Insulin receptor tyrosine kinase activity is reduced in monocytes from non-obese normoglycaemic insulin-resistant subjects

Diabetologia

Volumn 36, Issue 11, 1993, Pages 1163-1167

  Frittitta, L ^a   Grasso, G ^a   Munguira, M E ^a   Vigneri, R ^a   Trischitta, V ^a,b  

^a UNIVERSITY OF CATANIA   (Italy)

^b GARIBALDI HOSPITAL   (Italy)

Author keywords

human monocytes; Insulin receptor; insulin resistance; internalization; tyrosine kinase

Indexed keywords

INSULIN RECEPTOR; PROTEIN TYROSINE KINASE;

ADULT; ARTICLE; FEMALE; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; MONOCYTE; PRIORITY JOURNAL;

ADULT; ANALYSIS OF VARIANCE; BLOOD GLUCOSE; FEMALE; HUMAN; INSULIN; INSULIN RESISTANCE; KINETICS; MALE; MONOCYTES; RECEPTOR, INSULIN; REFERENCE VALUES;

EID: 0027429574     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/BF00401061     Document Type: Article

References (20)

1. Banting Lecture: role of insulin resistance in human disease
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5. Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes
6. Defective insulin receptor tyrosine-kinase in human skeletal muscle in obesity and type 2 (non-insulin-dependent) diabetes mellitus
7. Relationship of insulin binding and insulin-stimulated tyrosine-kinase activity is altered in type II diabetes
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11. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance
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15. Relationship between insulin receptor tyrosine-kinase activity and internalization in monocytes of NIDDM patients
16. Insulin-stimulated glucose transport in circulating mononuclear cells from nondiabetic and IDDM subjects
17. Defect insulin receptor kinase activation in skeletal muscle in young non-obese first degree relatives of patients with NIDDM
18. Mutations in the insulin receptor gene
19. Alterations in the tyrosine kinase activity of the insulin receptor produced by in vitro hyperinsulinemia
20. Defective insulin receptor function in down-regulated HEpG2 cells