.H. Quastel (eds.), Metabolic Inhibitors, Vol. II, pp. 503-516. New York: Academic Press, 1963.
    • (1963) Metabolic Inhibitors , vol.2 , pp. 503-516
    • Slater, E.C.1
  • 23
    • 0023902264 scopus 로고
    • Therapeutic attack of hypoxic cells of solid tumors: presidential address
    • Sartorelli, A. C., Therapeutic attack of hypoxic cells of solid tumors: presidential address. Cancer Res., 48: 775-778, 1988.
    • (1988) Cancer Res. , vol.48 , pp. 775-778
    • Sartorelli, A.C.1
  • 24
    • 0345508847 scopus 로고
    • Chemotherapeutic approaches to cell populations of tumors
    • In: A. C., Sartorelli, J. S., Lazo, and J.R. Bertino (eds.), New York: Academic Press
    • Kennedy, K. A., Teicher, B. A., Rockwell, S. and Sartorelli, A. C., Chemotherapeutic approaches to cell populations of tumors. In: A. C., Sartorelli, J. S., Lazo, and J.R. Bertino (eds.), Molecular Actions and Targets for Cancer Chemotherapeutic Agents, pp. 85-101. New York: Academic Press, 1981.
    • (1981) Molecular Actions and Targets for Cancer Chemotherapeutic Agents , pp. 85-101
    • Kennedy, K.A.1    Teicher, B.A.2    Rockwell, S.3    Sartorelli, A.C.4
  • 25
    • 0001896852 scopus 로고
    • Potential bioreductive alkylating agents
    • In: A. C. Sartorelli (ed.), Washington, DC: American Chemical Society
    • Lin, A. J., Cosby, L. A., and Sartorelli, A. C., Potential bioreductive alkylating agents. In: A. C. Sartorelli (ed.), Cancer Chemotherapy, pp. 71-86. Washington, DC: American Chemical Society, 1976.
    • (1976) Cancer Chemotherapy , pp. 71-86
    • Lin, A.J.1    Cosby, L.A.2    Sartorelli, A.C.3
  • 26
    • 0023547926 scopus 로고
    • Metabolism and reactions of quinoid anticancer agents
    • Powis, G. Metabolism and reactions of quinoid anticancer agents. Pharmacol. & Ther., 35: 57-162, 1987.
    • (1987) Pharmacol. & Ther. , vol.35 , pp. 57-162
    • Powis, G.1
  • 28
    • 0000231792 scopus 로고
    • Pharmacology of mitomycin C. III. In vitro metabolism by rat liver
    • Schwartz, H. S., Pharmacology of mitomycin C. III. In vitro metabolism by rat liver. J. Pharmacol. Exp. Then, 136: 250-258, 1962.
    • (1962) J. Pharmacol. Exp. Then , vol.136 , pp. 250-258
    • Schwartz, H.S.1
  • 29
    • 0022408368 scopus 로고
    • Effects of glutathione and ethylxanthate on mitomycin C activation by isolated rat hepatic or EMT6 mouse mammary tumor nuclei
    • Kennedy, K. A., Mimnaugh, E. G., Trash, M. A., and Sinha, B. K., Effects of glutathione and ethylxanthate on mitomycin C activation by isolated rat hepatic or EMT6 mouse mammary tumor nuclei. Cancer Res., 45: 4071-4076, 1985.
    • (1985) Cancer Res. , vol.45 , pp. 4071-4076
    • Kennedy, K.A.1    Mimnaugh, E.G.2    Trash, M.A.3    Sinha, B.K.4
  • 30
  • 31
    • 0014667960 scopus 로고
    • One-electron-transfer reactions in biochemical systems. III. One-electron reduction of quinones by microsomal flavin enzymes
    • Iyanagi, T. and Yamazaki, I. One-electron-transfer reactions in biochemical systems. III. One-electron reduction of quinones by microsomal flavin enzymes. Biochim. Biophys. Acta, 172: 370-381, 1969.
    • (1969) Biochim. Biophys. Acta , vol.172 , pp. 370-381
    • Iyanagi, T.1    Yamazaki, I.2
  • 32
    • 0018875204 scopus 로고
    • Relationship of the single-electron reduction potential of quinones to their reduction by flavoproteins
    • Powis, G. and Appel, P. L., Relationship of the single-electron reduction potential of quinones to their reduction by flavoproteins. Biochem. Pharmacol., 29: 2567-2572, 1980.
    • (1980) Biochem. Pharmacol. , vol.29 , pp. 2567-2572
    • Powis, G.1    Appel, P.L.2
  • 33
    • 0019442177 scopus 로고
    • Quinone-stimulated superoxide formation by subcellular fractions, isolated hepatocytes, and other cells
    • Powis, G., Svingen, B. A., and Appel, P. Quinone-stimulated superoxide formation by subcellular fractions, isolated hepatocytes, and other cells. Mol. Pharmacol., 20: 387-394, 1981.
    • (1981) Mol. Pharmacol. , vol.20 , pp. 387-394
    • Powis, G.1    Svingen, B.A.2    Appel, P.3
  • 35
    • 77956936983 scopus 로고
    • Flavin-containing dehydrogenases
    • In: P.D. Boyer (ed.), Ed. 3, New York: Academic Press
    • Williams, C. H., Jr. Flavin-containing dehydrogenases. In: P.D. Boyer (ed.), The Enzymes, Ed. 3, Vol. XIII, pp. 89-173. New York: Academic Press, 1976.
    • (1976) The Enzymes , vol.13 , pp. 89-173
    • Williams, C.H.1
  • 36
    • 0017265763 scopus 로고
    • Studies related to antitumor antibiotics. Part V. Reactions of mitomycin C with DNA examined by ethidium fluorescence assay
    • Lown, J. W., Begleiter, A., Johnson, D. and Morgan, A. R., Studies related to antitumor antibiotics. Part V. Reactions of mitomycin C with DNA examined by ethidium fluorescence assay. Can. J. Biochem., 54: 110-119, 1976.
    • (1976) Can. J. Biochem. , vol.54 , pp. 110-119
    • Lown, J.W.1    Begleiter, A.2    Johnson, D.3    Morgan, A.R.4
  • 37
    • 0000684751 scopus 로고
    • Alkylation reactions of mitomycin C at acid pH.J
    • Tomasz, M. and Lipman, R. Alkylation reactions of mitomycin C at acid pH.J. Am. Chem. Soc., 101: 6063-6067, 1979.
    • (1979) Am. Chem. Soc. , vol.101 , pp. 6063-6067
    • Tomasz, M.1    Lipman, R.2
  • 38
    • 0024328012 scopus 로고
    • Increased sensitivity of quinone resistant cells to mitomycin C
    • Begleiter, A., Robotham, E., Lacey, G. and Leith, M. K., Increased sensitivity of quinone resistant cells to mitomycin C. Cancer Lett., 45: 173-176, 1989.
    • (1989) Cancer Lett. , vol.45 , pp. 173-176
    • Begleiter, A.1    Robotham, E.2    Lacey, G.3    Leith, M.K.4
  • 39
    • 0027052362 scopus 로고
    • Enhancement of xanthine dehydrogenase mediated mitomycin C metabolism by dicumarol
    • Gustafson, D. L., and Pritsos, C. A. Enhancement of xanthine dehydrogenase mediated mitomycin C metabolism by dicumarol. Cancer Res., 52: 6936-6939, 1992.
    • (1992) Cancer Res. , vol.52 , pp. 6936-6939
    • Gustafson, D.L.1    Pritsos, C.A.2
  • 40
    • 0026347496 scopus 로고
    • Cytotoxicity and DNA cross-links produced by mitomycin analogs in aerobic and hypoxic EMT6 cells
    • Keyes, S. R., Loomis, R., DiGiovanna, M. P., Pritsos, C. A., Rockwell, S. and Sartorelli, A. C., Cytotoxicity and DNA cross-links produced by mitomycin analogs in aerobic and hypoxic EMT6 cells. Cancer Commun., 3: 351-356, 1991.
    • (1991) Cancer Commun. , vol.3 , pp. 351-356
    • Keyes, S.R.1    Loomis, R.2    DiGiovanna, M.P.3    Pritsos, C.A.4    Rockwell, S.5    Sartorelli, A.C.6
  • 41
    • 70449221375 scopus 로고
    • Studies of electron transport enzymes. II. Isolation and some properties of a cytochrome-specific reduced diphos-phopyridine nucleotide dehydrogenase from pig liver
    • Mahler, H. R., Raw, I., Molinari, R. and do Amaral, D. F., Studies of electron transport enzymes. II. Isolation and some properties of a cytochrome-specific reduced diphos-phopyridine nucleotide dehydrogenase from pig liver. J. Biol. Chem., 233: 230-239, 1958.
    • (1958) J. Biol. Chem. , vol.233 , pp. 230-239
    • Mahler, H.R.1    Raw, I.2    Molinari, R.3    do Amaral, D.F.4
  • 42
    • 0022532889 scopus 로고
    • Modification of the cytotoxic activity of mitomycin C by oxygen and ascorbic acid in Chinese hamster ovary cells and a repair-deficient mutant
    • Marshall, R. S., and Rauth, A. M., Modification of the cytotoxic activity of mitomycin C by oxygen and ascorbic acid in Chinese hamster ovary cells and a repair-deficient mutant. Cancer Res., 46: 2709-2713, 1986.
    • (1986) Cancer Res. , vol.46 , pp. 2709-2713
    • Marshall, R.S.1    Rauth, A.M.2
  • 43
    • 0025981909 scopus 로고
    • Mechanisms of oxidant-induced changes in erythrocytes
    • Hatherill, J. R., Till, G. O., and Ward, P. A., Mechanisms of oxidant-induced changes in erythrocytes. Agents Actions, 32: 351-358, 1991.
    • (1991) Agents Actions , vol.32 , pp. 351-358
    • Hatherill, J.R.1    Till, G.O.2    Ward, P.A.3
  • 45
    • 0023122747 scopus 로고
    • Mitomycin C-induced hemolytic uremic syndrome. Six case reports and review of the literature on renal, pulmonary, and cardiac side effects of the drag
    • Verweij, J. van der Burg, M.E.L. and Pinedo, H. M., Mitomycin C-induced hemolytic uremic syndrome. Six case reports and review of the literature on renal, pulmonary, and cardiac side effects of the drag. Radiother. Oncol., 8: 33-41, 1987.
    • (1987) Radiother. Oncol. , vol.8 , pp. 33-41
    • Verweij, J.1    van der Burg, M.E.L.2    Pinedo, H.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.