Human Urinary Trypsin Inhibitor, Urinastatin, Prevents Pancreatic Injuries Induced by Pancreaticobiliary Duct Obstruction With Cerulein Stimulation and Systemic Hypotension in the Rat

Archives of Surgery

Volumn 128, Issue 12, 1993, Pages 1322-1329

  Hirano, Tetsuya ^a   Manabe, Tadao ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CERULETIDE; TRYPSIN; ULINASTATIN;

ACUTE PANCREATITIS; ANIMAL MODEL; ARTICLE; DRUG EFFECT; DRUG MECHANISM; HYPOTENSION; NONHUMAN; PANCREAS DUCT; PANCREAS DUCT STENOSIS; PANCREAS INJURY; PRIORITY JOURNAL; RAT;

ACUTE DISEASE; ADENOSINE DIPHOSPHATE; ADENOSINE MONOPHOSPHATE; ADENOSINE TRIPHOSPHATE; AMYLASES; ANIMAL; CAERULEIN; CATHEPSIN B; CHOLESTASIS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; GLYCOPROTEINS; HYPOTENSION; INFUSIONS, INTRAVENOUS; MALATE DEHYDROGENASE; MALE; PANCREATITIS; RATS; RATS, WISTAR; SUPPORT, NON-U.S. GOV'T; TRYPSIN; TRYPSIN INHIBITORS;

EID: 0027421998     PISSN: 00040010     EISSN: 15383644     Source Type: Journal    
DOI: 10.1001/archsurg.1993.01420240030004     Document Type: Article

References (35)

1. Ohshio G. Saluja A, Steer ML. Effects of short-term pancreatic duct obstruction. Gastroenterology. 1991;100:196-202.
2. Hirano T, Manabe T, Tobe T. Changes of acinar cells in the pancreatico-biliary duct ligation with exocrine pancreatic stimulation model in rats: protective effects of a new potent protease inhibitor, ONO3307. Arch Jpn Chir. 1991;60: 342-353.
3. Hirano T, Saluja A, Ramarao P, Lerch MM, Steer ML. Apical secretion of lysosomal enzymes in rabbit pancreas occurs via a secretagogue-regulated pathway and is increased after pancreatic duct obstruction. J Clin Invest. 1991; 87:865-869.
4. Printz H, Saluja A, Leli U, Sengupta A, Steer M. Effects of hemorrhagic shock, aspirin, and ethanol on secretagogue-induced experimental pancreatitis. Int J Pancreatol. 1990;6:207-217.
5. Saluja A, Hashimoto S, Saluja M, Powers RE, Meldolesi J, Steer ML. Subcellular redistribution of lysosomal enzymes during caerulein supramaximal stimulation. Am J Physiol. 1987;253:G508-G516.
6. Ohshio G, Saluja A, Leli U, Sengputa A, Steer ML. Esterase inhibitors prevent lysosomal enzyme redistribution in two noninvasive models of experimental pancreatitis. Gastroenterology. 1989;96:853-859.
7. Steer ML, Meldolesi J. The cell biology of experimental pancreatitis. N Engl J Med. 1987;316:144-150.
8. Greenbaum LM, Hirshkowitz A, Schoichet I. The activation of trypsinogen by cathepsin B. J Biol Chem. 1959;234:2885-2890.
9. Rinderknecht H. Activation of pancreatic zymogens: normal activation, premature intrapancreatic activation, protective mechanism against inappropriate activation. Dig Dis Sci. 1986;31:314-321.
10. Hirano T, Manabe T, Tobe T. Protection by gabexate mesilate (FOY) of the exocrine pancreas in rats with acute pancreatitis induced by a supramaximal dose of caerulein. J Gastroenterol Hepatol. 1991;6:260-264.
11. Hirano T, Manabe T, Tobe T. Protective effects of gabexate mesilate (FOY) against impaired pancreatic energy metabolism in rat acute pancreatitis induced by caerulein. Life Sci. 1991;49:PL-179–PL-184.
12. Faarvang HJ, Knudesn PJ. Hyaluronidase inhibitor and trypsin inhibitor in preparations from human urine. Proc Soc Exp Biol Med. 1961;108:591-592.
13. Sumi H, Takada H, Takada A. Studies on human urinary trypsin inhibitor, I: its modification on treatment of urine with acid. Thromb Res. 1977;1:747-754.
14. Faarvang HJ. Urinary trypsin inhibitor in man. Scand J Clin Lab Invest. 1965; 17:1-78.
15. Bauer J, Reich Z. Uber die antitryptische Wirkung des Harns. Med Klin. 1969; 46:1744-1747.
16. Shikimi T, Hanada M. Inhibitory effect of human urinary trypsin inhibitor (urinastatin) on lysosomal thiol proteinases. Jpn J Pharmacol. 1986;42:571-574.
17. Oda T, Miyawaki T, Sameshima T, Miyao J. Antishock effects of urinary trypsin inhibitor, MR-20. Anesthesiology. 1984;33:137-142.
18. Hirano T, Manabe T, Tobe T. Pancreatic lysosomal enzyme secretion is changed by hepatectomy in rats. Scand J Gastroenterol. 1990;25:1274-1280.
19. Hirano T, Manabe T, Tobe T. Changes of lysosomal enzyme and fragility of pancreatic acinar cells in hepatectomized rats. J Jpn Surg Soc. 1991;92:175-180.
20. Atkinson DE. The energy charge of the adenylate pool as a regulatory parameter. Biochemistry. 1966;7:4030-4034.
21. Irie A, Hunaki M, Bando K, Kawai K. Activation of α-amylase in urine. Clin Chem Acta. 1974;51:241-245.
22. McDonald JK, Ellis S. On the substrate specificity of cathepsin B1 and B2 including a new fluorogenic substrate for cathepsin B1. Life Sci. 1975;17:1269-1276.
23. Bergmeyer HU. Malate dehydrogenase. In: Bergmeyer HU, ed. Methods of Enzymatic Analysis. Orlando, Fla: Academic Press Inc; 1971:485-486.
24. Labarca C, Paigen K. A simple, rapid and sensitive DNA assay procedure. Anal Biochem. 1980;102:334-352.
25. Hummel BC. A modified spectrophotometric determination of chymotrypsin, trypsin and thrombin. Can J Biochem. 1959:37:1393-1399.
26. Lamprecht W, Trautschold I. Adenosine-5′-triphosphate: determination with hexokinase and glucose-6-phosphate. In: Bergmeyer HU, ed. Methods of Enzymatic Analysis. Orlando, Fla: Academic Press Inc; 1974:2101-2110.
27. Jaworek D, Gruber W, Bergmeyer HU. Adenosine-5′-diphosphate and adenosine-5′-monophosphate, I. In: Bergmeyer HU, ed. Methods of Enzymatic Analysis. Orlando, Fla: Academic Press Inc; 1974:2127-2129.
28. Weiss NA, Hassett MJ. Analysis of variance. In: Introductory Statistics. 2nd ed. Reading, Mass: Addison-Wesley Publishing Co; 1987:565-595.
29. Bartz AE. The Tukey method. In: Basic Statistical Concepts. 3rd ed. New York, NY: Macmillan Publishing Co Inc; 1988:294-296.
30. Opie EL. The etiology of acute hemorrhagic pancreatitis. Bull Johns Hopkins Hosp. 1901;12:182-188.
31. Broe P, Zuidema G, Cameron J. The role of ischemia in acute pancreatitis: studies with an isolated perfused canine pancreas. Surgery. 1982;91:377-382.
32. Sanfey H, Bulkley G, Cameron J. The role of oxygen-derived free radicals in the pathogenesis of acute pancreatitis. Ann Surg. 1984;200:405-413.
33. Geokas MC, Murphy DR, McKenna RD. The role of elastase in acute pancreatitis. Arch Pathol. 1968;86:117-126.
34. Trapnell JE. Pathophysiology of acute pancreatitis. World J Surg. 1981;5:319-327.
35. Büchler M, Malferttheiner P, UhI W, et al. The German multicenter double-blind randomized study of gabexate mesilate (4 g/day i.v.) in acute pancreatitis. Gastroenterology. 1990;98:A214.