Increased protein degradation and decreased protein synthesis in skeletal muscle during cancer cachexia

British Journal of Cancer

Volumn 67, Issue 4, 1993, Pages 680-685

  Smith, K L ^a   Tisdale, M J ^a  

^a ASTON UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NITROGEN; PHENYLALANINE;

ADENOCARCINOMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY MASS; CACHEXIA; DEGRADATION; FEMALE; GASTROCNEMIUS MUSCLE; IN VITRO STUDY; ISOTOPE LABELING; MOUSE; MUSCLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN SYNTHESIS; PROTEIN SYNTHESIS INHIBITION; SERUM; SKELETAL MUSCLE; TUMOR MODEL; WEIGHT REDUCTION;

ANIMAL; BODY COMPOSITION; BODY WEIGHT; CACHEXIA; FEMALE; MICE; MICE, INBRED STRAINS; MUSCLE PROTEINS; MUSCLES; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; NITROGEN; SUPPORT, NON-U.S. GOV'T;

EID: 0027414482     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.1993.126     Document Type: Article

References (22)

1. BARACOS, V.E. & GOLDBERG, A.L. (1986). Maintenance of normal length improves protein balance and energy status in isolated rat skeletal muscle. Am. J. Physiol., 251, C588.
2. BECK, S.A. & TISDALE, M.J. (1987). Production of lipolytic and proteolytic factors by a murine tumor-producing cachexia in the host. Cancer Res., 47, 5919.
3. BECK, S.A. & TISDALE, M.J. (1989). Nitrogen excretion in cancer cachexia and its modification by a high fat diet. Cancer Res., 49, 3800.
4. BELIZARIO, J.E., KATZ, M., CHENKER, K.E. & RAW, I. (1991). Bioactivity of skeletal muscle proteolysis-inducing factors in the plasma proteins from cancer patients with weight loss. Br. J. Cancer, 63, 705.
5. BIBBY, M.C., DOUBLE, J.A., ALI, S.A., FEARON, K.C.H., BRENNAN, R.A. & TISDALE, M.J. (1987). Characterisation of a transplantable adenocarcinoma of the mouse colon producing cachexia in recipient animals. J. Natl Cancer Inst., 78, 539.
6. CARRASCOSA, J.M., MARTINEZ, P. & NUNEZ DE CASTRO, I. (1984). Nitrogen movement between host and tumour in mice inoculated with Ehrlich ascitic tumour cells. Cancer Res., 44, 3831.
7. CLARK, C.M. & GOODLAD, G.A.J. (1971). Depletion of proteins of phasic and tonic muscles in tumor-bearing rats. Eur. J. Cancer, 7, 3.
8. de WYS, W.D. (1986). Weight loss and nutritional abnormalities in cancer patients: incidence, severity and significance. In Clinics in Oncology. Nutritional Support for the Cancer Patient. 5, p. 251, Caiman, K.C. & Fearon, K.C.H. (eds) W.B. Saunders Co: London.
9. EMERY, P.W., EDWARDS, R.H.T., RENNIE, M.J., SOUHAMI, R.L. & HALLIDAY, D. (1984). Protein synthesis in muscle measured in vivo in cachectic patients with cancer. Br. Med. J., 289, 584.
10. FLORES, E.A., BISTRIAN, B.R., POMPOSELLI, J.J., DINARELLO, C.A., BLACKBURN, G.L. & ISTFAN, N.N. (1989). Infusion of tumor necrosis factor/cachectin promotes muscle catabolism in the rat. A synergistic effect with interleukin 1. J. Clin. Invest., 83, 1614.
11. HELLERSTEIN, M.K., MEYDANI, S.N., MEYDAN, M., WU, K. & DINARELLO, C. (1989). Interleukin 1-induced anorexia in the rat. Influence of prostglandins. J. Clin. Invest., 84, 228.
12. LUNDHOLM, K., BYLUND, A C., HOLM, J., & SCHERSTEN, T. (1976). Skeletal muscle metabolism in patients with malignant tumour. Eur. J. Cancer, 12, 465.
13. MULLIGAN, H.D., MAHONY, S.M., ROSS, J.A. & TISDALE, M.J. (1992). Weight loss in a murine cachexia model is not associated with the cytokines tumour necrosis factor-alpha or interleukin-6. Cancer Lett., (in press).
14. NORTON, J.A., SHAMBERGER, R. & STEIN, T.P. (1981). The influence of tumour-bearing on protein metabolism in the rat. J. Surg. Res., 30, 456.
15. O’KEEFE, S.J.D., OGDEN, J., RAMJEE, G., & RUND, J. (1990). Contribution of elevated protein turnover and anorexia to cachexia in patients with hepatocellular carcinoma. Cancer Res., 50, 1226.
16. 2 a influence rates of protein turnover in skeletal and cardiac muscle. J. Biol. Chem., 257, 1632.
17. ROTMAN, E.I., BROSTROM, M.A. & BROSTROM, C O. (1992). Inhibition of protein synthesis in intact mammalian cells by arachidonic acid. Biochem. J., 282, 487.
18. SHAW, J.H., HUMBERSTONE, D.A., DOUGLAS, R.G. & KOEA, J. (1991). Leucine kinetics in patients with benign disease, nonweight-losing cancer and cancer cachexia: studies at the whole body and tissue level and the response to nutritional support. Surgery, 109, 37.
19. STRELKOV, A.B., FIELDS, A.L.A. & BARCOS, V.E. (1989). Effects of systemic inhibition of prostaglandin production on protein metabolism in tumor-bearing rats. Am. J. Physiol., 257, C261.
20. TESSITORE, L., BONNELLI, G., & BACCINO, F. (1987). Early development of protein metabolic perturbations in the liver and skeletal muscle of tumour-bearing rats. Biochem. J., 241, 153.
21. WAALKES, T.P. & UNDENFRIEND, S. (1957). A fluorimetric method for the estimation of tyrosine in plasma and tissues. J. Lab. Clin. Med., 50, 733.
22. WU, G. & THOMPSON, J R. (1988). The effect of ketone bodies on alanine and glutamine metabolism in isolated skeletal muscle from the fasted chick. Biochem. J., 255, 139.