The effect of antioxidant supplementation on a serum marker of free radical activity and abnormal serum biochemistry in alcoholic patients admitted for detoxification

Journal of Hepatology

Volumn 19, Issue 1, 1993, Pages 105-109

  Butcher, Graham P ^a   Rhodes, Johnathan M ^a   Walker, Robin ^b   Krasner, Neville ^b   Jackson, Malcolm J ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b WALTON HOSPITAL   (United Kingdom)

Author keywords

Alcohol; Alpha tocopherol; Antioxidant; Ascorbic acid; Beta carotene; Diene conjugate; Free radical

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; BETA CAROTENE; LINOLEIC ACID; PLACEBO; SELENIUM;

ADULT; AGED; ALCOHOLISM; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DETOXIFICATION; FEMALE; HUMAN; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ADULT; AGED; ANTIOXIDANTS; ASCORBIC ACID; BETA CAROTENE; BIOLOGICAL MARKERS; CAROTENOIDS; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; ETHANOL; FEMALE; FREE RADICALS; HEMATOLOGIC TESTS; HUMAN; LIVER DISEASES, ALCOHOLIC; MALE; MIDDLE AGE; SELENIUM; SUBSTANCE WITHDRAWAL SYNDROME; SUPPORT, NON-U.S. GOV'T; VITAMIN E;

EID: 0027424998     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(05)80183-7     Document Type: Article

References (31)

1. Could superoxide cause cirrhosis?
2. Increased free radical activity in alcoholics
3. Depressed hepatic glutathione and increased diene conjugates in alcoholic liver disease
4. Radiation and hydrogen peroxide induced free radical damage to DNA
5. Protein denaturation by hydrogen peroxide
6. A method for the measurement of a diene-conjugated derivative of linoleic acid, 18:2 (9,11), in serum phospholipid and possible origins
7. The effect of dimethylsulphoxide and other hydroxyl radical scavengers on the oxidation of ethanol by rat liver microsomes
8. NADPH production of oxy radicals by purified components of the rat liver mixed-function oxidase system. Role in microsomal oxidation of ethanol
9. Increased microsomal oxidation of hydroxyl radical scavenging agents and ethanol after chronic consumption of ethanol
10. Respective role of superoxide and hydroxyl radical in the activity of the reconstituted microsomal ethanol oxidising system
11. The relative contribution of vitamin E urate ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma
12. Decreased hepatic selenium content in alcoholic cirrhosis
13. Plasma selenium levels in alcoholic liver disease and primary biliary cirrhosis
14. The relation of diet cigarette smoking and alcohol consumption to plasma beta carotene and alpha tocopherol levels
15. A mild rapid efficient method of lipid extraction for use in determining vitamin E/lipid ratios
16. Increased microsomal oxidation of hydroxyl radical scavenging agents and ethanol after chronic consumption of ethanol
17. Hepatic iron stores and markers of iron overload in alcoholics and patients with idiopathic haemochromatosis
18. Protein denaturation by hydrogen peroxide
19. Radiation and hydrogen peroxide induced free radical damage to DNA
20. Is vitamin E the only lipid soluble chain breaking antioxidant in human blood plasma and erythrocyte membranes?
21. Beta carotene — An unusual type of lipid antioxidant
22. Antioxidant action of carotenoids
23. Regeneration of vitamin E from α-chromanoxy radical by glutathione and vitamin C
24. 3-O alkylascorbic acids as free radical quenchers: synthesis and inhibitory effect on lipid peroxidation
25. Novel 21-aminosteroids that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma
26. Biohydrogenation of unsaturated fatty acids