Role of the p53 Iimor Suppressor Gene in Cell Cycle Arrest and Radiosensitivity of Burkitt's Lymphoma Cell Line

Cancer Research

Volumn 53, Issue 20, 1993, Pages 4776-4780

  O'Connor, Patrick M ^a   Jackman, Joany ^a   Jondle, Daniel ^a   Bhatia, Kishor ^a   Magrath, Ian ^a   Kohn, Kurt W ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BURKITT LYMPHOMA; CANCER GENETICS; CELL CYCLE; CELL CYCLE G2 PHASE; CELL DEATH; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN CELL; IONIZING RADIATION; PRIORITY JOURNAL; RADIATION DOSE; RADIOSENSITIVITY; SUPPRESSOR GENE;

BURKITT LYMPHOMA; CELL CYCLE; CELL LINE; CELL SURVIVAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLOW CYTOMETRY; G1 PHASE; GAMMA RAYS; GENES, P53; HUMAN; PROTEIN P53; TUMOR CELLS, CULTURED;

EID: 0027421045     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Hollstein, M., Sidransky, D., Vogelstein, B., and Harris, C. C. p53 mutations in human cancers. Science (Washington DC), 253: 49-52, 1991.
2. Vogelstein, B., and Kinzler, K. W. p53 function and dysfunction. Cell, 70: 523-526, 1992.
3. Levine, A., Momand, J., and Finlay, C. A. The p53 tumor suppressor gene. Nature (Lond.), 351: 453-456, 1991.
4. El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W. and Vogelstein, B. Definition of a consensus binding site for p53. Nat. Gen., 1: 45-49, 1992.
5. Funk, W. D., Pak, D. T., Karas, R. H., Wright, W. E. and Shay, J. W A transcriptionally active DNA-binding site for human p53 protein complexes. Mol. Cell. Biol., 12: 2866-2871, 1992.
6. Mack, D. H., Vartikar, J., Pipas, J. M. and Laimins, L. A. Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53. Nature (Lond.), 363: 281-283, 1993.
7. Xiangwei, Wu. Bayle, J. H., Olson, D., and Levine, A. J. The p53-mdm-2 autoregu-latory feedback loop. Genes & Dev., 7: 1126-1132, 1993.
8. Fornace, A. J. Jr. Alamo, I. Jr. and Hollander, M. C. DNA damage-inducible transcripts in mammalian cells. Proc. Natl. Acad. Sci. USA, 85: 8800-8804, 1988.
9. Kastan, M. B., Zhan, Q. El-Deiry, W S., Carrier, R., Jacks, T., Walsh, W. V., Plunkett, B., Vogelstein, B., and Fornace, A. J. Jr. A mammalian cell cycle checkpoint utilizing p53 and GADD45 is defective in ataxia telangiectasia. Cell, 71: 587-597, 1992.
10. Hainaut, P., and Milner, J. A structural role for metal ions in the “wild-type” conformation of the tumor suppressor protein p53. Cancer Res., 53: 1739-1742, 1993.
11. Milner, J., and Medcalf, E. A. Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation. Cell, 65: 765-774, 1991.
12. Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A. Jr. Butel, J. S. and Bradley, A. Mice deficient for p53 are developmental normal but susceptible to spontaneous tumors. Nature (Lond.), 356: 215-221, 1992.
13. Laviguer, A., Maltby, V., Mock, D., Rossant, J., Pawson, T., and Bernstein, A. High incidence of lung, bone and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene. Mol. Cell. Biol., 9: 3982-3991, 1989.
14. Malkin, D., Li, F. P., Strong, L. C., Fraumeni, J. F. Jr. Nelson, C. E., Kim, D. H., Kassel, J., Gryka, M. A., Bischoff, F. Z., Tainsky, M. A. and Friend, S. H. Germ line p53 mutations in a familial syndrome of breast cancer, sarcoma's and other neoplasms. Science (Washington DC), 250: 1233-1238, 1990.
15. Srivastava, S., Zou, Z., Pirollo, K., Blattner, W., and Chang, E. H. Germ-line transmission of a cancer-prone family with Li-Fraumeni syndrome. Nature (Lond.), 348: 141-14% 1990.
16. Michalovitz, D., Halevy, O., and Oren, M. Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53. Cell, 62: 671-680, 1990.
17. Kastan, M. B., Onyekwere, O., Sidransky, D., Vogelstein, B., and Craig, R. W. Participation of p53 in the cellular response to DNA damage. Cancer Res., 51: 6304-6311, 1992.
18. Kuerbitz, S. J., Plunkett, B. S., Walsh, W. V. and Kastan, M. B. Wild-type p53 is a cell cycle checkpoint determinant following radiation. Proc. Natl. Acad. Sci. USA, 89: 7491-7495, 1992.
19. Weinert, T. A. and Hartwell, L. Characterization of RAD9 of Saccharomyces cer-evisiae and evidence that its function acts post-translationally in cell cycle arrest after DNA damage. Mol. Cell. Biol., 10: 6554-6564, 1990.
20. Livingstone, L. R., White, A., Sprouse, J., Livanos, E., Jacks, T., and Tlsty, T. D. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell, 70: 923-935, 1992.
21. Fingert, H. J., Chang, J. D. and Pardee, A. B., Cytotoxic, cell cycle and chromosomal effects of methylxanthines in human tumor cells treated with alkylating agents. Cancer Res., 46: 2463-2467, 1986.
22. O'Connor, P. M., Ferris, D. K., Pagano, M., Draetta, G., Pines, J., Hunter, T., Longo, D. L. and Kohn, K. W. G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin Bl/cdc2-kinase complexes differently. J. Biol. Chem., 268: 8298-8308, 1993.
23. Bhatia, K., Goldschmidts, W., Gutterrez, M., Gaidano, G. Dalla-Favera, R., and Magrath, I. Hemi- or homozygosity: a requirement for some but not other p53 mutant proteins to accumulate and exert a pathogenic event. FASEB J., 7: 951-956, 1993.
24. O'Connor, P. M., Wassermann, K., Sarang, M., Magrath, I., Bohr, V. A. and Kohn, K. W. Relationship between DNA crosslinks, cell cycle and apoptosis in Burkitt's lymphoma cell lines differing in sensitivity to nitrogen mustard. Cancer Res., 51: 6550-6557, 1991.
25. Kessis, T., Slebos, R. J., Nelson, W. G., Kastan, M. B., Plunkett, B. S., Han, S. M., Lorincz, A. T., Hedrick, L., and Cho, K. R. Human papillomavirus 16 E6 expression disrupts the p53 mediated cellular response to DNA damage. Proc. Natl. Acad. Sci. USA, 90: 3988-3992, 1993.
26. Maltzman, W., and Czyzyk, L. UV irradiation stimulates levels of p53 cellular antigen in nontransformed mouse cells. Mol. Cell. Biol., 4: 1689-1694, 1984.
27. Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A. and Jacks, T., p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature (Lond.), 362: 847-849, 1993.
28. Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L. and Wyllie, A. H. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature (Lond.), 362: 849-852, 1993.
29. Wang, Y., Ramqvist, T., Szekely, L., Axelson, H., Klein, G., and Wiman, K. G. Reconstitution of wild-type p53 expression triggers apoptosis in ap. 3-negative v-myc retrovirus-induced T-cell lymphoma line. Cell Growth & Differ., 4: 467-473, 1993.
30. Magrath, I. The pathogenesis of Burkitt's lymphoma. Adv. Cancer Res., 5: 133-270, 1990.