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Volumn 29, Issue 1, 1993, Pages 3-14

Anticancer drug screening and discovery in the 1990s: a European perspective

(2)  Schwartsmann, G a   Workman, P a  

a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT;

EID: 0027420205     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/0959-8049(93)90567-Y     Document Type: Note
Times cited : (17)

References (126)
  • 4
    • 0025111606 scopus 로고
    • Current Status of cancer drug development: Failure or limited success?
    • (1990) Cancer Cells , vol.2 , pp. 163-171
    • Grindley1
  • 8
    • 13344262221 scopus 로고
    • Drug evaluation in experimental tumour systems: Potential and limitations in 1961
    • (1962) Cancer Chemother Rep , vol.2 , pp. 11-19
    • Skipper1
  • 11
    • 0019274431 scopus 로고
    • Progress report on the screening program at the Division of Cancer Treatment, National Cancer Institute
    • (1980) Cancer Treat Rev , vol.7 , pp. 167-176
    • Goldin1    Venditti2
  • 13
  • 15
    • 84965822602 scopus 로고
    • Feasibility of drug screening with panels of human tumor cell lines using a microculture tetraolium assay
    • (1988) Cancer Res , vol.48 , pp. 589-601
    • Alley1    Scudiero2    Monks3
  • 17
    • 0025248103 scopus 로고
    • Some marine ecological phenomena: Chemical basis and biomedical potential
    • (1990) Science , vol.248 , pp. 173-177
    • Scheuer1
  • 19
    • 0025367455 scopus 로고
    • Comparison of in vitro anticancer drug screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines
    • (1990) J Natl Cancer Inst , vol.82 , pp. 1113-1118
    • Rubinstein1    Shoemaker2    Paull3
  • 20
    • 0024312538 scopus 로고
    • Display and analysis of patterns of differential activity of drugs against human tumour cell lines: Development of mean graph and COMPARE algorithm
    • (1989) J Natl Cancer Inst , vol.81 , pp. 1088-1092
    • Paull1    Shoemaker2    Hodes3
  • 21
  • 22
  • 23
    • 0024346209 scopus 로고
    • Association of DNA cross-linking with potentiation of the morpholino derivative of doxorubicin by human liver microsomes
    • (1989) J Natl Cancer Inst , vol.81 , pp. 1034-1038
    • Lau1    Lewis2    Sikic3
  • 25
    • 0025893246 scopus 로고
    • The role of NAD(P)H: Quinone reductase (EC 1.6.99.2, DT-diaphorase) in the reductive bioactivation of the novel indoloquinone antitumor agent EO9
    • (1991) Cancer Comm , vol.3 , pp. 199-206
    • Walton1    Smith2    Workman3
  • 31
    • 0025062388 scopus 로고
    • He's not going to talk about in vitro predictive assays again, is he?
    • (1990) J Natl Cancer Inst , vol.82 , pp. 96-101
    • Von Hoff1
  • 32
  • 34
    • 84969017306 scopus 로고
    • Chloroquinoxaline sulfonamide: A Phase I study of a unique agent with preclinical and clinical activity in non-small cell lung cancer
    • (1991) Proc Am Assoc Cancer Res , vol.10 , pp. A918
    • Rigas1    Tong2    Kris3
  • 37
    • 0020543018 scopus 로고
    • Clinical productivity of transplantable tumor systems in the selection of new drugs for solid tumors: Rationale for a three-stage strategy
    • (1983) Cancer Treat Rep , vol.67 , pp. 753-765
    • Staquet1    Byar2    Green3    Rozencweig4
  • 39
    • 0019846038 scopus 로고
    • Human tumor xenografts in athymic nude mice as a preclinical screen for anticancer agents
    • (1981) Semin Oncol , vol.8 , pp. 386-393
    • Ovejera1    Houchens2
  • 43
    • 84908822366 scopus 로고
    • New anticancer drug development: Results of a five-year cooperative program between the EORTC-NDDO and the Freiburg preclinical anticancer drug development group
    • (1992) Annal Oncol , vol.3 , pp. 106
    • Berger1    Winterhalter2    Dengler3
  • 46
    • 0024346207 scopus 로고
    • Therapeutic index: A vital component in selection of anticancer agents for clinical trial
    • (1989) J Natl Cancer Inst , vol.81 , pp. 988-994
    • Double1    Bibby2
  • 47
    • 0026569989 scopus 로고
    • Selectivity and potency; Are we doing the right things to find anti-cancer agents with these properties?
    • (1992) Br J Cancer , vol.65 , pp. 143-144
    • Double1
  • 48
    • 0021795414 scopus 로고
    • Experimental antitumour activity against murine model systems of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (mitozolomide), a novel broad spectrum agent
    • (1985) Cancer Res , vol.45 , pp. 3008-3013
    • Hickman1    Stevens2    Gibson3
  • 49
    • 0023605735 scopus 로고
    • Antitumour activity and pharmacokinetics in mice of 8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine
    • (1987) Cancer Res , vol.47 , pp. 5846-5852
    • Stevens1    Hickman2    Langdon3
  • 51
    • 0025195404 scopus 로고
    • 6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating, carcinogenic and therapeutic agents
    • (1990) Cancer Res , vol.50 , pp. 6119-6129
    • Pegg1
  • 53
    • 0026089375 scopus 로고
    • Tumor-dependent increased plasma nitrate concentrations as an indication of the antitumour effect of flavone-8-acetic acid and analogs in mice
    • (1991) Cancer Res , vol.51 , pp. 77-81
    • Thomsen1    Ching2    Zhuang3    Gavin4    Baguley5
  • 54
    • 0024365556 scopus 로고
    • Identification of anthracyclines and related agents that retain preferential activity over adriamycin in multidrug resistant cell lines, and further resistance modification by verapamil and cyclosporin A
    • (1989) Cancer Chemother Pharmacol , vol.24 , pp. 284-290
    • Coley1    Twentyman2    Workman3
  • 56
    • 0026030442 scopus 로고
    • Retention of activity by selected anthracyclines in a multidrug resistant human large cell lung carcinoma line without P-glycoprotein hyperexpression
    • (1991) Br J Cancer , vol.63 , pp. 351-357
    • Coley1    Twentymann2    Workman3
  • 57
    • 0026553237 scopus 로고
    • In vivo antitumour activity of FCE 23762, a methoxymorpholinyl derivative of doxorubicin active on doxorubicin-resistant tumour cells
    • (1992) Br J Cancer , vol.65 , pp. 703-707
    • Ripamonti1    Pezzoni2    Pesenti3
  • 58
    • 0025871969 scopus 로고
    • The role of murine tumour models and their acquired platinum-resistant counterparts in the evaluation of novel platinum antitumour agents: A cautionary note
    • (1991) Annal Oncol , vol.2 , pp. 535-540
    • Goddard1    Valenti2    Harrap3
  • 59
    • 84908852433 scopus 로고    scopus 로고
    • Cancer Research Campaign Clinical Trials Committee Brochure.
  • 61
  • 62
    • 0022471541 scopus 로고
    • Treatment of advanced postmenopausal breast cancer with an aromatase inhibitor,4-hydroxyandrostenedione: Phase II report
    • (1986) Cancer Res , vol.46 , pp. 4823-4826
    • Goss1    Powles2    Dowsett3
  • 64
    • 0026316096 scopus 로고
    • Growth factors and cancer
    • (1991) Science , vol.254 , pp. 1146-1153
    • Aaranson1
  • 65
    • 0026337295 scopus 로고
    • Tumor suppressor genes
    • (1991) Science , vol.254 , pp. 1138-1146
    • Weinberg1
  • 66
    • 0025728353 scopus 로고
    • Signalling targets for anticancer drug development
    • (1991) Trends Pharm Sci , vol.12 , pp. 188-194
    • Powis1
  • 68
    • 0025366920 scopus 로고
    • The cell membrane and cell signals: new targets for novel anticancer drugs
    • (1990) Annals Oncol , vol.1 , pp. 100-111
    • Workman1
  • 70
    • 0023145547 scopus 로고
    • The molecular genetics of cancer
    • (1987) Science , vol.235 , pp. 305-311
    • Bishop1
  • 71
    • 0023651349 scopus 로고
    • A thousand and one protein kinases
    • (1987) Cell , vol.50 , pp. 823-829
    • Hunter1
  • 72
  • 77
    • 11944264245 scopus 로고
    • Potent and specific inhibitors of protein kinase C of microbial origin
    • (1990) Biotechnology , vol.8 , pp. 732-735
    • Tamaoki1    Nakano2
  • 80
    • 0025861450 scopus 로고
    • Antitumour ether lipids. Membrane-interactive lipids as experimental anticancer drugs
    • (1991) Br J Cancer , vol.64 , pp. 208-211
    • Berdel1
  • 81
    • 0025952954 scopus 로고
    • Selective inhibition of isoprenylation of 21–26KDa proteins by the anticarcinogen d-limonene and its metabolites
    • (1991) J Biol Chem , vol.266 , pp. 17679-17685
    • Crowell1    Chang2    Ren3    Elson4    Gould5
  • 82
    • 0026690842 scopus 로고
    • Signal transduction through small GTPases—a tale of two GAPs
    • (1992) Cell , vol.69 , pp. 389-391
    • Hall1
  • 88
    • 0026079112 scopus 로고
    • Selective DNA interaction of the novel distamycin derivative FCE 24517
    • (1991) Cancer Res , vol.51 , pp. 199-204
    • Broggini1    Erba2    Ponti3
  • 89
    • 0026718016 scopus 로고
    • Designed enediynes: A new class of DNA-cleaving molecules with potent and selective anticancer activity
    • (1992) Science , vol.256 , pp. 1172-1178
    • Nicolaou1    Dai2    Tsay3    Estavez4    Wrasidlo5
  • 91
    • 0025344948 scopus 로고
    • How to kill cancer cells: Membranes and cell signaling as targets in cancer chemotherapy
    • (1990) Cancer Cells , vol.2 , pp. 95-105
    • Tritton1    Hickman2
  • 92
    • 0027109075 scopus 로고
    • p53, Guardian of the genome
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane1
  • 93
    • 0023910405 scopus 로고
    • Hypoxia in tumors: A paradigm for the approach to biochemical and physiologic heterogeneity
    • (1988) J Natl Cancer Inst , vol.80 , pp. 310-317
    • Coleman1
  • 95
    • 84908852432 scopus 로고    scopus 로고
    • Hendriks H, Pizao PE, Berger DP, et al. EO9, a novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bone marrow toxicity in preclinical models. Eur J Cancer (in press).
  • 97
    • 0025023154 scopus 로고
    • Synthesis and evaluation of .alpha.-[[(2-haloethyl)amino]methyl]-2-nitro-1H-imidazole-1-ethanols as prodrugs of .alpha.-[(1-aziridinyl)methyl]-2-nitro-1H-imidazole-1-ethanol (RSU-1069) and its analogs which are radiosensitizers and bioreductively activated cytotoxins
    • (1990) Journal of Medicinal Chemistry , vol.33 , pp. 2603-2610
    • Jenkins1    Naylor2    O'Neill3
  • 100
    • 0024316466 scopus 로고
    • DNA topoisomerase poisons as antitumour drugs
    • (1989) Ann Rev Biochem , vol.58 , pp. 351-375
    • Liu1
  • 103
    • 0024358188 scopus 로고
    • DNA topoisomerase I-targeted chemotherapy of human colon cancer xenografts
    • (1989) Science , vol.246 , pp. 1046-1048
    • Giovanella1    Stehlin2    Wall3
  • 104
    • 0024427745 scopus 로고
    • Antimitotic natural products combrestatin A-4 and combretastatin A-2: Studies on the mechanism of their inhibition of the binding of colchicine to tubulin
    • (1989) Biochemistry , vol.28 , pp. 6981-6984
    • Lin1    Ho2    Pettit3    Hamel4
  • 110
    • 0025275582 scopus 로고
    • Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein in GTP hydrolysis
    • (1990) Nature , vol.345 , pp. 309-315
    • Schlichting1    Almo2    Rapp3
  • 111
    • 0024587230 scopus 로고
    • Protein structure determination in solution by nuclear magnetic resonance spectroscopy
    • (1989) Science , vol.243 , pp. 45-50
    • Wutrich1
  • 115
    • 0025112794 scopus 로고
    • Searching for peptide ligands with an epitope library
    • (1990) Science , vol.249 , pp. 386-390
    • Scott1    Smith2
  • 119
  • 121
    • 0027126095 scopus 로고
    • Biology approaches the teraflop era
    • Anon.
    • (1992) Science , vol.256 , pp. 440-442
  • 124
    • 0026342401 scopus 로고
    • Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase
    • (1991) Science , vol.253 , pp. 407-414
    • Knighton1    Zheng2    Ten Eyck3
  • 125
    • 0026326821 scopus 로고
    • Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase
    • (1992) Science , vol.253 , pp. 414-420
    • Knighton1    Zheng2    Ten Eyck3
  • 126
    • 0027124186 scopus 로고
    • Fishing in src-infested waters
    • (1992) Nature , vol.358 , pp. 625-626
    • Petsko1


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